Senior Statistical Programmer Jobs
Senior Statistical Programmer jobs are open across pharmaceutical, biotech, clinical research, and government sectors, from mid-level to principal, with specializations in clinical trials programming, SAS macro development, and regulatory submission outputs. Find a role that fits from the openings below and apply directly.
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INTRODUCTION
About Certara
Certara accelerates the potential of bringing medicines to market and to patients using biosimulation software, technology, and services to transform traditional drug discovery and development. Our clients include more than 2,400 biopharmaceutical companies, academic institutions, and regulatory agencies across 70 countries.
Our goal is to enable the life sciences industry’s use of data, modeling, and analytics to make better decisions across the various phases of discovery and drug development. Our software and scientists incorporate modern advances in scientific understanding, drug development experience, data analysis, and AI resulting in significant opportunities to decrease the cost and increase the probability of success for new drug approval and commercialization.
Responsibilities
As a Statistical Programming Consultant, you will use your SAS and R programming skills to prepare SDTM and ADaM datasets, Tables, Listings, & Figures (TLFs), as well as create related documents such as aCRF, programming specifications, and define packages (including reviewer’s guides) for Phase 1 to Phase 4 clinical trials. Advanced SAS macro programming experience is required for the development of global tools that will increase the efficiency and capacity of the Statistical Programming group. Preclinical SEND dataset preparation is a plus. Experience with NDA/IND-type regulatory submissions is preferred.
In addition, you will conduct quality control and quality assurance activities on datasets and outputs and may participate in company initiatives to improve the efficiency of end-to-end statistical programming activities, analysis, and reporting (IT, methodology, automation, quality). You will work closely in teams led by statistical programmers, statisticians, and drug development consultants, supporting a variety of client projects across various therapeutic areas and complexities.
BASIC QUALIFICATIONS
- B.Sc., M.Sc., or equivalent education in Biostatistics/Statistics, Bioinformatics, Life Sciences, Mathematics, Physical Sciences, or related fields.
- At least 6 years of Clinical trials related work experience in SAS programming, analysis and reporting in the context of drug development projects is required.
- Well experienced in the Pinnacle 21 validation process, generating Define.xml using Pinnacle 21.
- Extensive experience in implementing CDISC standards, as well as annotating CRFs, creating specifications for SDTM and ADaM datasets.
- Experienced in creating Define.xml and the corresponding Reviewers’ Guide for SDTM and ADaM datasets.
- Good verbal and written communications skills in English.
- Demonstrated knowledge of clinical drug development.
- Proficiency in conducting advanced statistical analyses.
- Must be independent, attention to detail, accountable to quality and timely delivery.
- Ability to work on multiple collaborative projects, team player mentality.
- Experience with the R software platform (in addition to SAS) is a plus.
Certara bases all employment-related decision on merit, taking into consideration qualifications, skills, achievement, and performance. We treat all applicants and employees without regard to personal characteristics such as race, color, ethnicity, religion, sex, sexual orientation, age, nationality, marital status, pregnancy, physical or mental condition, genetic information, military service, or other characteristic protected by law.
INTRODUCTION
About Certara
Certara accelerates the potential of bringing medicines to market and to patients using biosimulation software, technology, and services to transform traditional drug discovery and development. Our clients include more than 2,400 biopharmaceutical companies, academic institutions, and regulatory agencies across 70 countries.
Our goal is to enable the life sciences industry’s use of data, modeling, and analytics to make better decisions across the various phases of discovery and drug development. Our software and scientists incorporate modern advances in scientific understanding, drug development experience, data analysis, and AI resulting in significant opportunities to decrease the cost and increase the probability of success for new drug approval and commercialization.
Responsibilities
As a Statistical Programming Consultant, you will use your SAS and R programming skills to prepare SDTM and ADaM datasets, Tables, Listings, & Figures (TLFs), as well as create related documents such as aCRF, programming specifications, and define packages (including reviewer’s guides) for Phase 1 to Phase 4 clinical trials. Advanced SAS macro programming experience is required for the development of global tools that will increase the efficiency and capacity of the Statistical Programming group. Preclinical SEND dataset preparation is a plus. Experience with NDA/IND-type regulatory submissions is preferred.
In addition, you will conduct quality control and quality assurance activities on datasets and outputs and may participate in company initiatives to improve the efficiency of end-to-end statistical programming activities, analysis, and reporting (IT, methodology, automation, quality). You will work closely in teams led by statistical programmers, statisticians, and drug development consultants, supporting a variety of client projects across various therapeutic areas and complexities.
BASIC QUALIFICATIONS
- B.Sc., M.Sc., or equivalent education in Biostatistics/Statistics, Bioinformatics, Life Sciences, Mathematics, Physical Sciences, or related fields.
- At least 6 years of Clinical trials related work experience in SAS programming, analysis and reporting in the context of drug development projects is required.
- Well experienced in the Pinnacle 21 validation process, generating Define.xml using Pinnacle 21.
- Extensive experience in implementing CDISC standards, as well as annotating CRFs, creating specifications for SDTM and ADaM datasets.
- Experienced in creating Define.xml and the corresponding Reviewers’ Guide for SDTM and ADaM datasets.
