Advanced Practice Provider Jobs in South Carolina
Advanced Practice Provider jobs in South Carolina are concentrated in hospital systems, federally qualified health centers, and outpatient specialty clinics, with demand running from newly credentialed nurse practitioners and physician assistants to experienced clinical leads. The largest hiring activity is in Columbia, Charleston, and Greenville, where anchor employers such as Prisma Health, MUSC Health, and Bon Secours St. Francis maintain deep and ongoing APP pipelines. The most in-demand specialties across the state are primary care, urgent care, and cardiology. Find a role that fits below and apply directly.
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Commonwealth Pain & Spine is a pain management network dedicated to improving the lives of our patients by treating their pain with the utmost respect and providing them with the most innovative, safe, responsible, and clinically proven pain relief possible.
Our team of best-in-class physicians, administrators, and staff empathizes with the needs of our patients. We recognize that their pain is exhausting and debilitating and limits their quality of life. Relief from chronic pain is achievable in various degrees through our intelligent and multimodal team-based approach. Our entire team is committed to providing levels of patient satisfaction and overall clinical outcomes that far exceed the expectations of the medical community, referring physicians, and our customers.
Duties and Responsibilities:
- Identify and assess patient’s clinical issues and health care needs
- Record physical findings, and formulates plan and prognosis, based on patient’s condition and the doctor’s plan of treatment
- Evaluations and Re-evaluations of established patients
- Refers patients to Physician for consultation or to specialized health resources for treatment when needed.
- Discusses the case with Physician and other health professionals to prepare a comprehensive patient care plan
- Performs pain management injections for specific diagnoses according to practice protocols
- Prescribe/Order as medically indicated:- Diagnostics- Therapeutics- Medication- Pain Management Procedures- DME
- Eagerness and ability to work independently as well as part of a team with flexibility and willingness to learn and take initiative on variety of tasks and projects
- Supports the vision and culture of the organization. Demonstrates personal commitment through active involvement in the performance improvement process
- All other duties as assigned
Skills and Abilities:
- Highly proficient with computers especially: EMR Software, Meaningful Use, Microsoft Word, Excel, Outlook
- Ability to manage high levels of stress and capable of making sound difficult decisions
- Very structured, organized, consistent, pleasant, cheerful, yet professional personality, who will earn the respect of patients and co-workers immediately
- Must be incredibly punctual. Great attendance, required
Qualifications, Education, and Experience (APRN):
- Active, valid (APRN) Nurse Practitioner certificate, required
- DEA Registration, preferred
- Qualifications, Education, and Experience (PA-C):
- Must have a valid, unrestricted professional license in state of Indiana and be able to obtain clinical privileges to practice medicine
Common Conditions We Treat:
Back/Neck Pain, Spinal Stenosis, Degenerative Disc Disease, Herniated Disc, Radicular Pain, Facet Disease, Joint Pain, Arthritis, Neuropathic Pain, Myofascial Pain
Common Pain Management Treatments We Offer:
- Facet Injections, Medical / Opioid Management, Epidurals, Spinal Cord Stimulation, Medial Branch Blocks, Radiofrequency Ablation, Joint Injections, Occipital Nerve Blocks, Trigger Point Injections
- Our Physicians: All of our physicians are Board Certified and Fellowship Trained in Pain Medicine and Board Certified in Anesthesiology.
Physical Requirements:
The physical demands of this position will include sitting and standing with occasional light to medium lifting. Ability to help lift patients and transport in wheelchair from clinic to parking lot. An employee must meet these requirements to successfully perform the essential duties of this job. Reasonable accommodation will be made in accordance with ADA rules and regulations.
Commonwealth Pain and Spine is an Equal Employment Opportunity Employer!
#PIQ
Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights (https://www.eeoc.gov/poster) notice from the Department of Labor.
Commonwealth Pain & Spine is a pain management network dedicated to improving the lives of our patients by treating their pain with the utmost respect and providing them with the most innovative, safe, responsible, and clinically proven pain relief possible.
Our team of best-in-class physicians, administrators, and staff empathizes with the needs of our patients. We recognize that their pain is exhausting and debilitating and limits their quality of life. Relief from chronic pain is achievable in various degrees through our intelligent and multimodal team-based approach. Our entire team is committed to providing levels of patient satisfaction and overall clinical outcomes that far exceed the expectations of the medical community, referring physicians, and our customers.
Duties and Responsibilities:
- Identify and assess patient’s clinical issues and health care needs
- Record physical findings, and formulates plan and prognosis, based on patient’s condition and the doctor’s plan of treatment
- Evaluations and Re-evaluations of established patients
- Refers patients to Physician for consultation or to specialized health resources for treatment when needed.
