Loyal Jobs Hiring Now
Loyal is hiring for 5 open roles on Migrate Mate as of July 16, 2026, concentrated in healthcare administration and business strategy, with listed salaries up to about $425,000. Migrate Mate updates Loyal's live openings daily. Loyal is a biotechnology and life sciences company focused on drug development and clinical research, as evidenced by its roles spanning regulatory affairs, clinical development, and pharmaceutical science.
Find Loyal JobsOverview
Loyal hiring data on Migrate Mate, as of July 16, 2026.
- Open jobs
- 5
- Top team
- Healthcare Administration
- Seniority
- Manager level or above
- Work type
- 100% remote or hybrid
- Top location
- Remote
- Salary range
- $155,000–$425,000
Listed salaries for Loyal roles on Migrate Mate range from about $155,000 to $425,000 per year across 5 open roles, as of July 16, 2026.
Open Roles at Loyal
Showing 5 of 5+ Loyal jobs
About Loyal
Loyal is a clinical-stage veterinary medicine company developing longevity drugs for dogs. Our mission is to help dogs live longer, healthier lives.
We're pioneering a new category of veterinary prescription drugs that proactively and preventatively target the underlying drivers of aging, delaying the onset of disease and preserving quality of life as dogs age. We've already made significant progress in our mission to develop the first FDA-approved drugs to extend canine lifespan: as of early 2026 we've completed two of three major FDA review sections for our lead program, LOY-002, and are targeting submission of the third and final section later this year.
Loyal is a well-funded startup with teams of scientists, veterinarians, engineers, operators, and creatives. You'll help us continue on our path of earning FDA approval for the first lifespan extension medicine for any species — and change what's possible for the dogs we love.
About the role
Loyal is seeking a Senior Principal Scientist, Drug Substance to serve as the technical leader for drug substance process development and manufacturing from early development through commercialization. This high-impact, externally-facing role will drive drug substance process development and manufacturing, and deliver flawless execution across CDMO partners while serving as the internal subject matter expert informing cross-functional decision-making and long-term development strategy across Loyal's growing pipeline.
You will be reporting to our VP of Manufacturing
Your daily work will include
- Lead end-to-end drug substance process development and manufacturing for small molecule APIs from synthetic route assessment and impurity control through scale-up, technology transfer, and commercial manufacturing readiness at CDMOs.
- Serve as the primary technical interface with drug substance CDMOs spanning partner selection, day-to-day oversight, troubleshooting, PAI preparation and performance management; ensure drug substance supply continuity, including second source qualification and starting material supply risk strategy, in support of clinical and commercial manufacturing.
- Lead RSM designation, ICH Q11 assessments, impurity fate and purge strategies and ICH M7 mutagenic impurity risk assessments; establish CQAs, CPPs, and ICH Q6A-aligned control strategies.
- Lead drug substance process validation from PPQ protocol development through batch execution and CPP/CQA verification; align PPQ timelines and batch disposition with drug product process validation and registration batch campaigns.
- Author, review, and approve drug substance CMC sections for regulatory submissions (VMF, INAD/NADA); represent drug substance CMC in agency interactions and ensure a technically integrated and consistent regulatory package.
- Partner with drug product development to translate drug substance CQAs into formulation design, excipient selection, container closure strategy and final dosage form decisions.
- Partner with analytical development to define method development, qualification, and validation strategy for drug substance release and stability testing.
- Partner with Quality to align drug substance specifications, batch disposition, and GMP compliance across CDMOs, and to support inspection and regulatory submission readiness.
- Manage drug substance post-approval change control strategy for manufacturing changes at CDMOs.
About you
- Ph.D. in Chemistry, Chemical Engineering, Biochemistry, or a related discipline.
- 12+ years of industry experience in drug substance process development and manufacturing, with demonstrated ownership from early development through regulatory submission and commercialization phase.
- Hands-on expertise in small molecule API process development, including synthetic process understanding, impurity profiling, ICH Q11 RSM assessment, and ICH M7 mutagenic impurity control.
- Proven experience selecting, managing, and technically overseeing CDMOs for small molecule drug substance development, scale-up, technology transfer and PPQ.
- Demonstrated experience authoring and defending drug substance CMC regulatory submissions (INAD/NADA, VMF or equivalent) and interacting with regulatory agencies on CMC questions.
- Deep knowledge of applicable regulatory frameworks: ICH Q7, Q8, Q9, Q10, Q11, Q6A, M7, and relevant VICH guidelines for veterinary drug substances.
- Demonstrated ability to operate effectively in a dynamic, fast-paced startup environment with a high degree of autonomy and accountability.
- Experience with large biomolecule drug substance development (peptides, proteins, or other biological entities) preferred but not required.
- Veterinary dosage form experience preferred but not required.
Salary Range: $175,000 - $230,000
Loyal benefits
- Full-coverage health insurance — medical, dental and vision — for you and your dependents
- $1,000 home office equipment stipend
- $1,200/year learning budget for books, courses, etc.
