NP Jobs in South Carolina
NP jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where major health systems like Prisma Health, MUSC Health, and Bon Secours St. Francis actively recruit across primary care, psychiatry, and acute care. Demand reaches from new graduate NPs entering federally qualified health centers to seasoned practitioners taking on autonomous practice roles under South Carolina's full-practice authority law. Family practice and urgent care posts see the most consistent volume statewide. Find a role that fits below and apply directly.
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Job Summary
Provides primary health care to a specific patient population within the guidelines of written protocols. Follows established nursing standards, procedures, and practices.Accountabilities
- Engages in the diagnosis and treatment of disease, defects or injuries and recommend or prescribe treatments for the relief or cure of physical, mental or functional ailments or defects.
- Performs all charting, summaries, correspondence and assorted paperwork that is required for purposes of documenting care and billing.
- Participates in physician educational programs provided by Employer relative to capitated medicine and its implications on physician practice patterns.
- Participates in responding to requests for proposals for managed care contracts.
Participates in:
Establishment of quality assurance programs
Establishment of utilization management programs
Selection of management information systems
Development of patient education services
Development of patient satisfaction surveys- Assists in the development of operational and capital budgets.
- Participates in operational assessments in search of revenue enhancement, expense reductions, consolidation efficiencies and billing opportunities.
General Job Expectations:
Maintain courteous and cooperative working relationships with all levels of management and employees, physicians, patients, guarantors and the general public.- Participates in activities that would further the public's image of the Employer.
Supervisory/Management Responsibility
This is a non-management job that will report to a supervisor, manager, director, or executive.
Minimum Requirements
Master's Degree in Nursing; Nurse Practitioner Degree Emphasis or Program Certificate equivalent.
Required Certifications/Registrations/Licenses
- Official Recognition as a Nurse Practitioner in the state the team member is working
- Prescriptive Authority for the state in which the team member is working
- Controlled Substance license for the state in which the team member is working. Federal DEA license
Work Shift
Day (United States of America)Location
Seneca Medical AssociatesFacility
Seneca Medical AssociatesDepartment
Rural HealthShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
Inspire health. Serve with compassion. Be the difference.
Job Summary
Provides primary health care to a specific patient population within the guidelines of written protocols. Follows established nursing standards, procedures, and practices.Accountabilities
- Engages in the diagnosis and treatment of disease, defects or injuries and recommend or prescribe treatments for the relief or cure of physical, mental or functional ailments or defects.
- Performs all charting, summaries, correspondence and assorted paperwork that is required for purposes of documenting care and billing.
- Participates in physician educational programs provided by Employer relative to capitated medicine and its implications on physician practice patterns.
- Participates in responding to requests for proposals for managed care contracts.
Participates in:
Establishment of quality assurance programs
Establishment of utilization management programs
Selection of management information systems
Development of patient education services
Development of patient satisfaction surveys- Assists in the development of operational and capital budgets.
- Participates in operational assessments in search of revenue enhancement, expense reductions, consolidation efficiencies and billing opportunities.
General Job Expectations:
Maintain courteous and cooperative working relationships with all levels of management and employees, physicians, patients, guarantors and the general public.- Participates in activities that would further the public's image of the Employer.
Supervisory/Management Responsibility
This is a non-management job that will report to a supervisor, manager, director, or executive.
Minimum Requirements
Master's Degree in Nursing; Nurse Practitioner Degree Emphasis or Program Certificate equivalent.
Required Certifications/Registrations/Licenses
- Official Recognition as a Nurse Practitioner in the state the team member is working
- Prescriptive Authority for the state in which the team member is working
- Controlled Substance license for the state in which the team member is working. Federal DEA license
Work Shift
Day (United States of America)Location
Seneca Medical AssociatesFacility
Seneca Medical AssociatesDepartment
Rural HealthShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 75 NP Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find NP JobsNP Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
NP Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- TeamHealth10
- Prisma Health5
- Your Health Organization5
- Concentra3
- PruittHealth3
Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in NP jobs across South Carolina.
- Active NP license issued or recognized by the South Carolina Board of Nursing
- Current national certification from AANP, ANCC, or other accredited certifying body
- Master of Science in Nursing or Doctor of Nursing Practice from an accredited program
- Current and unencumbered RN license in South Carolina or a Nurse Licensure Compact state
- Current BLS certification and ACLS certification for acute care or emergency settings
- One or more years of clinical experience in a relevant NP specialty or patient population
NP Jobs in South Carolina: Frequently Asked Questions
How do you become a np in South Carolina?
To become an NP in South Carolina, you must hold a current RN license issued or recognized by the South Carolina Board of Nursing, complete a graduate-level NP program, and obtain national certification from a body such as AANP or ANCC. You then apply for advanced practice registered nurse licensure through the South Carolina Board of Nursing. South Carolina recognizes full practice authority for NPs, so no physician collaboration agreement is required once licensed.
Which companies hire nps in South Carolina?
Employers hiring nps in South Carolina right now include TeamHealth, Prisma Health, and Your Health Organization, based on current listings on Migrate Mate as of August 2026. South Carolina's largest systems, including Prisma Health and MUSC Health, maintain consistent pipelines for primary care, behavioral health, and specialty NP roles across both urban medical centers and rural outpatient clinics.
Which South Carolina cities have the most np jobs?
Columbia, Greenville, and Rock Hill lead South Carolina for np openings. Columbia anchors the market as the state capital and home to Prisma Health's flagship campuses, while Charleston draws heavy volume from MUSC Health and a dense network of outpatient and specialty practices, and Greenville reflects the fast-growing Upstate corridor where Bon Secours St. Francis and large urgent care groups are expanding NP staffing.
Are there remote np jobs in South Carolina?
Yes, but they're rare. About 53% of np openings tied to South Carolina are remote or hybrid as of August 2026, reflecting the hands-on nature of most clinical NP work. The positions most likely to offer remote or hybrid arrangements are those focused on telehealth primary care, behavioral health counseling, or utilization review, where patient encounters happen via video platform rather than in person.
How can I get hired as a np in South Carolina with little or no experience?
The most realistic entry path is a new-graduate NP residency or fellowship program, and both Prisma Health and MUSC Health run structured transition-to-practice programs that prioritize candidates without post-graduate NP experience. Federally qualified health centers operating across rural South Carolina counties also hire new graduates specifically to fill primary care gaps. Coming from an RN background in a relevant specialty, such as ICU or emergency nursing, strengthens an application considerably, as does completing clinical hours at the hiring facility during your NP program.
Where can I find and apply to np jobs in South Carolina?
You can find and apply to np jobs in South Carolina on Migrate Mate, which lists current South Carolina openings updated regularly. Search the listings, find roles that match your specialty and preferred location, and apply directly to the employers posting them. No sign-up is required to see the openings.
See All 75 NP Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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