Clinical Registered Nurse Jobs in South Carolina
Clinical Registered Nurse jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where major systems like Prisma Health, MUSC Health, and Bon Secours St. Francis keep sustained demand across acute care, oncology, and critical care. Openings exist at every experience level, from new-graduate residency candidates through seasoned charge nurses and clinical educators. South Carolina's growing coastal and Upstate populations have made it one of the more active hiring markets in the Southeast for clinical nurses. See the openings below and apply to the ones that match your experience.
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We are seeking an experienced and compassionate Hospice Clinical Liaison to join our team. In this role, you will ensure that intake and referral processes are completed efficiently and effectively to meet the needs of patients, families, referral sources, and the organization. You will play a vital part in building strong professional relationships, coordinating admissions, and supporting community awareness of hospice services.
Essential Responsibilities
- Receive and respond to referrals from hospitals, home health, physicians, case managers, skilled nursing facilities, and other healthcare professionals
- Assess patient eligibility for hospice services by reviewing medical records, conducting clinical evaluations, and communicating with physicians and families
- Educate patients and families on what hospice care includes, how it works, and why it matters—providing clarity, reassurance, and compassion
- Complete necessary documentation and coordinate the intake and admission process, ensuring all legal, clinical, and payer requirements are met
- Serve as a liaison between referral sources and our hospice care team—ensuring seamless handoffs, clear communication, and rapid response to needs
- Make daily visits to hospitals and facilities, maintaining visibility and accessibility with discharge planners, case managers, and physicians
- Build and maintain strong relationships with referral partners and identify new outreach opportunities to increase awareness of hospice services
Education
- Licensed Nurse with three to five years of hospice experience required.
- BSN with five or more years of hospice experience preferred.
- Minimum of three years of hospice experience required.
- Prior experience as a discharge planner, case manager, or educator preferred.
- Current RN license to practice nursing in the state of employment.
- CPR certification.
- Valid driver’s license and automobile insurance.
- Strong knowledge of hospice care and the unique needs of patients and families.
- Familiarity with community resources and referral networks.
- Excellent patient assessment and documentation skills.
- Ability to supervise staff, coordinate services, and manage programs effectively.
- Strong communication and interpersonal skills with sensitivity to diverse backgrounds.
- Compassion and sensitivity to the needs of terminally ill patients and their families.
- Flexibility to manage a variety of tasks and shifting priorities.
- Professional maturity, collaboration, and tact in working with interdisciplinary teams.
- Ability to influence and educate referral sources, patients, and families.
- Demonstrated commitment to patient advocacy and quality care.
We are seeking an experienced and compassionate Hospice Clinical Liaison to join our team. In this role, you will ensure that intake and referral processes are completed efficiently and effectively to meet the needs of patients, families, referral sources, and the organization. You will play a vital part in building strong professional relationships, coordinating admissions, and supporting community awareness of hospice services.
Essential Responsibilities
- Receive and respond to referrals from hospitals, home health, physicians, case managers, skilled nursing facilities, and other healthcare professionals
- Assess patient eligibility for hospice services by reviewing medical records, conducting clinical evaluations, and communicating with physicians and families
- Educate patients and families on what hospice care includes, how it works, and why it matters—providing clarity, reassurance, and compassion
- Complete necessary documentation and coordinate the intake and admission process, ensuring all legal, clinical, and payer requirements are met
- Serve as a liaison between referral sources and our hospice care team—ensuring seamless handoffs, clear communication, and rapid response to needs
- Make daily visits to hospitals and facilities, maintaining visibility and accessibility with discharge planners, case managers, and physicians
- Build and maintain strong relationships with referral partners and identify new outreach opportunities to increase awareness of hospice services
Education
- Licensed Nurse with three to five years of hospice experience required.
- BSN with five or more years of hospice experience preferred.
- Minimum of three years of hospice experience required.
- Prior experience as a discharge planner, case manager, or educator preferred.
- Current RN license to practice nursing in the state of employment.
- CPR certification.
- Valid driver’s license and automobile insurance.
- Strong knowledge of hospice care and the unique needs of patients and families.
- Familiarity with community resources and referral networks.
- Excellent patient assessment and documentation skills.
- Ability to supervise staff, coordinate services, and manage programs effectively.
- Strong communication and interpersonal skills with sensitivity to diverse backgrounds.
- Compassion and sensitivity to the needs of terminally ill patients and their families.
- Flexibility to manage a variety of tasks and shifting priorities.
- Professional maturity, collaboration, and tact in working with interdisciplinary teams.
- Ability to influence and educate referral sources, patients, and families.
- Demonstrated commitment to patient advocacy and quality care.
See All 66 Clinical Registered Nurse Jobs in South Carolina
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Find JobsClinical Registered Nurse Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Clinical Registered Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
- Education
What South Carolina Employers Look For
The qualifications that appear most often in clinical registered nurse jobs across South Carolina.
- Active RN license issued or recognized by the South Carolina Board of Nursing
- Current BLS certification required at time of hire or within ninety days
- Associate or Bachelor of Science in Nursing degree from an accredited program
- Minimum one to two years of acute care or specialty clinical experience preferred
- Strong documentation skills and proficiency with electronic health record systems
- Ability to meet physical requirements of direct patient care in a clinical setting
Clinical Registered Nurse Jobs in South Carolina: Frequently Asked Questions
How do you become a clinical registered nurse in South Carolina?
To become a clinical registered nurse in South Carolina, you must earn an associate or bachelor's degree in nursing from an accredited program, pass the NCLEX-RN examination, and obtain an active license through the South Carolina Board of Nursing. South Carolina participates in the Nurse Licensure Compact, so nurses licensed in other compact states may practice in South Carolina without obtaining a separate state license, provided they meet compact requirements.
How much do clinical registered nurses make in South Carolina?
Clinical registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire clinical registered nurses in South Carolina?
South Carolina clinical registered nurse roles are posted by Prisma Health, Lexington Health, and Fresenius Medical Care and others right now, based on current listings on Migrate Mate as of August 2026. Large integrated health systems anchored in Columbia, Charleston, and Greenville drive the majority of sustained hiring volume across the state.
Which South Carolina cities have the most clinical registered nurse jobs?
Columbia, Myrtle Beach, and Aiken have the most clinical registered nurse openings in South Carolina right now. Columbia leads as the state capital and home to Prisma Health's flagship facilities, Charleston drives volume through MUSC Health and a growing medical tourism corridor, and Greenville reflects the Upstate's rapid population growth and Bon Secours Saint Francis's expanding network.
Are there remote clinical registered nurse jobs in South Carolina?
Yes, but they're rare. Clinical registered nursing is a hands-on, bedside role that requires in-person patient contact by nature, so the vast majority of openings require on-site presence. About 9% of clinical registered nurse openings tied to South Carolina are remote or hybrid as of August 2026, and those positions tend to concentrate in telephonic triage, utilization review, or case management functions.
How can I get hired as a clinical registered nurse in South Carolina with little or no experience?
The most realistic entry path is applying to a nurse residency program through a large South Carolina health system. Prisma Health and MUSC Health both operate structured new-graduate residency cohorts in Columbia and Charleston that accept candidates directly out of nursing school. Candidates can also move laterally from patient care technician or licensed practical nurse roles within the same facility. Holding an active South Carolina RN license and a BLS certification before applying is the single factor that most reliably moves an inexperienced candidate past the first screening.
Where can I find and apply to clinical registered nurse jobs in South Carolina?
You can find and apply to clinical registered nurse jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search by city or specialty to narrow the results to roles that fit your background and experience level, then apply directly to the ones that match.
See All 66 Clinical Registered Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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