Registered Nurse Operating Room Jobs in South Carolina
Registered Nurse Operating Room jobs in South Carolina are concentrated in large acute-care hospital systems and specialty surgical centers, with consistent demand from entry-level perioperative nurses through experienced scrub and circulating RNs. The busiest hiring markets are Columbia, Charleston, and Greenville, where systems like Prisma Health, MUSC Health, and Bon Secours St. Francis Health System maintain active perioperative programs. Surgical services, cardiac OR, and orthopedic OR teams see the most sustained openings across the state. See the openings below and apply to the ones that match your experience.
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Showing 5 of 54+ Registered Nurse Operating Room jobs
Operating Room
Full Time
Any
0600-1430
Sign-On Bonus: 20,000.00
Lexington Health is a comprehensive network of care that includes six community medical and urgent care centers, nearly 80 physician practices, more than 9,000 health care professionals and Lexington Medical Center, a 607-bed teaching hospital in West Columbia, South Carolina. It was selected by Modern Healthcare as one of the Best Places to Work in Healthcare and was first in the state to achieve Magnet with Distinction status for excellence in nursing care. Consistently ranked as best in the Columbia Metro area by U.S. News & World Report, Lexington Health delivers more than 4,000 babies each year, performs more than 34,000 surgeries annually and is the region's third largest employer.
Lexington Health also includes an accredited Cancer Center of Excellence, the state’s first HeartCARE Center, the largest skilled nursing facility in the Carolinas, and an Alzheimer’s care center. Its postgraduate medical education programs include family medicine and transitional year residencies, as well as an informatics fellowship.
Job Summary
The Nurse Supervisor is responsible for the operational functions of all staff within their assigned perioperative department and coordinates the daily activities pertaining to nursing care in all areas. All responsibilities are carried out in accordance with the mission, vision, strategic imperatives and standards of Lexington Medical Center (LMC), American Nurses Association Standards and in accordance with the provisions set forth by the South Carolina Nurse Practice Act.
Minimum Qualifications
Minimum Education: Bachelor of Science in Nursing
Minimum Years of Experience: 3 Years of Perioperative Nursing Experience
Substitutable Education & Experience (Optional): None.
Required Certifications/Licensure: Current RN license to practice in the state of South Carolina;
National nursing certification in specialty of area assigned or must obtain within 1 year of hire date into the position.
Required Training: None.
Essential Functions
- Works in a cooperative manner, which fosters relations between employees and patients, patients' families, visitors, fellow employees, and the medical staff. Accepts chain of command, supervision, and constructive criticism.
- Exhibits commitment and pride through personal example by speaking positively about LMC, the department employees, and guests.
- Must be competent in all areas of assigned specialty and able to assist with all procedures across the entire department. Willing and able to demonstrate the ability to perform all procedures working alongside the staff.
- Contributes to teamwork and creates harmonious, effective and positive working relationships with others by:
- Responding to requests in a cooperative and responsive manner.
- Speaking respectfully of/to other employees and guests by minimizing criticism and adversarial behaviors.
- Assuming responsibility without making excuses, offering assistance whenever possible without being asked.
- Communicates clearly and in a timely manner both verbally and in writing.
- Responsible for resolving conflicts and problem-solving by:
- Remaining calm when confronted.
- Listening carefully.
- Acknowledging that the problem is valid to the other person's perception.
- Attempting to identify solutions and/or referring person to the appropriate authority.
- Attempting to deliver more than is expected.
- Exhibits telephone courtesy by:
- Answering promptly with proper name and department.
- Speaking with a pleasant tone while focusing attention to caller.
- Transferring calls correctly and promptly.
- Attending to calls on hold in a timely manner.
- Maintains confidentiality by:
- Discouraging gossip.
- Using discretion when discussing patient, work or LMC related information with others.
- Discussing employee information.
Duties & Responsibilities
- Business Acumen:
- Demonstrates proficiency in using technological applications.
- Assesses equipment and technology needs of the department.
- Demonstrates good time management and ability to prioritize.
- Demonstrates proficiency in human resource management to ensure safe and effective operations.
- Documents staffing and scheduling changes.
- Assesses daily staffing needs and makes daily staffing assignments as needed.
- Accurately completes and maintains records and reports.
- Leadership by:
- Identifies and recognizes individual strengths and contributions verbally with ongoing feedback and formally through LMC Gold and Award of Excellence.
