4D Molecular Therapeutics Jobs Hiring Now
4D Molecular Therapeutics is hiring for 8 open roles on Migrate Mate as of July 16, 2026, concentrated in clinical support and program management, with listed salaries up to about $398,000. Migrate Mate updates 4D Molecular Therapeutics's live openings daily. 4D Molecular Therapeutics is a clinical-stage biopharmaceutical company focused on developing gene therapies using its proprietary adeno-associated virus engineering platform.
Find 4D Molecular Therapeutics JobsOverview
4D Molecular Therapeutics hiring data on Migrate Mate, as of July 16, 2026.
- Open jobs
- 8
- Top team
- Clinical Support
- Seniority
- Manager level or above
- Work type
- 75% remote or hybrid
- Top location
- Emeryville
- Salary range
- $150,000–$398,000
Listed salaries for 4D Molecular Therapeutics roles on Migrate Mate range from about $150,000 to $398,000 per year across 8 open roles, as of July 16, 2026. Some roles list hourly contract rates.
Open Roles at 4D Molecular Therapeutics
Showing 8 of 8+ 4D Molecular Therapeutics jobs
Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.
4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery
GENERAL SUMMARY
The Executive Medical Director will report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development, and will be responsible for the design, execution, and analysis of clinical trials in the ophthalmology therapeutic area
MAJOR DUTIES & RESPONSIBILITIES:
- Clinical Development Leadership
- Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
- Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
- Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
- Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
- Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
- Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
- Biomarker & Translational Strategy
- Lead development and implementation of biomarker strategies for GA and broader retina programs
- Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
- Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
- Regulatory & Clinical Documentation
- Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
- Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
- Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
- External Scientific Leadership
- Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.
- Works with the research organization and the portfolio management team to identify and support new project opportunities.
- Collaborates to identify program risks, and to create and implement mitigation strategies
- Other duties as assigned
QUALIFICATIONS:
Education:
- Medical Degree (M.D.), other degrees considered with relevant experience
- Residency training in Ophthalmology with a preference for subspecialty training in retina
- Board certification/retina fellowship training are a plus
Experience:
- 10+ years of clinical ophthalmology research in the biopharmaceutical industry
- Experience with medical monitoring and oversight of Phase 1 retina clinical trials
- Experience with gene therapy clinical studies
- Experience in other phases (Phase 2, 3) of clinical research.
- Experience with NDA/BLA/MAA submission planning and execution
- Experience in data analysis, data interpretation, and medical writing
Other Qualifications/Skills:
- Knowledge of ICH-GCP and FDA regulatory guidelines.
- Knowledge of international regulatory guidelines
- Effective written and verbal communication skills, including public speaking
Travel: up to 20%
Physical Requirements and Working Conditions:
- Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word.
- Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
- Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).
Base salary compensation range: $350,000 - 398,000
Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate's geographical location, relevant work experience, skills, and years of experience.
Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.
4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery
GENERAL SUMMARY
The Executive Medical Director will report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development, and will be responsible for the design, execution, and analysis of clinical trials in the ophthalmology therapeutic area
MAJOR DUTIES & RESPONSIBILITIES:
- Clinical Development Leadership
- Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
- Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
- Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
- Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
- Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
- Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
- Biomarker & Translational Strategy
- Lead development and implementation of biomarker strategies for GA and broader retina programs
- Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
- Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
- Regulatory & Clinical Documentation
- Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
- Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
- Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
- External Scientific Leadership
- Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.
- Works with the research organization and the portfolio management team to identify and support new project opportunities.
- Collaborates to identify program risks, and to create and implement mitigation strategies
- Other duties as assigned
QUALIFICATIONS:
Education:
- Medical Degree (M.D.), other degrees considered with relevant experience
- Residency training in Ophthalmology with a preference for subspecialty training in retina
- Board certification/retina fellowship training are a plus
Experience:
- 10+ years of clinical ophthalmology research in the biopharmaceutical industry
- Experience with medical monitoring and oversight of Phase 1 retina clinical trials
- Experience with gene therapy clinical studies
- Experience in other phases (Phase 2, 3) of clinical research.
- Experience with NDA/BLA/MAA submission planning and execution
- Experience in data analysis, data interpretation, and medical writing
Other Qualifications/Skills:
- Knowledge of ICH-GCP and FDA regulatory guidelines.
- Knowledge of international regulatory guidelines
- Effective written and verbal communication skills, including public speaking
Travel: up to 20%
Physical Requirements and Working Conditions:
- Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word.
- Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
- Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).
Base salary compensation range: $350,000 - 398,000
Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate's geographical location, relevant work experience, skills, and years of experience.
Job Roles at 4D Molecular Therapeutics
Working at 4D Molecular Therapeutics
4D Molecular Therapeutics's 8 open roles are manager level or above, and about 75% are remote or hybrid. The most active teams are clinical support, program management, and business development. 4D Molecular Therapeutics is a clinical-stage biopharmaceutical company developing next-generation gene therapies across disease areas including retinal conditions and lung disease. The company operates at the intersection of translational science and clinical development, with roles spanning medical affairs, clinical operations, financial planning, and research informatics. Most 4D Molecular Therapeutics roles are based in Emeryville.
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Browse jobs by role4D Molecular Therapeutics Jobs: Frequently Asked Questions
How many jobs is 4D Molecular Therapeutics hiring for right now?
4D Molecular Therapeutics is hiring for 8 open roles on Migrate Mate as of July 16, 2026, updated daily, concentrated in clinical support and program management. Roles range from clinical operations and medical affairs to financial planning and research informatics. Migrate Mate pulls 4D Molecular Therapeutics's listings directly so the count reflects what is actively open.
What kinds of roles does 4D Molecular Therapeutics hire for?
The most active teams are clinical support, program management, and business development. 4D Molecular Therapeutics hires across clinical development, medical affairs, regulatory, finance, and research functions, including positions such as clinical trial managers, medical directors, clinical operations directors, and research informatics analysts. Contract and full-time positions are both available. Most postings are manager level or above.
Are 4D Molecular Therapeutics jobs remote or in-person?
Mostly remote. About 75% of 4D Molecular Therapeutics's open roles on Migrate Mate are remote or hybrid as of July 16, 2026, with the rest based in Emeryville. Each 4D Molecular Therapeutics listing shows its work location so you can filter before applying.
How do I apply to a job at 4D Molecular Therapeutics?
Find a role that fits your background in the 4D Molecular Therapeutics listings on Migrate Mate, then follow the link through to 4D Molecular Therapeutics' own careers page to submit your application directly. 4D Molecular Therapeutics manages its own hiring process, including screening, interviews, and offers. Migrate Mate does not accept or forward applications on the company's behalf.
What do 4D Molecular Therapeutics jobs pay?
Listed salaries for 4D Molecular Therapeutics roles on Migrate Mate range from about $150,000 to $398,000 per year as of July 16, 2026, with most postings at manager level or above. Some roles list hourly contract rates. Exact pay is set by 4D Molecular Therapeutics and shown on each listing.
Does 4D Molecular Therapeutics hire entry-level?
Most of 4D Molecular Therapeutics's open roles on Migrate Mate are manager level or above as of July 16, 2026. Entry-level openings are limited. Check individual 4D Molecular Therapeutics listings for stated experience requirements.
Where is 4D Molecular Therapeutics hiring?
Most 4D Molecular Therapeutics roles are based in Emeryville, and about 75% offer remote or hybrid work as of July 16, 2026. Migrate Mate shows the location on each listing.