Principal Scientist Jobs in USA with Visa Sponsorship
Principal Scientist positions commonly qualify for H-1B visa, O-1, and EB-2 visa sponsorship due to their advanced degree requirements and specialized research expertise. Companies like Pfizer, Johnson & Johnson, and Genentech regularly sponsor these roles. The position typically requires a PhD in life sciences, chemistry, or related fields, making visa approval rates favorable given the clear specialty occupation criteria.
See All Principal Scientist JobsOverview
Showing 5 of 452+ Principal Scientist jobs
Have you applied for this role?
Have you applied for this role?
Have you applied for this role?
Have you applied for this role?
Have you applied for this role?
See all 452+ Principal Scientist jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Principal Scientist roles.
Get Access To All JobsINTRODUCTION
At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice.
Principal Scientist, Computational Biology Oncology
Bayer is a biopharmaceutical company committed to applying our scientific leadership in Oncology to transform the lives of patients with cancer. We are growing rapidly with an active research and discovery pipeline. We are seeking an agile innovator who brings excitement for drug discovery in cancer biology, as well as a passion for the cultural transformation of Dynamic Shared Ownership.
The Principal Scientist, Computational Biology is responsible for the evaluation of therapeutic hypotheses via integration and quantitative analyses of internal & external multi-omics data sources (DNA, RNA, CRISPR, ChIP-seq, methylation, and proteomics). Significant contributions to innovative research and development projects or collaborations, such as: identifying new targets with multi-omics evidence for a defined patient population; assessing the link between targets and disease biology; proposing indication selection and expansion hypotheses; proposing pharmacodynamic biomarkers; evaluating biomarker hypotheses from clinical trial specimens; assessing novel technologies; supporting therapeutic lifecycle management. You will adopt and contribute to Best Practices for novel technologies, quantitative analyses, visualizations, and biological insight generation from multi-omics data sources.
YOUR TASKS AND RESPONSIBILITIES
The primary responsibilities of this role, Principal Scientist, Computational Biologist are to:
- Evaluate and contextualize the molecular evidence supporting a therapeutic hypothesis with relevant internal and external multi-omics data (DNA, RNA, CRISPR, ChIP-seq, methylation, and proteomics);
- Design, execute, and interpret complex quantitative analyses to address precision drug development criteria. Examples of precision drug development criteria include RAISE dimensions, translational science strategy, proof-of-mechanism, and lifecycle management;
- Contribute to Product Team scientific strategy and prosecution of critical path objectives, such as the identification of novel targets, biomarkers, or patient selection hypotheses. These contributions use state-of-the art computational biology methods to analyze large and complex data sets;
- Deliver biological insights on therapeutic assets and disease biology understanding to Product Teams, who apply these insights towards stage-gate decisions, portfolio prioritization, and/or submissions to Health Authorities;
- Educate Product Teams on innovations in disease understanding, especially molecular mechanisms of tumor vulnerabilities that may represent unmet medical need;
- Develop, evaluate, implement, and apply Best Practices for the execution and validity of quantitative analyses, integration, visualizations, and interpretation of multi-omics data. Demonstrate a growth mindset towards updating Best Practices with the emergence of new experimental or computational technologies;
- Build cross-functional relationships to collaboratively partner across Pharma R&D and effectively network within disease understanding and data science communities of experts.
WHO YOU ARE
Bayer seeks an incumbent who possesses the following:
Required Qualifications:
- PhD degree in Life Sciences (Bioinformatics, Computational Biology, Biology, Genetics, Molecular Biology, or other related discipline) with very strong computational focus;
- Demonstrated experience in statistical analysis of DNA-seq, RNA-seq, proteomics, single-cell, or imaging datasets with proficiency in a programming environment (such as R or Python);
- Demonstrated peer-reviewed publications in computational biology;
- Expert level of proficiency to choose fit-for-purpose quantitative analyses;
- Demonstrated ability to propose, catalyze, and implement the development of interdisciplinary, systematic solutions that create business value;
- Evidence of providing tactical and strategic guidance to the pharma portfolio or data science ecosystem;
- Strong communication competencies, including capability to present even very complex issues clearly and convincingly to project teams or decision bodies;
- Demonstrates advanced business acumen, people and project leadership competencies, and technical expertise;
- Can manage a high degree of organizational and technical complexity;
- Learning agility, highly self-motivated, with an aspiration of continuous improvement of oneself and others.
Preferred Qualifications:
- 5+ years industry experience in drug development or biotech role with clear understanding of applying multi-omics data analyses to advance a portfolio of drug discovery or clinical development projects.
Employees can expect to be paid a salary between $136,000.00 - $204,000.00. Additional compensation may include a bonus or commission (if relevant). Additional benefits include health care, vision, dental, retirement, PTO, sick leave, etc.
This salary range is merely an estimate and may vary based on an applicant’s location, market data/ranges, an applicant’s skills and prior relevant experience, certain degrees and certifications, and other relevant factors.
