NP Jobs in South Carolina

NP jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where major health systems like Prisma Health, MUSC Health, and Bon Secours St. Francis actively recruit across primary care, psychiatry, and acute care. Demand reaches from new graduate NPs entering federally qualified health centers to seasoned practitioners taking on autonomous practice roles under South Carolina's full-practice authority law. Family practice and urgent care posts see the most consistent volume statewide. Find a role that fits below and apply directly.

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Overview

Open roles81
Top employerPrisma Health Urgent Care
Top cityColumbia, SC
Cities hiring44
Work type56% On-site
Top industryInsurance

Showing 5 of 81+ NP jobs

Remote Virtual Nurse Practitioner
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Added 1d ago
Remote Virtual Nurse Practitioner
Remote Care Partners
Columbia, South Carolina
Administrative & Office Support
Customer Service
Project Management
$95k - $115k/yr
Remote (US)

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Psychiatric Nurse Practitioner
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Added 3d ago
Psychiatric Nurse Practitioner
Armor Health
Columbia, South Carolina
Allied Health
Healthcare Administration
Nursing
CPR Certification
1,001-5,000

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Nurse Practitioner
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Added 3d ago
Nurse Practitioner
Armor Health
Columbia, South Carolina
Allied Health
Healthcare Administration
Nursing
CPR Certification
1,001-5,000

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Family Nurse Practitioner
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Added 3d ago
Family Nurse Practitioner
Sandhills Medical
Sumter, South Carolina
Allied Health
Healthcare Administration
Nursing
Master's degree in nursing

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Nurse Practitioner
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Added 3d ago
Nurse Practitioner
Milan Laser Hair Removal
Columbia, South Carolina
Allied Health
Healthcare Administration
Nursing
1,001-5,000

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NP Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Charleston
5 jobs
Anderson
4 jobs
Aiken
3 jobs
Greer
3 jobs
Conway
3 jobs
Lexington
3 jobs
Spartanburg
3 jobs
Myrtle Beach
3 jobs

NP Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health Urgent Care12
  • Your Health Organization9
  • CVS Health3
  • Lowcountry Urgent Care3
  • Armor Health2

Top Industries Hiring

  • Insurance
  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in NP jobs across South Carolina.

  • Active NP license issued or recognized by the South Carolina Board of Nursing
  • Current national certification from AANP, ANCC, or other accredited certifying body
  • Master of Science in Nursing or Doctor of Nursing Practice from an accredited program
  • Current and unencumbered RN license in South Carolina or a Nurse Licensure Compact state
  • Current BLS certification and ACLS certification for acute care or emergency settings
  • One or more years of clinical experience in a relevant NP specialty or patient population

NP Jobs in South Carolina: Frequently Asked Questions

How do you become a np in South Carolina?

To become an NP in South Carolina, you must hold a current RN license issued or recognized by the South Carolina Board of Nursing, complete a graduate-level NP program, and obtain national certification from a body such as AANP or ANCC. You then apply for advanced practice registered nurse licensure through the South Carolina Board of Nursing. South Carolina recognizes full practice authority for NPs, so no physician collaboration agreement is required once licensed.

Which companies hire nps in South Carolina?

Employers hiring nps in South Carolina right now include Prisma Health Urgent Care, Your Health Organization, and CVS Health, based on current listings on Migrate Mate as of October 2026. South Carolina's largest systems, including Prisma Health and MUSC Health, maintain consistent pipelines for primary care, behavioral health, and specialty NP roles across both urban medical centers and rural outpatient clinics.

Which South Carolina cities have the most np jobs?

Columbia, Charleston, and Anderson lead South Carolina for np openings. Columbia anchors the market as the state capital and home to Prisma Health's flagship campuses, while Charleston draws heavy volume from MUSC Health and a dense network of outpatient and specialty practices, and Greenville reflects the fast-growing Upstate corridor where Bon Secours St. Francis and large urgent care groups are expanding NP staffing.

Are there remote np jobs in South Carolina?

Yes, but they're rare. About 44% of np openings tied to South Carolina are remote or hybrid as of October 2026, reflecting the hands-on nature of most clinical NP work. The positions most likely to offer remote or hybrid arrangements are those focused on telehealth primary care, behavioral health counseling, or utilization review, where patient encounters happen via video platform rather than in person.

How can I get hired as a np in South Carolina with little or no experience?

The most realistic entry path is a new-graduate NP residency or fellowship program, and both Prisma Health and MUSC Health run structured transition-to-practice programs that prioritize candidates without post-graduate NP experience. Federally qualified health centers operating across rural South Carolina counties also hire new graduates specifically to fill primary care gaps. Coming from an RN background in a relevant specialty, such as ICU or emergency nursing, strengthens an application considerably, as does completing clinical hours at the hiring facility during your NP program.

Where can I find and apply to np jobs in South Carolina?

You can find and apply to np jobs in South Carolina on Migrate Mate, which lists current South Carolina openings updated regularly. Search the listings, find roles that match your specialty and preferred location, and apply directly to the employers posting them. No sign-up is required to see the openings.

See All 81 NP Jobs in South Carolina

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