- Establish and maintain ongoing coaching and mentoring role with assigned staff to include annual evaluations, performance improvement and clinical education needs assessments.
- Involvement in recruiting, interviewing, hiring and orientation processes.
- Involvement in investigation and resolution of patient, visitor and staff concerns.
- Represents Nurse Manager in their absence.
- Involvement in Unit Base governance.
- Demonstrates knowledge and ability to address LMC guidelines and policies.
- Following the appropriate chain of command in dealing with issues
- Caring Practice by:
- Embracing diversity by recognizing differences in cultures and patient needs and striving to meet the needs of patients, visitors and staff.
- Coordinating the care of patients within the assigned department and across department boundaries.
- Oversees compliance and adherence to patient Bill of Rights.
- Functions as a positive agent of change by communicating and implementing practice changes and upholding standards in a positive manner.
- Professional Practice by:
- Reviewing trends and recommending opportunities for improvement.
- Demonstrating personal effectiveness and manages emotions.
- Acquiring appropriate leadership and clinical education credits as dictated by designated specialty certifying agency.
- Assessing staff performance at critical interval, reviews disciplinary action with employees and completes annual Performance Appraisals.
- Promoting staff and patient satisfaction.
- Utilizing the service recovery process to resolve complaints (GIFT).
- Mentoring of assigned staff on an ongoing basis, with structured periodic feedback.
- Hospital-wide responsibilities by:
- Completing yearly safety training and other mandatory classes.
- Completing employee health workup and mandatory check-offs.c. Maintains all certifications current.
- Ensures staff compliance with all LMC requirements and certifications.
- Ensure Hazardous Waste or Hazardous Waste Pharmaceuticals are discarded, stored, and managed with other compatible waste streams in containers that are properly labeled and closed prior to being shipped offsite for proper disposal. Initial RCRA training is received within 6 months of the hire date and continuing with annual RCRA training.
- Performs all other duties as assigned.
We are committed to offering quality, cost-effective benefits choices for our benefit eligible employees and their families:
- Day ONE medical, dental and life insurance benefits
- Health care and dependent care flexible spending accounts (FSAs)
- Employees are eligible for enrollment into the 403(b) match plan day one. LHI matches dollar for dollar up to 6%.
- Employer paid life insurance – equal to 1x salary
- Employee may elect supplemental life insurance with low cost premiums up to 3x salary
- Adoption assistance
- LHI provides its full-time employees employer paid short-term disability and long-term disability coverage after 90 days of eligible employment
- Tuition reimbursement
- Student loan forgiveness
Equal Opportunity Employer
It is the policy of Lexington Health to provide equal opportunity of employment for all individuals, and to remain compliant with applicable state and federal laws and regulations. Lexington Health strives to provide a discrimination-free environment, and to recruit, select, on-board, and employ all employees without regard to race, color, religion, sex, age, disability, national origin, veteran status, or pregnancy, childbirth, or related medical conditions, including but not limited to, lactation. Lexington Health endeavors to upgrade and promote employees from within the hospital where possible and consistent with the employee’s desires and abilities and the hospital’s needs.
Operating Room
Full Time
Any
0600-1430
Sign-On Bonus: 20,000.00
Lexington Health is a comprehensive network of care that includes six community medical and urgent care centers, nearly 80 physician practices, more than 9,000 health care professionals and Lexington Medical Center, a 607-bed teaching hospital in West Columbia, South Carolina. It was selected by Modern Healthcare as one of the Best Places to Work in Healthcare and was first in the state to achieve Magnet with Distinction status for excellence in nursing care. Consistently ranked as best in the Columbia Metro area by U.S. News & World Report, Lexington Health delivers more than 4,000 babies each year, performs more than 34,000 surgeries annually and is the region's third largest employer.
Lexington Health also includes an accredited Cancer Center of Excellence, the state’s first HeartCARE Center, the largest skilled nursing facility in the Carolinas, and an Alzheimer’s care center. Its postgraduate medical education programs include family medicine and transitional year residencies, as well as an informatics fellowship.
Job Summary
The Nurse Supervisor is responsible for the operational functions of all staff within their assigned perioperative department and coordinates the daily activities pertaining to nursing care in all areas. All responsibilities are carried out in accordance with the mission, vision, strategic imperatives and standards of Lexington Medical Center (LMC), American Nurses Association Standards and in accordance with the provisions set forth by the South Carolina Nurse Practice Act.