- $250/month wellness budget for gym, cleaners, spa, food, etc.
- All 3-day weekends are turned into 4-day weekends
- Unlimited vacation and paid holidays
- Paw-ternity leave — adopt a dog and get a day off with your new family member
- Competitive salary
- Company equity options grant for new hires
Loyal is founded and led by a first-gen female CEO and is proud to be an equal opportunity employer. We do not discriminate against applicants based on gender, race or color, ethnicity or national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or any other applicable characteristics protected by law.
Our values
Moonshots, derisked methodically
Bringing the first longevity drug to market is an extremely difficult technical and social pursuit. To achieve this we must take bigger bets than the field has historically made, paired with the technical rigor to de-risk them step by step. We plan on both short and extremely long timescales, and we have the conviction to see our vision through to success or failure.
Opportunity is at the intersection
We lean into combining disciplines, expertise, and perspectives not normally adjacent. We design our organization to facilitate cross-pollination and cross-collaboration. We reject silos.
Expertise without ego
Titles do not determine who has a voice. We push back on each other, ask questions instead of issuing orders, and try to prove ourselves wrong. We are emotionally attached to the outcome, not our personal hypotheses, and welcome being challenged instead of treating it as a threat.
High agency, high humility
Most of what we're doing has never been done before, so we can't rely on established precedents to guide our way. We move forward to generate clarity, build strategies resilient to the fact that we don't know what we don't know, and design small experiments where we can fail safely, without jeopardizing the bigger mission.
Lead with transparency and context
We proactively and consistently share the why behind our strategy - not just the what - because we believe sharing context enables great people to make great decisions.
Empathy and respect for all life
Our patients are not just numbers. We deeply respect the value of every life, large and small and take our ethical responsibility to the families we treat extremely seriously.
About Loyal
Loyal is a clinical-stage veterinary medicine company developing longevity drugs for dogs. Our mission is to help dogs live longer, healthier lives.
We're pioneering a new category of veterinary prescription drugs that proactively and preventatively target the underlying drivers of aging, delaying the onset of disease and preserving quality of life as dogs age. We've already made significant progress in our mission to develop the first FDA-approved drugs to extend canine lifespan: as of early 2026 we've completed two of three major FDA review sections for our lead program, LOY-002, and are targeting submission of the third and final section later this year.
Loyal is a well-funded startup with teams of scientists, veterinarians, engineers, operators, and creatives. You'll help us continue on our path of earning FDA approval for the first lifespan extension medicine for any species — and change what's possible for the dogs we love.
About the role
Loyal is seeking a Senior Principal Scientist, Drug Substance to serve as the technical leader for drug substance process development and manufacturing from early development through commercialization. This high-impact, externally-facing role will drive drug substance process development and manufacturing, and deliver flawless execution across CDMO partners while serving as the internal subject matter expert informing cross-functional decision-making and long-term development strategy across Loyal's growing pipeline.
You will be reporting to our VP of Manufacturing
Your daily work will include
- Lead end-to-end drug substance process development and manufacturing for small molecule APIs from synthetic route assessment and impurity control through scale-up, technology transfer, and commercial manufacturing readiness at CDMOs.
- Serve as the primary technical interface with drug substance CDMOs spanning partner selection, day-to-day oversight, troubleshooting, PAI preparation and performance management; ensure drug substance supply continuity, including second source qualification and starting material supply risk strategy, in support of clinical and commercial manufacturing.
- Lead RSM designation, ICH Q11 assessments, impurity fate and purge strategies and ICH M7 mutagenic impurity risk assessments; establish CQAs, CPPs, and ICH Q6A-aligned control strategies.
- Lead drug substance process validation from PPQ protocol development through batch execution and CPP/CQA verification; align PPQ timelines and batch disposition with drug product process validation and registration batch campaigns.
- Author, review, and approve drug substance CMC sections for regulatory submissions (VMF, INAD/NADA); represent drug substance CMC in agency interactions and ensure a technically integrated and consistent regulatory package.
- Partner with drug product development to translate drug substance CQAs into formulation design, excipient selection, container closure strategy and final dosage form decisions.
- Partner with analytical development to define method development, qualification, and validation strategy for drug substance release and stability testing.
- Partner with Quality to align drug substance specifications, batch disposition, and GMP compliance across CDMOs, and to support inspection and regulatory submission readiness.
- Manage drug substance post-approval change control strategy for manufacturing changes at CDMOs.
About you
- Ph.D. in Chemistry, Chemical Engineering, Biochemistry, or a related discipline.
- 12+ years of industry experience in drug substance process development and manufacturing, with demonstrated ownership from early development through regulatory submission and commercialization phase.
- Hands-on expertise in small molecule API process development, including synthetic process understanding, impurity profiling, ICH Q11 RSM assessment, and ICH M7 mutagenic impurity control.
