Clinical Nurse Specialist Jobs in South Carolina

Clinical Nurse Specialist jobs in South Carolina are open across Columbia, Charleston, and Florence and other South Carolina metros, with employers like Medical University of South Carolina, Fresenius Medical Care, and McLeod Health hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles26+
Top cityColumbia, SC
Cities hiring13
Work type96% On-site
Top industryHealthcare

Showing 5 of 26+ Clinical Nurse Specialist jobs

Medical University of South Carolina
Clinical Nurse Educator
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Medical University of South Carolina
Added 2w ago
Clinical Nurse Educator
Medical University of South Carolina
Lancaster, South Carolina
Nursing
Healthcare Administration
Corporate Training & Learning Development
On-Site
Bachelor's
10,000+

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Medical University of South Carolina
Clinical Practice Nurse Expert
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Medical University of South Carolina
Added 3w ago
Clinical Practice Nurse Expert
Medical University of South Carolina
Orangeburg, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

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PruittHealth
Registered Nurse Clinical Manager
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PruittHealth
Added 1mo ago
Registered Nurse Clinical Manager
PruittHealth
Columbia, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
Caregiving & Elderly Support
On-Site
None
10,000+

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Medical University of South Carolina
Clinical Practice Nurse Expert
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Medical University of South Carolina
Added 1mo ago
Clinical Practice Nurse Expert
Medical University of South Carolina
Orangeburg, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

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Self Regional Healthcare
Nurse Clinical Care Lead
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Self Regional Healthcare
Added 4mo ago
Nurse Clinical Care Lead
Self Regional Healthcare
Greenwood, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's

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See All 26 Clinical Nurse Specialist Jobs in South Carolina

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Clinical Nurse Specialist Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
5 jobs
Charleston
3 jobs
Florence
3 jobs
Greenwood
3 jobs
Orangeburg
3 jobs
Aiken
2 jobs
Georgetown
1 jobs
Greenville
1 jobs
Lancaster
1 jobs

Clinical Nurse Specialist Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Medical University of South Carolina
    Medical University of South Carolina8
  • Fresenius Medical Care
    Fresenius Medical Care4
  • McLeod Health
    McLeod Health3
  • Prisma Health
    Prisma Health3
  • Self Regional Healthcare
    Self Regional Healthcare3

Top Industries Hiring

  • Healthcare & Medical Services21
  • Education5
  • Biotechnology & Pharmaceuticals1

What South Carolina Employers Look For

The qualifications that appear most often in clinical nurse specialist jobs across South Carolina.

  • Active APRN license and CNS certification from AACN or NACNS in a recognized specialty
  • Master of Science in Nursing (MSN) or Doctor of Nursing Practice (DNP) from an accredited program
  • Minimum two to three years of clinical experience in the relevant patient population or specialty area
  • Demonstrated experience leading quality improvement initiatives, protocol development, or evidence-based practice projects
  • Strong skills in staff education, clinical coaching, and interdisciplinary team collaboration
  • Familiarity with electronic health record systems such as Epic, Cerner, or Meditech

Clinical Nurse Specialist Jobs in South Carolina: Frequently Asked Questions

How many clinical nurse specialist jobs are there in South Carolina?

There are 26+ clinical nurse specialist openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Charleston, and Florence. New positions post regularly as employers across South Carolina hire.

How much do clinical nurse specialists make in South Carolina?

Clinical nurse specialists in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Carolina cities have the most clinical nurse specialist jobs?

Columbia, Charleston, and Florence have the most clinical nurse specialist openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire clinical nurse specialists in South Carolina?

Employers hiring clinical nurse specialists in South Carolina include Medical University of South Carolina, Fresenius Medical Care, and McLeod Health, based on current listings on Migrate Mate as of June 2026.

Are there remote clinical nurse specialist jobs in South Carolina?

Yes. About 4% of clinical nurse specialist openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for clinical nurse specialist jobs in South Carolina?

You can apply to clinical nurse specialist jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 26 Clinical Nurse Specialist Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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