Ionis Pharmaceuticals, Inc. Jobs Hiring Now
Ionis Pharmaceuticals, Inc. is hiring for 12 open roles on Migrate Mate as of July 16, 2026, concentrated in laboratory research and patient services & wellbeing, with listed salaries up to about $265,000. Migrate Mate updates Ionis Pharmaceuticals, Inc.'s live openings daily. Ionis Pharmaceuticals is a biotechnology company focused on RNA-targeted drug discovery and development, with a pipeline spanning rare diseases, cardiovascular conditions, and neurological disorders.
Find Ionis Pharmaceuticals, Inc. JobsOverview
Ionis Pharmaceuticals, Inc. hiring data on Migrate Mate, as of July 16, 2026.
- Open jobs
- 12
- Top team
- Laboratory Research
- Seniority
- Manager level or above
- Work type
- 17% remote or hybrid
- Top location
- Carlsbad
- Salary range
- $80,000–$265,000
Listed salaries for Ionis Pharmaceuticals, Inc. roles on Migrate Mate range from about $80,000 to $265,000 per year across 12 open roles, as of July 16, 2026.
Open Roles at Ionis Pharmaceuticals, Inc.
Showing 12 of 12+ Ionis Pharmaceuticals, Inc. jobs
INTRODUCTION
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!
DIRECTOR, DMPK - PHARMACOKINETICS & CLINICAL PHARMACOLOGY
Responsibilities
- Drive DMPK strategy for programs in Discovery and Development phases and represent the DMPK function to project management and leadership teams
- Coordinate, design, and interpret Discovery and Development phase CRO-based ADME evaluations of novel RNA therapeutics including radio-labelled, CYP and transporter related DDI assessment, protein binding, plasma blood cell partition, and PK studies by working with PK scientists/project leads and provide guidance to Discovery and Development project teams
- Lead an internal lab for metabolism evaluation to provide guidance and expertise on metabolite ID with innovative methodologies and bioanalytical methodologies for new chemical entities including ASO, siRNA, ligand-conjugated targeting strategies, and other molecular modalities
- Interact with medicinal analytical chemistry team to support structural modifications to optimize ADME characteristics of compounds in lead optimization
- Provide expert advice and guidance on IND enabling ADME and PK studies from protocol to finalized reports
- Author DMPK sections of regulatory submissions (IND/CTA, IB, NDA, etc)
- Successfully identify and manage CROs regarding DMPK study execution and reporting to meet program timelines, develop effective relationships with external consultants
- Support PK modeling to inform clinical dosing strategies by working with PK/clin pharm scientists
- This position will have direct report(s)
Requirements
- Ph.D. in relevant biomedical research with 12+ years DMPK experience in pharmaceutical drug discovery and development
- Strong track record of publications and authoring submission documents, addressing regulatory questions
- Proven ability to drive drug discovery projects from early development through candidate selection and IND
- In-depth conceptual and technical expertise in drug metabolism and bioanalysis in NME discovery and development programs, especially ASO, siRNA and RNA therapeutics experiences are highly desirable
- Experience with in vitro/in vivo cross species ADME, mass balance, and DDI studies
- Expertise on metabolite ID and method development, extensive experience in LC-MS/MS, LC-ToF MS, and LC-HRMS
- Strong understanding and experience in interpreting DMPK data and the relationships between metabolism and pharmacokinetics
- Excellent verbal and written communication skills, as well as the ability to contribute effectively in fast-moving inter-disciplinary project teams
- Experience with external vendor management such as CROs and consultants
- Must have solid grasp of ICH regulatory guidance documents relevant to DMPK activities
COMPENSATION
- The pay scale for this position is $216,439 to $265,200
Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
INTRODUCTION
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!