- Proven experience selecting, managing, and technically overseeing CDMOs for small molecule drug substance development, scale-up, technology transfer and PPQ.
- Demonstrated experience authoring and defending drug substance CMC regulatory submissions (INAD/NADA, VMF or equivalent) and interacting with regulatory agencies on CMC questions.
- Deep knowledge of applicable regulatory frameworks: ICH Q7, Q8, Q9, Q10, Q11, Q6A, M7, and relevant VICH guidelines for veterinary drug substances.
- Demonstrated ability to operate effectively in a dynamic, fast-paced startup environment with a high degree of autonomy and accountability.
- Experience with large biomolecule drug substance development (peptides, proteins, or other biological entities) preferred but not required.
- Veterinary dosage form experience preferred but not required.
Salary Range: $175,000 - $230,000
Loyal benefits
- Full-coverage health insurance — medical, dental and vision — for you and your dependents
- $1,000 home office equipment stipend
- $1,200/year learning budget for books, courses, etc.
- $250/month wellness budget for gym, cleaners, spa, food, etc.
- All 3-day weekends are turned into 4-day weekends
- Unlimited vacation and paid holidays
- Paw-ternity leave — adopt a dog and get a day off with your new family member
- Competitive salary
- Company equity options grant for new hires
Loyal is founded and led by a first-gen female CEO and is proud to be an equal opportunity employer. We do not discriminate against applicants based on gender, race or color, ethnicity or national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or any other applicable characteristics protected by law.
Our values
Moonshots, derisked methodically
Bringing the first longevity drug to market is an extremely difficult technical and social pursuit. To achieve this we must take bigger bets than the field has historically made, paired with the technical rigor to de-risk them step by step. We plan on both short and extremely long timescales, and we have the conviction to see our vision through to success or failure.
Opportunity is at the intersection
We lean into combining disciplines, expertise, and perspectives not normally adjacent. We design our organization to facilitate cross-pollination and cross-collaboration. We reject silos.
Expertise without ego
Titles do not determine who has a voice. We push back on each other, ask questions instead of issuing orders, and try to prove ourselves wrong. We are emotionally attached to the outcome, not our personal hypotheses, and welcome being challenged instead of treating it as a threat.
High agency, high humility
Most of what we're doing has never been done before, so we can't rely on established precedents to guide our way. We move forward to generate clarity, build strategies resilient to the fact that we don't know what we don't know, and design small experiments where we can fail safely, without jeopardizing the bigger mission.
Lead with transparency and context
We proactively and consistently share the why behind our strategy - not just the what - because we believe sharing context enables great people to make great decisions.
Empathy and respect for all life
Our patients are not just numbers. We deeply respect the value of every life, large and small and take our ethical responsibility to the families we treat extremely seriously.
Job Roles at Loyal
Working at Loyal
Loyal's 5 open roles are manager level or above, and about 100% are remote or hybrid. The most active teams are healthcare administration and business strategy. Loyal operates in the biotechnology and life sciences sector, with work spanning drug substance development, clinical research, regulatory affairs, and executive leadership. The company's open positions reflect a focus on senior scientific and operational talent across pharmaceutical development disciplines. Most Loyal roles are based in Remote.
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Browse jobs by roleLoyal Jobs: Frequently Asked Questions
How many jobs is Loyal hiring for right now?
Loyal is hiring for 5 open roles on Migrate Mate as of July 16, 2026, updated daily, concentrated in healthcare administration and business strategy. Loyal's current openings span executive leadership, clinical development, regulatory affairs, and pharmaceutical science, with most positions at a senior level.
What kinds of roles does Loyal hire for?
The most active teams are healthcare administration and business strategy. Loyal hires across scientific, clinical, regulatory, and executive functions, including roles in drug substance development, clinical development strategy, regulatory affairs, and senior finance and operations leadership. Most postings are manager level or above, reflecting a team built around experienced professionals in biotechnology and life sciences.
Are Loyal jobs remote or in-person?
Mostly remote. About 100% of Loyal's open roles on Migrate Mate are remote or hybrid as of July 16, 2026, with the rest based in Remote. Each Loyal listing shows its work location so you can filter before applying.
How do I apply to a job at Loyal?
Find a Loyal role that fits your background on Migrate Mate, then follow the listing through to Loyal's own application process. Loyal manages its hiring directly, so the application, interviews, and any follow-up steps are handled by the company's own team.
What do Loyal jobs pay?
Listed salaries for Loyal roles on Migrate Mate range from about $155,000 to $425,000 per year as of July 16, 2026, with most postings at manager level or above. Exact pay is set by Loyal and shown on each listing.
Does Loyal hire entry-level?
Most of Loyal's open roles on Migrate Mate are manager level or above as of July 16, 2026. Entry-level openings are limited. Check individual Loyal listings for stated experience requirements.
Where is Loyal hiring?
Most Loyal roles are based in Remote, and about 100% offer remote or hybrid work as of July 16, 2026. Migrate Mate shows the location on each listing.