Cybersecurity Lead Jobs in Missouri
Cybersecurity Lead jobs in Missouri are open across O'Fallon, Chesterfield, and Creve Coeur and other Missouri metros, with employers like Mastercard, Bayer, and Nga Group hiring at every experience level. Find a role that fits below and apply directly.
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At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice.
Lead Cyber Security Architect
THE MISSION
Security should not slow innovation down — it should make it possible.
As a Lead Cyber Security Architect at Bayer, you will design the security foundations that allow global teams to build, scale, and innovate with confidence. From AI and emerging digital capabilities to cloud platforms and applications, you will help make secure design the default whilst enabling the business to move faster and deliver our bold purpose: Health for All, Hunger for None.
You'll join the Global Cybersecurity Architecture team building the strategy and foundations of secure system design for the entire enterprise - serving pharma, consumer health, and crop science across R&D, manufacturing, supply chain, and commercial operations globally. We operate with a startup mindset inside a global organization: small squads, fast cycles, high autonomy. We think about how to get things done - not why they can't be.
The primary location for this role will be Creve Coeur, MO (St. Louis, MO metro area).
What you will do
As Lead Cyber Security Architect, you will define, guide, and evolve the security architecture that protects Bayer’s applications, platforms, infrastructure, cloud environments, AI capabilities, and digital products. You will work across cyber security, IT platforms, engineering, product, and business teams to ensure that security is not a blocker, but truly a catalyst for trusted innovation.
Your key responsibilities will include:
- Shape Bayer’s security architecture direction by contributing to and applying Bayer’s Architecture Framework for Security across key technical domains, including cloud, network, application, platform, AI, and agentic AI security.
- Drive “Security by Default” by creating and maintaining practical security standards, reusable architecture patterns, and guardrails that make doing business securely the easiest way to do business.
- Enable the secure design for complex environments by acting as an expert reference for globally dispersed teams to develop tailored cyber security architectures.
- Translate strategy into action by converting business objectives and risk management priorities into clear security controls, architectural decisions, and technology-enabled solutions.
- Stay ahead of the threat landscape by monitoring emerging cyber threats, vulnerabilities, technologies, and regulatory expectations — and turning those insights into proactive security recommendations.
- Foster a unified cyber security approach by leading initiatives, shaping architecture decisions, and helping teams across Bayer manage risk consistently and effectively.
What makes this role exciting
This role sits at the intersection of strategy, architecture, technology, and transformation. You will not simply review designs or write standards — you will help define how security works at scale across a global enterprise.
You will have the opportunity to influence how Bayer secures emerging technologies, including cloud-native platforms, AI-enabled services, and agentic AI solutions. You will work with talented cyber, platform, engineering, data, and business teams to build security into the fabric of digital delivery.
WHO YOU ARE
We care more about how you think than what's on your résumé. If you’re someone with strong technical credibility, architectural judgement, and the ability to operate confidently in a global enterprise environment, we want to talk.
You should bring:
- A degree in information technology, cyber security, computer science, or a related field — or equivalent professional experience.
- 5+ years of experience in cybersecurity, previous experience in a security engineering role highly desired.
- Strong knowledge of cyber security principles, enterprise IT infrastructure, network architecture, cloud security, application security, and secure system design.
- Proven experience designing security architectures for complex applications, platforms, or enterprise technology environments.
- Familiarity with relevant cyber security frameworks, architecture methods, standards, and regulatory expectations.
- Excellent communication skills, with the ability to explain complex cyber security topics clearly to technical and non-technical audiences.
- The ability to influence across teams, build trusted relationships, and drive alignment between security, technology, and business outcomes.
Preferred experience
The following would be highly valued:
- Demonstrable knowledge and experience in AI security architecture, including agentic AI security concepts and controls.
- Professional certifications such as CISSP or CISM.
This posting will be available for application until at least 7/6/26.
Employees can expect to be paid a salary between $126,313.00 to $189,470.00. Additional compensation may include a bonus or commission (if relevant). Additional benefits include health care, vision, dental, retirement, PTO, sick leave, etc.
This salary range is merely an estimate and may vary based on an applicant’s location, market data/ranges, an applicant’s skills and prior relevant experience, certain degrees and certifications, and other relevant factors.
LI-US
YOUR APPLICATION
Bayer offers a wide variety of competitive compensation and benefits programs. If you meet the requirements of this unique opportunity, and want to impact our mission Health for all, Hunger for none, we encourage you to apply now. Be part of something bigger. Be you. Be Bayer.
To all recruitment agencies: Bayer does not accept unsolicited third party resumes.
Bayer is an Equal Opportunity Employer/Disabled/Veterans
Bayer is committed to providing access and reasonable accommodations in its application process for individuals with disabilities and encourages applicants with disabilities to request any needed accommodation(s) using the contact information below.
Equal Opportunity Employer Statement: Notice for U.S. Visitors: All information on this site is subject to compliance with local rule and regulations as they may vary from time to time and across different geographies, including, without limitation, U.S. Executive Orders.
Bayer is an E-Verify Employer.
Location: United States : Missouri : Creve Coeur
Division: Enabling Functions
Reference Code: 872805
Contact Us
Email: hrop_usa@bayer.com
See All 6 Cybersecurity Lead Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find Cybersecurity Lead JobsCybersecurity Lead Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Cybersecurity Lead Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
- Mastercard3

- Bayer1

- Nga Group1

- Refinitiv US1

Top Industries Hiring
- Technology & Software2
- Banking & Financial Services1
- Biotechnology & Pharmaceuticals1
- Fintech1
What Missouri Employers Look For
The qualifications that appear most often in cybersecurity lead jobs across Missouri.
- Seven or more years of progressive cybersecurity experience with at least two in a leadership role
- Hands-on proficiency with SIEM platforms such as Splunk, Microsoft Sentinel, or IBM QRadar
- Active CISSP, CISM, or equivalent enterprise security certification
- Experience developing and maintaining security policies aligned to NIST, ISO 27001, or SOC 2 frameworks
- Proven ability to lead incident response efforts and manage post-incident reviews
- Bachelor's degree in computer science, information security, or a closely related field
Cybersecurity Lead Jobs in Missouri: Frequently Asked Questions
How many cybersecurity lead jobs are there in Missouri?
There are 6+ cybersecurity lead openings in Missouri on Migrate Mate as of June 2026, with the most roles in O'Fallon, Chesterfield, and Creve Coeur. New positions post regularly as employers across Missouri hire.
How much do cybersecurity leads make in Missouri?
Cybersecurity leads in Missouri earn a median of about $103,440 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $60,700 for the lowest 10% to over $161,430 for the top 10%. Pay rises with experience, specialty, and employer.
Which Missouri cities have the most cybersecurity lead jobs?
O'Fallon, Chesterfield, and Creve Coeur have the most cybersecurity lead openings in Missouri right now, with additional roles spread across smaller metros statewide.
Which companies hire cybersecurity leads in Missouri?
Employers hiring cybersecurity leads in Missouri include Mastercard, Bayer, and Nga Group, based on current listings on Migrate Mate as of June 2026.
Are there remote cybersecurity lead jobs in Missouri?
Yes. About 0% of cybersecurity lead openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.
How do I apply for cybersecurity lead jobs in Missouri?
You can apply to cybersecurity lead jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.
See All 6 Cybersecurity Lead Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find Cybersecurity Lead Jobs