Scientist Jobs in USA with Visa Sponsorship
Scientist roles are among the most commonly sponsored positions in the U.S., with H-1B, O-1, and J-1 all being realistic pathways. Pharmaceutical companies, biotech firms, national labs, and universities regularly sponsor scientists, and academic positions are often H-1B cap-exempt. If you have a Ph.D. and publications, you're also a strong candidate for O-1A extraordinary ability or EB-1A green card petitions down the line. For detailed occupation requirements, see the O*NET profile.
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INTRODUCTION
The Talbot laboratory, embedded within the Department of Bone Marrow Transplantation and Cell Therapy at St. Jude Children’s Research Hospital, is seeking to hire a dedicated and exceptional Scientist to lead studies in pediatric immune-oncology and solid tumor CAR T cell development. Our laboratory is part of a larger team of collaborative scientists within the Departments of Surgery and BMTCT with the ultimate goal of improving T-cell based immunotherapy targeting solid tumors and a focus on clinically translatable processes and results. The Talbot laboratory is specifically focused on understanding how transgenic wild type and mutated chemokine receptors can be exploited to drive homing of immune cells towards target pediatric tumors and confer enhanced biology, as well as understanding underlying microenvironmental interactions.
ROLE AND RESPONSIBILITIES
We are seeking a highly motivated individual with an interest in immunotherapy and basic immunology who seeks a work environment in which he/she has the opportunity to drive forward projects independently within the scope of the PI’s overall research umbrella. Active questioning, hypothesis generation, independent experimental work, and scientific curiosity are particularly encouraged.
The ideal candidate will have:
- A PhD in immunology, immunotherapy, or a related discipline.
- Extensive experience studying immune cell biology, immunotherapy, or related disciplines.
- Extensive experience with aseptic cell tissue culture, flow cytometry, molecular biology, and in vivo work with survival surgery experience particularly appreciated.
- Experience working with immune competent tissues, including tumor and tissue dissociation and immune cell subset recovery and analysis.
- Experience with generation of single cell datasets from dissociated tissues.
- Ability to independently design and execute experiments and interpret data, inclusive of figure generation and statistical analysis.
- Ability to work in a multidisciplinary, highly collaborative environment with excellent interpersonal skills.
- Excellent oral and written communication skills.
- Excellent multitasking abilities.
- Strong publication record.
- Track record of success training junior scientists and colleagues.
Job responsibilities:
- Coordinates multiple aspects of research projects and carries out laboratory experiments utilizing various laboratory techniques, and determines whether additional or other tools or methods are required.
- Provides input regarding research protocols and experiments. Sets up protocols and assists in developing new laboratory techniques as required.
- Identifies experimental data pertinent to the analysis problem. Processes, organizes and summarizes data, reporting these experimental results as required. Monitors quality and integrity of recorded information and data. Maintains excellent laboratory and experimental records.
- May draft sections of research manuscripts and grant applications.
- Provides basic lab operation support to include equipment maintenance and purchasing. Monitors inventory levels and orders lab supplies as needed. Performs calibration of instruments and equipment. Troubleshoots instrument performance and equipment issues.
- Instructs other staff in laboratory techniques and procedures.
- Maintains regular and predictable attendance.
- Performs other related duties as assigned in order to meet the goals of the department and institution.
MINIMUM QUALIFICATIONS
- Bachelor's degree in relevant scientific area is required.
MINIMUM EXPERIENCE
- Eight (8) years of relevant work experience is required.
- Six (6) years of relevant work experience is required with a Master's degree.
- Three (3) years of relevant work experience is required with a PhD.
- Prior experience in lab techniques is preferred.
- Experience in lab and scientific project coordination, maintenance, and other research support activities preferred.
- Prior experience with the generation of GEMMs in immunology and/or cancer biology is highly preferred.
