Rare Disease Business Manager Jobs in Massachusetts
Rare Disease Business Manager jobs in Massachusetts are open across Cambridge and Boston and other Massachusetts metros, with employers like Biogen, Sanofi, and Leerink Partners hiring at every experience level. Find a role that fits below and apply directly.
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Showing 5 of 6+ Rare Disease Business Manager jobs
Job title: Head, Health System Strategy, Rare Diseases
Location: Cambridge, MA
7 Products + 2 Launches
$2.2B $3.1B (2030)
2 Direct Reports
Including landmark AATD Therapy, 1H 2027, VENG 2H 2026
About the job
Join the team transforming care for people with immune challenges, rare diseases, cancers, and neurological conditions. In Specialty Care, you’ll help deliver breakthrough treatments that bring hope to patients with some of the highest unmet needs.
As Head, Health System Strategy, Rare Diseases within our US Rare Disease Leadership Team, you'll lead provider-focused strategy across a $2.2B business with 7 marketed products and 2 pipeline launches, including a landmark AATD therapy in 1H 2027. You'll build strategic partnerships with health systems and IDNs, optimize care pathways, and accelerate patient diagnosis and treatment access. This role is a member of the US Leadership Team and reports directly to the General Manager. Ready to get started?
You'll be joining Sanofi's US Rare Disease business at a pivotal moment—managing a portfolio with clear growth trajectory to $3.1B by 2030, leading health system strategy for breakthrough therapies, and shaping how we partner with leading academic medical centers and integrated delivery networks to transform patient outcomes.
About Sanofi
We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people's lives.
Main responsibilities:
Health System Strategy & Care Pathway Optimization
- Lead integrated health system strategy to accelerate diagnosis, optimize care pathways, and improve treatment access across the rare disease portfolio
- Identify barriers across the patient journey—diagnosis, referral, treatment initiation, reimbursement—and develop targeted, scalable solutions
- Leverage patient journey analytics, health economics, and real-world evidence to guide pathway strategy and institutional engagement
- Champion launch readiness for the landmark AATD therapy (1H 2027) across provider and health system dimensions
- Collaborate with Health System leads across business units; share best practices and leverage common resources
Institutional Partnership & Shared Value Strategy
- Identify the shared strategic priorities—the "main thing"—between Sanofi Rare Disease and senior institutional leaders, finding the intersection where patient access goals align with the institution's own clinical, operational, and outcome objectives
- Build trust-based, mutually beneficial partnerships with health system executives, department chairs, and medical directors that go beyond transactional engagement toward genuine value co-creation
- Design and execute collaborative frameworks where Sanofi and institutional partners work toward a common purpose: getting the right rare disease patients diagnosed and treated faster
- Engage senior stakeholders at leading academic medical centers and IDNs to uncover and activate shared opportunities that benefit patients, providers, and the health system
- Navigate Legal & Compliance requirements for all health system partnerships and B2B solutions, ensuring all engagements are structured for sustainability and integrity
Provider Partnerships & B2B Solutions
- Build strategic partnerships with health systems, IDNs, and provider organizations across the rare disease landscape
- Design B2B solutions that address health system needs across health information technology (HIT), operations, and patient experience
- Expand key opinion leader relationships to uncover value-creation opportunities and advance rare disease awareness and diagnosis
Cross-Functional Leadership & Collaboration
- Serve as the US Leadership Team subject matter expert on health system dynamics, care delivery trends, and provider engagement strategy
- Integrate health system considerations into launch planning, lifecycle management, and portfolio strategy
- Monitor the competitive landscape and evolving care delivery models in partnership with Business Insights & Solutions
- Build, develop, and lead a high-performing team of 2 direct reports
About you
Required:
- Bachelor's degree required; advanced degree (MBA, MPH, MS, PhD) strongly preferred
- 10+ years of experience in pharma, biotech, healthcare (medical center or large practice), or payer environment
- 7+ years of leadership experience managing teams and cross-functional initiatives
- Demonstrated expertise in health system/provider strategy and partnerships with IDNs, health systems, and medical groups
- Proven track record in care pathway optimization and patient journey analytics
- Strong business acumen with understanding of health system economics and B2B solutions
- Excellent communication skills with ability to influence and negotiate at the executive level
- Ability to navigate complex, highly regulated environments while managing multiple priorities
Preferred:
- Experience in rare disease or specialty therapeutics
- Track record with organized customers and health system partnerships
- Experience with patient journey analytics, health economics, and real-world evidence
- Product launch experience, particularly in rare disease or specialty settings
- Experience with HIT integration and operational solutions for health systems
Why choose us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
- Lead health system strategy for a high-growth $2.2B rare disease business with a clear path to $3.1B
- Play a pivotal role in launching a landmark AATD therapy that will transform patient lives
- Join the US Leadership Team and shape strategy across the entire rare disease portfolio
- Partner with leading academic medical centers and health systems to co-create patient value
- Work at the intersection of innovation, patient access, and institutional partnership
- Be part of a mission-driven team chasing the miracles of science to improve patients' lives.
Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
GD-SG
LI-GZ
LI-HYBRID
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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
Job title: Head, Health System Strategy, Rare Diseases
Location: Cambridge, MA
7 Products + 2 Launches
$2.2B $3.1B (2030)
2 Direct Reports
Including landmark AATD Therapy, 1H 2027, VENG 2H 2026
About the job
Join the team transforming care for people with immune challenges, rare diseases, cancers, and neurological conditions. In Specialty Care, you’ll help deliver breakthrough treatments that bring hope to patients with some of the highest unmet needs.
As Head, Health System Strategy, Rare Diseases within our US Rare Disease Leadership Team, you'll lead provider-focused strategy across a $2.2B business with 7 marketed products and 2 pipeline launches, including a landmark AATD therapy in 1H 2027. You'll build strategic partnerships with health systems and IDNs, optimize care pathways, and accelerate patient diagnosis and treatment access. This role is a member of the US Leadership Team and reports directly to the General Manager. Ready to get started?
You'll be joining Sanofi's US Rare Disease business at a pivotal moment—managing a portfolio with clear growth trajectory to $3.1B by 2030, leading health system strategy for breakthrough therapies, and shaping how we partner with leading academic medical centers and integrated delivery networks to transform patient outcomes.
About Sanofi
We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people's lives.
Main responsibilities:
Health System Strategy & Care Pathway Optimization
- Lead integrated health system strategy to accelerate diagnosis, optimize care pathways, and improve treatment access across the rare disease portfolio
- Identify barriers across the patient journey—diagnosis, referral, treatment initiation, reimbursement—and develop targeted, scalable solutions
- Leverage patient journey analytics, health economics, and real-world evidence to guide pathway strategy and institutional engagement
- Champion launch readiness for the landmark AATD therapy (1H 2027) across provider and health system dimensions
- Collaborate with Health System leads across business units; share best practices and leverage common resources
Institutional Partnership & Shared Value Strategy
- Identify the shared strategic priorities—the "main thing"—between Sanofi Rare Disease and senior institutional leaders, finding the intersection where patient access goals align with the institution's own clinical, operational, and outcome objectives
- Build trust-based, mutually beneficial partnerships with health system executives, department chairs, and medical directors that go beyond transactional engagement toward genuine value co-creation
- Design and execute collaborative frameworks where Sanofi and institutional partners work toward a common purpose: getting the right rare disease patients diagnosed and treated faster
- Engage senior stakeholders at leading academic medical centers and IDNs to uncover and activate shared opportunities that benefit patients, providers, and the health system
- Navigate Legal & Compliance requirements for all health system partnerships and B2B solutions, ensuring all engagements are structured for sustainability and integrity
Provider Partnerships & B2B Solutions
- Build strategic partnerships with health systems, IDNs, and provider organizations across the rare disease landscape
- Design B2B solutions that address health system needs across health information technology (HIT), operations, and patient experience
- Expand key opinion leader relationships to uncover value-creation opportunities and advance rare disease awareness and diagnosis
Cross-Functional Leadership & Collaboration
- Serve as the US Leadership Team subject matter expert on health system dynamics, care delivery trends, and provider engagement strategy
- Integrate health system considerations into launch planning, lifecycle management, and portfolio strategy
- Monitor the competitive landscape and evolving care delivery models in partnership with Business Insights & Solutions
- Build, develop, and lead a high-performing team of 2 direct reports
About you
Required:
- Bachelor's degree required; advanced degree (MBA, MPH, MS, PhD) strongly preferred
- 10+ years of experience in pharma, biotech, healthcare (medical center or large practice), or payer environment
