TN Visa Senior Bioinformatics Scientist Jobs
Senior Bioinformatics Scientist roles qualify for TN visa sponsorship under the USMCA's Computer Systems Analyst and Scientific Technician categories, depending on how your employer frames the position. Canadian citizens can enter the U.S. at a port of entry without a visa stamp. Mexican nationals require a consular appointment first.
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Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.
Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.
Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.
The role
We are looking for a Senior Scientist, Molecular Biology with experience in protein engineering, complex DNA library design, and pooled screening to help build next-generation DNA constructs for programmable medicines. This role is a good fit for someone who has worked on CAR/binder design and is comfortable designing and testing large libraries to support discovery and optimization of engineered proteins.
You will help build and scale platforms for plasmid DNA design, construction, and optimization, with a focus on practical, high-throughput workflows and data-driven decision making. We are looking for someone who brings strong technical skills, thinks critically about experimental design, and is comfortable working in a fast-paced, collaborative environment.
This role reports to the Director of Molecular Biology and includes management of one direct report. You will work closely with other scientists and group leads across the R&D team.
Key responsibilities
- Using protein prediction models and ab initio modeling to develop proteins of novel function in silico and drive their selection and validation on wet bench
- Deep expertise characterizing protein structure and function including affinity, stability, etc.
- Design and build complex DNA libraries, including barcoding strategies, to enable pooled screening and variant tracking.
- Automation experience for arrayed screening and other biochemical assays
- Help build and scale high-throughput workflows for DNA and RNA production, screening, and data analysis.
- Track record of demonstration execution of large-scale library screens to support protein engineering and CAR optimization or binder identification and characterization
- Protein production and characterization in both bacteria and mammalian cells
- Contribute to plasmid and construct design for engineered proteins and cell-based systems.
- Own construct QC, sequence analysis, and tracking of variants, including NGS-based workflows.
- Work with external vendors as needed, balancing internal builds and outsourcing to meet timelines.
- Partner closely with other teams, including CMC, to provide designs, materials, and timelines.
- Mentor junior scientists and support strong practices in experimental design and data quality.
- Maintain clear and reproducible records (ELN, sequence tracking, sample management).
- Communicate results clearly to cross-functional teams and leadership.
Who you are
We encourage all candidates with exemplary experience in related fields to apply.
Technical Expertise
- BS with 14+ years, MS with 12+ years, or PhD with 5+ years of relevant industry experience in molecular biology, bioengineering, or a related field.
- Deep expertise in protein engineering and CAR
- Proven track record designing and building complex DNA libraries, including barcoding strategies for pooled screening.
- Strong command of molecular cloning and plasmid design in high-throughput settings.
- Demonstrated ownership of large-scale library screens, from design through execution and data interpretation.
- Expert-level experience with NGS-based library analysis, variant tracking, and sequence QC.
- Ability to operate effectively in cross-functional teams and drive work forward in a fast-paced environment.
- Experience mentoring or managing junior scientists.
Leadership & Collaboration
- Proven ability to lead complex projects and influence cross-functional teams.
- Strong mentorship skills with commitment to developing others. Previous technical or professional management experience.
- Excellent communication skills, with the ability to translate complex ideas across disciplines.
Values and Behaviors:
Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
Company Summary:
Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.
Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.
Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.
The role
We are looking for a Senior Scientist, Molecular Biology with experience in protein engineering, complex DNA library design, and pooled screening to help build next-generation DNA constructs for programmable medicines. This role is a good fit for someone who has worked on CAR/binder design and is comfortable designing and testing large libraries to support discovery and optimization of engineered proteins.
You will help build and scale platforms for plasmid DNA design, construction, and optimization, with a focus on practical, high-throughput workflows and data-driven decision making. We are looking for someone who brings strong technical skills, thinks critically about experimental design, and is comfortable working in a fast-paced, collaborative environment.
This role reports to the Director of Molecular Biology and includes management of one direct report. You will work closely with other scientists and group leads across the R&D team.
Key responsibilities
- Using protein prediction models and ab initio modeling to develop proteins of novel function in silico and drive their selection and validation on wet bench
- Deep expertise characterizing protein structure and function including affinity, stability, etc.
- Design and build complex DNA libraries, including barcoding strategies, to enable pooled screening and variant tracking.
- Automation experience for arrayed screening and other biochemical assays
- Help build and scale high-throughput workflows for DNA and RNA production, screening, and data analysis.
- Track record of demonstration execution of large-scale library screens to support protein engineering and CAR optimization or binder identification and characterization
- Protein production and characterization in both bacteria and mammalian cells
- Contribute to plasmid and construct design for engineered proteins and cell-based systems.
- Own construct QC, sequence analysis, and tracking of variants, including NGS-based workflows.
- Work with external vendors as needed, balancing internal builds and outsourcing to meet timelines.
- Partner closely with other teams, including CMC, to provide designs, materials, and timelines.
