Senior Level Principal Machine Learning Engineer Jobs

Senior level principal machine learning engineer jobs call for professionals who set technical direction, own end-to-end model development, and lead the cross-functional teams that bring production systems to scale. Openings are concentrated across Technology & Software, Biotechnology & Pharmaceuticals, and Medical Devices, with a strong mix of remote and on-site roles, and employers like Lila Sciences, Zillow, and Riot Games hiring at this level now.

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Overview

Open roles16
Top stateCalifornia
Top employerLila Sciences
Top cityLos Angeles, CA
Work type77% On-site
Top industryTechnology

Showing 5 of 16+ Senior Level Principal Machine Learning Engineer jobs

Principal Machine Learning Engineer, Ads Modeling
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Added 1mo ago
Principal Machine Learning Engineer, Ads Modeling
Unity Technologies
Bellevue, Washington
Engineering (Non-Software)
Software Engineering
Technical Program Management
$197k - $325k/yr
5,001-10,000

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Principal Machine Learning Engineer
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Added 2mo ago
Principal Machine Learning Engineer
Unity Technologies
Mountain View, California
AI (Artificial Intelligence)
Data Science
ML (Machine Learning)
Software Engineering
$197k - $325k/yr
5,001-10,000

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Principal Engineer, Data & ML Infrastructure
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Added 3mo ago
Principal Engineer, Data & ML Infrastructure
Motional
Pittsburgh, Pennsylvania
Data Science & Analytics
Cloud & DevOps
Technical Product & Program Management
Data Science
Cloud Engineering
Technical Program Management
$200k - $275k/yr
On-Site
Bachelor's
501-1,000

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Principal Machine Learning Engineer
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Added 5mo ago
Principal Machine Learning Engineer
Cambridge Mobile Telematics
Massachusetts
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
$177k - $221k/yr
On-Site
Bachelor's

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Principal Machine Learning Engineer
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Added 6mo ago
Principal Machine Learning Engineer
Airbnb
Remote
Software Engineering
Data Science & Analytics
Technical Product & Program Management
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
Technical Program Management
$365k/yr
Remote (US)
Doctorate

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Senior Level Principal Machine Learning Engineer Job Market

Who's Hiring

Lila Sciences3 open roles
Zillow2 open roles
Riot Games2 open roles

Top Industries Hiring

  • Technology & Software
  • Biotechnology & Pharmaceuticals
  • Medical Devices
  • E-Commerce & Online Marketplaces
  • Consulting & Professional Services

Senior Level Principal Machine Learning Engineer Jobs: Frequently Asked Questions

How do I get a senior level principal machine learning engineer job?

Employers at this level look for a portfolio of shipped production ML systems, not just research or prototypes. Demonstrating that you have driven model design decisions independently, mentored engineers, and translated ambiguous business problems into scalable solutions gives you a clear edge. Publishing work, contributing to open-source projects, and showing measurable business impact in your resume all strengthen your candidacy significantly.

Which companies hire senior level principal machine learning engineers?

Companies hiring senior level principal machine learning engineers right now include Lila Sciences, Zillow, and Riot Games, based on current listings on Migrate Mate as of November 2026. Hiring at this level comes from a wide range of organizations, including large technology platforms, enterprise software companies, and data-intensive firms in finance, healthcare, and logistics that rely on ML to drive core product decisions.

Are there remote senior level principal machine learning engineer jobs?

Yes, remote work is well established at this level given the seniority and autonomy these roles carry. About 23% of senior level principal machine learning engineer openings are remote or hybrid as of November 2026, reflecting strong employer flexibility for candidates who can demonstrate independent execution and distributed team leadership. On-site roles tend to cluster at companies with regulated data environments or hardware-adjacent ML work.

What makes a principal machine learning engineer role senior level?

Senior level principal machine learning engineer roles are defined by scope and ownership. You are expected to set the technical roadmap for ML systems, make high-stakes architectural decisions without close supervision, and mentor mid-level and junior engineers across the team. The work typically touches multiple products or business units, and your influence extends to research prioritization, tooling standards, and cross-functional collaboration with product and leadership.

Which industries hire the most senior level principal machine learning engineers?

Senior Level principal machine learning engineer roles concentrate in Technology & Software, Biotechnology & Pharmaceuticals, and Medical Devices, based on current listings on Migrate Mate as of November 2026. These sectors invest heavily at this level because they depend on custom, production-grade ML systems to power core products, manage risk, personalize user experiences, or process large volumes of proprietary data where off-the-shelf solutions fall short.