Clinical Registered Nurse Jobs in South Carolina
Clinical Registered Nurse jobs in South Carolina are open across Columbia, West Columbia, and Charleston and other South Carolina metros, with employers like Lexington Health, Medical University of South Carolina, and Fresenius Medical Care hiring at every experience level. Find a role that fits below and apply directly.
Find JobsOverview
Showing 5 of 39+ Clinical Registered Nurse jobs











Responsibilities:
- Fosters an environment that demonstrates care, compassion, and respect for all patients, families, visitors, and co-workers.
- Demonstrates proficiency in use of all medical equipment in the office.
- Adheres to procedural checklists for administering all immunizations/injections.
- Ensure that all examination rooms are clean and fully stocked with supplies, including replacing any expired supplies.
- Calls patients from the waiting area using appropriate title and last name to a clean, well-stocked examination room.
- Obtains and accurately documents vital signs and confirms chief complaint.
- Triages and performs in-house diagnostic testing according to orders.
- Manages patient workflow in the clinical area.
- Provides support and assistance as needed to patients, nurses, physicians, and other staff.
- Participates proactively in problem solving and process improvement activities through collaboration with clinical teams using Evidence Based Practices.
- Performs other duties as assigned.
Qualifications
- Basic Life Support certification must be obtained within 90 days of hire.
Requirements:
Licenses and Certifications:
- Basic Life Support
- Registered Nurse
If you would enjoy working in a dynamic environment and are looking for an opportunity to become part of a stellar team of professionals, we invite you to apply online today. We are an equal opportunity employer.
Founded in 1906, McLeod Health is a locally owned and managed, not for profit organization supported by the strength of more than 900 members on its medical staff and more than 2,900 licensed nurses. McLeod Health is also composed of approximately 15,000 team members and more than 90 physician practices throughout its 18-county service area. With seven hospitals, McLeod Health operates three Health and Fitness Centers, a Sports Medicine and Outpatient Rehabilitation Center, Hospice and Home Health Services. The system currently has 988 licensed beds, including Hospice and Behavioral Health. The hospitals within McLeod Health include: McLeod Regional Medical Center, McLeod Health Dillon, McLeod Health Loris, McLeod Health Seacoast, McLeod Health Cheraw, McLeod Health Clarendon and McLeod Behavioral Health.
See All 39 Clinical Registered Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find JobsClinical Registered Nurse Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Clinical Registered Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Lexington Health14

- Medical University of South Carolina6

- Fresenius Medical Care4

- McLeod Health4

- Prisma Health4

Top Industries Hiring
- Healthcare & Medical Services29
- Education4
What South Carolina Employers Look For
The qualifications that appear most often in clinical registered nurse jobs across South Carolina.
- Active RN licensure in the state of employment or compact license eligibility
- Current BLS and ACLS certification from an approved provider
- Associate or bachelor's degree in nursing from an accredited program
- Minimum one to two years of clinical nursing experience in an acute care setting
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong clinical assessment skills and experience with patient care documentation
Clinical Registered Nurse Jobs in South Carolina: Frequently Asked Questions
How many clinical registered nurse jobs are there in South Carolina?
There are 39+ clinical registered nurse openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, West Columbia, and Charleston. New positions post regularly as employers across South Carolina hire.
How much do clinical registered nurses make in South Carolina?
Clinical registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most clinical registered nurse jobs?
Columbia, West Columbia, and Charleston have the most clinical registered nurse openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire clinical registered nurses in South Carolina?
Employers hiring clinical registered nurses in South Carolina include Lexington Health, Medical University of South Carolina, and Fresenius Medical Care, based on current listings on Migrate Mate as of June 2026.
Are there remote clinical registered nurse jobs in South Carolina?
Yes. About 8% of clinical registered nurse openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for clinical registered nurse jobs in South Carolina?
You can apply to clinical registered nurse jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 39 Clinical Registered Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Jobs