Practice Assistant Jobs in South Carolina

Practice assistant jobs in South Carolina are consistently active, with demand concentrated in healthcare practice management, dental and medical offices, and veterinary clinics at both entry-level and experienced tiers. Columbia, Greenville, and Charleston drive the largest share of openings, where employers such as Prisma Health, MUSC Health, and Palmetto Primary Care Physicians regularly staff these roles. The most in-demand specialties include medical practice administration, dental assisting support, and front-office clinical coordination. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles6
Top employerPrisma Health
Top cityGreenville, SC
Cities hiring4
Top industryHealthcare
Companies hiring4

Showing 5 of 6+ Practice Assistant jobs

Maynard Nexsen
Legal Practice Assistant
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Maynard Nexsen
Added 1w ago
Legal Practice Assistant
Maynard Nexsen
Charleston, South Carolina
Customer Service
Customer Support
Hospitality & Guest Services
High school diploma or GED
501-1,000

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Carolina Nephrology, PA
Advanced Practice Provider (Nurse Practitioner or Physician Assistant) - Greenville, SC
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Carolina Nephrology, PA
Added 1mo ago
Advanced Practice Provider (Nurse Practitioner or Physician Assistant) - Greenville, SC
Carolina Nephrology, PA
Greenville, South Carolina
Allied Health
Healthcare Administration
Nursing
$90k - $130k/yr
BLS Certification
11-50

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Carolina Nephrology, PA
ASC Advanced Practice Provider - APP (Nurse Practitioner or Physician Assistant)
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Carolina Nephrology, PA
Added 3mo ago
ASC Advanced Practice Provider - APP (Nurse Practitioner or Physician Assistant)
Carolina Nephrology, PA
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$90k - $130k/yr
BLS Certification
11-50

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Bon Secours
Certified Medical Assistant (CMA) - Powdersville Family Practice
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Bon Secours
Added 3mo ago
Certified Medical Assistant (CMA) - Powdersville Family Practice
Bon Secours
Easley, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians
CCMA Certification
10,000+

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Prisma Health
Nurse Practitioner / Physician Assistant - Hillcrest Family Practice - PT
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Prisma Health
Added 4mo ago
Nurse Practitioner / Physician Assistant - Hillcrest Family Practice - PT
Prisma Health
Simpsonville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Master's degree in nursing
10,000+

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See All 6 Practice Assistant Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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Practice Assistant Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Greenville
3 jobs
Easley
1 job
Charleston
1 job
Simpsonville
1 job

Practice Assistant Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Prisma Health
Prisma Health2 open roles
Carolina Nephrology, PA
Carolina Nephrology, PA2 open roles
Bon Secours
Bon Secours1 open role

Top Industries Hiring

  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in practice assistant jobs across South Carolina.

  • Active South Carolina medical or dental assistant registration or applicable state credential recognized in South Carolina
  • Minimum one year of experience in a clinical or medical office setting
  • Proficiency with electronic health record systems such as Epic or Athenahealth
  • Strong knowledge of medical billing, coding, and insurance verification procedures
  • Ability to perform front-desk and patient intake duties in a fast-paced practice environment
  • Excellent written and verbal communication skills for patient and provider interaction

Practice Assistant Jobs in South Carolina: Frequently Asked Questions

How do you become a practice assistant in South Carolina?

Most practice assistant positions in South Carolina require a high school diploma or GED plus a recognized credential such as a Certified Medical Assistant credential through the American Association of Medical Assistants or a Certified Clinical Medical Assistant designation. South Carolina does not maintain a single state licensing board for practice assistants, but many employers require proof of certification and familiarity with state-specific healthcare compliance rules. Completing a medical assisting or health administration program at a South Carolina technical college strengthens your application considerably.

Which companies hire practice assistants in South Carolina?

South Carolina practice assistant roles are posted by Prisma Health, Carolina Nephrology, PA, and Bon Secours and others right now, based on current listings on Migrate Mate as of August 2026. Large health systems and multi-site specialty practices across the Midlands and Upstate regions tend to post the most consistent volume throughout the year.

Which South Carolina cities have the most practice assistant jobs?

Greenville, Easley, and Charleston account for the most practice assistant openings in South Carolina. Columbia leads because of the large concentration of state government health programs and major hospital systems headquartered there, while Greenville and Charleston drive volume through fast-growing health systems and the expanding suburban medical campuses that have developed around both metros in recent years.

How can I get hired as a practice assistant in South Carolina with little or no experience?

The most realistic entry path is applying for a front-office medical receptionist or patient services representative role at a large South Carolina health system such as Prisma Health or MUSC Health, both of which run structured new-hire onboarding programs. Completing a medical assisting certificate at a South Carolina Technical College System campus gives you the credential most employers look for. Lateral moves from adjacent roles like pharmacy technician or dental receptionist are also common stepping stones into practice assistant positions across the state.

Where can I find and apply to practice assistant jobs in South Carolina?

You can find and apply to practice assistant jobs in South Carolina on Migrate Mate, which lists current South Carolina openings updated in real time. Search the listings, find the roles that match your experience and preferred location, and apply directly to the ones that fit.

See All 6 Practice Assistant Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Practice Assistant Jobs