Cybersecurity Lead Jobs in Missouri

Cybersecurity Lead jobs in Missouri are open across O'Fallon, Chesterfield, and Creve Coeur and other Missouri metros, with employers like Mastercard, Bayer, and Nga Group hiring at every experience level. Find a role that fits below and apply directly.

Find Cybersecurity Lead Jobs

Overview

Open roles6+
Top employerMastercard
Top cityO'Fallon, MO
Cities hiring4
Work type100% On-site
Top industryTechnology

Showing 5 of 6+ Cybersecurity Lead jobs

Bayer
Lead Cyber Security Architect
We won't show you this job again
Bayer
Added 3d ago
Lead Cyber Security Architect
Bayer
Creve Coeur, Missouri
Cybersecurity
Cloud & DevOps
Technical Product & Program Management
Security Engineering
Cloud Engineering
$126k - $189k/yr
On-Site
Bachelor's
10,000+

Have you applied for this role?

Mastercard
Lead, Enterprise Operations - Messaging
We won't show you this job again
Mastercard
Added 1w ago
Lead, Enterprise Operations - Messaging
Mastercard
O'Fallon, Missouri
IT Support & Systems Administration
Cloud & DevOps
Cybersecurity
Technical Product & Program Management
IT Support
Technical Program Management
$122k - $207k/yr
On-Site
None
10,000+

Have you applied for this role?

Nga Group, Inc.
Project Lead System Engineer (Network Operations)
We won't show you this job again
Nga Group, Inc.
Added 2w ago
Project Lead System Engineer (Network Operations)
Nga Group, Inc.
Chesterfield, Missouri
Technical Product & Program Management
IT Support & Systems Administration
Cloud & DevOps
Cybersecurity
Systems Administration
On-Site
Bachelor's

Have you applied for this role?

Refinitiv US
Technical Lead - Site Reliability Engineering
We won't show you this job again
Refinitiv US
Added 1mo ago
Technical Lead - Site Reliability Engineering
Refinitiv US
St. Louis, Missouri
Cloud & DevOps
Technical Product & Program Management
Cybersecurity
Solutions Engineering & Architecture
On-Site
Associate's

Have you applied for this role?

Mastercard
Lead Site Reliability Engineer
We won't show you this job again
Mastercard
Added 1mo ago
Lead Site Reliability Engineer
Mastercard
O'Fallon, Missouri
Cloud & DevOps
Technical Product & Program Management
Cybersecurity
DevOps
Cloud Engineering
Technical Program Management
$122k - $207k/yr
On-Site
Bachelor's
10,000+

Have you applied for this role?

See All 6 Cybersecurity Lead Jobs in Missouri

Find roles in Missouri that match your experience and apply in just a few clicks.

Find Cybersecurity Lead Jobs

Cybersecurity Lead Jobs by City in Missouri

Where Missouri roles are concentrated, by current openings.

O'Fallon
3 jobs
Chesterfield
1 jobs
Creve Coeur
1 jobs
St. Louis
1 jobs

Cybersecurity Lead Job Market in Missouri

A snapshot from current Missouri openings, updated as new roles post.

Who's Hiring

  • Mastercard
    Mastercard3
  • Bayer
    Bayer1
  • Nga Group
    Nga Group1
  • Refinitiv US
    Refinitiv US1

Top Industries Hiring

  • Technology & Software2
  • Banking & Financial Services1
  • Biotechnology & Pharmaceuticals1
  • Fintech1

What Missouri Employers Look For

The qualifications that appear most often in cybersecurity lead jobs across Missouri.

  • Seven or more years of progressive cybersecurity experience with at least two in a leadership role
  • Hands-on proficiency with SIEM platforms such as Splunk, Microsoft Sentinel, or IBM QRadar
  • Active CISSP, CISM, or equivalent enterprise security certification
  • Experience developing and maintaining security policies aligned to NIST, ISO 27001, or SOC 2 frameworks
  • Proven ability to lead incident response efforts and manage post-incident reviews
  • Bachelor's degree in computer science, information security, or a closely related field

Cybersecurity Lead Jobs in Missouri: Frequently Asked Questions

How many cybersecurity lead jobs are there in Missouri?

There are 6+ cybersecurity lead openings in Missouri on Migrate Mate as of June 2026, with the most roles in O'Fallon, Chesterfield, and Creve Coeur. New positions post regularly as employers across Missouri hire.

How much do cybersecurity leads make in Missouri?

Cybersecurity leads in Missouri earn a median of about $103,440 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $60,700 for the lowest 10% to over $161,430 for the top 10%. Pay rises with experience, specialty, and employer.

Which Missouri cities have the most cybersecurity lead jobs?

O'Fallon, Chesterfield, and Creve Coeur have the most cybersecurity lead openings in Missouri right now, with additional roles spread across smaller metros statewide.

Which companies hire cybersecurity leads in Missouri?

Employers hiring cybersecurity leads in Missouri include Mastercard, Bayer, and Nga Group, based on current listings on Migrate Mate as of June 2026.

Are there remote cybersecurity lead jobs in Missouri?

Yes. About 0% of cybersecurity lead openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.

How do I apply for cybersecurity lead jobs in Missouri?

You can apply to cybersecurity lead jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.

See All 6 Cybersecurity Lead Jobs in Missouri

Find roles in Missouri that match your experience and apply in just a few clicks.

Find Cybersecurity Lead Jobs