Senior Statistical Programmer Jobs
Senior Statistical Programmer jobs are open across pharmaceutical, biotech, clinical research, and government sectors, from mid-level to principal, with specializations in clinical trials programming, SAS macro development, and regulatory submission outputs. Find a role that fits from the openings below and apply directly.
Find JobsOverview
Showing 5 of 19+ Senior Statistical Programmer jobs
Job Description
Provide support for clinical studies through dual expertise in statistical programming compliant with CDISC standards (SDTM/ADaM) and applied biostatistics. The role includes the production, validation, and review of CDISC deliverables, as well as the execution and support of statistical analyses.
Responsibilities
Participate in the design of clinical studies in collaboration with biostatisticians.
Contribute to the writing and review of Statistical Analysis Plans (SAPs).
Program and validate SDTM and ADaM datasets.
Produce, validate, and review SDTM/ADaM deliverables (annotated CRFs, specifications, datasets).
Ensure regulatory compliance using Pinnacle 21.
Participate in and validate regulatory submission deliverables (Define.xml, submission packages).
Perform Quality Control (QC) activities.
Produce and validate Tables, Listings, and Figures (TLFs).
Collaborate closely with clinical and regulatory teams.
Profile
Master's degree (MSc) or PhD in Biostatistics, Statistics, Mathematics, or a related field (e.g., ENSAI or equivalent).
Minimum of 6–8 years of experience in statistical programming for clinical trials, with strong expertise in CDISC standards (SDTM/ADaM).
Experience with regulatory submissions and CRO management is highly desirable.
Technical Skills
Proficiency in SAS (Base SAS, SAS Studio, SAS Viya).
Strong expertise in CDISC SDTM and ADaM standards.
Good knowledge of TLFs (Tables, Listings, and Figures) and regulatory requirements.
Experience using Pinnacle 21.
Solid understanding of clinical statistics.
Fluent English (written and spoken).
Behavioral Competencies
Curiosity
Continue exploring new horizons. Constantly ask "Why?" and, more importantly, "Why not?"
Courage
Take smart risks and support one another in continuously improving. Push boundaries, turn challenges into opportunities, and take ownership of our decisions, opinions, and actions.
Collaboration
Learn from one another. Grow and develop as a multicultural, international team working toward shared goals.
Credibility
Strive for excellence in everything we do. Transparency and expertise are the foundation of our relationships with patients, partners, and shareholders. Data and results are at the heart of our commitment.
Job Description
Provide support for clinical studies through dual expertise in statistical programming compliant with CDISC standards (SDTM/ADaM) and applied biostatistics. The role includes the production, validation, and review of CDISC deliverables, as well as the execution and support of statistical analyses.
Responsibilities
Participate in the design of clinical studies in collaboration with biostatisticians.
Contribute to the writing and review of Statistical Analysis Plans (SAPs).
Program and validate SDTM and ADaM datasets.
Produce, validate, and review SDTM/ADaM deliverables (annotated CRFs, specifications, datasets).
Ensure regulatory compliance using Pinnacle 21.
Participate in and validate regulatory submission deliverables (Define.xml, submission packages).
Perform Quality Control (QC) activities.
Produce and validate Tables, Listings, and Figures (TLFs).
Collaborate closely with clinical and regulatory teams.
Profile
Master's degree (MSc) or PhD in Biostatistics, Statistics, Mathematics, or a related field (e.g., ENSAI or equivalent).
Minimum of 6–8 years of experience in statistical programming for clinical trials, with strong expertise in CDISC standards (SDTM/ADaM).
Experience with regulatory submissions and CRO management is highly desirable.
Technical Skills
Proficiency in SAS (Base SAS, SAS Studio, SAS Viya).
Strong expertise in CDISC SDTM and ADaM standards.
Good knowledge of TLFs (Tables, Listings, and Figures) and regulatory requirements.
Experience using Pinnacle 21.
Solid understanding of clinical statistics.
Fluent English (written and spoken).
Behavioral Competencies
Curiosity
Continue exploring new horizons. Constantly ask "Why?" and, more importantly, "Why not?"
Courage
Take smart risks and support one another in continuously improving. Push boundaries, turn challenges into opportunities, and take ownership of our decisions, opinions, and actions.
Collaboration
Learn from one another. Grow and develop as a multicultural, international team working toward shared goals.