This posting will be available for application until at least 05/12/2026.
YOUR APPLICATION
Bayer offers a wide variety of competitive compensation and benefits programs. If you meet the requirements of this unique opportunity, and want to impact our mission Health for all, Hunger for none, we encourage you to apply now. Be part of something bigger. Be you. Be Bayer.
To all recruitment agencies: Bayer does not accept unsolicited third party resumes.
Bayer is an Equal Opportunity Employer/Disabled/Veterans
Bayer is committed to providing access and reasonable accommodations in its application process for individuals with disabilities and encourages applicants with disabilities to request any needed accommodation(s) using the contact information below.
Equal Opportunity Employer Statement: Notice for U.S. Visitors: All information on this site is subject to compliance with local rule and regulations as they may vary from time to time and across different geographies, including, without limitation, U.S. Executive Orders.
Bayer is an E-Verify Employer.
LOCATION
Location: United States : Massachusetts : Cambridge
Division: Pharmaceuticals
Reference Code: 868028
Contact Us
Email: hrop_usa@bayer.com
INTRODUCTION
At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice.
Principal Scientist, Computational Biology Oncology
Bayer is a biopharmaceutical company committed to applying our scientific leadership in Oncology to transform the lives of patients with cancer. We are growing rapidly with an active research and discovery pipeline. We are seeking an agile innovator who brings excitement for drug discovery in cancer biology, as well as a passion for the cultural transformation of Dynamic Shared Ownership.
The Principal Scientist, Computational Biology is responsible for the evaluation of therapeutic hypotheses via integration and quantitative analyses of internal & external multi-omics data sources (DNA, RNA, CRISPR, ChIP-seq, methylation, and proteomics). Significant contributions to innovative research and development projects or collaborations, such as: identifying new targets with multi-omics evidence for a defined patient population; assessing the link between targets and disease biology; proposing indication selection and expansion hypotheses; proposing pharmacodynamic biomarkers; evaluating biomarker hypotheses from clinical trial specimens; assessing novel technologies; supporting therapeutic lifecycle management. You will adopt and contribute to Best Practices for novel technologies, quantitative analyses, visualizations, and biological insight generation from multi-omics data sources.
YOUR TASKS AND RESPONSIBILITIES
The primary responsibilities of this role, Principal Scientist, Computational Biologist are to:
- Evaluate and contextualize the molecular evidence supporting a therapeutic hypothesis with relevant internal and external multi-omics data (DNA, RNA, CRISPR, ChIP-seq, methylation, and proteomics);
- Design, execute, and interpret complex quantitative analyses to address precision drug development criteria. Examples of precision drug development criteria include RAISE dimensions, translational science strategy, proof-of-mechanism, and lifecycle management;
- Contribute to Product Team scientific strategy and prosecution of critical path objectives, such as the identification of novel targets, biomarkers, or patient selection hypotheses. These contributions use state-of-the art computational biology methods to analyze large and complex data sets;
- Deliver biological insights on therapeutic assets and disease biology understanding to Product Teams, who apply these insights towards stage-gate decisions, portfolio prioritization, and/or submissions to Health Authorities;
- Educate Product Teams on innovations in disease understanding, especially molecular mechanisms of tumor vulnerabilities that may represent unmet medical need;
- Develop, evaluate, implement, and apply Best Practices for the execution and validity of quantitative analyses, integration, visualizations, and interpretation of multi-omics data. Demonstrate a growth mindset towards updating Best Practices with the emergence of new experimental or computational technologies;
- Build cross-functional relationships to collaboratively partner across Pharma R&D and effectively network within disease understanding and data science communities of experts.
WHO YOU ARE
Bayer seeks an incumbent who possesses the following:
Required Qualifications:
- PhD degree in Life Sciences (Bioinformatics, Computational Biology, Biology, Genetics, Molecular Biology, or other related discipline) with very strong computational focus;
- Demonstrated experience in statistical analysis of DNA-seq, RNA-seq, proteomics, single-cell, or imaging datasets with proficiency in a programming environment (such as R or Python);
- Demonstrated peer-reviewed publications in computational biology;
- Expert level of proficiency to choose fit-for-purpose quantitative analyses;
- Demonstrated ability to propose, catalyze, and implement the development of interdisciplinary, systematic solutions that create business value;
- Evidence of providing tactical and strategic guidance to the pharma portfolio or data science ecosystem;
- Strong communication competencies, including capability to present even very complex issues clearly and convincingly to project teams or decision bodies;
- Demonstrates advanced business acumen, people and project leadership competencies, and technical expertise;
- Can manage a high degree of organizational and technical complexity;
- Learning agility, highly self-motivated, with an aspiration of continuous improvement of oneself and others.
Preferred Qualifications:
- 5+ years industry experience in drug development or biotech role with clear understanding of applying multi-omics data analyses to advance a portfolio of drug discovery or clinical development projects.
