Senior Statistical Programmer Jobs in Missouri
Senior Statistical Programmer jobs in Missouri are open across Kansas City, St. Louis, and St Louis and other Missouri metros, with employers like Burns & McDonnell, Clayco, and Mastercard hiring at every experience level. Find a role that fits below and apply directly.
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Our Purpose
Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we’re helping build a sustainable economy where everyone can prosper. We support a wide range of digital payments choices, making transactions secure, simple, smart and accessible. Our technology and innovation, partnerships and networks combine to deliver a unique set of products and services that help people, businesses and governments realize their greatest potential.
Title and Summary
Senior Technical Program Manager
Overview
The Payment Enablement team is seeking a Senior Technical Program Manager who can lead the planning and organization of an agile team. The ideal candidate is a proficient agile scrum master and project manager that takes ownership of the effectiveness of their squad and delivery of their projects.
Role
- Facilitates scrum ceremonies for an agile team; i.e. daily stand-up, sprint planning, sprint reviews, backlog grooming, retrospective, and demos.
- Provides agile coaching, helping the team self-organize, enforce team agreements, and employ best practices and processes.
- Recognizes discordant views and takes part in constructive dialog to resolve them.
- Tracks and manages manifest definitions, release integration, timing, scope and delivery.
- Provides ongoing updates (with data) on the state of delivery.
- Proactively manages dependencies, ensuring all outputs are production ready at launch.
- Understands the business context and the associated customer use case.
- Understands team's technologies and able to evaluate system designs and architecture as they participate in solution discussions.
- Improves team processes that accelerate delivery, drive innovation, lower costs, and improve quality.
- Looked to as the first point of contact for team's projects.
- Experienced in and understands industry technologies.
- Understands their program, product, or Technology domain to sufficient depth/credibility to be effective with teams they work with.
- Can competently represent team’s services to stakeholders and other teams.
All About You
- Bachelor’s degree in Project Management, Information Technology, Computer Science or equivalent.
- Relevant experience as a scrum master, project manager, or related field.
- Experience working on enterprise level projects and managing software projects with advanced knowledge of the Software Development Lifecycle.
- Excellent written and verbal communication skills.
- Strong leadership skills.
- Proficient at building and maintaining strong business relationships.
- Proficient with MS Office tools.
- Proficient with project tracking tools such as JIRA. Familiarity with Aha! is a plus.
Mastercard is a merit-based, inclusive, equal opportunity employer that considers applicants without regard to gender, gender identity, sexual orientation, race, ethnicity, disabled or veteran status, or any other characteristic protected by law. We hire the most qualified candidate for the role. In the US or Canada, if you require accommodations or assistance to complete the online application process or during the recruitment process, please contact reasonable_accommodation@mastercard.com and identify the type of accommodation or assistance you are requesting. Do not include any medical or health information in this email. The Reasonable Accommodations team will respond to your email promptly.
Corporate Security Responsibility
All activities involving access to Mastercard assets, information, and networks comes with an inherent risk to the organization and, therefore, it is expected that every person working for, or on behalf of, Mastercard is responsible for information security and must:
- Abide by Mastercard’s security policies and practices;
- Ensure the confidentiality and integrity of the information being accessed;
- Report any suspected information security violation or breach, and
- Complete all periodic mandatory security trainings in accordance with Mastercard’s guidelines.
In line with Mastercard’s total compensation philosophy and assuming that the job will be performed in the US, the successful candidate will be offered a competitive base salary and may be eligible for an annual bonus or commissions depending on the role. The base salary offered may vary depending on multiple factors, including but not limited to location, job-related knowledge, skills, and experience. Mastercard benefits for full time (and certain part time) employees generally include: insurance (including medical, prescription drug, dental, vision, disability, life insurance); flexible spending account and health savings account; paid leaves (including 16 weeks of new parent leave and up to 20 days of bereavement leave); 80 hours of Paid Sick and Safe Time, 25 days of vacation time and 5 personal days, pro-rated based on date of hire; 10 annual paid U.S. observed holidays; 401k with a best-in-class company match; deferred compensation for eligible roles; fitness reimbursement or on-site fitness facilities; eligibility for tuition reimbursement; and many more. Mastercard benefits for interns generally include: 56 hours of Paid Sick and Safe Time; jury duty leave; and on-site fitness facilities in some locations.
Pay Ranges
O'Fallon, Missouri: $96,000 - $163,000 USD
See All 583+ Senior Statistical Programmer Jobs in Missouri
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Find JobsSenior Statistical Programmer Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Senior Statistical Programmer Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
- Burns & McDonnell32

- Clayco28

- Mastercard25

- KPMG14

- Washington University in St. Louis14

Top Industries Hiring
- Consulting & Professional Services157
- Construction & Real Estate99
- Technology & Software51
- Education45
- Healthcare & Medical Services35
What Missouri Employers Look For
The qualifications that appear most often in senior statistical programmer jobs across Missouri.
- Five or more years of SAS programming experience in a clinical or regulatory environment
- Proficiency with CDISC standards including SDTM and ADaM dataset development
- Experience supporting regulatory submissions such as INDs, NDAs, or BLAs
- Bachelor's or master's degree in statistics, biostatistics, computer science, or a related field
- Familiarity with CDISC Pilot, define.xml, and reviewer's guide generation
- Experience working in validated computing environments under 21 CFR Part 11 compliance
Senior Statistical Programmer Jobs in Missouri: Frequently Asked Questions
How many senior statistical programmer jobs are there in Missouri?
There are 583+ senior statistical programmer openings in Missouri on Migrate Mate as of June 2026, with the most roles in Kansas City, St. Louis, and St Louis. New positions post regularly as employers across Missouri hire.
How much do senior statistical programmers make in Missouri?
Senior statistical programmers in Missouri earn a median of about $66,330 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $46,450 for the lowest 10% to over $118,850 for the top 10%. Pay rises with experience, specialty, and employer.
Which Missouri cities have the most senior statistical programmer jobs?
Kansas City, St. Louis, and St Louis have the most senior statistical programmer openings in Missouri right now, with additional roles spread across smaller metros statewide.
Which companies hire senior statistical programmers in Missouri?
Employers hiring senior statistical programmers in Missouri include Burns & McDonnell, Clayco, and Mastercard, based on current listings on Migrate Mate as of June 2026.
Are there remote senior statistical programmer jobs in Missouri?
Yes. About 16% of senior statistical programmer openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.
How do I apply for senior statistical programmer jobs in Missouri?
You can apply to senior statistical programmer jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.
See All 583+ Senior Statistical Programmer Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
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