Senior Statistical Programmer Jobs
Senior Statistical Programmer jobs are open across pharmaceutical, biotech, clinical research, and government sectors, from mid-level to principal, with specializations in clinical trials programming, SAS macro development, and regulatory submission outputs. Find a role that fits from the openings below and apply directly.
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Showing 5 of 23+ Senior Statistical Programmer jobs
What we offer:
Resources that support your whole life – Employee assistance programs and work/life balance tools
Investment in your growth – Referral bonuses, tuition reimbursement, on-the-job training, certification assistance, and continuing education support
Time to recharge – Paid holidays, vacation, and sick time
Pathways forward – Career development opportunities across One WCG
We practice transparency in everything we do, including compensation. The salary range for this position reflects our commitment to fair, competitive pay based on your qualifications, experience, skills, education, and location. Together, we'll find the right fit for your expertise and our shared mission.
The Senior Principal Statistical Programmer serves as a senior technical leader and subject matter expert in statistical programming, with deep expertise supporting clinical trials and Data Monitoring Committee (DMC) deliverables. This role combines advanced hands-on programming capabilities with technical leadership, driving the design, development, and standardization of high-quality statistical outputs. The Senior Principal Statistical Programmer independently leads complex programming initiatives, provides expert-level guidance across projects, and plays a key role in shaping programming standards, tools, and best practices. This role partners closely with biostatistics, project management, data management and cross-functional stakeholders to ensure high-quality, compliant, and efficient delivery of programming outputs.
ESSENTIAL DUTIES/RESPONSIBILITIES: To perform this job successfully, an individual must be able to perform each essential duty and responsibility satisfactorily. The accountabilities listed below are representative of the knowledge, skills, and/or ability required.
- Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
- Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
- Lead the development, validation, and continuous improvement of DMC macros and programming standards.
- Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
- Drive the establishment and adoption of programming standards, best practices, and process improvements.
- Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
- Independently manage and prioritize programming activities across multiple studies or initiatives.
- Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
- Contribute technical expertise to proposals, project planning, and scope discussions as needed.
- Partner with IT and technology teams to support SAS environments, tools, and system validation efforts.
- Provide technical oversight for programming activities supporting regulatory submissions and inspection readiness.
- Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
- Influence programming approaches, standards, and best practices across multiple studies or programs.
- Serve as a technical escalation point for complex programming, data, or deliverable issues, leading resolution of highly complex or ambiguous challenges.
- Provide expert interpretation of statistical analysis plans (SAPs), protocols, and study documents, translating requirements into programming strategy.
- Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.
- Other duties as assigned by supervisor. These may, on occasion, be unrelated to the position described here.
EDUCATION REQUIREMENTS: Master’s degree required. In limited circumstances, an equivalent combination of education and directly relevant professional experience may be considered.
QUALIFICATIONS/EXPERIENCE:
- Minimum 8–10 years of statistical programming experience in a clinical trial environment.
- Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
- Proficiency in R programming is a must.
- Demonstrated experience with CDISC standards and regulatory requirements.
- Proven ability to independently lead complex programming efforts across studies.
- Experience mentoring staff and driving technical standards or best practices.
- Demonstrated ability to independently coordinate biostatistical projects, including planning and oversight of programming activities, with minimal direction from senior leadership.
TRAVEL REQUIREMENTS:
- 0% – 5%
5% - 10%
10% - 20%
20% - 50%
>50%
#LI-Remote
Pay Range: USD $131,100.00 - USD $160,000.00 /Yr. EEOC Statement:
What we offer:
Resources that support your whole life – Employee assistance programs and work/life balance tools
Investment in your growth – Referral bonuses, tuition reimbursement, on-the-job training, certification assistance, and continuing education support
Time to recharge – Paid holidays, vacation, and sick time
Pathways forward – Career development opportunities across One WCG
We practice transparency in everything we do, including compensation. The salary range for this position reflects our commitment to fair, competitive pay based on your qualifications, experience, skills, education, and location. Together, we'll find the right fit for your expertise and our shared mission.
The Senior Principal Statistical Programmer serves as a senior technical leader and subject matter expert in statistical programming, with deep expertise supporting clinical trials and Data Monitoring Committee (DMC) deliverables. This role combines advanced hands-on programming capabilities with technical leadership, driving the design, development, and standardization of high-quality statistical outputs. The Senior Principal Statistical Programmer independently leads complex programming initiatives, provides expert-level guidance across projects, and plays a key role in shaping programming standards, tools, and best practices. This role partners closely with biostatistics, project management, data management and cross-functional stakeholders to ensure high-quality, compliant, and efficient delivery of programming outputs.
ESSENTIAL DUTIES/RESPONSIBILITIES: To perform this job successfully, an individual must be able to perform each essential duty and responsibility satisfactorily. The accountabilities listed below are representative of the knowledge, skills, and/or ability required.
- Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
- Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
- Lead the development, validation, and continuous improvement of DMC macros and programming standards.
- Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
- Drive the establishment and adoption of programming standards, best practices, and process improvements.
- Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
- Independently manage and prioritize programming activities across multiple studies or initiatives.
- Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
- Contribute technical expertise to proposals, project planning, and scope discussions as needed.
- Partner with IT and technology teams to support SAS environments, tools, and system validation efforts.
- Provide technical oversight for programming activities supporting regulatory submissions and inspection readiness.
- Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
- Influence programming approaches, standards, and best practices across multiple studies or programs.
- Serve as a technical escalation point for complex programming, data, or deliverable issues, leading resolution of highly complex or ambiguous challenges.