DIRECTOR, DMPK - PHARMACOKINETICS & CLINICAL PHARMACOLOGY
Responsibilities
- Drive DMPK strategy for programs in Discovery and Development phases and represent the DMPK function to project management and leadership teams
- Coordinate, design, and interpret Discovery and Development phase CRO-based ADME evaluations of novel RNA therapeutics including radio-labelled, CYP and transporter related DDI assessment, protein binding, plasma blood cell partition, and PK studies by working with PK scientists/project leads and provide guidance to Discovery and Development project teams
- Lead an internal lab for metabolism evaluation to provide guidance and expertise on metabolite ID with innovative methodologies and bioanalytical methodologies for new chemical entities including ASO, siRNA, ligand-conjugated targeting strategies, and other molecular modalities
- Interact with medicinal analytical chemistry team to support structural modifications to optimize ADME characteristics of compounds in lead optimization
- Provide expert advice and guidance on IND enabling ADME and PK studies from protocol to finalized reports
- Author DMPK sections of regulatory submissions (IND/CTA, IB, NDA, etc)
- Successfully identify and manage CROs regarding DMPK study execution and reporting to meet program timelines, develop effective relationships with external consultants
- Support PK modeling to inform clinical dosing strategies by working with PK/clin pharm scientists
- This position will have direct report(s)
Requirements
- Ph.D. in relevant biomedical research with 12+ years DMPK experience in pharmaceutical drug discovery and development
- Strong track record of publications and authoring submission documents, addressing regulatory questions
- Proven ability to drive drug discovery projects from early development through candidate selection and IND
- In-depth conceptual and technical expertise in drug metabolism and bioanalysis in NME discovery and development programs, especially ASO, siRNA and RNA therapeutics experiences are highly desirable
- Experience with in vitro/in vivo cross species ADME, mass balance, and DDI studies
- Expertise on metabolite ID and method development, extensive experience in LC-MS/MS, LC-ToF MS, and LC-HRMS
- Strong understanding and experience in interpreting DMPK data and the relationships between metabolism and pharmacokinetics
- Excellent verbal and written communication skills, as well as the ability to contribute effectively in fast-moving inter-disciplinary project teams
- Experience with external vendor management such as CROs and consultants
- Must have solid grasp of ICH regulatory guidance documents relevant to DMPK activities
COMPENSATION
- The pay scale for this position is $216,439 to $265,200
Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Job Roles at Ionis Pharmaceuticals, Inc.
Working at Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc.'s 12 open roles are manager level or above, and about 17% are remote or hybrid. The most active teams are laboratory research, patient services & wellbeing, and allied health. Ionis Pharmaceuticals is a biotechnology company specializing in RNA-targeted therapeutics, employing scientists, clinicians, and research professionals across drug discovery, analytical development, pharmacokinetics, and medical affairs. The work spans early research through clinical-stage programs in areas including rare and cardiometabolic diseases. Most Ionis Pharmaceuticals, Inc. roles are based in Carlsbad, with some in Boston and Remote.
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Browse jobs by roleIonis Pharmaceuticals, Inc. Jobs: Frequently Asked Questions
How many jobs is Ionis Pharmaceuticals, Inc. hiring for right now?
Ionis Pharmaceuticals, Inc. is hiring for 12 open roles on Migrate Mate as of July 16, 2026, updated daily, concentrated in laboratory research and patient services & wellbeing. Roles range from research associate positions to director-level openings across scientific and clinical functions. Migrate Mate pulls the latest postings directly so the count reflects what is actively open.
What kinds of roles does Ionis Pharmaceuticals, Inc. hire for?
The most active teams are laboratory research, patient services & wellbeing, and allied health. Ionis Pharmaceuticals hires across scientific research, analytical development and quality control, medicinal chemistry, drug metabolism and pharmacokinetics, clinical pharmacology, and medical writing. Most postings are manager level or above, with titles spanning research associate, senior scientist, and director levels. Both laboratory-based and clinical development roles appear regularly in the active listings.
Are Ionis Pharmaceuticals, Inc. jobs remote or in-person?
Mostly on-site. About 17% of Ionis Pharmaceuticals, Inc.'s open roles on Migrate Mate are remote or hybrid as of July 16, 2026, with the rest based in Carlsbad. Each Ionis Pharmaceuticals, Inc. listing shows its work location so you can filter before applying.
How do I apply to a job at Ionis Pharmaceuticals, Inc.?
Find a role that fits your background in Ionis Pharmaceuticals, Inc.'s listings on Migrate Mate, then follow the listing through to Ionis Pharmaceuticals' own careers page to submit your application. Ionis Pharmaceuticals, Inc. manages its own hiring process, including screening, interviews, and offers. Migrate Mate does not collect applications or act as an intermediary.
What do Ionis Pharmaceuticals, Inc. jobs pay?
Listed salaries for Ionis Pharmaceuticals, Inc. roles on Migrate Mate range from about $80,000 to $265,000 per year as of July 16, 2026, with most postings at manager level or above. Exact pay is set by Ionis Pharmaceuticals, Inc. and shown on each listing.
Does Ionis Pharmaceuticals, Inc. hire entry-level?
Most of Ionis Pharmaceuticals, Inc.'s open roles on Migrate Mate are manager level or above as of July 16, 2026. Entry-level openings are limited. Check individual Ionis Pharmaceuticals, Inc. listings for stated experience requirements.
Where is Ionis Pharmaceuticals, Inc. hiring?
Most Ionis Pharmaceuticals, Inc. roles are based in Carlsbad, with some in Boston and Remote, and about 17% offer remote or hybrid work as of July 16, 2026. Migrate Mate shows the location on each listing.