PROFESSIONAL GROWTH OPPORTUNITIES
The Talbot lab can provide access to the Center of Excellence for Pediatric Immuno-oncology, which provides a vibrant research environment with access to advanced tools and resources, including state-of-the-art imaging platforms and cutting-edge molecular biology techniques. CEPIO fosters a culture of collaboration, offering opportunities for professional development and advancement.
We invite motivated scientists passionate about preclinical murine models and immuno-oncology to apply and join us in pushing the boundaries of immuno-oncology and immunotherapy in the fight against pediatric cancers.
COMPENSATION
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist - Talbot Laboratory, Departments of Surgery and Bone Marrow Transplantation and Cell Therapy.
Explore our exceptional benefits!
St. Jude is an Equal Opportunity Employer
No Search Firms
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

How to Get Visa Sponsorship as a Scientist
Prioritize universities and nonprofit research institutions
H-1B petitions filed by universities, teaching hospitals, and nonprofit research organizations are exempt from the annual cap. This means no lottery and year-round filing, which is especially valuable in a field where research timelines do not align with the March registration window.
Build a publication record to unlock premium visa pathways
A strong citation history can qualify you for an O-1A visa or EB-1A green card, both of which bypass the H-1B lottery entirely. Even a few well-cited papers in peer-reviewed journals can significantly strengthen your case for extraordinary ability.
Use postdoctoral positions as a visa bridge
Postdoc roles at U.S. universities typically come with J-1 or cap-exempt H-1B sponsorship. These positions let you build the credentials needed for O-1A or EB-2 NIW petitions while maintaining legal work status.
Target interdisciplinary roles in high-demand areas
Positions combining data analysis with scientific research - such as computational biology or materials informatics - tend to have strong sponsorship demand. Employers filling these hybrid roles often have fewer qualified domestic candidates, which can strengthen the labor market case.
Leverage conference presentations and peer review service
Serving as a peer reviewer for journals and presenting at major scientific conferences count as evidence of extraordinary ability for O-1A and EB-1 petitions. Start building this record early, even while in a junior scientist role.
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Get Access To All JobsFrequently Asked Questions
What visa options are available for scientists in the U.S.?
Scientists commonly qualify for H-1B visas as specialty occupation workers, and positions at universities and nonprofit research institutions are cap-exempt. Those with significant publications and citations may qualify for O-1A visas for extraordinary ability in the sciences. For permanent residency, EB-1A (extraordinary ability) and EB-2 NIW (National Interest Waiver) are strong pathways for scientists with a demonstrated research track record.
Do national laboratories sponsor visas for scientists?
Many U.S. national laboratories - including Los Alamos, Sandia, Oak Ridge, and Lawrence Berkeley - regularly sponsor H-1B visas for research scientists. These positions are often cap-exempt because the labs are affiliated with or operated by universities and nonprofit organizations. This means no lottery is required, and petitions can be filed year-round.
Can I self-petition for a green card as a scientist?
Scientists with advanced degrees and a record of impactful research may qualify for an EB-2 National Interest Waiver, which does not require employer sponsorship. You petition on your own behalf by demonstrating your work benefits the U.S. national interest. A strong publication record, citations, and evidence of real-world impact strengthen the case.
What makes a scientist's H-1B petition strong?
A strong petition clearly connects the job duties to a specific scientific discipline requiring at least a bachelor's degree. Detailed descriptions of research methodologies, specialized techniques, and how the role advances the employer's mission all help. Roles tied to recognized science SOC codes like 19-1042 (Medical Scientists) or 19-2031 (Chemists) reinforce the specialty occupation argument.
What is the prevailing wage requirement for sponsored Scientist jobs?
When a U.S. employer sponsors a foreign worker for a work visa, they are legally required to pay at least the "prevailing wage" — the average wage paid to workers in the same occupation, in the same geographic area, with similar experience. This is set by the Department of Labor to prevent employers from hiring foreign workers at below-market rates. The prevailing wage varies significantly by role, location, and experience level — for example, a scientist in California will have a different prevailing wage than the same role in a smaller state. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search.
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