Credibility
Strive for excellence in everything we do. Transparency and expertise are the foundation of our relationships with patients, partners, and shareholders. Data and results are at the heart of our commitment.
Senior Statistical Programmer Jobs by Experience Level
See All 19 Senior Statistical Programmer Jobs
Find roles that match your experience and apply in just a few clicks.
Find JobsSenior Statistical Programmer Job Market
Who's Hiring
Top Industries Hiring
- Consulting & Professional Services
- Technology & Software
- Biotechnology & Pharmaceuticals
What Employers Look For
The qualifications that appear most often in senior statistical programmer jobs.
- Five or more years of SAS programming experience in a clinical or regulatory environment
- Proficiency with CDISC standards including SDTM and ADaM dataset development
- Experience supporting regulatory submissions such as INDs, NDAs, or BLAs
- Bachelor's or master's degree in statistics, biostatistics, computer science, or a related field
- Familiarity with CDISC Pilot, define.xml, and reviewer's guide generation
- Experience working in validated computing environments under 21 CFR Part 11 compliance
Tips for Your Senior Statistical Programmer Job Search
Tailor your resume to CDISC standards
Hiring managers in clinical settings scan for CDISC, SDTM, and ADaM proficiency immediately. Call out specific submissions you've supported, the therapeutic areas involved, and whether you programmed define.xml or reviewer's guides, not just that you know SAS.
Filter openings by submission phase
IND-stage and NDA-stage roles demand very different experience. When you search, note whether a listing mentions Phase I through IV, PDUFA deadlines, or FDA submission work so you target openings where your specific pipeline experience is directly relevant.
Apply early to roles that fit
Migrate Mate lists senior statistical programmer openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Highlight validated environment experience explicitly
Many job listings require 21 CFR Part 11 or GAMP 5 compliance work. If your resume just says 'SAS programming,' you'll be filtered out. Name the validated environments, audit-trail processes, and quality systems you've worked inside directly.
Prepare a technical code walkthrough for interviews
Interviewers at CROs and sponsors routinely ask you to walk through a macro or TLF program live. Bring a clean, commented example from a mock or real project, and practice explaining design decisions, not just what the code does.
Negotiate scope before accepting an offer
Senior statistical programmer roles vary widely between hands-on programming seats and lead positions that review junior work. Before accepting, confirm the ratio of independent programming to oversight so the day-to-day matches what you're targeting.
Senior Statistical Programmer Jobs: Frequently Asked Questions
Which companies are hiring the most senior statistical programmers?
The companies hiring the most senior statistical programmers right now include Katalyst Healthcares & Life Sciences, Everest Clinical Research, and BD, with the largest share of openings in New Jersey, California, and Massachusetts, based on current listings on Migrate Mate as of August 2026. CROs and large pharma sponsors tend to post the highest volume of openings across the country.
How many senior statistical programmer jobs are remote?
About 73% of senior statistical programmer openings are fully remote or hybrid as of August 2026, reflecting the role's strong compatibility with distributed clinical trial teams. Regulatory submission programming and SAS macro development tend to be the sub-areas most frequently offered on a fully remote basis.
How do you become a senior statistical programmer?
Start with a degree in biostatistics, statistics, or computer science, then build hands-on SAS programming experience inside a clinical trial or CRO environment. Move into CDISC-compliant SDTM and ADaM dataset work, take on TLF programming responsibilities for regulated submissions, and progressively own larger study deliverables until you're leading programming across a full clinical program.
How do you get hired as a senior statistical programmer with limited experience?
Target CRO positions that accept candidates with three to four years of SAS programming and some CDISC exposure rather than holding out for big pharma sponsors. Complete a CDISC training certification, build a portfolio of mock SDTM or ADaM datasets to demonstrate standards knowledge, and apply to studies in earlier development phases where competition for senior roles is lower.
What does the senior statistical programmer interview process look like?
Most processes run three to four stages: a recruiter screen, a technical phone interview covering SAS macro development and CDISC standards, a live or take-home programming exercise where you build or review an ADaM dataset, and a final interview with a statistical programming lead or biostatistics manager focused on regulatory submission experience and cross-functional collaboration.
Where can I find and apply to senior statistical programmer jobs?
You can find and apply to senior statistical programmer jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your experience in SAS programming, CDISC standards, or clinical submissions, and apply directly to each one that fits.
See All 19 Senior Statistical Programmer Jobs
Find roles that match your experience and apply in just a few clicks.
Find Jobs