Nurse Practitioner Jobs in South Carolina
Nurse Practitioner jobs in South Carolina are open across Columbia, Greenville, and Charleston and other South Carolina metros, with employers like Prisma Health, Medical University of South Carolina, and Self Regional Healthcare hiring at every experience level. Find a role that fits below and apply directly.
Find Nurse Practitioner JobsOverview
Showing 5 of 187+ Nurse Practitioner jobs
INTRODUCTION
Advanced Practice Practitioner - Primary Care Outpatient
Piedmont Healthcare is recruiting for an Advanced Practice Practitioner to join the Primary Care team at our Outpatient Practice. The position is full time, Monday through Friday.
Responsibilities
In this role you will:
- Provide medical services to individuals, families and/or groups.
- Emphasize health promotion as well as acute and chronic disease management.
- Augment a physician’s ability to provide medical services to patients.
- Collect and document data, conduct diagnostic and therapeutic procedures, order and schedules laboratory studies and professional consultations and provide direct patient care services.
- The APP will work collaboratively with multiple IM providers in the care of the PCPs patient panel.
Piedmont benefits:
- Competitive Compensation
- Enhanced Packages
- Comprehensive Benefits
- EPIC
- Quality, Service, and Reputation
- Patient Center Medical Home
QUALIFICATIONS
Qualified candidates will have at least 2 years experience working as a Physician Assistant or Nurse Practitioner.
Masters, Bachelor’s Degree from an Accredited PA program and National Board Certification
-or-
Licensed as a Nurse and approved to practice as a NP by State of Georgia with National Certification
Business Unit: Company Name: Piedmont Medical Care Corporation
INTRODUCTION
Advanced Practice Practitioner - Primary Care Outpatient
Piedmont Healthcare is recruiting for an Advanced Practice Practitioner to join the Primary Care team at our Outpatient Practice. The position is full time, Monday through Friday.
Responsibilities
In this role you will:
- Provide medical services to individuals, families and/or groups.
- Emphasize health promotion as well as acute and chronic disease management.
- Augment a physician’s ability to provide medical services to patients.
- Collect and document data, conduct diagnostic and therapeutic procedures, order and schedules laboratory studies and professional consultations and provide direct patient care services.
- The APP will work collaboratively with multiple IM providers in the care of the PCPs patient panel.
Piedmont benefits:
- Competitive Compensation
- Enhanced Packages
- Comprehensive Benefits
- EPIC
- Quality, Service, and Reputation
- Patient Center Medical Home
QUALIFICATIONS
Qualified candidates will have at least 2 years experience working as a Physician Assistant or Nurse Practitioner.
Masters, Bachelor’s Degree from an Accredited PA program and National Board Certification
-or-
Licensed as a Nurse and approved to practice as a NP by State of Georgia with National Certification
Business Unit: Company Name: Piedmont Medical Care Corporation
See All 187+ Nurse Practitioner Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Nurse Practitioner JobsNurse Practitioner Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Nurse Practitioner Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Prisma Health72
- Medical University of South Carolina34
- Self Regional Healthcare20
- Lexington Health16
- CVS Health9
Top Industries Hiring
- Healthcare & Medical Services164
- Consulting & Professional Services27
- Education17
- Biotechnology & Pharmaceuticals2
What South Carolina Employers Look For
The qualifications that appear most often in nurse practitioner jobs across South Carolina.
- Current NP certification from ANCC or AANP in a recognized specialty
- Active, unencumbered state license as an Advanced Practice Registered Nurse
- Master of Science in Nursing or Doctor of Nursing Practice degree
- Current BLS and ACLS certification from the American Heart Association
- Minimum one to two years of clinical NP or RN experience in a relevant setting
- Experience with electronic health record systems such as Epic or Cerner
Nurse Practitioner Jobs in South Carolina: Frequently Asked Questions
How many nurse practitioner jobs are there in South Carolina?
There are 187+ nurse practitioner openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Greenville, and Charleston. New positions post regularly as employers across South Carolina hire.
How much do nurse practitioners make in South Carolina?
Nurse practitioners in South Carolina earn a median of about $123,290 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $97,080 for the lowest 10% to over $160,170 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most nurse practitioner jobs?
Columbia, Greenville, and Charleston have the most nurse practitioner openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire nurse practitioners in South Carolina?
Employers hiring nurse practitioners in South Carolina include Prisma Health, Medical University of South Carolina, and Self Regional Healthcare, based on current listings on Migrate Mate as of June 2026.
Are there remote nurse practitioner jobs in South Carolina?
Yes. About 4% of nurse practitioner openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for nurse practitioner jobs in South Carolina?
You can apply to nurse practitioner jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 187+ Nurse Practitioner Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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