- Provide expert interpretation of statistical analysis plans (SAPs), protocols, and study documents, translating requirements into programming strategy.
- Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.
- Other duties as assigned by supervisor. These may, on occasion, be unrelated to the position described here.
EDUCATION REQUIREMENTS: Master’s degree required. In limited circumstances, an equivalent combination of education and directly relevant professional experience may be considered.
QUALIFICATIONS/EXPERIENCE:
- Minimum 8–10 years of statistical programming experience in a clinical trial environment.
- Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
- Proficiency in R programming is a must.
- Demonstrated experience with CDISC standards and regulatory requirements.
- Proven ability to independently lead complex programming efforts across studies.
- Experience mentoring staff and driving technical standards or best practices.
- Demonstrated ability to independently coordinate biostatistical projects, including planning and oversight of programming activities, with minimal direction from senior leadership.
TRAVEL REQUIREMENTS:
- 0% – 5%
5% - 10%
10% - 20%
20% - 50%
>50%
#LI-Remote
Pay Range: USD $131,100.00 - USD $160,000.00 /Yr. EEOC Statement:
Senior Statistical Programmer Jobs by Experience Level
See All 23 Senior Statistical Programmer Jobs
Find roles that match your experience and apply in just a few clicks.
Find JobsSenior Statistical Programmer Job Market
Who's Hiring
- Katalyst Healthcares & Life Sciences10
- Chemtrade2
- WCG Clinical2
- Cytel1
- Penumbra1
Top Industries Hiring
- Consulting & Professional Services
- Technology & Software
- Biotechnology & Pharmaceuticals
What Employers Look For
The qualifications that appear most often in senior statistical programmer jobs.
- Five or more years of SAS programming experience in a clinical or regulatory environment
- Proficiency with CDISC standards including SDTM and ADaM dataset development
- Experience supporting regulatory submissions such as INDs, NDAs, or BLAs
- Bachelor's or master's degree in statistics, biostatistics, computer science, or a related field
- Familiarity with CDISC Pilot, define.xml, and reviewer's guide generation
- Experience working in validated computing environments under 21 CFR Part 11 compliance
Tips for Your Senior Statistical Programmer Job Search
Tailor your resume to CDISC standards
Hiring managers in clinical settings scan for CDISC, SDTM, and ADaM proficiency immediately. Call out specific submissions you've supported, the therapeutic areas involved, and whether you programmed define.xml or reviewer's guides, not just that you know SAS.
Filter openings by submission phase
IND-stage and NDA-stage roles demand very different experience. When you search, note whether a listing mentions Phase I through IV, PDUFA deadlines, or FDA submission work so you target openings where your specific pipeline experience is directly relevant.
Apply early to roles that fit
Migrate Mate lists senior statistical programmer openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Highlight validated environment experience explicitly
Many job listings require 21 CFR Part 11 or GAMP 5 compliance work. If your resume just says 'SAS programming,' you'll be filtered out. Name the validated environments, audit-trail processes, and quality systems you've worked inside directly.
Prepare a technical code walkthrough for interviews
Interviewers at CROs and sponsors routinely ask you to walk through a macro or TLF program live. Bring a clean, commented example from a mock or real project, and practice explaining design decisions, not just what the code does.
Negotiate scope before accepting an offer
Senior statistical programmer roles vary widely between hands-on programming seats and lead positions that review junior work. Before accepting, confirm the ratio of independent programming to oversight so the day-to-day matches what you're targeting.
Senior Statistical Programmer Jobs: Frequently Asked Questions
Which companies are hiring the most senior statistical programmers?
The companies hiring the most senior statistical programmers right now include Katalyst Healthcares & Life Sciences, Chemtrade, and WCG Clinical, with the largest share of openings in California, New Jersey, and New York, based on current listings on Migrate Mate as of November 2026. CROs and large pharma sponsors tend to post the highest volume of openings across the country.
How many senior statistical programmer jobs are remote?
About 85% of senior statistical programmer openings are fully remote or hybrid as of November 2026, reflecting the role's strong compatibility with distributed clinical trial teams. Regulatory submission programming and SAS macro development tend to be the sub-areas most frequently offered on a fully remote basis.
How do you become a senior statistical programmer?
Start with a degree in biostatistics, statistics, or computer science, then build hands-on SAS programming experience inside a clinical trial or CRO environment. Move into CDISC-compliant SDTM and ADaM dataset work, take on TLF programming responsibilities for regulated submissions, and progressively own larger study deliverables until you're leading programming across a full clinical program.
How do you get hired as a senior statistical programmer with limited experience?
Target CRO positions that accept candidates with three to four years of SAS programming and some CDISC exposure rather than holding out for big pharma sponsors. Complete a CDISC training certification, build a portfolio of mock SDTM or ADaM datasets to demonstrate standards knowledge, and apply to studies in earlier development phases where competition for senior roles is lower.
What does the senior statistical programmer interview process look like?
Most processes run three to four stages: a recruiter screen, a technical phone interview covering SAS macro development and CDISC standards, a live or take-home programming exercise where you build or review an ADaM dataset, and a final interview with a statistical programming lead or biostatistics manager focused on regulatory submission experience and cross-functional collaboration.
Where can I find and apply to senior statistical programmer jobs?
You can find and apply to senior statistical programmer jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your experience in SAS programming, CDISC standards, or clinical submissions, and apply directly to each one that fits.
See All 23 Senior Statistical Programmer Jobs
Find roles that match your experience and apply in just a few clicks.
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