Senior Level CNC Machinist Programmer Jobs
Senior level cnc machinist programmer jobs place experienced machinists in charge of complex programming decisions, process ownership, and the precision manufacturing outcomes that less experienced team members look to them to set. Openings are predominantly on-site in Technology & Software, Consulting & Professional Services, and Fashion & Apparel, with employers like Knoll, Roblox, and SMX Services & Consulting hiring at this level now.
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Showing 5 of 18+ Senior Level CNC Machinist Programmer jobs
Durham, United States of America | Full time | Home-based | R1577809
Job Title: Principal Statistical Programmer
Position Summary
We are seeking a Principal Statistical Programmer to provide full end‑to‑end statistical programming support across clinical development programs. This role requires deep technical expertise, leadership, and hands‑on delivery, covering SDTM, ADaM, TLF development, and regulatory submission support. The Principal Statistical Programmer will serve as a subject matter expert, ensure high‑quality deliverables, and contribute to programming standards and best practices.
Key Responsibilities
- Provide end‑to‑end statistical programming support for clinical studies from study setup through submission
- Lead and perform development and validation of:
- SDTM datasets
- ADaM datasets
- Tables, Listings, and Figures (TLFs)
- Ensure all deliverables are compliant with CDISC standards and regulatory requirements
- Support regulatory submissions (e.g., FDA, EMA), including define.xml, submission‑ready datasets, and reviewer’s guides
- Serve as a Principal‑level programmer, providing technical leadership and guidance to other programmers as needed
- Contribute to and help maintain programming standards, macros, and validation processes
- Review and approve programming deliverables to ensure accuracy, consistency, and quality
- Collaborate closely with Biostatistics, Data Management, Clinical Operations, and Regulatory teams
- Proactively identify risks and propose efficient, compliant solutions within timelines
Required Qualifications
- Bachelor’s or Master’s degree in Statistics, Mathematics, Computer Science, Life Sciences, or related field
- Extensive experience as a statistical programmer, with demonstrated Principal‑level responsibilities
- Strong hands‑on experience with:
- SDTM and ADaM dataset development
- TLF programming
- Regulatory submission deliverables
- Expert proficiency in base SAS and Advanced SAS with good hands on SAS Macros
- In‑depth knowledge of CDISC standards, regulatory guidelines, and submission requirements
- Proven ability to manage complex studies independently from start to finish
IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at https://jobs.iqvia.com
IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe
IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.
The potential base pay range for this role, when annualized, is $98,200.00 - $273,200.00. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.Where you'll work
Home-based
You’ll work remotely, with the flexibility to do your best work from home. Supported by collaborative tools and a global team, you’ll stay connected while enjoying the autonomy and balance that comes with a fully remote role.
Culture
Culture at IQVIA is built on a shared belief: that when people are empowered with better data, smarter technology and deeper expertise, they can change what’s possible for patients. Across every team and every corner of the globe, you’ll find colleagues who genuinely care — about the mission and about each other. That’s what makes this a place where people tend to stay, grow and do the best work of their careers.
Durham, United States of America | Full time | Home-based | R1577809
Job Title: Principal Statistical Programmer
Position Summary
We are seeking a Principal Statistical Programmer to provide full end‑to‑end statistical programming support across clinical development programs. This role requires deep technical expertise, leadership, and hands‑on delivery, covering SDTM, ADaM, TLF development, and regulatory submission support. The Principal Statistical Programmer will serve as a subject matter expert, ensure high‑quality deliverables, and contribute to programming standards and best practices.
Key Responsibilities
- Provide end‑to‑end statistical programming support for clinical studies from study setup through submission
- Lead and perform development and validation of:
- SDTM datasets
- ADaM datasets
- Tables, Listings, and Figures (TLFs)
- Ensure all deliverables are compliant with CDISC standards and regulatory requirements
- Support regulatory submissions (e.g., FDA, EMA), including define.xml, submission‑ready datasets, and reviewer’s guides
- Serve as a Principal‑level programmer, providing technical leadership and guidance to other programmers as needed
- Contribute to and help maintain programming standards, macros, and validation processes
- Review and approve programming deliverables to ensure accuracy, consistency, and quality
- Collaborate closely with Biostatistics, Data Management, Clinical Operations, and Regulatory teams
- Proactively identify risks and propose efficient, compliant solutions within timelines
Required Qualifications
- Bachelor’s or Master’s degree in Statistics, Mathematics, Computer Science, Life Sciences, or related field
- Extensive experience as a statistical programmer, with demonstrated Principal‑level responsibilities
- Strong hands‑on experience with:
- SDTM and ADaM dataset development
- TLF programming
- Regulatory submission deliverables
- Expert proficiency in base SAS and Advanced SAS with good hands on SAS Macros
- In‑depth knowledge of CDISC standards, regulatory guidelines, and submission requirements
- Proven ability to manage complex studies independently from start to finish
IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at https://jobs.iqvia.com
IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe
IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.
The potential base pay range for this role, when annualized, is $98,200.00 - $273,200.00. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.Where you'll work
Home-based
You’ll work remotely, with the flexibility to do your best work from home. Supported by collaborative tools and a global team, you’ll stay connected while enjoying the autonomy and balance that comes with a fully remote role.
Culture
Culture at IQVIA is built on a shared belief: that when people are empowered with better data, smarter technology and deeper expertise, they can change what’s possible for patients. Across every team and every corner of the globe, you’ll find colleagues who genuinely care — about the mission and about each other. That’s what makes this a place where people tend to stay, grow and do the best work of their careers.
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Senior Level CNC Machinist Programmer Jobs: Frequently Asked Questions
How do I get a senior level cnc machinist programmer job?
Employers at this level look for demonstrated ownership of full machining cycles, from G-code and CAM programming through first-article inspection and process optimization. What gives candidates an edge is a portfolio of complex multi-axis work, experience training or guiding junior machinists, and a history of reducing cycle times or scrap rates on production runs. Certifications in advanced CAM software and geometric dimensioning and tolerancing strengthen your candidacy considerably.
Which companies hire senior level cnc machinist programmers?
Companies hiring senior level cnc machinist programmers right now include Knoll, Roblox, and SMX Services & Consulting, based on current listings on Migrate Mate as of November 2026. At this level, hiring tends to come from aerospace and defense contractors, precision medical device manufacturers, and industrial equipment producers that need programmers who can own complex, tight-tolerance work with minimal oversight.
Are there remote senior level cnc machinist programmer jobs?
Yes, though remote opportunities are limited given that most cnc machinist programmer work requires direct access to machines and shop floor collaboration. About 44% of senior level cnc machinist programmer openings are remote or hybrid as of November 2026, and those roles typically involve off-site CAM programming, toolpath development, or technical consulting for manufacturers who separate programming from machine operation.
What makes a cnc machinist programmer role senior level?
A senior level cnc machinist programmer role is defined by the scope of ownership and technical complexity expected. Senior programmers independently develop and optimize programs for multi-axis and high-precision machining, troubleshoot process failures without escalation, establish programming standards, and mentor junior staff. They are accountable for quality outcomes across entire part families or production lines, not just individual setups or single-operation programs.
Which industries hire the most senior level cnc machinist programmers?
Senior Level cnc machinist programmer roles concentrate in Technology & Software, Consulting & Professional Services, and Fashion & Apparel, based on current listings on Migrate Mate as of November 2026. These sectors drive demand because they require tight tolerances, complex geometries, and regulatory compliance that only experienced programmers with deep process knowledge can consistently deliver at production volume.