Nurse Practitioner Or Physician Assistant Jobs in South Carolina
Nurse Practitioner Or Physician Assistant jobs in South Carolina are in strong and consistent demand, concentrated in primary care, urgent care, and hospital-based specialty settings across the state at every experience level from new graduate to senior clinician. The largest hiring markets are Columbia, Greenville, and Charleston, where major health systems including Prisma Health, MUSC Health, and Roper St. Francis Healthcare maintain ongoing recruitment. Family practice, emergency medicine, and orthopedics are among the most active specialties for this role statewide. See the openings below and apply to the ones that match your experience.
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Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are relentlessly dedicated to ensure the delivery of exceptional customer service by putting patients’ needs first.
Prisma Health Urgent Care has emerged as a leading provider of accessible, high-quality healthcare services with over 20+ centers in SC. Our journey has been marked by a commitment to delivering uncompromising medical care while ensuring convenience and compassion for our patients. Becoming a member of our team is not just a job; it's a meaningful purpose we all share - "To ensure that our patients and team members feel valued and well cared for!".
A role with Prisma Health Urgent Care would be more than a career; it's an opportunity to make a positive impact in the lives of those we serve. To provide uncompromising care one patient at a time.
So, we would like to invite you to be part of something bigger, to contribute to a purposeful endeavor that goes beyond the ordinary. Your skills and passion are not just valued; they are essential to our collective success.
The perks of being a Prisma Health Urgent Care team member:
- Life/Work Balance - We offer a flexible 3-day/12-hour week schedule for FT status. No overnight shifts required!
- Competitive Compensation Package + Bonus Plan
- Full Time Benefits at 30 hours or more!
- CME Allowance + Paid Time Off
- Fully covered malpractice including tail coverage
- Competitive benefits including Medical, Dental and Vision insurance and MORE
- Matching 401K plan
- Career Growth opportunities
WHAT WILL YOU DO:
- Our Talented Advanced Practice Providers plan, evaluate, and implement high quality medical care with appropriate resource management to patients, both adults and children in cooperation with center physicians
- Adheres to the service and courtesy standard of Prisma Health Urgent Care by delivering the highest standard of patient satisfaction at all times
- Provides patient care within the respective clinical area which complies with the Professional Staff Bylaws, rules and regulations and Prisma Health Urgent Care policies and procedures
- Provides and/or serves as a resource for patient/family and staff
- Provides an authenticated report of all services rendered and maintains accurate and complete records in an acceptable manner
- Completes necessary documentation and ensures communication to facilitate patient care and appropriate reimbursement
- Participates in meetings/activities as required to support operations of the urgent care
- Participates in activities that enhance professional development, complete and maintain certification in BLS, ACLS, ATLS, PALS, or NALS and maintains any additional specialty training/certifications as required by the area assigned
- This position will report to the Regional Medical Director (RMD) and/or Area Clinical Operations Director (ACOD)
MINIMUM QUALIFICATIONS:
- Board Certified (or Board Eligible) and Licensed to practice medicine in the state of practice
- Advanced degree from an accredited Nurse Practitioner or Physician Assistant program of study
- Licensed Nurse Practitioner/Physician Assistant in accordance with the state of South Carolina
- Current DEA registration
- Must be DOT certified
- Experience with procedures including suturing and drainage of abscesses
- Experience with reading diagnostic studies including x-rays and EKGs
- BLS certification (we will provide this if needed)
- Meets eligibility requirements for credentialing set forth by WellStreet Urgent Care
- Experience in Urgent Care, Family Medicine or Emergency Medicine preferred
- Demonstrated ability to communicate effectively with patients, families and other employees
PERSONAL CHARACTERISTICS:
- Outstanding bedside manner with children and adults
- Ability to communicate effectively with patients, families and other employees
- Positive, energetic attitude which inspires other team members
- Sense of service and team orientation absent of hubris
- Desire to contribute to building and maintaining a great organization
In addition to the above requirements, we are seeking team members with the following qualities:
- Willingness at all times to go the extra mile to create an outstanding experience for customers and to train and lead the center team to do the same.
- A desire to work in concert with others in an upbeat and supportive atmosphere while reinforcing the organizations mission to provide uncompromising service.
- A compelling desire to serve others, improve your community’s health, and have fun every day!
#INDNP
Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights (https://www.eeoc.gov/poster) notice from the Department of Labor.
See All 54 Nurse Practitioner Or Physician Assistant Jobs in South Carolina
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Find JobsNurse Practitioner Or Physician Assistant Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Nurse Practitioner Or Physician Assistant Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Prisma Health Urgent Care14

