Senior Level Principal Applied Scientist Jobs

Senior level principal applied scientist jobs place experienced researchers at the forefront of technical direction, owning complex modeling systems and leading the cross-functional teams that deliver them at scale. Roles are concentrated across Retail, Technology & Software, and E-Commerce & Online Marketplaces, with 20% remote or hybrid availability, and employers like Amazon, UiPath, and lululemon hiring at this level now.

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Overview

Open roles9
Top stateNew York
Top employerAmazon
Top cityNew York, NY
Work type80% On-site
Top industryRetail

Showing 5 of 9+ Senior Level Principal Applied Scientist jobs

Principal Applied Scientist
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Added 2w ago
Principal Applied Scientist
Amazon.com
Boston, Massachusetts
Software Engineering
Data Science & Analytics
Data Engineering
Technical Product & Program Management
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
Technical Program Management
$199k - $269k/yr
On-Site
Doctorate
10,000+

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Principal Applied Scientist
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Added 3w ago
Principal Applied Scientist
Amazon.com
Denver, Colorado
Data Science & Analytics
Software Engineering
Data Science
AI (Artificial Intelligence)
$199k - $269k/yr
On-Site
Doctorate
10,000+

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Principal AI/ML Applied Scientist
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Added 5mo ago
Principal AI/ML Applied Scientist
lululemon
Seattle, Washington
Business Analysis
Data Analytics
Data Science
$267k - $350k/yr
On-Site
Bachelor's degree in engineering
10,000+

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Principal Applied Scientist
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Added 5mo ago
Principal Applied Scientist
UiPath
Bellevue, Washington
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
$200k - $250k/yr
Hybrid
Master's

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Principal Applied Scientist, Music Catalog and Search, Amazon Music Search and Catalog
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Added 6mo ago
Principal Applied Scientist, Music Catalog and Search, Amazon Music Search and Catalog
Amazon.com
San Francisco, California
AI (Artificial Intelligence)
Data Analytics
Data Science
Data Science & Analytics
$229k - $309k/yr
Master's degree
10,000+

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Senior Level Principal Applied Scientist Job Market

Who's Hiring

Amazon6 open roles
UiPath1 open role
lululemon1 open role

Top Industries Hiring

  • Retail
  • Technology & Software
  • E-Commerce & Online Marketplaces
  • Distribution & Wholesale
  • Consulting & Professional Services

Senior Level Principal Applied Scientist Jobs: Frequently Asked Questions

How do I get a senior level principal applied scientist job?

Candidates who land these roles typically demonstrate a portfolio of shipped, production-scale ML or AI systems alongside documented impact on business or research outcomes. Employers at this level look for evidence of technical leadership, cross-team influence, and the ability to set a research agenda independently. Publishing peer-reviewed work, holding patents, or having led a team through a major product milestone gives a strong edge.

Which companies hire senior level principal applied scientists?

Companies hiring senior level principal applied scientists right now include Amazon, UiPath, and lululemon, based on current listings on Migrate Mate as of November 2026. Hiring at this level tends to concentrate in large technology firms, AI-focused enterprises, and research-intensive organizations that run dedicated applied science teams rather than embedding individual contributors.

Are there remote senior level principal applied scientist jobs?

Yes, though availability varies by employer and research domain. About 20% of senior level principal applied scientist openings are remote or hybrid as of November 2026, reflecting strong demand for top-tier talent regardless of geography. Fully on-site roles do still exist, particularly at organizations with lab infrastructure or classified research environments that require physical presence.

What makes a principal applied scientist role senior level?

A senior level principal applied scientist is expected to own an entire problem space, not just execute within one. That means setting the technical direction for a research area, making architectural decisions that affect multiple teams, and mentoring junior and mid-level scientists. The scope is broader, the ambiguity is higher, and the expectation is that you drive outcomes without close oversight from above.

Which industries hire the most senior level principal applied scientists?

Senior Level principal applied scientist roles concentrate in Retail, Technology & Software, and E-Commerce & Online Marketplaces, based on current listings on Migrate Mate as of November 2026. These sectors drive hiring at this level because they invest heavily in proprietary AI and ML capabilities where deep applied research translates directly into competitive product advantages.