Practice Manager Jobs in South Carolina

Practice Manager jobs in South Carolina concentrate in healthcare, with strong demand across physician group practices, behavioral health clinics, and specialty medical offices in Columbia, Greenville, and Charleston. Major systems and employers such as MUSC Health, Prisma Health, and AnMed Health maintain lasting hiring pipelines for practice managers at both entry and senior levels. Ambulatory care operations, revenue cycle oversight, and multi-site clinic management are among the most in-demand specialties in the state. Find a role that fits below and apply directly.

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Overview

Open roles13
Top employerAmerican Veterinary
Top citySpartanburg, SC
Cities hiring11
Work type100% Remote
Top industryHealthcare

Showing 5 of 13+ Practice Manager jobs

Spartanburg Regional Healthcare System
Senior Practice Manager
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Spartanburg Regional Healthcare System
Added 1d ago
Senior Practice Manager
Spartanburg Regional Healthcare System
Spartanburg, South Carolina
Business Development
Customer Success
Program Management
Project Management
Experience equivalent to degree accepted

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Prisma Health
Physician Practice Manager-Orthopedics-Foot and Ankle
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Prisma Health
Added 3d ago
Physician Practice Manager-Orthopedics-Foot and Ankle
Prisma Health
Lexington, South Carolina
Compliance & Risk
Project Management
Security & Protective Services
Bachelor's degree in business administration
10,000+

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Self Regional Healthcare
Practice Manager II, Self Regional Neurology, Full Time, First Shift
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Self Regional Healthcare
Added 1w ago
Practice Manager II, Self Regional Neurology, Full Time, First Shift
Self Regional Healthcare
Greenwood, South Carolina
Business Operations
Customer Service
Project Management
Bachelor of Science
1,001-5,000

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Heartland Dental
Practice Manager of Operations
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Heartland Dental
Added 1w ago
Practice Manager of Operations
Heartland Dental
Summerville, South Carolina
Business Operations
Program Management
Project Management
Associate's degree
10,000+

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Banfield Pet Hospital
Practice Manager- Anderson
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Banfield Pet Hospital
Added 1w ago
Practice Manager- Anderson
Banfield Pet Hospital
Anderson, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians
$57k - $83k/yr
Bachelor's degree in business
10,000+

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Practice Manager Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Spartanburg
2 jobs
Aiken
1 job
Okatie
1 job
Anderson
1 job
Beaufort
1 job
Greenwood
1 job
Jefferson
1 job
Lexington
1 job
Charleston
1 job

Practice Manager Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

American Veterinary
American Veterinary2 open roles
Beaufort Memorial Hospital
Beaufort Memorial Hospital2 open roles
Prisma Health
Prisma Health1 open role

Top Industries Hiring

  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in practice manager jobs across South Carolina.

  • Bachelor's degree in healthcare administration, business, or a closely related field required
  • Minimum two to five years of clinical or medical office management experience preferred
  • Proficiency with electronic health record systems such as Epic or athenahealth expected
  • Knowledge of medical billing, coding compliance, and revenue cycle management processes required
  • Strong leadership experience overseeing clinical and administrative support staff in a practice setting
  • Familiarity with HIPAA regulations and healthcare quality improvement standards consistently expected

Practice Manager Jobs in South Carolina: Frequently Asked Questions

How do you become a practice manager in South Carolina?

Most practice manager roles in South Carolina require a bachelor's degree in healthcare administration, business, or a related field, though some employers accept equivalent experience in lieu of a degree. South Carolina does not issue a state license specific to practice managers, but many employers prefer candidates who hold the Certified Medical Manager credential through the Professional Association of Health Care Office Management, which demonstrates standardized competency. Gaining experience in medical billing, front-office operations, or clinical coordination at a South Carolina physician group or health system is the most direct path into the role.

Which companies hire practice managers in South Carolina?

Companies currently hiring practice managers in South Carolina include American Veterinary, Beaufort Memorial Hospital, and Prisma Health, per current listings on Migrate Mate as of August 2026. South Carolina's large integrated health systems, including MUSC Health and Prisma Health, consistently post practice manager openings across their ambulatory and specialty clinic networks throughout the year.

Which South Carolina cities have the most practice manager jobs?

Spartanburg, South Carolina, and Aiken account for the largest concentration of practice manager openings in South Carolina. Columbia leads because it is home to major health systems, state government-affiliated clinics, and a dense network of specialty practices, while Greenville's rapid population growth has expanded Prisma Health's ambulatory footprint, and Charleston's medical corridor anchors MUSC Health's extensive outpatient operations.

Are there remote practice manager jobs in South Carolina?

Yes, but they're rare. About 100% of practice manager openings tied to South Carolina are remote or hybrid as of August 2026, reflecting that the role typically requires on-site oversight of staff, patient flow, and daily clinic operations. The tasks most likely to shift to remote or hybrid arrangements are administrative duties such as credentialing coordination, reporting, and vendor communication rather than full practice management responsibilities.

How can I get hired as a practice manager in South Carolina with little or no experience?

The most realistic entry path is to move into a practice manager role from a medical office coordinator, patient services supervisor, or billing team lead position within a South Carolina health system. MUSC Health and Prisma Health both offer structured leadership development programs that give high-performing administrative staff a pathway into management. Earning the Certified Medical Administrative Assistant credential while working in a front-office or scheduling role signals readiness to employers and is achievable without prior management experience. Targeting smaller independent practices or federally qualified health centers in South Carolina also lowers the experience threshold compared to large system roles.

Where can I find and apply to practice manager jobs in South Carolina?

You can find and apply to practice manager jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the available roles, identify the ones that match your experience and preferred location, and apply directly to each position that fits.

See All 13 Practice Manager Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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