- Mentor junior scientists and support strong practices in experimental design and data quality.
- Maintain clear and reproducible records (ELN, sequence tracking, sample management).
- Communicate results clearly to cross-functional teams and leadership.
Who you are
We encourage all candidates with exemplary experience in related fields to apply.
Technical Expertise
- BS with 14+ years, MS with 12+ years, or PhD with 5+ years of relevant industry experience in molecular biology, bioengineering, or a related field.
- Deep expertise in protein engineering and CAR
- Proven track record designing and building complex DNA libraries, including barcoding strategies for pooled screening.
- Strong command of molecular cloning and plasmid design in high-throughput settings.
- Demonstrated ownership of large-scale library screens, from design through execution and data interpretation.
- Expert-level experience with NGS-based library analysis, variant tracking, and sequence QC.
- Ability to operate effectively in cross-functional teams and drive work forward in a fast-paced environment.
- Experience mentoring or managing junior scientists.
Leadership & Collaboration
- Proven ability to lead complex projects and influence cross-functional teams.
- Strong mentorship skills with commitment to developing others. Previous technical or professional management experience.
- Excellent communication skills, with the ability to translate complex ideas across disciplines.
Values and Behaviors:
Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
See all 7,443+ TN Visa Senior Bioinformatics Scientist Jobs
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Get Access To All JobsTips for Finding TN Visa Sponsorship as a Senior Bioinformatics Scientist
Frame your degree in biological sciences
TN visa classification for bioinformatics depends on your degree field matching the job category. A degree in computational biology, genetics, or biochemistry strengthens your case more than a generic computer science credential when USCIS evaluates specialty occupation alignment under TN visa requirements.
Target employers with wet lab and computational teams
Pharmaceutical companies, genomics firms, and academic medical centers routinely hire bioinformatics scientists and have in-house HR familiar with TN filings. Startups without immigration counsel often misclassify the role, which delays your start date.
Clarify your job category before the offer letter
Ask your hiring manager whether the position will be filed under Scientific Technician or Computer Systems Analyst. The category determines what documentation CBP expects, and a mismatched offer letter is a common reason for TN denials at the border.
Search TN-ready bioinformatics roles on Migrate Mate
Use Migrate Mate to find Senior Bioinformatics Scientist openings from employers who already understand TN sponsorship. Filtering by visa type cuts out the back-and-forth with recruiters unfamiliar with USMCA professional categories.
Prepare your credential documentation before border crossing
Canadian nationals present their TN package directly to CBP at a port of entry, so your degree transcripts, professional license if applicable, and the employer support letter must be complete and consistent before you travel. Incomplete packets are turned away on the spot.
Understand Mexican nationals need a consular TN appointment
If you hold Mexican citizenship, you must apply for a TN visa stamp at a U.S. consulate rather than at a land border. Schedule your appointment as soon as your employer finalizes the support letter, since consulate wait times vary significantly by location and season.
Senior Bioinformatics Scientist TN Visa: Frequently Asked Questions
Does a Senior Bioinformatics Scientist role qualify for TN visa sponsorship?
Yes, but the classification depends on how the role is defined in your offer letter. Most bioinformatics positions qualify under the Scientific Technician or Computer Systems Analyst USMCA category. Your employer's support letter must explicitly connect your daily responsibilities and your degree field to one of those categories. A mismatch between the two is the leading cause of TN denials for this role.
How does TN compare to H-1B for Senior Bioinformatics Scientists?
TN has no annual lottery, no cap for Canadian citizens, and no multi-month USCIS adjudication wait. A Canadian national with a qualifying job offer can enter the U.S. in TN status the same day at a port of entry. H-1B visa requires entering a lottery, waiting up to six months for USCIS processing, and is subject to an annual cap of 85,000. For bioinformatics professionals who qualify, TN is significantly faster and more predictable.
How can I find Senior Bioinformatics Scientist jobs that offer TN visa sponsorship?
Use Migrate Mate to search specifically for bioinformatics roles from employers who are open to TN sponsorship. Most general job searches don't filter by visa type, which means you spend time on roles where the employer won't support a TN filing. Migrate Mate surfaces positions where sponsorship is already part of the hiring conversation.
Can my employer sponsor my TN visa renewal if my role evolves over time?
Yes, but your renewal support letter must still accurately describe your current duties and tie them to a qualifying USMCA category. If your role has shifted toward management or project oversight with less direct scientific work, CBP may scrutinize whether the position still meets the definition. Your employer should revisit the job description each time you renew, not simply reuse the original letter.
What happens to my TN status if I change employers mid-project?
Your TN status is tied to the specific employer listed on your filing. If you accept a new position, your new employer must issue a qualifying support letter and you must obtain a new TN, either at a U.S. port of entry if you're Canadian or through a consular appointment if you hold Mexican citizenship. There is no transfer mechanism like the H-1B portability rule under USMCA.