Nurse Practitioner Jobs in South Carolina
Nurse Practitioner jobs in South Carolina are consistently active, with demand concentrated in primary care, psychiatric and behavioral health, and family practice settings across hospital systems, federally qualified health centers, and rural clinics. The largest hiring activity centers on Columbia, Greenville, and Charleston, where major employers such as Prisma Health, MUSC Health, and Bon Secours anchor much of the market. Urgent care, oncology, and gerontology specialties see particularly steady openings as the state's aging population and underserved rural communities drive sustained need at every experience level. See the openings below and apply to the ones that match your experience.
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Job Summary
Provides primary health care to a specific patient population within the guidelines of written protocols. Follows established nursing standards, procedures, and practices.Accountabilities
- Engages in the diagnosis and treatment of disease, defects or injuries and recommend or prescribe treatments for the relief or cure of physical, mental or functional ailments or defects.
- Performs all charting, summaries, correspondence and assorted paperwork that is required for purposes of documenting care and billing.
- Participates in physician educational programs provided by Employer relative to capitated medicine and its implications on physician practice patterns.
- Participates in responding to requests for proposals for managed care contracts.
Participates in:
Establishment of quality assurance programs
Establishment of utilization management programs
Selection of management information systems
Development of patient education services
Development of patient satisfaction surveys- Assists in the development of operational and capital budgets.
- Participates in operational assessments in search of revenue enhancement, expense reductions, consolidation efficiencies and billing opportunities.
General Job Expectations:
Maintain courteous and cooperative working relationships with all levels of management and employees, physicians, patients, guarantors and the general public.- Participates in activities that would further the public's image of the Employer.
Supervisory/Management Responsibility
This is a non-management job that will report to a supervisor, manager, director, or executive.
Minimum Requirements
Master's Degree in Nursing; Nurse Practitioner Degree Emphasis or Program Certificate equivalent.
Required Certifications/Registrations/Licenses
- Official Recognition as a Nurse Practitioner in the state the team member is working
- Prescriptive Authority for the state in which the team member is working
- Controlled Substance license for the state in which the team member is working. Federal DEA license
Work Shift
Day (United States of America)Location
Seneca Medical AssociatesFacility
Seneca Medical AssociatesDepartment
Rural HealthShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
Inspire health. Serve with compassion. Be the difference.
Job Summary
Provides primary health care to a specific patient population within the guidelines of written protocols. Follows established nursing standards, procedures, and practices.Accountabilities
- Engages in the diagnosis and treatment of disease, defects or injuries and recommend or prescribe treatments for the relief or cure of physical, mental or functional ailments or defects.
- Performs all charting, summaries, correspondence and assorted paperwork that is required for purposes of documenting care and billing.
- Participates in physician educational programs provided by Employer relative to capitated medicine and its implications on physician practice patterns.
- Participates in responding to requests for proposals for managed care contracts.
Participates in:
Establishment of quality assurance programs
Establishment of utilization management programs
Selection of management information systems
Development of patient education services
Development of patient satisfaction surveys- Assists in the development of operational and capital budgets.
- Participates in operational assessments in search of revenue enhancement, expense reductions, consolidation efficiencies and billing opportunities.
General Job Expectations:
Maintain courteous and cooperative working relationships with all levels of management and employees, physicians, patients, guarantors and the general public.- Participates in activities that would further the public's image of the Employer.
Supervisory/Management Responsibility
This is a non-management job that will report to a supervisor, manager, director, or executive.
Minimum Requirements
Master's Degree in Nursing; Nurse Practitioner Degree Emphasis or Program Certificate equivalent.
Required Certifications/Registrations/Licenses
- Official Recognition as a Nurse Practitioner in the state the team member is working
- Prescriptive Authority for the state in which the team member is working
- Controlled Substance license for the state in which the team member is working. Federal DEA license
Work Shift
Day (United States of America)Location
Seneca Medical AssociatesFacility
Seneca Medical AssociatesDepartment
Rural HealthShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 75 Nurse Practitioner Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Nurse Practitioner JobsNurse Practitioner Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Nurse Practitioner Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- TeamHealth10
- Prisma Health5
- Your Health Organization5
- Concentra3
- PruittHealth3
Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in nurse practitioner jobs across South Carolina.
- Active nurse practitioner license issued or recognized by the South Carolina Board of Nursing
- Master of Science in Nursing or Doctor of Nursing Practice from an accredited program
- National board certification as a nurse practitioner from ANCC or AANP
- Current DEA registration and prescriptive authority under South Carolina collaborative practice requirements
- Minimum one to three years of clinical experience in a relevant specialty area
- Current BLS and ACLS certification required for hospital and acute care settings
Nurse Practitioner Jobs in South Carolina: Frequently Asked Questions
How do you become a nurse practitioner in South Carolina?
You must hold an active advanced practice registered nurse license issued by the South Carolina Board of Nursing, which requires completing an accredited graduate-level nurse practitioner program and passing a national certification exam through ANCC or AANP. South Carolina also requires nurse practitioners to maintain a collaborative practice agreement with a physician for prescriptive authority. Applications are submitted directly to the South Carolina Board of Nursing, which oversees all APRN licensure in the state.
How much do nurse practitioners make in South Carolina?
Nurse practitioners in South Carolina earn a median of about $123,290 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $97,080 for the lowest 10% to over $160,170 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire nurse practitioners in South Carolina?
Companies currently hiring nurse practitioners in South Carolina include TeamHealth, Prisma Health, and Your Health Organization, per current listings on Migrate Mate as of August 2026. Large integrated health systems such as Prisma Health and MUSC Health represent a significant share of ongoing openings across the state.
Which South Carolina cities have the most nurse practitioner jobs?
Columbia, Greenville, and Rock Hill have the most nurse practitioner openings in South Carolina. Columbia and Greenville lead because of their large hospital systems and growing outpatient clinic networks, while Charleston's concentration of academic medical centers and specialty practices, anchored by MUSC Health, drives strong demand there as well.
Are there remote nurse practitioner jobs in South Carolina?
Yes, but they're rare. About 53% of nurse practitioner openings tied to South Carolina are remote or hybrid as of August 2026, reflecting how hands-on patient care limits fully remote arrangements. The roles most likely to offer remote or telehealth components are psychiatric and behavioral health positions, where virtual visits have become a standard part of practice in South Carolina.
How can I get hired as a nurse practitioner in South Carolina with little or no experience?
The most realistic entry path is applying for new-graduate nurse practitioner residency or fellowship programs, which Prisma Health and MUSC Health both offer for candidates transitioning from RN roles into advanced practice. Working as a registered nurse in a specialty you intend to practice in, such as family medicine or psychiatry, strengthens your application and satisfies the clinical familiarity many South Carolina employers expect. Completing your national board certification promptly after graduation and securing your South Carolina APRN license before applying gives you a clear edge over candidates still awaiting credentials.
Where can I find and apply to nurse practitioner jobs in South Carolina?
You can find and apply to nurse practitioner jobs in South Carolina on Migrate Mate, which lists current openings from employers across the state. Search the listings for roles that match your specialty and experience level, then apply directly to the positions that fit.
See All 75 Nurse Practitioner Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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