Minimum Qualifications
Minimum Education: Bachelor of Science in Nursing
Minimum Years of Experience: 3 Years of Perioperative Nursing Experience
Substitutable Education & Experience (Optional): None.
Required Certifications/Licensure: Current RN license to practice in the state of South Carolina;
National nursing certification in specialty of area assigned or must obtain within 1 year of hire date into the position.
Required Training: None.
Essential Functions
- Works in a cooperative manner, which fosters relations between employees and patients, patients' families, visitors, fellow employees, and the medical staff. Accepts chain of command, supervision, and constructive criticism.
- Exhibits commitment and pride through personal example by speaking positively about LMC, the department employees, and guests.
- Must be competent in all areas of assigned specialty and able to assist with all procedures across the entire department. Willing and able to demonstrate the ability to perform all procedures working alongside the staff.
- Contributes to teamwork and creates harmonious, effective and positive working relationships with others by:
- Responding to requests in a cooperative and responsive manner.
- Speaking respectfully of/to other employees and guests by minimizing criticism and adversarial behaviors.
- Assuming responsibility without making excuses, offering assistance whenever possible without being asked.
- Communicates clearly and in a timely manner both verbally and in writing.
- Responsible for resolving conflicts and problem-solving by:
- Remaining calm when confronted.
- Listening carefully.
- Acknowledging that the problem is valid to the other person's perception.
- Attempting to identify solutions and/or referring person to the appropriate authority.
- Attempting to deliver more than is expected.
- Exhibits telephone courtesy by:
- Answering promptly with proper name and department.
- Speaking with a pleasant tone while focusing attention to caller.
- Transferring calls correctly and promptly.
- Attending to calls on hold in a timely manner.
- Maintains confidentiality by:
- Discouraging gossip.
- Using discretion when discussing patient, work or LMC related information with others.
- Discussing employee information.
Duties & Responsibilities
- Business Acumen:
- Demonstrates proficiency in using technological applications.
- Assesses equipment and technology needs of the department.
- Demonstrates good time management and ability to prioritize.
- Demonstrates proficiency in human resource management to ensure safe and effective operations.
- Documents staffing and scheduling changes.
- Assesses daily staffing needs and makes daily staffing assignments as needed.
- Accurately completes and maintains records and reports.
- Leadership by:
- Identifies and recognizes individual strengths and contributions verbally with ongoing feedback and formally through LMC Gold and Award of Excellence.
- Establish and maintain ongoing coaching and mentoring role with assigned staff to include annual evaluations, performance improvement and clinical education needs assessments.
- Involvement in recruiting, interviewing, hiring and orientation processes.
- Involvement in investigation and resolution of patient, visitor and staff concerns.
- Represents Nurse Manager in their absence.
- Involvement in Unit Base governance.
- Demonstrates knowledge and ability to address LMC guidelines and policies.
- Following the appropriate chain of command in dealing with issues
- Caring Practice by:
- Embracing diversity by recognizing differences in cultures and patient needs and striving to meet the needs of patients, visitors and staff.
- Coordinating the care of patients within the assigned department and across department boundaries.
- Oversees compliance and adherence to patient Bill of Rights.
- Functions as a positive agent of change by communicating and implementing practice changes and upholding standards in a positive manner.
- Professional Practice by:
- Reviewing trends and recommending opportunities for improvement.
- Demonstrating personal effectiveness and manages emotions.
- Acquiring appropriate leadership and clinical education credits as dictated by designated specialty certifying agency.
- Assessing staff performance at critical interval, reviews disciplinary action with employees and completes annual Performance Appraisals.
- Promoting staff and patient satisfaction.
- Utilizing the service recovery process to resolve complaints (GIFT).
- Mentoring of assigned staff on an ongoing basis, with structured periodic feedback.
- Hospital-wide responsibilities by:
- Completing yearly safety training and other mandatory classes.
- Completing employee health workup and mandatory check-offs.c. Maintains all certifications current.
- Ensures staff compliance with all LMC requirements and certifications.
- Ensure Hazardous Waste or Hazardous Waste Pharmaceuticals are discarded, stored, and managed with other compatible waste streams in containers that are properly labeled and closed prior to being shipped offsite for proper disposal. Initial RCRA training is received within 6 months of the hire date and continuing with annual RCRA training.
