Practice Manager Jobs in South Carolina
Practice Manager jobs in South Carolina concentrate in healthcare, with strong demand across physician group practices, behavioral health clinics, and specialty medical offices in Columbia, Greenville, and Charleston. Major systems and employers such as MUSC Health, Prisma Health, and AnMed Health maintain lasting hiring pipelines for practice managers at both entry and senior levels. Ambulatory care operations, revenue cycle oversight, and multi-site clinic management are among the most in-demand specialties in the state. Find a role that fits below and apply directly.
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Showing 5 of 21+ Practice Manager jobs
Will manage 2 practices - Aiken and Graniteville.
When you join Piedmont, you’re not just changing your work environment. We open doors to real change in the lives we touch — especially yours. We’re committed to bringing award-winning care to communities across Georgia and celebrating the strength our diversity creates. Together, we’re doing big things. One employee, one team, and one community at a time.
Piedmont is a place where your work truly matters—and where you’re supported to do your best every day. We offer a collaborative culture, innovative resources, and leadership that is genuinely invested in your growth. With competitive benefits, wellness programs, and opportunities for advancement, you’ll have what you need to thrive now and build a strong future.
Responsibilities: Supports the overall day-today administrative and clinical activities of a practice. Works with Director of Physician Operations to help implement and oversee operational activities and programs to ensure the attainment of the business plans. Works collaboratively with area director and practice physicians to ensure the efficient and effective daily operation of assigned practices including but not limited to the supervision and evaluation of the practice staff. Ensures that each office maintains an effective operating environment, assuring efficient and safe operations of all services in response to patient, physician and staff needs. The scope is medium based on providers, staff and locations. Qualifications: Education
- Bachelor’s Degree in Business Administration, Health Administration or a closely related field Required or
- In Lieu of degree six (6) years of relevant work experience will be accepted in addition to the experience requirement Required
- 4 years of experience in a medical practice, hospital or other health care setting with demonstrated leadership experience or equivalent combination of education and experience Required or
- In lieu of degree a total of ten (10) years of experience Required
- None Required
Will manage 2 practices - Aiken and Graniteville.
When you join Piedmont, you’re not just changing your work environment. We open doors to real change in the lives we touch — especially yours. We’re committed to bringing award-winning care to communities across Georgia and celebrating the strength our diversity creates. Together, we’re doing big things. One employee, one team, and one community at a time.
Piedmont is a place where your work truly matters—and where you’re supported to do your best every day. We offer a collaborative culture, innovative resources, and leadership that is genuinely invested in your growth. With competitive benefits, wellness programs, and opportunities for advancement, you’ll have what you need to thrive now and build a strong future.
Responsibilities: Supports the overall day-today administrative and clinical activities of a practice. Works with Director of Physician Operations to help implement and oversee operational activities and programs to ensure the attainment of the business plans. Works collaboratively with area director and practice physicians to ensure the efficient and effective daily operation of assigned practices including but not limited to the supervision and evaluation of the practice staff. Ensures that each office maintains an effective operating environment, assuring efficient and safe operations of all services in response to patient, physician and staff needs. The scope is medium based on providers, staff and locations. Qualifications: Education
- Bachelor’s Degree in Business Administration, Health Administration or a closely related field Required or
- In Lieu of degree six (6) years of relevant work experience will be accepted in addition to the experience requirement Required
- 4 years of experience in a medical practice, hospital or other health care setting with demonstrated leadership experience or equivalent combination of education and experience Required or
- In lieu of degree a total of ten (10) years of experience Required
- None Required
See All 21 Practice Manager Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Practice Manager JobsPractice Manager Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Practice Manager Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
What South Carolina Employers Look For
The qualifications that appear most often in practice manager jobs across South Carolina.
- Bachelor's degree in healthcare administration, business, or a closely related field required
- Minimum two to five years of clinical or medical office management experience preferred
- Proficiency with electronic health record systems such as Epic or athenahealth expected
- Knowledge of medical billing, coding compliance, and revenue cycle management processes required
- Strong leadership experience overseeing clinical and administrative support staff in a practice setting
- Familiarity with HIPAA regulations and healthcare quality improvement standards consistently expected
Practice Manager Jobs in South Carolina: Frequently Asked Questions
How do you become a practice manager in South Carolina?
Most practice manager roles in South Carolina require a bachelor's degree in healthcare administration, business, or a related field, though some employers accept equivalent experience in lieu of a degree. South Carolina does not issue a state license specific to practice managers, but many employers prefer candidates who hold the Certified Medical Manager credential through the Professional Association of Health Care Office Management, which demonstrates standardized competency. Gaining experience in medical billing, front-office operations, or clinical coordination at a South Carolina physician group or health system is the most direct path into the role.
Which companies hire practice managers in South Carolina?
Companies currently hiring practice managers in South Carolina include SynergyVet, Banfield Pet Hospital, and Benevis, per current listings on Migrate Mate as of October 2026. South Carolina's large integrated health systems, including MUSC Health and Prisma Health, consistently post practice manager openings across their ambulatory and specialty clinic networks throughout the year.
Which South Carolina cities have the most practice manager jobs?
Greenville, Charleston, and South Carolina account for the largest concentration of practice manager openings in South Carolina. Columbia leads because it is home to major health systems, state government-affiliated clinics, and a dense network of specialty practices, while Greenville's rapid population growth has expanded Prisma Health's ambulatory footprint, and Charleston's medical corridor anchors MUSC Health's extensive outpatient operations.
Are there remote practice manager jobs in South Carolina?
Yes, but they're rare. About 0% of practice manager openings tied to South Carolina are remote or hybrid as of October 2026, reflecting that the role typically requires on-site oversight of staff, patient flow, and daily clinic operations. The tasks most likely to shift to remote or hybrid arrangements are administrative duties such as credentialing coordination, reporting, and vendor communication rather than full practice management responsibilities.
How can I get hired as a practice manager in South Carolina with little or no experience?
The most realistic entry path is to move into a practice manager role from a medical office coordinator, patient services supervisor, or billing team lead position within a South Carolina health system. MUSC Health and Prisma Health both offer structured leadership development programs that give high-performing administrative staff a pathway into management. Earning the Certified Medical Administrative Assistant credential while working in a front-office or scheduling role signals readiness to employers and is achievable without prior management experience. Targeting smaller independent practices or federally qualified health centers in South Carolina also lowers the experience threshold compared to large system roles.
Where can I find and apply to practice manager jobs in South Carolina?
You can find and apply to practice manager jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the available roles, identify the ones that match your experience and preferred location, and apply directly to each position that fits.
See All 21 Practice Manager Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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