Mental Health Nurse Practitioner Jobs in South Carolina

Mental Health Nurse Practitioner jobs in South Carolina are concentrated in Columbia, Greenville, and Charleston, where demand for psychiatric and behavioral health specialists remains strong across inpatient facilities, community mental health centers, and integrated primary care settings. Major employers with lasting presences in the state include Prisma Health, MUSC Health, and the South Carolina Department of Mental Health. The most sought-after specialties are child and adolescent psychiatry, substance use disorder treatment, and telehealth-based outpatient care. Find a role that fits below and apply directly.

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Overview

Open roles7
Top employerLegion Health
Top cityGreer, SC
Cities hiring7
Work type67% On-site
Top credentialDoctoral degree

Showing 5 of 7+ Mental Health Nurse Practitioner jobs

Nurse Practitioner - Psychiatric Mental Health
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Added 5d ago
Nurse Practitioner - Psychiatric Mental Health
US Department of Veterans Affairs
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$119k - $173k/yr
On-Site
Post-Master's Certificate (Nursing)
10,000+

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PMHNP Psychiatric Mental Health Nurse Practitioner
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Added 1w ago
PMHNP Psychiatric Mental Health Nurse Practitioner
LifeSource, Inc
Florence, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$89k.48 - $107k.79/yr
On-Site
Master's degree
51-200

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Psychiatric Mental Health Nurse Practitioner South Carolina
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Added 2w ago
Psychiatric Mental Health Nurse Practitioner South Carolina
Midlands Behavioral Health Hospital
Sumter, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$55 - $57/hr

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Psychiatric Mental Health Nurse Practitioner
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Added 3w ago
Psychiatric Mental Health Nurse Practitioner
ReGenesis Health Care
Spartanburg, South Carolina
Customer Service
Customer Support
Hospitality & Guest Services
$96k - $115k/yr
BLS Certification
51-200

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Board-Certified Psychiatric Mental Health Nurse Practitioner
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Added 1mo ago
Board-Certified Psychiatric Mental Health Nurse Practitioner
Psychiatric Associates and Addiction Medicine
Greenville, South Carolina
Allied Health
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling

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See All 7 Mental Health Nurse Practitioner Jobs in South Carolina

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Mental Health Nurse Practitioner Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Greer
1 job
Seneca
1 job
Sumter
1 job
Columbia
1 job
Florence
1 job
Greenville
1 job
Spartanburg
1 job

Mental Health Nurse Practitioner Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Legion Health1 open role
LifeSource1 open role
ReGenesis Health Care1 open role

What South Carolina Employers Look For

The qualifications that appear most often in mental health nurse practitioner jobs across South Carolina.

  • Active South Carolina APRN license with psychiatric-mental health nurse practitioner certification required
  • Current national PMHNP-BC certification from ANCC or equivalent certifying body
  • Master of Science in Nursing or Doctor of Nursing Practice in psychiatric-mental health
  • Prescriptive authority registration with the South Carolina Board of Nursing
  • Experience conducting psychiatric evaluations, diagnosing disorders, and managing psychotropic medications
  • Familiarity with electronic health records platforms and collaborative care documentation standards

Mental Health Nurse Practitioner Jobs in South Carolina: Frequently Asked Questions

How do you become a mental health nurse practitioner in South Carolina?

You must earn a graduate degree in nursing with a psychiatric-mental health nurse practitioner concentration, then pass the ANCC PMHNP-BC board certification exam. After that, you apply to the South Carolina Board of Nursing for APRN licensure and register for prescriptive authority in the state. South Carolina operates under a collaborative practice agreement model, so new practitioners typically work with a collaborating physician until they meet the experience threshold to practice more independently.

How much do mental health nurse practitioners make in South Carolina?

Mental health nurse practitioners in South Carolina earn a median of about $123,290 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $97,080 for the lowest 10% to over $160,170 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire mental health nurse practitioners in South Carolina?

Employers hiring mental health nurse practitioners in South Carolina right now include Legion Health, LifeSource, and ReGenesis Health Care, based on current listings on Migrate Mate as of October 2026. South Carolina's large integrated health systems and the state's public behavioral health network both maintain consistent hiring pipelines for this specialty.

Which South Carolina cities have the most mental health nurse practitioner jobs?

Greer, Seneca, and Sumter have the most mental health nurse practitioner openings in South Carolina. Columbia leads as the state capital and home to MUSC Health's behavioral health services and the South Carolina Department of Mental Health's central operations, while Greenville and Charleston drive demand through rapidly growing regional hospital systems and expanding outpatient behavioral health clinics.

Are there remote mental health nurse practitioner jobs in South Carolina?

Yes, but they are limited compared to purely desk-based fields because psychiatric evaluations and medication management often require in-person or secure telehealth encounters. About 33% of mental health nurse practitioner openings tied to South Carolina are remote or hybrid as of October 2026. The roles most likely to offer full telehealth schedules are outpatient therapy management and medication follow-up positions with established behavioral health telehealth networks.

How can I get hired as a mental health nurse practitioner in South Carolina with little or no experience?

The most realistic entry path is a new-graduate or residency fellowship program, and Prisma Health and MUSC Health both run structured APRN residencies that accept newly certified PMHNPs. Candidates without direct PMHNP experience can also pursue lateral moves from roles like registered psychiatric nurse or inpatient behavioral health RN at South Carolina Department of Mental Health facilities. Completing your South Carolina collaborative practice agreement with a supervising psychiatrist and holding a clean APRN license puts you ahead of candidates still awaiting credentialing.

Where can I find and apply to mental health nurse practitioner jobs in South Carolina?

You can find and apply to mental health nurse practitioner jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the listings, find roles that match your credentials and preferred setting, and apply directly to the employers posting them.

See All 7 Mental Health Nurse Practitioner Jobs in South Carolina

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