Data Science Lead Jobs in Missouri
Data Science Lead jobs in Missouri are open across Clayton, Kansas City, and O'Fallon and other Missouri metros, with employers like Aaa Texas, BAE Systems USA, and Bass Pro Shops hiring at every experience level. Find a role that fits below and apply directly.
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You could be the one who changes everything for our 28 million members by using technology to improve health outcomes around the world. As a diversified, national organization, Centene's technology professionals have access to competitive benefits including a fresh perspective on workplace flexibility.
EMPLOYER: Centene Management Company, LLC
POSITION: Lead Data Engineers
JOB ID No.: 1641450
DUTIES:
- Design, build, test, and maintain scalable technology solutions to meet business needs.
- Develop production processes utilizing best practices and adhering to team standards.
- Run operational ETL jobs, produce reports, troubleshoot issues, investigate data issues, and assist business personnel in answering data-related questions.
- Contribute to the entire implementation process including driving the definition of improvements based on business need and architectural improvements.
- Meet with business partners to understand business needs.
- Responsible for overall design of the solution.
- Design, build, and test applications.
- Conduct root cause analysis and advanced performance tuning for complex business processes and functionality.
- Support actuarial-based Medicaid compliance reporting processes.
- Responsible for transition legacy reports and ETL processes to Next Gen development framework.
- Share knowledge and experience in one or more of the following technologies: SAS, Teradata, Greenplum, or Power BI.
- Position reports to Centene headquarters at 7700 Forsyth Boulevard, St. Louis, MO 63105 and various unanticipated worksites throughout the U.S. Telecommuting permitted 100% of the time. No additional national or international travel is anticipated.
MINIMUM REQUIREMENTS:
- PRIMARY REQUIREMENTS: Bachelor’s degree in Computer Science, Managing Information Technology, Statistics, Mathematics, Engineering, or related, or its foreign equivalent, or equivalent experience acquired through accomplishments of applicable knowledge, duties, scope and skill reflective of the level of this position, and 6 years of relevant work experience.
- In addition, experience with the following skills is required:
1) Developing and maintaining large-scale health insurance systems in support of reporting and analytics using a combination of data storage, data processing (ETL), and data presentation solutions;
2) Utilizing knowledge of Medicaid regulatory financial reporting state requirements, internal information systems (including claims processing, configuration, and provider/member management), and enterprise data sources to deliver solutions to internal and external stakeholders;
3) Designing, developing, and maintaining Teradata and Greenplum ETL processes to capture and transform data in support of reporting and analytics;
4) Designing, developing, and maintaining Teradata and Greenplum databases to store and make data available in support of reporting and analytics, including indexing, partitioning, archival, and query optimization; and
5) Designing and developing reports, analytics, and dashboards in Microsoft Power BI to meet the functional requirements of business users.
JOB SITE: 7700 Forsyth Boulevard, St. Louis, MO 63105
WORK HOURS: Monday-Friday, 40 hours/week [8:00 am to 5:00 pm]
PAY RANGE: $145,858.60 to $190,500.00 per year
Centene offers a comprehensive benefits package including: competitive pay, health insurance, 401K and stock purchase plans, tuition reimbursement, paid time off plus holidays, and a flexible approach to work with remote, hybrid, field or office work schedules. Actual pay will be adjusted based on an individual's skills, experience, education, and other job-related factors permitted by law. Total compensation may also include additional forms of incentives.
To apply, please visit Centene’s web page at http://jobs.centene.com/#careers. Create a candidate profile and apply to requisition 1641450.
Centene is an equal opportunity employer that is committed to diversity, and values the ways in which we are different. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or other characteristic protected by applicable law.
Qualified applicants with arrest or conviction records will be considered in accordance with the LA County Ordinance and the California Fair Chance Act.
See All 6 Data Science Lead Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find Data Science Lead JobsData Science Lead Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Data Science Lead Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
- Aaa Texas1

- BAE Systems USA1

- Bass Pro Shops1

- Catalent Pharma Solutions1

- Centene1

Top Industries Hiring
- Biotechnology & Pharmaceuticals1
- Consulting & Professional Services1
- Hospitality & Tourism1
- Insurance1
- Retail1
What Missouri Employers Look For
The qualifications that appear most often in data science lead jobs across Missouri.
- 5+ years of experience in data science with at least 2 years in a lead or senior role
- Proficiency in Python or R along with SQL for data manipulation and modeling workflows
- Experience deploying machine learning models to production environments at scale
- Familiarity with cloud platforms such as AWS, Azure, or Google Cloud for data infrastructure
- Demonstrated ability to mentor junior data scientists and manage cross-functional projects
- Graduate degree in statistics, computer science, mathematics, or a closely related field
Data Science Lead Jobs in Missouri: Frequently Asked Questions
How many data science lead jobs are there in Missouri?
There are 6+ data science lead openings in Missouri on Migrate Mate as of June 2026, with the most roles in Clayton, Kansas City, and O'Fallon. New positions post regularly as employers across Missouri hire.
How much do data science leads make in Missouri?
Data science leads in Missouri earn a median of about $97,090 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $58,960 for the lowest 10% to over $151,380 for the top 10%. Pay rises with experience, specialty, and employer.
Which Missouri cities have the most data science lead jobs?
Clayton, Kansas City, and O'Fallon have the most data science lead openings in Missouri right now, with additional roles spread across smaller metros statewide.
Which companies hire data science leads in Missouri?
Employers hiring data science leads in Missouri include Aaa Texas, BAE Systems USA, and Bass Pro Shops, based on current listings on Migrate Mate as of June 2026.
Are there remote data science lead jobs in Missouri?
Yes. About 17% of data science lead openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.
How do I apply for data science lead jobs in Missouri?
You can apply to data science lead jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.
See All 6 Data Science Lead Jobs in Missouri
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