Clinical Assistant Jobs in South Carolina

Clinical assistant jobs in South Carolina are consistently active, with demand concentrated in hospital systems, physician group practices, and outpatient specialty clinics across a range of seniority levels from entry-level medical assistants to experienced clinical coordinators. The heaviest hiring is in Columbia, Greenville, and Charleston, where major employers such as Prisma Health, MUSC Health, and Bon Secours have built large and growing clinical footprints. Cardiology, orthopedics, and primary care are the specialties producing the most consistent openings statewide. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles34
Top employerPrisma Health Urgent Care
Top cityRichland, SC
Cities hiring16
Work type100% On-site
Top industryEducation

Showing 5 of 34+ Clinical Assistant jobs

Assistant Professor (Tenure Track) or Clinical Professor of Business (Management)
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Added 4d ago
Assistant Professor (Tenure Track) or Clinical Professor of Business (Management)
Coker University
Hartsville, South Carolina
Clinical Support
Healthcare Administration
Patient Services & Wellbeing
Master's degree

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Clinical Assistant Professor in Teacher Education
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Added 6d ago
Clinical Assistant Professor in Teacher Education
State of South Carolina
Richland County, SC
Clinical Support
Healthcare Administration
Patient Services & Wellbeing
On-Site
Doctoral degree in curriculum and instruction
10,000+

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Clinical Assistant Professor in STEM Education
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Added 6d ago
Clinical Assistant Professor in STEM Education
State of South Carolina
Richland County, SC
Administrative & Office Support
Project & Program Management
Project Management
On-Site
Doctoral degree in curriculum and instruction
10,000+

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Clinical Services Rep. Medical Assistant (Dorchester)
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Added 6d ago
Clinical Services Rep. Medical Assistant (Dorchester)
Prisma Health Urgent Care
North Charleston, South Carolina
Clinical Support
Healthcare Administration
Patient Services & Wellbeing
EMT Certification

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Clinical Services Rep. Medical Assistant (Bluffton)
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Added 6d ago
Clinical Services Rep. Medical Assistant (Bluffton)
Prisma Health Urgent Care
Bluffton, South Carolina
Clinical Support
Healthcare Administration
Medical Specialists
EMT Certification

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Clinical Assistant Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Richland
4 jobs
North Charleston
4 jobs
Little River
3 jobs
Myrtle Beach
3 jobs
Aiken
2 jobs
Seneca
2 jobs
Anderson
2 jobs
Charleston
2 jobs
Murrells Inlet
2 jobs

Clinical Assistant Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Prisma Health Urgent Care8 open roles
McLeod Health5 open roles
University of South Carolina4 open roles

Top Industries Hiring

  • Education
  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in clinical assistant jobs across South Carolina.

  • Active South Carolina-recognized medical assistant certification such as CMA or RMA preferred
  • Completion of an accredited clinical assistant or medical assistant diploma or associate program
  • Proficiency with electronic health record systems such as Epic or Cerner
  • Demonstrated ability to perform clinical duties including vital signs, phlebotomy, and EKG
  • Strong written and verbal communication skills for patient-facing and team environments
  • Ability to work in a fast-paced clinical setting with rotating schedules or on-call requirements

Clinical Assistant Jobs in South Carolina: Frequently Asked Questions

How do you become a clinical assistant in South Carolina?

South Carolina does not impose a state-issued license specifically for clinical assistants, but most employers require a nationally recognized certification such as the Certified Medical Assistant credential from the American Association of Medical Assistants or the Registered Medical Assistant credential from American Medical Technologists. Candidates typically complete an accredited diploma or associate degree program at a South Carolina technical college such as Midlands Technical College or Trident Technical College before sitting for the certification exam.

Which companies hire clinical assistants in South Carolina?

Companies currently hiring clinical assistants in South Carolina include Prisma Health Urgent Care, McLeod Health, and University of South Carolina, per current listings on Migrate Mate as of October 2026. Large integrated health systems with campuses across multiple South Carolina regions generate particularly steady volume throughout the year.

Which South Carolina cities have the most clinical assistant jobs?

Richland, North Charleston, and Richland County have the most clinical assistant openings in South Carolina. Columbia leads because of its dense concentration of Prisma Health facilities and state government health services, while Greenville's rapid population growth has driven major expansion at Prisma Health Upstate, and Charleston's academic medical environment at MUSC Health anchors demand along the coast.

Are there remote clinical assistant jobs in South Carolina?

Yes, but they're rare. About 0% of clinical assistant openings tied to South Carolina are remote or hybrid as of October 2026, reflecting the hands-on nature of most clinical assistant duties. The roles most likely to offer remote or hybrid arrangements are those centered on prior authorization, care coordination, or telehealth patient intake rather than direct in-clinic patient care.

How can I get hired as a clinical assistant in South Carolina with little or no experience?

The most realistic entry path is completing a medical assistant program at a South Carolina technical college and applying for new-graduate openings or externship placements that many programs include in their curriculum. Prisma Health and MUSC Health run new-grad and associate-level onboarding tracks for clinical support roles. Candidates coming from adjacent positions such as patient access representative, phlebotomy technician, or certified nursing assistant roles are frequently considered, and holding a current CPR certification gives an immediate edge in screening.

Where can I find and apply to clinical assistant jobs in South Carolina?

You can find and apply to clinical assistant jobs in South Carolina on Migrate Mate, which lists current South Carolina openings in one place. Search the listings, identify the roles that match your credentials and location, and apply directly to the ones that fit.

See All 34 Clinical Assistant Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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