Nurse Practitioner Or Physician Assistant Jobs in South Carolina

Nurse Practitioner Or Physician Assistant jobs in South Carolina are in strong and consistent demand, concentrated in primary care, urgent care, and hospital-based specialty settings across the state at every experience level from new graduate to senior clinician. The largest hiring markets are Columbia, Greenville, and Charleston, where major health systems including Prisma Health, MUSC Health, and Roper St. Francis Healthcare maintain ongoing recruitment. Family practice, emergency medicine, and orthopedics are among the most active specialties for this role statewide. See the openings below and apply to the ones that match your experience.

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Overview

Open roles54
Top employerPrisma Health Urgent Care
Top cityColumbia, SC
Cities hiring31
Work type100% On-site
Top industryHealthcare

Showing 5 of 54+ Nurse Practitioner Or Physician Assistant jobs

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Urgent Care Nurse Practitioner or Physician Assistant- Columbia, SC (Float)
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Added 1d ago
Urgent Care Nurse Practitioner or Physician Assistant- Columbia, SC (Float)
Prisma Health Urgent Care
Lexington, South Carolina
Clinical Support
Healthcare Administration
Project Management
BLS Certification

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Self Regional Healthcare
Nurse Practitioner or Physician Assistant, Hospital Medicine Specialist
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Self Regional Healthcare
Added 2d ago
Nurse Practitioner or Physician Assistant, Hospital Medicine Specialist
Self Regional Healthcare
Greenwood, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
1,001-5,000

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Altea Healthcare
Nurse Practitioner or Physician Assistant-Certified***Weekends***
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Altea Healthcare
Added 6d ago
Nurse Practitioner or Physician Assistant-Certified***Weekends***
Altea Healthcare
Anderson, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$460 - $550/hr
On-Site
201-500

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Tandem Health
Behavioral Health Provider (PMHNP, NP or PA)
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Tandem Health
Added 1w ago
Behavioral Health Provider (PMHNP, NP or PA)
Tandem Health
Sumter, South Carolina
Healthcare Administration
Human Resources
Pharmacy
CPR Certification

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West Coast Wound & Skin Care
Nurse Practitioner / Physician Assistant (FT or PT)
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West Coast Wound & Skin Care
Added 1w ago
Nurse Practitioner / Physician Assistant (FT or PT)
West Coast Wound & Skin Care
Charleston, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$140k - $150k/yr
On-Site
CPR Certification

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See All 54 Nurse Practitioner Or Physician Assistant Jobs in South Carolina

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Nurse Practitioner Or Physician Assistant Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
7 jobs
Greenwood
6 jobs
Greenville
5 jobs
Anderson
3 jobs
Conway
2 jobs
Seneca
2 jobs
Sumter
2 jobs
Laurens
2 jobs
Florence
2 jobs

Nurse Practitioner Or Physician Assistant Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health Urgent Care
    Prisma Health Urgent Care14
  • Self Regional Healthcare
    Self Regional Healthcare7
  • Curana Health
    Curana Health6
  • Optum
    Optum4
  • Concentra
    Concentra3

Top Industries Hiring

  • Healthcare & Medical Services
  • Consulting & Professional Services
  • Education
  • Non-Profit & Social Services

What South Carolina Employers Look For

The qualifications that appear most often in nurse practitioner or physician assistant jobs across South Carolina.

  • Active South Carolina nurse practitioner or physician assistant license or license recognized by South Carolina
  • Master's degree or doctoral degree in nursing or physician assistant studies from an accredited program
  • National board certification such as NCCPA for PAs or AANP or ANCC for NPs
  • Current DEA registration and state-level prescriptive authority where applicable
  • Experience in the relevant clinical specialty such as primary care, emergency medicine, or orthopedics
  • Current BLS and ACLS certification required by most South Carolina health systems

Nurse Practitioner Or Physician Assistant Jobs in South Carolina: Frequently Asked Questions

How do you become a nurse practitioner or physician assistant in South Carolina?

Nurse practitioners in South Carolina must hold an active advanced practice registered nurse license issued by the South Carolina Board of Nursing, while physician assistants must be licensed through the South Carolina Board of Medical Examiners. NPs complete a master's or doctoral nursing program and pass the AANP or ANCC board exam, and PAs complete an accredited PA program and pass the PANCE. Both roles require national certification to practice in the state.

Which companies hire nurse practitioner or physician assistants in South Carolina?

Companies currently hiring nurse practitioner or physician assistants in South Carolina include Prisma Health Urgent Care, Self Regional Healthcare, and Curana Health, per current listings on Migrate Mate as of August 2026. Large integrated health systems such as Prisma Health and MUSC Health account for a significant share of ongoing openings across the state.

Which South Carolina cities have the most nurse practitioner or physician assistant jobs?

The cities with the most nurse practitioner or physician assistant openings in South Carolina are Columbia, Greenwood, and Greenville. Columbia and Greenville are driven by their large academic medical centers and regional health system headquarters, while Charleston's concentration of MUSC Health facilities and the broader coastal healthcare network sustains steady demand even in surrounding communities.

Are there remote nurse practitioner or physician assistant jobs in South Carolina?

Yes, but they're rare. About 0% of nurse practitioner or physician assistant openings tied to South Carolina are remote or hybrid as of August 2026, reflecting how hands-on clinical practice limits fully remote arrangements. The portions of the role most compatible with remote work include telehealth consultations and some psychiatric or chronic disease management services.

How can I get hired as a nurse practitioner or physician assistant in South Carolina with little or no experience?

The most realistic entry path is a new-graduate or post-professional residency program, which Prisma Health and MUSC Health both offer to candidates completing their first year of clinical practice. Applicants without experience often move into the role from positions as registered nurses, paramedics, or surgical technologists, which are valued backgrounds for South Carolina health systems seeking candidates who already understand clinical workflows and patient care settings.

Where can I find and apply to nurse practitioner or physician assistant jobs in South Carolina?

You can find and apply to nurse practitioner or physician assistant jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the listings, identify the roles that fit your specialty and experience level, and apply directly to the ones that match.

See All 54 Nurse Practitioner Or Physician Assistant Jobs in South Carolina

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