- Self Regional Healthcare7

- Curana Health6

- Optum4

- Concentra3

Top Industries Hiring
- Healthcare & Medical Services
- Consulting & Professional Services
- Education
- Non-Profit & Social Services
What South Carolina Employers Look For
The qualifications that appear most often in nurse practitioner or physician assistant jobs across South Carolina.
- Active South Carolina nurse practitioner or physician assistant license or license recognized by South Carolina
- Master's degree or doctoral degree in nursing or physician assistant studies from an accredited program
- National board certification such as NCCPA for PAs or AANP or ANCC for NPs
- Current DEA registration and state-level prescriptive authority where applicable
- Experience in the relevant clinical specialty such as primary care, emergency medicine, or orthopedics
- Current BLS and ACLS certification required by most South Carolina health systems
Nurse Practitioner Or Physician Assistant Jobs in South Carolina: Frequently Asked Questions
How do you become a nurse practitioner or physician assistant in South Carolina?
Nurse practitioners in South Carolina must hold an active advanced practice registered nurse license issued by the South Carolina Board of Nursing, while physician assistants must be licensed through the South Carolina Board of Medical Examiners. NPs complete a master's or doctoral nursing program and pass the AANP or ANCC board exam, and PAs complete an accredited PA program and pass the PANCE. Both roles require national certification to practice in the state.
Which companies hire nurse practitioner or physician assistants in South Carolina?
Companies currently hiring nurse practitioner or physician assistants in South Carolina include Prisma Health Urgent Care, Self Regional Healthcare, and Curana Health, per current listings on Migrate Mate as of August 2026. Large integrated health systems such as Prisma Health and MUSC Health account for a significant share of ongoing openings across the state.
Which South Carolina cities have the most nurse practitioner or physician assistant jobs?
The cities with the most nurse practitioner or physician assistant openings in South Carolina are Columbia, Greenwood, and Greenville. Columbia and Greenville are driven by their large academic medical centers and regional health system headquarters, while Charleston's concentration of MUSC Health facilities and the broader coastal healthcare network sustains steady demand even in surrounding communities.
Are there remote nurse practitioner or physician assistant jobs in South Carolina?
Yes, but they're rare. About 0% of nurse practitioner or physician assistant openings tied to South Carolina are remote or hybrid as of August 2026, reflecting how hands-on clinical practice limits fully remote arrangements. The portions of the role most compatible with remote work include telehealth consultations and some psychiatric or chronic disease management services.
How can I get hired as a nurse practitioner or physician assistant in South Carolina with little or no experience?
The most realistic entry path is a new-graduate or post-professional residency program, which Prisma Health and MUSC Health both offer to candidates completing their first year of clinical practice. Applicants without experience often move into the role from positions as registered nurses, paramedics, or surgical technologists, which are valued backgrounds for South Carolina health systems seeking candidates who already understand clinical workflows and patient care settings.
Where can I find and apply to nurse practitioner or physician assistant jobs in South Carolina?
You can find and apply to nurse practitioner or physician assistant jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the listings, identify the roles that fit your specialty and experience level, and apply directly to the ones that match.
See All 54 Nurse Practitioner Or Physician Assistant Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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