- Discusses the case with Physician and other health professionals to prepare a comprehensive patient care plan
- Performs pain management injections for specific diagnoses according to practice protocols
- Prescribe/Order as medically indicated:- Diagnostics- Therapeutics- Medication- Pain Management Procedures- DME
- Eagerness and ability to work independently as well as part of a team with flexibility and willingness to learn and take initiative on variety of tasks and projects
- Supports the vision and culture of the organization. Demonstrates personal commitment through active involvement in the performance improvement process
- All other duties as assigned
Skills and Abilities:
- Highly proficient with computers especially: EMR Software, Meaningful Use, Microsoft Word, Excel, Outlook
- Ability to manage high levels of stress and capable of making sound difficult decisions
- Very structured, organized, consistent, pleasant, cheerful, yet professional personality, who will earn the respect of patients and co-workers immediately
- Must be incredibly punctual. Great attendance, required
Qualifications, Education, and Experience (APRN):
- Active, valid (APRN) Nurse Practitioner certificate, required
- DEA Registration, preferred
- Qualifications, Education, and Experience (PA-C):
- Must have a valid, unrestricted professional license in state of Indiana and be able to obtain clinical privileges to practice medicine
Common Conditions We Treat:
Back/Neck Pain, Spinal Stenosis, Degenerative Disc Disease, Herniated Disc, Radicular Pain, Facet Disease, Joint Pain, Arthritis, Neuropathic Pain, Myofascial Pain
Common Pain Management Treatments We Offer:
- Facet Injections, Medical / Opioid Management, Epidurals, Spinal Cord Stimulation, Medial Branch Blocks, Radiofrequency Ablation, Joint Injections, Occipital Nerve Blocks, Trigger Point Injections
- Our Physicians: All of our physicians are Board Certified and Fellowship Trained in Pain Medicine and Board Certified in Anesthesiology.
Physical Requirements:
The physical demands of this position will include sitting and standing with occasional light to medium lifting. Ability to help lift patients and transport in wheelchair from clinic to parking lot. An employee must meet these requirements to successfully perform the essential duties of this job. Reasonable accommodation will be made in accordance with ADA rules and regulations.
Commonwealth Pain and Spine is an Equal Employment Opportunity Employer!
#PIQ
Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights (https://www.eeoc.gov/poster) notice from the Department of Labor.
See All 29 Advanced Practice Provider Jobs in South Carolina
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Find JobsAdvanced Practice Provider Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Advanced Practice Provider Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Insurance
What South Carolina Employers Look For
The qualifications that appear most often in advanced practice provider jobs across South Carolina.
- Active South Carolina advanced practice registered nurse license or physician assistant license required
- Master's degree or doctorate in a relevant clinical field from an accredited program
- National board certification such as NCCPA, AANP, or ANCC in applicable specialty
- Current DEA registration and South Carolina prescriptive authority for roles requiring medication management
- Minimum one to three years of clinical experience in a relevant specialty or care setting
- Active BLS certification with ACLS required for acute care and emergency department positions
Advanced Practice Provider Jobs in South Carolina: Frequently Asked Questions
How do you become a advanced practice provider in South Carolina?
To practice as an advanced practice provider in South Carolina, nurse practitioners must obtain licensure through the South Carolina Board of Nursing after completing an accredited graduate-level NP program and passing a national certification exam such as the AANP or ANCC. Physician assistants are licensed through the South Carolina Board of Medical Examiners following graduation from an accredited PA program and passage of the PANCE. Both roles require separate application for prescriptive authority with the appropriate board.
How much do advanced practice providers make in South Carolina?
Advanced practice providers in South Carolina earn a median of about $123,290 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $97,080 for the lowest 10% to over $160,170 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire advanced practice providers in South Carolina?
Companies currently hiring advanced practice providers in South Carolina include CVS Health, ReGenesis Health Care, and Commonwealth Pain & Spine, per current listings on Migrate Mate as of October 2026. South Carolina's largest health systems, including Prisma Health and MUSC Health, consistently maintain some of the most active APP recruitment pipelines in the state.
Which South Carolina cities have the most advanced practice provider jobs?
Greenville, Charleston, and Columbia have the most advanced practice provider openings in South Carolina. Columbia and Charleston lead because they are home to major academic medical centers and large regional health systems, while Greenville's rapid population growth has driven expansion at Prisma Health's Upstate campuses and a growing network of specialty and urgent care practices.
Are there remote advanced practice provider jobs in South Carolina?
Yes, but they're rare. Advanced practice provider work is primarily hands-on and clinic or hospital-based, so fully remote roles represent a small share of total openings. About 0% of advanced practice provider openings tied to South Carolina are remote or hybrid as of October 2026, and those positions are mostly in telehealth primary care, behavioral health consultation, and utilization review rather than direct procedural or acute care roles.
How can I get hired as a advanced practice provider in South Carolina with little or no experience?
The most realistic entry path is applying directly to new-graduate APP residency or fellowship programs, such as those run by MUSC Health and Prisma Health, which are specifically structured for candidates without post-graduate clinical experience. Roles in primary care, urgent care, and retail clinic settings tend to have the lowest experience thresholds and serve as a common first placement for new APPs. Having a South Carolina license in hand before applying and a specialty certification aligned to the posting gives candidates a meaningful edge over unlicensed applicants.
Where can I find and apply to advanced practice provider jobs in South Carolina?
You can find and apply to advanced practice provider jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the listings for roles that match your specialty, experience level, and preferred location, then apply directly to the ones that fit.
See All 29 Advanced Practice Provider Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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