Nurse Manager Jobs in South Carolina
Nurse manager jobs in South Carolina are concentrated in hospital systems, long-term care networks, and outpatient surgery centers, with consistent demand from entry-level charge nurse transitions through senior nursing leadership roles. Columbia, Greenville, and Charleston are the largest hiring markets, home to major systems like Prisma Health, Bon Secours, and MUSC Health. The most in-demand specialties are med-surg, critical care, and behavioral health. See the openings below and apply to the ones that match your experience.
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Job Overview
The Registered Nurse Case Manager delivers high-quality, patient-centered nursing and clinical case management in the home health setting. This role assesses patients, develops and manages individualized care plans, coordinates interdisciplinary services, and evaluates outcomes. The RN Case Manager supports patients’ health and independence while helping reduce avoidable hospitalizations and ensuring care meets applicable regulatory standards. NEW COMPANY CAR AVAILABLE FOR FULL TIME RNS.
Responsibilities
- Conduct comprehensive patient assessments in the home and identify care needs.
- Develop, implement, and update individualized care plans.
- Coordinate nursing care and interdisciplinary services to support continuity.
- Monitor patient progress and evaluate outcomes, adjusting plans as needed.
- Your impact: Coordinated, individualized home health care helps patients maintain independence and supports better continuity of care.
Skills
- Current, valid Registered Nurse (RN) licensure is required.
- Nursing experience and clinical case management skills.
- Ability to assess patient needs and manage individualized care plans.
- Strong coordination and communication skills for working with patients and interdisciplinary care teams.
- Knowledge of home health practice and applicable regulatory requirements.
Pay: $85,000.00 - $92,000.00 per year
Benefits:
- 401(k) matching
- Dental insurance
- Disability insurance
- Flexible schedule
- Health insurance
- Life insurance
- Mileage reimbursement
- Paid sick time
- Paid time off
- Retirement plan
- Vision insurance
Work Location: On the road
See All 77 Nurse Manager Jobs in South Carolina
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Find Nurse Manager JobsNurse Manager Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Nurse Manager Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Prisma Health17
- Your Health Organization14
- Fresenius Medical Care5
- Lexington Health4
- CenterWell3
Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in nurse manager jobs across South Carolina.
- Active registered nurse license issued or recognized by the South Carolina Board of Nursing
- Bachelor of Science in Nursing required, with master's degree preferred for senior leadership roles
- Minimum of two to five years of clinical nursing experience in an acute care setting
- Prior charge nurse, team lead, or supervisory experience within a hospital or health system
- Nursing leadership certification such as NE-BC or CENP strongly preferred by most employers
- Demonstrated proficiency with electronic health records systems such as Epic or Cerner
Nurse Manager Jobs in South Carolina: Frequently Asked Questions
How do you become a nurse manager in South Carolina?
You become a nurse manager in South Carolina by first holding an active registered nurse license issued by the South Carolina Board of Nursing, which requires passing the NCLEX-RN exam. Most employers require a Bachelor of Science in Nursing at minimum, and many South Carolina health systems prefer candidates who hold a master's degree in nursing or healthcare administration. Clinical experience in a supervisory or charge nurse role is typically the most direct path into management.
Which companies hire nurse managers in South Carolina?
Employers hiring nurse managers in South Carolina right now include Prisma Health, Your Health Organization, and Fresenius Medical Care, based on current listings on Migrate Mate as of October 2026. South Carolina's largest health systems, anchored in Columbia, Greenville, and Charleston, drive a significant share of ongoing nurse manager demand across acute care, ambulatory, and specialty settings.
Which South Carolina cities have the most nurse manager jobs?
Greenville, Columbia, and West Columbia have the highest concentration of nurse manager openings in South Carolina. Columbia leads as the state capital and home to major systems like Prisma Health, while Charleston's position as a regional academic medical center hub supports strong demand at MUSC Health and surrounding facilities, and Greenville's growing Upstate health corridor anchors activity in the northwestern part of the state.
Are there remote nurse manager jobs in South Carolina?
Yes, but they're rare. About 50% of nurse manager openings tied to South Carolina are remote or hybrid as of October 2026, reflecting the hands-on, floor-based nature of most nursing leadership roles. The portions of the job most likely to be performed remotely include administrative tasks, staff scheduling, compliance reporting, and virtual team meetings, particularly in larger multi-site health systems.
How can I get hired as a nurse manager in South Carolina with little or no experience?
The most realistic path is moving into a charge nurse or assistant nurse manager role first, which is how most South Carolina health systems develop internal leadership candidates. Prisma Health, Bon Secours, and MUSC Health all run nurse residency and leadership development programs that give clinical nurses structured exposure to management responsibilities. Earning a nursing leadership certification like NE-BC while still in a staff role signals readiness and gives candidates without formal management experience a measurable edge in South Carolina interviews.
Where can I find and apply to nurse manager jobs in South Carolina?
You can find and apply to nurse manager jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search by city or specialty to see roles that match your background, then apply directly to the ones that fit your experience and schedule.
See All 77 Nurse Manager Jobs in South Carolina
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