Clinical Assistant Jobs in South Carolina
Clinical Assistant jobs in South Carolina are open across Columbia, Charleston, and Greenville and other South Carolina metros, with employers like Medical University of South Carolina, Prisma Health, and McLeod Health hiring at every experience level. Find a role that fits below and apply directly.
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Inspire health. Serve with compassion. Be the difference.
Job Summary
Performs assigned patient care and related administrative duties under the direct supervision of the physician(s). Performs a variety of office/clerical duties as assigned by the office manager. Specific duties and responsibilities assigned to the individual will be determined by the supervising physician(s) and office manager after competency is established.
Essential Functions
- All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
- Records patient data prior to office visits including but not limited to vital signs, height, weight, and allergies.
- Prepare exam and treatment rooms. Prepare and maintain supplies and equipment for treatments, cleaning/sterilizing instruments as needed.
- Responsible for phlebotomy and specimen handling including blood, sputum, stool and oral/nasal once competency validation is complete.
- Assists with exams and procedures. Performs EKGs as appropriate.
- Document data and care in the patient medical record. Maintain as confidential.
- Complete medical insurance and other related forms for physician review. Communicate as needed with the patient, referral source and payor between visits. Complete patient registration, scheduling and billing tasks, pre-authorization and other general office/clerical duties as assigned. Schedule tests and treatments, as ordered by the physician.
- Performs other duties as assigned.
Supervisory/Management Responsibilities
This is a non-management job that will report to a supervisor, manager, director or executive.
Minimum Requirements
- Education - Completion of an accredited medical assistant program
- Experience - No experience required.
In Lieu Of
- In lieu of completion of a medical assistant program, will accept at least 3 months of healthcare related experience such as nursing assistant or medical assistant with on-the-job training.
- In lieu of completion of a medical assistant program, will accept a bachelor's degree in a related field.
Required Certifications, Registrations, Licenses
Team members in this job will be encouraged to voluntarily enroll and complete an accredited medical assistant program and work towards obtaining medical assistant certification as recognized by the State of South Carolina.
Knowledge, Skills and Abilities
NA
Work Shift
Day (United States of America)
Location
104 Saluda Pointe Dr Lexington
Facility
3425 Orthopedics Upper Extremity
Department
34251000 Orthopedics Upper Extremity-Practice Operations
Share your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 316+ Clinical Assistant Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Clinical Assistant JobsClinical Assistant Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Clinical Assistant Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Medical University of South Carolina92

- Prisma Health65

- McLeod Health33

- Lexington Health30

- Self Regional Healthcare20

Top Industries Hiring
- Healthcare & Medical Services240
- Education59
- Animal Care & Pet Services8
- Consulting & Professional Services7
- Biotechnology & Pharmaceuticals4
What South Carolina Employers Look For
The qualifications that appear most often in clinical assistant jobs across South Carolina.
- High school diploma or equivalent with a medical assisting certificate or associate degree preferred
- Certified Medical Assistant (CMA) or Registered Medical Assistant (RMA) credential
- Proficiency with electronic health record systems such as Epic, Cerner, or Athenahealth
- Current CPR and Basic Life Support certification
- Experience taking patient vital signs, collecting specimens, and preparing exam rooms
- Strong written and verbal communication skills for patient-facing and team coordination tasks
Clinical Assistant Jobs in South Carolina: Frequently Asked Questions
How many clinical assistant jobs are there in South Carolina?
There are 316+ clinical assistant openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Charleston, and Greenville. New positions post regularly as employers across South Carolina hire.
Which South Carolina cities have the most clinical assistant jobs?
Columbia, Charleston, and Greenville have the most clinical assistant openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire clinical assistants in South Carolina?
Employers hiring clinical assistants in South Carolina include Medical University of South Carolina, Prisma Health, and McLeod Health, based on current listings on Migrate Mate as of June 2026.
Are there remote clinical assistant jobs in South Carolina?
Yes. About 0% of clinical assistant openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for clinical assistant jobs in South Carolina?
You can apply to clinical assistant jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 316+ Clinical Assistant Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Clinical Assistant Jobs