Karyopharm Therapeutics Jobs Hiring Now
Karyopharm Therapeutics is hiring for 41 open roles on Migrate Mate as of July 16, 2026, concentrated in clinical support and medical specialists, with listed salaries up to about $380,000. Migrate Mate updates Karyopharm Therapeutics's live openings daily. Karyopharm Therapeutics is a commercial-stage biopharmaceutical company focused on the development and commercialization of oncology therapies, with a portfolio concentrated in hematology and solid tumor indications.
Find Karyopharm Therapeutics JobsOverview
Karyopharm Therapeutics hiring data on Migrate Mate, as of July 16, 2026.
- Open jobs
- 41
- Top team
- Clinical Support
- Seniority
- Across all levels
- Work type
- 0% remote or hybrid
- Top location
- Remote
- Salary range
- $115,000–$380,000
Listed salaries for Karyopharm Therapeutics roles on Migrate Mate range from about $115,000 to $380,000 per year across 41 open roles, as of July 16, 2026.
Open Roles at Karyopharm Therapeutics
Showing 25 of 41+ Karyopharm Therapeutics jobs
RESPONSIBILITIES:
- Represent department as medical safety lead on cross-functional study and program teams for assigned products and studies, providing expert guidance regarding safety matters and issues.
- Provide timely and sound medical review of individual case safety reports from clinical trials or post-marketing sources as needed.
- Participate in protocol development, specifically the monitoring and collection of safety information in clinical trial protocols, as well as statistical analysis plans.
- Participate in the analysis of safety data from on-going and completed clinical trials and representation in Clinical Study Reports.
- Contribute to preparation and review of periodic reports (IND, Annual Safety, DSUR, PBRERs,).
- Review and provide medical content, as needed, for key study-related documents, e.g. protocols, IB, ICF, IDMC Charter.
- Participate in departmental development activities including SOP and Work Instructions development.
- Provide guidance to staff regarding optimal practice regarding collection, evaluation and processing of adverse experience reports, from a medical perspective.
- Provide a contributory role in Partner /Affiliate agreements and interactions, as needed.
- As directed by the PV Head, assume primary responsibility/chair for the conduct of one or more Safety Team(s) for assigned products.
- Participate in the regular review of safety data for assigned products for the identification of new safety signals, in accordance with signal detection practices.
- Participate in Risk Management Strategy.
- Other activities, as needed or as requested by manager.
- MD, DO or MBBS.
- Minimum of 15 years Drug Safety/Pharmacovigilance
- Solid knowledge of General Medicine
- Residency training preferred
- Adequate knowledge of GCP, ICH and Global regulations.
- Prior NDA experience and oncology experience preferred.
- Knowledge of principles of epidemiology and statistics required
- Experienced in the evaluation and interpretation of data.
- Ability to multi-task.
- Solid written and oral communication skills.
- Solid judgment and decision-making skills, including the identification and communication of relevant safety- related issues or concerns to Medical Safety Management in an appropriate and timely manner.
- Experienced in safety reviews of AEs/SAEs, IBs, protocols, clinical study reports, informed consents, and other safety-related documents
At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $310 K - $380 K USD.
This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs.
Our lead therapy, XPOVIO® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor.
As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.
Learn more at Karyopharm Therapeutics.
RESPONSIBILITIES:
- Represent department as medical safety lead on cross-functional study and program teams for assigned products and studies, providing expert guidance regarding safety matters and issues.
- Provide timely and sound medical review of individual case safety reports from clinical trials or post-marketing sources as needed.
- Participate in protocol development, specifically the monitoring and collection of safety information in clinical trial protocols, as well as statistical analysis plans.
- Participate in the analysis of safety data from on-going and completed clinical trials and representation in Clinical Study Reports.
- Contribute to preparation and review of periodic reports (IND, Annual Safety, DSUR, PBRERs,).
- Review and provide medical content, as needed, for key study-related documents, e.g. protocols, IB, ICF, IDMC Charter.
- Participate in departmental development activities including SOP and Work Instructions development.
- Provide guidance to staff regarding optimal practice regarding collection, evaluation and processing of adverse experience reports, from a medical perspective.
- Provide a contributory role in Partner /Affiliate agreements and interactions, as needed.