- 7+ years of leadership experience managing teams and cross-functional initiatives
- Demonstrated expertise in health system/provider strategy and partnerships with IDNs, health systems, and medical groups
- Proven track record in care pathway optimization and patient journey analytics
- Strong business acumen with understanding of health system economics and B2B solutions
- Excellent communication skills with ability to influence and negotiate at the executive level
- Ability to navigate complex, highly regulated environments while managing multiple priorities
Preferred:
- Experience in rare disease or specialty therapeutics
- Track record with organized customers and health system partnerships
- Experience with patient journey analytics, health economics, and real-world evidence
- Product launch experience, particularly in rare disease or specialty settings
- Experience with HIT integration and operational solutions for health systems
Why choose us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
- Lead health system strategy for a high-growth $2.2B rare disease business with a clear path to $3.1B
- Play a pivotal role in launching a landmark AATD therapy that will transform patient lives
- Join the US Leadership Team and shape strategy across the entire rare disease portfolio
- Partner with leading academic medical centers and health systems to co-create patient value
- Work at the intersection of innovation, patient access, and institutional partnership
- Be part of a mission-driven team chasing the miracles of science to improve patients' lives.
Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
GD-SG
LI-GZ
LI-HYBRID
vhd
All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
See All 6 Rare Disease Business Manager Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find JobsRare Disease Business Manager Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Rare Disease Business Manager Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
- Biogen2
- Sanofi2
- Leerink Partners1
- Navigate Biopharma Services1
Top Industries Hiring
- Biotechnology & Pharmaceuticals3
- Healthcare & Medical Services2
- Banking & Financial Services1
What Massachusetts Employers Look For
The qualifications that appear most often in rare disease business manager jobs across Massachusetts.
- Minimum two to five years of specialty pharmaceutical or rare disease sales experience
- Demonstrated experience working with specialty pharmacies, patient hubs, and access programs
- Bachelor's degree in life sciences, business, or a related field
- Proven ability to engage key opinion leaders, academic medical centers, and specialists
- Strong understanding of payer landscape, prior authorization processes, and reimbursement pathways
- Proficiency with CRM platforms and ability to analyze territory data and sales reports
Rare Disease Business Manager Jobs in Massachusetts: Frequently Asked Questions
How many rare disease business manager jobs are there in Massachusetts?
There are 6+ rare disease business manager openings in Massachusetts on Migrate Mate as of June 2026, with the most roles in Cambridge and Boston. New positions post regularly as employers across Massachusetts hire.
Which Massachusetts cities have the most rare disease business manager jobs?
Cambridge and Boston have the most rare disease business manager openings in Massachusetts right now, with additional roles spread across smaller metros statewide.
Which companies hire rare disease business managers in Massachusetts?
Employers hiring rare disease business managers in Massachusetts include Biogen, Sanofi, and Leerink Partners, based on current listings on Migrate Mate as of June 2026.
Are there remote rare disease business manager jobs in Massachusetts?
Yes. About 33% of rare disease business manager openings tied to Massachusetts are remote or hybrid as of June 2026. The rest are on-site roles based in Massachusetts metros.
How do I apply for rare disease business manager jobs in Massachusetts?
You can apply to rare disease business manager jobs in Massachusetts directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Massachusetts location, then apply to each one that fits.
See All 6 Rare Disease Business Manager Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
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