Principal Engineer Jobs in Boston, MA

Principal Engineer jobs in Boston are concentrated in the Seaport District, Kendall Square adjacent corridors, and the Back Bay, across healthtech, enterprise software, defense technology, and biotech. Employers hiring right now include Vertex Pharmaceuticals, Klaviyo, and RxSense. See the openings below and apply to the ones that match your experience.

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Overview

Open roles218+
Top employerVertex Pharmaceuticals
Work type42% Hybrid
Top credentialBachelor's degree
Companies hiring26

Showing 5 of 218+ Principal Engineer jobs

Pickle Robot Company
Principal Motion Planning Engineer
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Pickle Robot Company
Added 2d ago
Principal Motion Planning Engineer
Pickle Robot Company
Boston, Massachusetts
Specialized Engineering
Software Engineering
Engineering (Non-Software)
Robotics Engineering
$150k - $170k/yr
Hybrid
None

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BNY
SVP, Principal Full Stack Engineer - Performance Product Engineering
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BNY
Added 2d ago
SVP, Principal Full Stack Engineer - Performance Product Engineering
BNY
Boston, Massachusetts
Business Strategy
Product Management
Project & Program Management
Project Management
10,000+

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CVS Health
Principal Software Development Engineer
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CVS Health
Added 5d ago
Principal Software Development Engineer
CVS Health
Boston, Massachusetts
Software Engineering
Data Science & Analytics
Cloud & DevOps
Technical Product & Program Management
Backend Engineering
Data Science
Technical Program Management
$144k - $288k/yr
On-Site
Bachelor's
10,000+

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Vertex Pharmaceuticals
Principal Engineer, VaiDA Mobile Experience
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Vertex Pharmaceuticals
Added 6d ago
Principal Engineer, VaiDA Mobile Experience
Vertex Pharmaceuticals
Boston, Massachusetts
Executive Leadership & C-Suite
Program Management
Project Management
$167k - $250k/yr
Hybrid
Bachelor's degree
5,001-10,000

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ArcBest
Principal Engineer - Robotics Safety and Compliance
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ArcBest
Added 1w ago
Principal Engineer - Robotics Safety and Compliance
ArcBest
Boston, Massachusetts
Product Management
Project & Program Management
Specialized Engineering
Compliance & Legal
Project Management
Engineering (Non-Software)
Compliance & Risk
On-Site
Bachelor's
10,000+

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See All 218+ Principal Engineer Jobs in Boston

Find roles in Boston that match your experience and apply in just a few clicks.

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Principal Engineer Job Market in Boston

Who's Hiring

  • Vertex Pharmaceuticals
    Vertex Pharmaceuticals28
  • Klaviyo
    Klaviyo17
  • RxSense
    RxSense17
  • Motional
    Motional17
  • ArcBest
    ArcBest11

Top Industries Hiring

  • Technology & Software61
  • Insurance17
  • Manufacturing6
  • Agriculture & Farming6
  • Investment & Asset Management6

Principal Engineer Jobs in Boston: Frequently Asked Questions

How do I get a principal engineer job in Boston?

Focus your search on Boston's Seaport District, Kendall Square corridor, and Back Bay, where healthtech, defense technology, enterprise software, and biotech firms concentrate their engineering leadership hiring. Candidates with a history of driving system architecture decisions at scale stand out here. Demonstrating cross-functional influence, not just individual technical output, is what separates principal-level hires from senior engineers in Boston's market.

Which companies hire principal engineers in Boston?

Employers hiring principal engineers in Boston right now include Vertex Pharmaceuticals, Klaviyo, and RxSense, based on current listings on Migrate Mate as of August 2026. Boston's hiring mix skews toward growth-stage healthtech companies, established defense contractors with large engineering organizations, and enterprise software firms with significant local R&D footprints.

Are there remote principal engineer jobs in Boston?

Yes, though availability depends heavily on the role: principal engineers in software architecture and platform engineering tend to work remotely more often, while those embedded in hardware, lab, or defense programs are almost always on-site. About 63% of principal engineer openings tied to Boston are remote or hybrid as of August 2026. Software-focused roles in Boston's healthtech and enterprise sectors offer the strongest remote options locally.

How can I get a principal engineer job in Boston with little or no experience?

The most realistic entry path is landing a senior engineer role at a Boston-area growth-stage startup or mid-size healthtech company, where the gap between senior and principal moves faster than at large enterprises. Boston's biotech and defense corridors also hire engineers into lead roles with defined advancement tracks. Building visibility by contributing to local technical communities or open-source projects used by Boston employers helps accelerate that progression.

Which industries hire the most principal engineers in Boston?

Boston principal engineer roles concentrate in Technology & Software, Insurance, and Manufacturing, based on current listings on Migrate Mate as of August 2026. Boston's deep research institution ecosystem, anchored by major hospitals and universities, feeds a persistent pipeline of healthtech and biotech companies that require experienced engineering leadership to bring complex products to scale.

See All 218+ Principal Engineer Jobs in Boston

Find roles in Boston that match your experience and apply in just a few clicks.

Find Principal Engineer Jobs