- Performs all other duties as assigned.
We are committed to offering quality, cost-effective benefits choices for our benefit eligible employees and their families:
- Day ONE medical, dental and life insurance benefits
- Health care and dependent care flexible spending accounts (FSAs)
- Employees are eligible for enrollment into the 403(b) match plan day one. LHI matches dollar for dollar up to 6%.
- Employer paid life insurance – equal to 1x salary
- Employee may elect supplemental life insurance with low cost premiums up to 3x salary
- Adoption assistance
- LHI provides its full-time employees employer paid short-term disability and long-term disability coverage after 90 days of eligible employment
- Tuition reimbursement
- Student loan forgiveness
Equal Opportunity Employer
It is the policy of Lexington Health to provide equal opportunity of employment for all individuals, and to remain compliant with applicable state and federal laws and regulations. Lexington Health strives to provide a discrimination-free environment, and to recruit, select, on-board, and employ all employees without regard to race, color, religion, sex, age, disability, national origin, veteran status, or pregnancy, childbirth, or related medical conditions, including but not limited to, lactation. Lexington Health endeavors to upgrade and promote employees from within the hospital where possible and consistent with the employee’s desires and abilities and the hospital’s needs.
See All 54 Registered Nurse Operating Room Jobs in South Carolina
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Find JobsRegistered Nurse Operating Room Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Registered Nurse Operating Room Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in registered nurse operating room jobs across South Carolina.
- Active South Carolina RN license or a Compact license recognized in South Carolina
- Current BLS certification and ACLS certification required for OR settings
- Minimum one to two years of perioperative or surgical nursing experience preferred
- CNOR certification strongly preferred or required by many South Carolina surgical employers
- Demonstrated competency in scrub and circulating roles within an acute-care OR
- Familiarity with sterile technique, surgical instrumentation, and AORN practice standards
Registered Nurse Operating Room Jobs in South Carolina: Frequently Asked Questions
How do you become a registered nurse operating room in South Carolina?
You must hold an active RN license issued by the South Carolina Board of Nursing or a valid Compact RN license recognized in South Carolina, earned after completing an accredited nursing program and passing the NCLEX-RN. From there, most South Carolina hospital systems require completing a perioperative nurse residency or on-the-job OR orientation before independent practice. Earning the CNOR credential strengthens your candidacy considerably with South Carolina surgical employers.
How much do registered nurse operating rooms make in South Carolina?
Registered nurse operating rooms in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire registered nurse operating rooms in South Carolina?
South Carolina registered nurse operating room roles are posted by McLeod Health, Prisma Health, and American Traveler and others right now, based on current listings on Migrate Mate as of August 2026. South Carolina's largest health systems, including those anchored in Columbia, Charleston, and Greenville, account for the majority of perioperative nursing openings across the state.
Which South Carolina cities have the most registered nurse operating room jobs?
Columbia, Charleston, and South Carolina have the most registered nurse operating room openings in South Carolina. Columbia leads as the state capital and home to Prisma Health's flagship campus, while Charleston's concentration of academic medical centers and specialty surgical facilities drives strong demand, and Greenville's growing healthcare corridor supports active perioperative hiring across Bon Secours and other regional systems.
Are there remote registered nurse operating room jobs in South Carolina?
Yes, but they're rare. About 0% of registered nurse operating room openings tied to South Carolina are remote or hybrid as of August 2026, reflecting that hands-on surgical care cannot be performed off-site. The only registered nurse operating room work that occasionally appears remote involves clinical education, perioperative case review, or surgical services coordination roles.
How can I get hired as a registered nurse operating room in South Carolina with little or no experience?
The most realistic path is applying to a perioperative nurse residency program, which Prisma Health and MUSC Health both run for RNs without OR backgrounds. These structured programs train new perioperative nurses in scrub and circulating skills before independent assignment. Nurses transitioning from medical-surgical, emergency, or procedural backgrounds are strong candidates, and holding or actively pursuing CNOR eligibility gives an additional edge with South Carolina hiring managers.
Where can I find and apply to registered nurse operating room jobs in South Carolina?
You can find and apply to registered nurse operating room jobs in South Carolina on Migrate Mate, which lists current openings tied to South Carolina employers. Search the available roles, identify the ones that match your experience and certifications, and apply directly to the positions that fit.
See All 54 Registered Nurse Operating Room Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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