Employees can expect to be paid a salary between $136,000.00 - $204,000.00. Additional compensation may include a bonus or commission (if relevant). Additional benefits include health care, vision, dental, retirement, PTO, sick leave, etc.
This salary range is merely an estimate and may vary based on an applicant’s location, market data/ranges, an applicant’s skills and prior relevant experience, certain degrees and certifications, and other relevant factors.
This posting will be available for application until at least 05/12/2026.
YOUR APPLICATION
Bayer offers a wide variety of competitive compensation and benefits programs. If you meet the requirements of this unique opportunity, and want to impact our mission Health for all, Hunger for none, we encourage you to apply now. Be part of something bigger. Be you. Be Bayer.
To all recruitment agencies: Bayer does not accept unsolicited third party resumes.
Bayer is an Equal Opportunity Employer/Disabled/Veterans
Bayer is committed to providing access and reasonable accommodations in its application process for individuals with disabilities and encourages applicants with disabilities to request any needed accommodation(s) using the contact information below.
Equal Opportunity Employer Statement: Notice for U.S. Visitors: All information on this site is subject to compliance with local rule and regulations as they may vary from time to time and across different geographies, including, without limitation, U.S. Executive Orders.
Bayer is an E-Verify Employer.
LOCATION
Location: United States : Massachusetts : Cambridge
Division: Pharmaceuticals
Reference Code: 868028
Contact Us
Email: hrop_usa@bayer.com
See all 452+ Principal Scientist jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Principal Scientist roles.
Get Access To All JobsTips for Finding Visa Sponsorship as a Principal Scientist
Target pharmaceutical and biotech companies with established visa programs
Large pharma companies like Merck, Bristol Myers Squibb, and Moderna have dedicated immigration teams and regularly sponsor Principal Scientists for H-1B and other work visas.
Highlight your PhD and specialized research expertise in applications
Principal Scientist roles require advanced scientific training that clearly meets specialty occupation requirements, making visa approval more straightforward than generalist positions.
Consider O-1 if you have publications, patents, or peer review experience
Principal Scientists with significant research publications, patent filings, or peer review work may qualify for O-1 extraordinary ability visas with faster processing.
Research companies' pipeline and therapeutic areas before applying
Demonstrating knowledge of a company's specific drug development programs or therapeutic focus areas shows genuine interest and increases sponsorship likelihood.
Leverage industry conferences and professional networks for connections
Scientific conferences like AACR or BIO provide networking opportunities with hiring managers who understand visa sponsorship processes in pharmaceutical research.
Consider contract-to-hire positions as visa sponsorship pathways
Many biotech companies start Principal Scientists as contractors through agencies, then sponsor for permanent positions once they prove their research value.
Principal Scientist jobs are hiring across the US. Find yours.
Find Principal Scientist JobsFrequently Asked Questions
Do Principal Scientist positions qualify for H-1B sponsorship?
Yes, Principal Scientist roles consistently qualify for H-1B sponsorship because they require specialized knowledge in life sciences, chemistry, or related fields that directly corresponds to advanced degree requirements. The PhD requirement makes specialty occupation criteria straightforward to demonstrate.
What degree do I need for visa sponsorship as a Principal Scientist?
Most employers require a PhD in life sciences, chemistry, biology, biochemistry, or related scientific field for Principal Scientist positions. Some companies accept a Master's degree with 8+ years of relevant research experience, but PhD holders have stronger visa cases.
Can Principal Scientists get O-1 visas instead of H-1B?
Principal Scientists with significant research achievements may qualify for O-1 extraordinary ability visas. Strong indicators include first-author publications in high-impact journals, patent filings, peer review experience, or recognition through scientific awards or speaking engagements at major conferences.
Which companies commonly sponsor Principal Scientists for work visas?
Large pharmaceutical companies like Pfizer, Johnson & Johnson, Merck, and Bristol Myers Squibb regularly sponsor Principal Scientists. Major biotech firms including Genentech, Gilead, Moderna, and Biogen also have established visa sponsorship programs for senior research roles.
How to find Principal Scientist jobs with visa sponsorship?
Use Migrate Mate to find Principal Scientist positions with visa sponsorship at biotech companies, pharmaceutical firms, and research institutions. These roles typically qualify for H-1B, O-1, or EB-2 visas given their specialized nature. Focus your search on companies with established R&D departments that regularly sponsor international talent for senior scientific positions requiring advanced degrees and extensive research experience.
How does research experience abroad help with visa applications?
International research experience demonstrates specialized knowledge and can strengthen visa applications, especially if it involved unique methodologies or collaborations. Postdoc positions at prestigious international institutions or experience with region-specific diseases or populations can differentiate candidates in competitive sponsorship processes.
What is the prevailing wage requirement for sponsored Principal Scientist jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.
See which Principal Scientist employers are hiring and sponsoring visas right now.
Search Principal Scientist Jobs