Senior Physical Design Engineer Jobs in Connecticut

Company Description

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins laboratories work with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. The Eurofins network of companies is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. It also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products. In over 30 years, Eurofins has grown from one laboratory in Nantes, France to 58,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 54 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products. In 2021, Eurofins generated total revenues of EUR 6.72 billion, and has been among the best performing stocks in Europe over the past 20 years.

Job Description

We are seeking a highly innovative Materials Scientist with deep expertise in non-traditional solid-form strategies for beyond Rule-of-5 (bRo5) molecules, including PROTACs, RIPTACs, and molecular glues. This role will support the design of advanced solid form screening approaches, amorphous solid dispersion (ASD) formulations, predictive mathematical models. The position is based in Groton, CT (USA).

Role Responsibilities

- Conduct advanced solid-state characterization of large bRo5 molecules of pharmaceutical relevance.
- Apply novel crystallization techniques to recrystallize bRo5 molecules.
- Support multidisciplinary project teams and collaborate with colleagues to define and implement crystallization, polymorph, salt, and co-crystal screening activities according to project timelines.
- Collaborate with colleagues in Medicinal Chemistry, Formulation and Biopharmaceutics to define and implement screening and characterization strategies consistent with solid form selection for clinical studies.
- Solve scientific problems using contemporary Materials Science experimental techniques.
- Contribute to the development of new scientific approaches and knowledge within the Materials Science organization.
- Ensure contemporaneous and accurate entries are made in the electronic laboratory notebook system according to accepted good practice.

Qualifications

- Master’s Degree (MS) with 2+ years of experience or a PhD in pharmaceutical science, chemistry, chemical engineering, or related field.
- Experience in pharmaceutical solid state characterization techniques (such as x-ray powder diffraction, polarized light microscopy, differential scanning calorimetry, thermogravimetric analysis, spectroscopy, etc.). Strong data analysis and interpretation skills.
- Experience and understanding of infrared spectroscopy (FTIR, NIR, FT-Raman) and/or SSNMR.
- Experience with solving Materials Science problems related to large molecules, e.g., solid state chemistry and particle characterization using experimental approaches and team collaboration.
- Experience with amorphous solid dispersion strategies and ability to develop innovative solid form screening strategies.
- Understanding of physical, analytical, and organic chemistry.
- Good organizational skills, the ability to work independently, and excellent oral and written communication skills are required.
- Experience in mathematical modeling.

Additional Information

- The position is full-time, M-F 8 am to 5 pm.
- May be requested to work on weekends, overtime, and holidays based on business needs.
- Candidates currently living within a commutable distance of Groton, CT are encouraged to apply.
- Excellent full-time benefits, including comprehensive medical coverage, dental, and vision options.
- Life and disability insurance.
- 401(k) with company match.
- Paid vacation and holidays.

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.