Novo Nordisk, Inc. Jobs Hiring Now

Principal Scientist - Global Drug Discovery, Obesity Pharmacology (US)

• Demonstrate proven subject matter expertise and scientific excellence in cardiometabolic biology, including obesity, MASH, and CVD.
• Demonstrate specialized depth and/or breadth of expertise and actively engage with key areas relevant to pharmaceutical drug development.
• Identify and drive novel hypotheses toward a next generation of medicines to combat obesity and related comorbidities, with a focus on superior tolerability profiles.
• Extensive experience working in a matrix organization driving cross-collaborations with different line of businesses and key stakeholders.
• Plan and design in vivo pharmacology studies in collaboration with technical scientists; advise on experimental execution, interpretation, and communication of results from complex, state-of-the-art in vivo experiments related to obesity, CVD, and MASH.
• Provide expert-level guidance to project teams on experimental strategies to evaluate emerging targets, biology, and technologies.
• Collaborate effectively across global sites to set project strategy by leading cross-functional project teams spanning in vitro, omics, translational, and clinical disciplines.
• Contribute subject matter expertise to develop the research agenda, with clear understanding of the link between scientific goals and overall long-term business needs.
• Propose new projects that support the strategic agenda and address gaps in technological capabilities and therapeutic areas related to obesity and appetite regulation.
• Represent the organization through external communication of impactful scientific research via presentations at external conferences, peer-reviewed publications, and patent activity.
• Maintain deep theoretical knowledge and remain actively connected to the external scientific community through continuous evaluation of relevant literature and emerging technologies.
• Guide and/or lead global, cross-functional experimental teams to achieve project goals.
• Provide mentorship and training to colleagues within the field of expertise.
• Maintain, identify, and initiate key relationships with KOLs and academic partners.
• Guide other research teams on suitable assays/techniques to interpret and translate in vivo studies to progress the obesity pipeline.

• PhD with 10 years relevant industry or post-doctorate experience is required.
• Master’s degree with 16 years relevant industry or post-doctorate experience can be considered.
• Bachelor’s degree with 22+ years relevant experience can be considered.
  • Extensive hands-on expertise in in vivo models related to Obesity, CVD, and MASH.
  • Experience in women’s health is a strong plus.
  • Technical expertise and high attention to detail in planning and designing complex in vivo models.
  • Prior experience using small molecules and/or siRNA in obesity pharmacology drug discovery. Experience with Obesity, MESH and CVD models (telemetry, liver elastography, metabolic cages etc.), along with alternative routes of administration in rodents (e.g., PO, SC, IV, minipump).
  • Proven success leading drug discovery programs and processes in cardiometabolic biology (including, but not limited to, novel target identification, target engagement markers, and collaboration with translational and clinical teams).
  • Experience applying human genetics and omics approaches for target discovery/identification.
  Preferred experience includes:
  • Experience working with external CROs and/or academic collaborators.
  • Demonstrated excellent verbal and written communication skills.