Clinical Registered Nurse Jobs in South Carolina

Clinical Registered Nurse jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where major systems like Prisma Health, MUSC Health, and Bon Secours St. Francis keep sustained demand across acute care, oncology, and critical care. Openings exist at every experience level, from new-graduate residency candidates through seasoned charge nurses and clinical educators. South Carolina's growing coastal and Upstate populations have made it one of the more active hiring markets in the Southeast for clinical nurses. See the openings below and apply to the ones that match your experience.

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Overview

Open roles81
Top employerLexington Health
Top cityColumbia, SC
Cities hiring24
Work type100% On-site
Top industryHealthcare

Showing 5 of 81+ Clinical Registered Nurse jobs

Clinical Coordinator - CMA, LPN, RN
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Added 1d ago
Clinical Coordinator - CMA, LPN, RN
Your Health Organization
Myrtle Beach, South Carolina
Administrative & Office Support
Customer Service
Project Management
$35k - $55k/yr
1,001-5,000

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RN Clinical Manager Home Health
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Added 3d ago
RN Clinical Manager Home Health
Optum
Mount Pleasant, South Carolina
Customer Service
Healthcare Administration
Human Resources
$73k - $110k/yr
CPR Certification
10,000+

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Clinical Coordinator - Clinic CMA, LPN, RN
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Added 4d ago
Clinical Coordinator - Clinic CMA, LPN, RN
Your Health Organization
Murrells Inlet, South Carolina
Administrative & Office Support
Office Management
Project Management
1,001-5,000

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Clinical | RN Emergency Services - Contract - Nights
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Added 4d ago
Clinical | RN Emergency Services - Contract - Nights
HealthTrust Workforce Solutions
Hartsville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$0.75 - $0.78/hr
1,001-5,000

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Registered Nurse -Lung Cancer Screening Clinical Coordinator
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Added 5d ago
Registered Nurse -Lung Cancer Screening Clinical Coordinator
US Department of Veterans Affairs
Charleston, South Carolina
Business Operations
Logistics & Fleet Management
Project Management
$68k - $138k/yr
On-Site
Doctoral degree
10,000+

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See All 81 Clinical Registered Nurse Jobs in South Carolina

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Clinical Registered Nurse Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
13 jobs
West Columbia
12 jobs
Charleston
10 jobs
Spartanburg
8 jobs
Greenville
6 jobs
Aiken
5 jobs
Myrtle Beach
4 jobs
Ladson
2 jobs
Bluffton
2 jobs

Clinical Registered Nurse Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Lexington Health15
  • Spartanburg Regional Healthcare System8
  • Your Health Organization7
  • HCA Healthcare Trident Hospital7
  • Prisma Health6

Top Industries Hiring

  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in clinical registered nurse jobs across South Carolina.

  • Active RN license issued or recognized by the South Carolina Board of Nursing
  • Current BLS certification required at time of hire or within ninety days
  • Associate or Bachelor of Science in Nursing degree from an accredited program
  • Minimum one to two years of acute care or specialty clinical experience preferred
  • Strong documentation skills and proficiency with electronic health record systems
  • Ability to meet physical requirements of direct patient care in a clinical setting

Clinical Registered Nurse Jobs in South Carolina: Frequently Asked Questions

How do you become a clinical registered nurse in South Carolina?

To become a clinical registered nurse in South Carolina, you must earn an associate or bachelor's degree in nursing from an accredited program, pass the NCLEX-RN examination, and obtain an active license through the South Carolina Board of Nursing. South Carolina participates in the Nurse Licensure Compact, so nurses licensed in other compact states may practice in South Carolina without obtaining a separate state license, provided they meet compact requirements.

How much do clinical registered nurses make in South Carolina?

Clinical registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire clinical registered nurses in South Carolina?

South Carolina clinical registered nurse roles are posted by Lexington Health, Spartanburg Regional Healthcare System, and Your Health Organization and others right now, based on current listings on Migrate Mate as of October 2026. Large integrated health systems anchored in Columbia, Charleston, and Greenville drive the majority of sustained hiring volume across the state.

Which South Carolina cities have the most clinical registered nurse jobs?

Columbia, West Columbia, and Charleston have the most clinical registered nurse openings in South Carolina right now. Columbia leads as the state capital and home to Prisma Health's flagship facilities, Charleston drives volume through MUSC Health and a growing medical tourism corridor, and Greenville reflects the Upstate's rapid population growth and Bon Secours Saint Francis's expanding network.

Are there remote clinical registered nurse jobs in South Carolina?

Yes, but they're rare. Clinical registered nursing is a hands-on, bedside role that requires in-person patient contact by nature, so the vast majority of openings require on-site presence. About 0% of clinical registered nurse openings tied to South Carolina are remote or hybrid as of October 2026, and those positions tend to concentrate in telephonic triage, utilization review, or case management functions.

How can I get hired as a clinical registered nurse in South Carolina with little or no experience?

The most realistic entry path is applying to a nurse residency program through a large South Carolina health system. Prisma Health and MUSC Health both operate structured new-graduate residency cohorts in Columbia and Charleston that accept candidates directly out of nursing school. Candidates can also move laterally from patient care technician or licensed practical nurse roles within the same facility. Holding an active South Carolina RN license and a BLS certification before applying is the single factor that most reliably moves an inexperienced candidate past the first screening.

Where can I find and apply to clinical registered nurse jobs in South Carolina?

You can find and apply to clinical registered nurse jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search by city or specialty to narrow the results to roles that fit your background and experience level, then apply directly to the ones that match.

See All 81 Clinical Registered Nurse Jobs in South Carolina

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