Senior Level Principal Applied Scientist Jobs
Senior level principal applied scientist jobs place experienced researchers at the forefront of technical direction, owning complex modeling systems and leading the cross-functional teams that deliver them at scale. Roles are concentrated across Retail, Technology & Software, and E-Commerce & Online Marketplaces, with 20% remote or hybrid availability, and employers like Amazon, UiPath, and lululemon hiring at this level now.
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DESCRIPTION
We are looking for a Principal Applied Scientist to drive the research and development of real-time multimodal conversational AI. You will operate across two focus areas: advancing foundation models for speech and audio, and building the post-training systems (reward modeling, reinforcement learning) that shape natural, human-like conversational behavior.
You will be the expert in your area while contributing across the full model lifecycle — from pre-training and architecture design through post-training alignment and real-time deployment. You will work at the frontier of what's possible in conversational AI, with the compute, data, and runway to pursue problems that few teams in the world have the resources to tackle.
As a Principal Scientist, you will set the technical direction for your research area, influence the broader roadmap, and work closely with inference engineers to ensure your models are designed for real-time production deployment from inception.
Key job responsibilities
Foundation Model Scaling
- Build and train large-scale multimodal foundation models for real-time speech and audio generation, from architecture design through production-scale training
- Advance the scaling and efficiency of conversational modes, including the relationship between data, model size, and real-time performance
- Design model architectures informed by hardware constraints and inference requirements, working with inference engineers to ensure models are servable from inception
- Develop training methodologies for multimodal models that jointly process and generate speech, language, and audio in real-time streaming contexts
Post-Training & Reinforcement Learning
- Design and build reward models and reward functions for speech systems — capturing naturalness, fluency, conversational quality, and real-time responsiveness
- Develop and apply reinforcement learning methods to shape conversational behavior — teaching models natural timing, responsiveness, and fluid interaction
- Build the post-training pipeline from SFT through RL alignment, optimized for real-time multimodal outputs rather than text-only generation
- Design evaluation frameworks that capture the quality dimensions unique to real-time conversation
Real-Time Perception & Generation
- Advance the team's capabilities in real-time perception
- Work at the intersection of model architecture and production constraints to ensure multimodal capabilities function within hard real-time latency budgets
About the team
We are a small, focused group of scientists and engineers building the next generation of real-time conversational AI at Amazon — models that interact naturally across speech and audio. We operate with the autonomy and pace of a research lab, backed by frontier-scale compute and a multi-year investment horizon.
BASIC QUALIFICATIONS
- Experience distilling informal customer requirements into problem definitions, dealing with ambiguity and competing objectives
- PhD in Computer Science, Machine Learning, Electrical Engineering, Speech/Audio Processing, or equivalent quantitative field
- 10+ years of applied research experience (industry or combined academic + industry)
- Demonstrated experience training large-scale foundation models — hands-on involvement in scaling exercises, not just using pre-trained models
- Experience with multimodal model architectures that jointly process or generate across speech, text, and audio modalities
- Strong understanding of transformer architectures and their application to speech/audio domains
- Publication record at top-tier venues (NeurIPS, ICML, ICLR, Interspeech, ICASSP, ACL, or equivalent)
- Demonstrated Principal/Staff+ scientific leadership — setting research direction, mentoring researchers, influencing multi-team decisions
PREFERRED QUALIFICATIONS
- 10+ years of relevant work in industry or academia experience
- Hands-on experience building real-time AI systems — speech, audio, or video
- Track record with post-training methods: reinforcement learning, reward modeling, RLHF/RLAIF, or alignment techniques applied to generative models
- Experience with real-time interactive systems — models that handle concurrent input and output
- Experience building speech-to-speech or audio-to-audio generative models (codec models, autoregressive audio generation)
- Hands-on design of reward models or reward functions specifically for speech/audio quality, naturalness, or conversational behavior
- Experience with distributed training at scale — including parallelism strategies, training stability, and curriculum design
- Familiarity with hardware-informed model design — understanding how architecture choices affect inference latency, memory, and cost
- Background in speech recognition, speech synthesis (TTS), or speech enhancement
- Experience shipping research to production at scale — models serving real users, not just benchmark results
- Contributions to open-source speech/audio ML systems or widely used research codebases
- History of mentoring and growing research teams from individual contributors to technical leaders
Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status.
Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company’s reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.
Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit https://amazon.jobs/content/en/how-we-hire/accommodations for more information. If the country/region you’re applying in isn’t listed, please contact your Recruiting Partner.
The base salary range for this position is listed below. Your Amazon package will include sign-on payments and restricted stock units (RSUs). Final compensation will be determined based on factors including experience, qualifications, and location. Amazon also offers comprehensive benefits including health insurance (medical, dental, vision, prescription, Basic Life & AD&D insurance and option for Supplemental life plans, EAP, Mental Health Support, Medical Advice Line, Flexible Spending Accounts, Adoption and Surrogacy Reimbursement coverage), 401(k) matching, paid time off, and parental leave. Learn more about our benefits at https://amazon.jobs/en/benefits.
USA, CA, Sunnyvale - 228,700.00 - 309,400.00 USD annually
USA, MA, Boston - 198,900.00 - 269,000.00 USD annually
USA, WA, Seattle - 198,900.00 - 269,000.00 USD annually
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Senior Level Principal Applied Scientist Jobs: Frequently Asked Questions
How do I get a senior level principal applied scientist job?
Candidates who land these roles typically demonstrate a portfolio of shipped, production-scale ML or AI systems alongside documented impact on business or research outcomes. Employers at this level look for evidence of technical leadership, cross-team influence, and the ability to set a research agenda independently. Publishing peer-reviewed work, holding patents, or having led a team through a major product milestone gives a strong edge.
Which companies hire senior level principal applied scientists?
Companies hiring senior level principal applied scientists right now include Amazon, UiPath, and lululemon, based on current listings on Migrate Mate as of November 2026. Hiring at this level tends to concentrate in large technology firms, AI-focused enterprises, and research-intensive organizations that run dedicated applied science teams rather than embedding individual contributors.
Are there remote senior level principal applied scientist jobs?
Yes, though availability varies by employer and research domain. About 20% of senior level principal applied scientist openings are remote or hybrid as of November 2026, reflecting strong demand for top-tier talent regardless of geography. Fully on-site roles do still exist, particularly at organizations with lab infrastructure or classified research environments that require physical presence.
What makes a principal applied scientist role senior level?
A senior level principal applied scientist is expected to own an entire problem space, not just execute within one. That means setting the technical direction for a research area, making architectural decisions that affect multiple teams, and mentoring junior and mid-level scientists. The scope is broader, the ambiguity is higher, and the expectation is that you drive outcomes without close oversight from above.
Which industries hire the most senior level principal applied scientists?
Senior Level principal applied scientist roles concentrate in Retail, Technology & Software, and E-Commerce & Online Marketplaces, based on current listings on Migrate Mate as of November 2026. These sectors drive hiring at this level because they invest heavily in proprietary AI and ML capabilities where deep applied research translates directly into competitive product advantages.