Principal Applied Scientist Jobs

Principal Applied Scientist jobs are open across technology, healthcare, financial services, and defense, from senior to distinguished-level, with specializations in machine learning, natural language processing, and computer vision. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles56
Top stateWashington
Top employerAmazon
Top cityRedmond, WA
Work type44% Hybrid
Top industryRetail

Showing 5 of 56+ Principal Applied Scientist jobs

Principal AI Engineer/ AI Applied Scientist
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Added 2d ago
Principal AI Engineer/ AI Applied Scientist
FICO
Remote
AI (Artificial Intelligence)
Data Science
ML (Machine Learning)
$172k - $270k/yr
Remote (US)
Master's degree
1,001-5,000

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Principal Applied Scientist - ML & Deep Learning
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Added 2d ago
Principal Applied Scientist - ML & Deep Learning
Microsoft
Redmond, Washington
AI (Artificial Intelligence)
Data Science
Research & Academia
$143k - $304k/yr
Doctoral degree in statistics
10,000+

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Principal Applied Scientist
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Added 6d ago
Principal Applied Scientist
Microsoft
Redmond, Washington
Biotech & Life Sciences
Clinical Trials
Laboratory Research
Research & Academia
$166k - $331k/yr
Hybrid
Doctoral degree in statistics
10,000+

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Principal Data and Applied Scientist
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Added 1w ago
Principal Data and Applied Scientist
Microsoft
Redmond, Washington
Biotech & Life Sciences
Environmental & Physical Sciences
Laboratory Research
Research & Academia
$143k - $304k/yr
Doctoral degree in statistics
10,000+

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Principal Applied Scientist, Items and Relationships Platform
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Added 1w ago
Principal Applied Scientist, Items and Relationships Platform
Amazon.com
Seattle, Washington
Biotech & Life Sciences
Environmental & Physical Sciences
Laboratory Research
Research & Academia
$199k - $269k/yr
Doctoral degree in Computer Science
10,000+

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Principal Applied Scientist Jobs by Experience Level

See All 56 Principal Applied Scientist Jobs

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Principal Applied Scientist Job Market

Who's Hiring

  • Amazon23
  • Microsoft11
  • Amazon Web Services9
  • FICO1
  • NVIDIA1

Top Industries Hiring

  • Retail
  • Technology & Software
  • E-Commerce & Online Marketplaces
  • Distribution & Wholesale
  • Consulting & Professional Services

What Employers Look For

The qualifications that appear most often in principal applied scientist jobs.

  • PhD in computer science, statistics, or a related quantitative field
  • 7 or more years of applied machine learning or data science experience
  • Proficiency in Python and deep learning frameworks such as PyTorch or TensorFlow
  • Proven record of deploying large-scale ML models to production systems
  • Experience mentoring senior scientists and leading multi-team research initiatives
  • Strong publication history or equivalent applied research contributions

Tips for Your Principal Applied Scientist Job Search

Align your resume to research impact

Principal applied scientist roles expect evidence of research-to-production impact, not just publications. Quantify how your models improved a product metric, reduced latency, or scaled to production. Hiring managers at this level read for scope and ownership, not titles.

Target postings that name your research area

Filter openings by your core specialization, whether that's reinforcement learning, large language models, or causal inference. Applying to roles aligned with your published work gives your application immediate credibility and reduces the chance of a skills mismatch early in the process.

Apply early to roles that fit

Migrate Mate lists principal applied scientist openings from across the United States in one place, so you can find roles that match and apply directly to each listing.

Prepare a system design narrative

Many principal-level interviews include an ML system design round where you architect a production system end to end. Practice explaining tradeoffs in feature pipelines, model serving, and evaluation frameworks out loud, not just on paper, before your first screen.

Signal cross-functional leadership explicitly

At this level, teams expect you to influence product roadmaps and mentor staff scientists. Your resume and cover materials should name specific instances where you shaped a product decision or defined a modeling strategy, not just executed one handed to you.

Negotiate scope and research time, not only pay

When you receive an offer, ask directly about the ratio of applied research to engineering work and whether the team publishes externally. These shape your day-to-day far more than base compensation alone, and most hiring managers expect principal candidates to ask.

Principal Applied Scientist Jobs: Frequently Asked Questions

Which companies are hiring the most principal applied scientists?

Amazon, Microsoft, and Amazon Web Services are hiring the most principal applied scientists right now, with openings concentrated in Washington, California, and New York, based on current listings on Migrate Mate as of November 2026. Demand is strongest at large technology companies and research-intensive enterprises building proprietary AI infrastructure.

How many principal applied scientist jobs are remote?

About 61% of principal applied scientist openings are fully remote or hybrid as of November 2026, reflecting broad employer flexibility at the senior end of the applied science ladder. Roles focused on modeling research and algorithm development tend to be more remote-compatible than those requiring close collaboration with hardware or infrastructure teams.

How do you become a principal applied scientist?

Most principal applied scientists progress through a combination of doctoral-level training and years of hands-on modeling work in production environments. Building a portfolio of shipped ML systems, contributing to peer-reviewed research, and demonstrating cross-functional leadership within a data science organization are the steps that consistently move candidates from senior to principal level.

Can you get a principal applied scientist role without deep research experience?

It is uncommon but not impossible. Some organizations define the principal level around engineering scale and production impact rather than research output. Candidates without a traditional research background strengthen their case by leading the architecture of a major ML platform, publishing internal technical reports, and accumulating evidence of measurable business impact across multiple projects.

What does the principal applied scientist interview process look like?

The process typically runs four to six rounds and includes a recruiter screen, a coding or ML fundamentals assessment, an ML system design session, a research presentation of past work, and a behavioral round focused on leadership and cross-functional influence. Finalists often meet with a director or VP to discuss research vision and team fit before an offer is extended.

Where can I find and apply to principal applied scientist jobs?

You can find and apply to principal applied scientist jobs on Migrate Mate, which lists current openings from across the United States in one place. Search the available roles, find the ones that fit your background and research focus, and apply directly to each listing that matches what you are looking for.

See All 56 Principal Applied Scientist Jobs

Find roles that match your experience and apply in just a few clicks.

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