- Good verbal and written communications skills in English.
- Demonstrated knowledge of clinical drug development.
- Proficiency in conducting advanced statistical analyses.
- Must be independent, attention to detail, accountable to quality and timely delivery.
- Ability to work on multiple collaborative projects, team player mentality.
- Experience with the R software platform (in addition to SAS) is a plus.
Certara bases all employment-related decision on merit, taking into consideration qualifications, skills, achievement, and performance. We treat all applicants and employees without regard to personal characteristics such as race, color, ethnicity, religion, sex, sexual orientation, age, nationality, marital status, pregnancy, physical or mental condition, genetic information, military service, or other characteristic protected by law.
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Find JobsSenior Statistical Programmer Job Market
A snapshot from current openings nationwide, updated as new roles post.
Who's Hiring
- Katalyst Healthcares & Life Sciences6
- ClinChoice3
- Neurocrine Biosciences2
- Redbock - an NES Fircroft company2
- Regeneron2
Top Industries Hiring
- Consulting & Professional Services13
- Biotechnology & Pharmaceuticals6
- Healthcare & Medical Services3
- Science & Research2
- Technology & Software1
What Employers Look For
The qualifications that appear most often in senior statistical programmer jobs.
- Five or more years of SAS programming experience in a clinical or regulatory environment
- Proficiency with CDISC standards including SDTM and ADaM dataset development
- Experience supporting regulatory submissions such as INDs, NDAs, or BLAs
- Bachelor's or master's degree in statistics, biostatistics, computer science, or a related field
- Familiarity with CDISC Pilot, define.xml, and reviewer's guide generation
- Experience working in validated computing environments under 21 CFR Part 11 compliance
Tips for Your Senior Statistical Programmer Job Search
Tailor your resume to CDISC standards
Hiring managers in clinical settings scan for CDISC, SDTM, and ADaM proficiency immediately. Call out specific submissions you've supported, the therapeutic areas involved, and whether you programmed define.xml or reviewer's guides, not just that you know SAS.
Filter openings by submission phase
IND-stage and NDA-stage roles demand very different experience. When you search, note whether a listing mentions Phase I through IV, PDUFA deadlines, or FDA submission work so you target openings where your specific pipeline experience is directly relevant.
Apply early to roles that fit
Migrate Mate lists senior statistical programmer openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Highlight validated environment experience explicitly
Many job listings require 21 CFR Part 11 or GAMP 5 compliance work. If your resume just says 'SAS programming,' you'll be filtered out. Name the validated environments, audit-trail processes, and quality systems you've worked inside directly.
Prepare a technical code walkthrough for interviews
Interviewers at CROs and sponsors routinely ask you to walk through a macro or TLF program live. Bring a clean, commented example from a mock or real project, and practice explaining design decisions, not just what the code does.
Negotiate scope before accepting an offer
Senior statistical programmer roles vary widely between hands-on programming seats and lead positions that review junior work. Before accepting, confirm the ratio of independent programming to oversight so the day-to-day matches what you're targeting.
Senior Statistical Programmer Jobs: Frequently Asked Questions
Which companies are hiring the most senior statistical programmers?
The companies hiring the most senior statistical programmers right now include Katalyst Healthcares & Life Sciences, ClinChoice, and Neurocrine Biosciences, with the largest share of openings in New Jersey, California, and North Carolina, based on current listings on Migrate Mate as of June 2026. CROs and large pharma sponsors tend to post the highest volume of openings across the country.
How many senior statistical programmer jobs are remote?
About 43% of senior statistical programmer openings are fully remote or hybrid as of June 2026, reflecting the role's strong compatibility with distributed clinical trial teams. Regulatory submission programming and SAS macro development tend to be the sub-areas most frequently offered on a fully remote basis.
How do you become a senior statistical programmer?
Start with a degree in biostatistics, statistics, or computer science, then build hands-on SAS programming experience inside a clinical trial or CRO environment. Move into CDISC-compliant SDTM and ADaM dataset work, take on TLF programming responsibilities for regulated submissions, and progressively own larger study deliverables until you're leading programming across a full clinical program.
How do you get hired as a senior statistical programmer with limited experience?
Target CRO positions that accept candidates with three to four years of SAS programming and some CDISC exposure rather than holding out for big pharma sponsors. Complete a CDISC training certification, build a portfolio of mock SDTM or ADaM datasets to demonstrate standards knowledge, and apply to studies in earlier development phases where competition for senior roles is lower.
What does the senior statistical programmer interview process look like?
Most processes run three to four stages: a recruiter screen, a technical phone interview covering SAS macro development and CDISC standards, a live or take-home programming exercise where you build or review an ADaM dataset, and a final interview with a statistical programming lead or biostatistics manager focused on regulatory submission experience and cross-functional collaboration.
Where can I find and apply to senior statistical programmer jobs?
You can find and apply to senior statistical programmer jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your experience in SAS programming, CDISC standards, or clinical submissions, and apply directly to each one that fits.
See All Senior Statistical Programmer Jobs
Jump back to the full list of openings and apply to any senior statistical programmer role that fits.
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