- As directed by the PV Head, assume primary responsibility/chair for the conduct of one or more Safety Team(s) for assigned products.
- Participate in the regular review of safety data for assigned products for the identification of new safety signals, in accordance with signal detection practices.
- Participate in Risk Management Strategy.
- Other activities, as needed or as requested by manager.
- MD, DO or MBBS.
- Minimum of 15 years Drug Safety/Pharmacovigilance
- Solid knowledge of General Medicine
- Residency training preferred
- Adequate knowledge of GCP, ICH and Global regulations.
- Prior NDA experience and oncology experience preferred.
- Knowledge of principles of epidemiology and statistics required
- Experienced in the evaluation and interpretation of data.
- Ability to multi-task.
- Solid written and oral communication skills.
- Solid judgment and decision-making skills, including the identification and communication of relevant safety- related issues or concerns to Medical Safety Management in an appropriate and timely manner.
- Experienced in safety reviews of AEs/SAEs, IBs, protocols, clinical study reports, informed consents, and other safety-related documents
At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $310 K - $380 K USD.
This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs.
Our lead therapy, XPOVIO® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor.
As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.
Learn more at Karyopharm Therapeutics.
Job Roles at Karyopharm Therapeutics
Working at Karyopharm Therapeutics
Karyopharm Therapeutics's 41 open roles are across all levels, and about 0% are remote or hybrid. The most active teams are clinical support, medical specialists, and sales. Karyopharm Therapeutics is a commercial-stage biopharmaceutical company that develops and markets therapies for cancer, with a focus on hematologic malignancies and solid tumors. Its roles span medical affairs, field-based oncology sales, quality systems, and clinical education, drawing professionals with backgrounds in oncology, pharmaceutical sciences, and regulated manufacturing. Most Karyopharm Therapeutics roles are based in Remote, with some in Newton and United States.
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Browse jobs by roleKaryopharm Therapeutics Jobs: Frequently Asked Questions
How many jobs is Karyopharm Therapeutics hiring for right now?
Karyopharm Therapeutics is hiring for 41 open roles on Migrate Mate as of July 16, 2026, updated daily, concentrated in clinical support and medical specialists. Roles span medical affairs, oncology field positions, quality systems, and clinical education. Migrate Mate pulls directly from Karyopharm Therapeutics's postings so the count reflects what is actively open.
What kinds of roles does Karyopharm Therapeutics hire for?
The most active teams are clinical support, medical specialists, and sales. Karyopharm Therapeutics hires across medical science liaison positions in hematology and solid tumors, hematology and oncology specialist roles, medical affairs clinical nurse educators, and quality management and GMP quality leadership. Most postings are across all levels, reflecting the company's need for experienced oncology and pharmaceutical professionals.
Are Karyopharm Therapeutics jobs remote or in-person?
Mostly on-site. About 0% of Karyopharm Therapeutics's open roles on Migrate Mate are remote or hybrid as of July 16, 2026, with the rest based in Remote. Each Karyopharm Therapeutics listing shows its work location so you can filter before applying.
How do I apply to a job at Karyopharm Therapeutics?
Find a role that fits your background in Karyopharm Therapeutics' listings on Migrate Mate, then follow the link through to Karyopharm Therapeutics's own careers site to submit your application. Karyopharm Therapeutics manages its hiring process directly, including application review, interviews, and offers. Migrate Mate does not collect or forward applications on the company's behalf.
What do Karyopharm Therapeutics jobs pay?
Listed salaries for Karyopharm Therapeutics roles on Migrate Mate range from about $115,000 to $380,000 per year as of July 16, 2026, with most postings at across all levels. Exact pay is set by Karyopharm Therapeutics and shown on each listing.
Does Karyopharm Therapeutics hire entry-level?
Most of Karyopharm Therapeutics's open roles on Migrate Mate are across all levels as of July 16, 2026. Check individual Karyopharm Therapeutics listings for stated experience requirements.
Where is Karyopharm Therapeutics hiring?
Most Karyopharm Therapeutics roles are based in Remote, with some in Newton and United States, and about 0% offer remote or hybrid work as of July 16, 2026. Migrate Mate shows the location on each listing.