Mental Health Nurse Practitioner Jobs in South Carolina
Mental Health Nurse Practitioner jobs in South Carolina are open across Charleston, Columbia, and Forest Acres and other South Carolina metros, with employers like LifeStance Health, Medical University of South Carolina, and Prisma Health hiring at every experience level. Find a role that fits below and apply directly.
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Showing 5 of 12+ Mental Health Nurse Practitioner jobs











At LifeStance Health, we believe in a truly healthy society where mental and physical healthcare are unified to make lives better. Our mission is to help people lead healthier, more fulfilling lives by improving access to trusted, affordable, and personalized mental healthcare. Everywhere. Every day. It’s a lofty goal; we know. But we make it happen with the best team in behavioral health.
Thank you for taking the time to explore a career with us. As the fastest growing behavioral health practice group in the country, now is the perfect time to join our clinical team!
We are actively looking to hire a talented Psychiatric Mental Health Nurse Practitioner in the Charleston area, who is passionate about patient care, committed to clinical excellence, and sees ages 6+.
We offer Nurse Practitioners:
- Competitive earnings package with uncapped potential
- Compensation range: $142,000-$190,000, compensation model based on productivity
- W2 employed position with flexible hybrid work schedules
- Collaborative work environment with unmatched support
- Sign-on bonus!
- Care Access and Quality Incentive: Annual cash bonus program
- Comprehensive benefit package
- 401k with up to 4% match
- CME reimbursement
- Strong work/life balance
Nurse Practitioners are a critical part of our clinical team. We’re seeking NPs that are:
- Local to and fully licensed (PMHNP) in South Carolina.
- Beyond 6 months of employed outpatient experience.
- Board Certified with full prescribing ability.
- Experienced in both medication management and therapy.
- Experienced with child and adolescent populations, ages 6+.
Location and Schedule:
- Conveniently located at Mark Clark Expy and Leeds Ave
- Start in fewer than 60 days
- Beautifully designed offices that are thoughtfully laid out
- Full-time, Monday-Friday with evenings/weekends optional
- Flexible hybrid schedule to accommodate work/life balance
Apply now or contact me today!
Leah Sweeney
Director, Practice Development, South Carolina
LifeStance Health, Inc.
(e) Leah.Sweeney@LifeStance.com
About LifeStance Health
LifeStance is a national provider of mental healthcare services focused on evidenced-based, medically driven treatment services for children, adolescents and adults suffering from a variety of mental health issues in an outpatient care setting, both in-person at its clinics nationwide and through its digital health telemedicine offering. The company employs psychiatrists, psychologists, psychiatric nurse practitioners, and licensed therapists throughout the US.
LifeStance Health is an equal opportunity employer. We celebrate diversity and are fully committed to creating an inclusive work environment for all our employees.
Our values:
Belonging: We cultivate a space where everyone can show up as their authentic self.
Empathy: We seek out diverse perspectives and listen to learn without judgment.
Courage: We are all accountable for doing the right thing - even when it's hard - because we know it's worth it.
One Team: We realize our full potential when we work together towards our shared purpose.
If you elect to interact with us via our website, please only use www.lifestance.com or www.careers.lifestance.com. Additionally, our recruiters utilize email addresses with the @lifestance.com domain. Other websites and domains are not affiliated with LifeStance Health and may represent threats to your data security.
LifeStance Health complies with federal and state disability laws and makes reasonable accommodations for applicants and employees with disabilities. If reasonable accommodation is needed to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please contact our Human Resources Team at ADA@lifestance.com or by calling +1-800-308-0994.
Please note: This contact is intended solely for accommodation requests. Inquiries regarding applications, resumes and applicant status should not be sent to this email address as they will not be reviewed or responded to. To apply for a position, please use our official careers page.
See All 12 Mental Health Nurse Practitioner Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find JobsMental Health Nurse Practitioner Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Mental Health Nurse Practitioner Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- LifeStance Health7

- Medical University of South Carolina2

- Prisma Health2

- Molina Healthcare1

Top Industries Hiring
- Healthcare & Medical Services12
- Consulting & Professional Services1
What South Carolina Employers Look For
The qualifications that appear most often in mental health nurse practitioner jobs across South Carolina.
- Active APRN license with psychiatric-mental health nurse practitioner certification (PMHNP-BC)
- Master's or doctoral degree in nursing with a psychiatric-mental health specialty focus
- DEA registration and full prescriptive authority in the applicable state
- Experience conducting psychiatric evaluations and managing psychotropic medication regimens
- Proficiency with electronic health record systems such as Epic, Cerner, or Athenahealth
- Familiarity with evidence-based psychotherapy modalities including CBT and motivational interviewing
Mental Health Nurse Practitioner Jobs in South Carolina: Frequently Asked Questions
How many mental health nurse practitioner jobs are there in South Carolina?
There are 12+ mental health nurse practitioner openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Charleston, Columbia, and Forest Acres. New positions post regularly as employers across South Carolina hire.
How much do mental health nurse practitioners make in South Carolina?
Mental health nurse practitioners in South Carolina earn a median of about $123,290 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $97,080 for the lowest 10% to over $160,170 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most mental health nurse practitioner jobs?
Charleston, Columbia, and Forest Acres have the most mental health nurse practitioner openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire mental health nurse practitioners in South Carolina?
Employers hiring mental health nurse practitioners in South Carolina include LifeStance Health, Medical University of South Carolina, and Prisma Health, based on current listings on Migrate Mate as of June 2026.
Are there remote mental health nurse practitioner jobs in South Carolina?
Yes. About 58% of mental health nurse practitioner openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for mental health nurse practitioner jobs in South Carolina?
You can apply to mental health nurse practitioner jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 12 Mental Health Nurse Practitioner Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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