Clinical Registered Nurse Jobs in Missouri
Clinical Registered Nurse jobs in Missouri are concentrated in hospital systems, acute care, and outpatient settings, with steady demand at every level from new graduate to seasoned charge nurse. The busiest hiring markets are Kansas City, St. Louis, and Springfield, where large systems like BJC HealthCare, Mercy Health, and Saint Luke's Health System consistently post openings. Critical care, medical-surgical, and emergency nursing are the most in-demand specialties across the state. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 87+ Clinical Registered Nurse jobs
It's more than a career, it's a calling
MO-SSM Health St. Clare Hospital - FentonWorker Type:
Job Highlights:
Location: St. Clare Hospital – Fenton, MO
Passionate about advancing clinical excellence through simulation-based learning? Join SSM Health as an RN Regional Simulation Clinical Educator and help strengthen critical thinking, clinical judgment, teamwork, and patient outcomes across the region.
In this role, you'll design and facilitate high-impact simulation experiences, lead debriefings, identify learning gaps, and partner with clinical leaders to improve staff competency, patient safety, and quality outcomes. You'll also support simulation technology, equipment, and educator training to ensure the ongoing success of our simulation program.
This is a unique opportunity to influence caregiver development and patient outcomes on a regional scale while helping shape the future of nursing education.
Job Summary:
Assesses, plans, implements and evaluates educational activities planning for an assigned service or population.Job Responsibilities and Requirements:
PRIMARY RESPONSIBILITIES
- Collaborates with nurse managers and staff to assess learning needs and competencies.
- Develops, implements, and evaluates educational plans/programs and utilizes methods, measurements and tools to evaluate achievement of learning goals.
- Identifies and/or develops teaching tools and instructional materials.
- Maintains training record of educational activities in the Learning Management System or similar system.
- Applies the existing body of evidence-based practice and scientific knowledge in health care to nursing practice, ensuring that nursing care is delivered based on patient’s age-specific needs and clinical needs.
- As an SSM Health nurse, I will demonstrate the professional nursing standards defined in the professional practice model. Uses the ANA Code of Ethics for Nurses to guide his/her response to the current and evolving health and nursing needs of our patients and our patient populations.
- Performs other duties as assigned.
EDUCATION
- Bachelor's degree
EXPERIENCE
- Three years' registered nurse experience
- Simulation, critical care, emergency services, or educator experience
- Strong facilitation, coaching, and debriefing skills
PHYSICAL REQUIREMENTS
- Frequent lifting/carrying and pushing/pulling objects weighing 0-25 lbs.
- Frequent sitting, standing, walking, reaching and repetitive foot/leg and hand/arm movements.
- Frequent use of vision and depth perception for distances near (20 inches or less) and far (20 feet or more) and to identify and distinguish colors.
- Frequent use of hearing and speech to share information through oral communication. Ability to hear alarms, malfunctioning machinery, etc.
- Frequent keyboard use/data entry.
- Occasional bending, stooping, kneeling, squatting, twisting and gripping.
- Occasional lifting/carrying and pushing/pulling objects weighing 25-50 lbs.
- Rare climbing.
REQUIRED PROFESSIONAL LICENSE AND/OR CERTIFICATIONS
State of Work Location: Illinois
- Basic Life Support HealthCare Provider (BLS HCP) - American Heart Association (AHA)
- And
- Registered Professional Nurse (RN) - Illinois Department of Financial and Professional Regulation (IDFPR)
State of Work Location: Missouri
- Basic Life Support HealthCare Provider (BLS HCP) - American Heart Association (AHA)
- And
- Registered Nurse (RN) - Missouri Division of Professional Registration
- Or
- Registered Nurse (RN) Issued by Compact State
State of Work Location: Oklahoma
- Basic Life Support HealthCare Provider (BLS HCP) - American Heart Association (AHA)
- And
- Registered Nurse (RN) Issued by Compact State
- Or
- Registered Nurse (RN) - Oklahoma Board of Nursing (OBN)
State of Work Location: Wisconsin
- Basic Life Support HealthCare Provider (BLS HCP) - American Heart Association (AHA)
- And
- Registered Nurse (RN) Issued by Compact State
- Or
- Registered Nurse (RN) - Wisconsin Department of Safety and Professional Services
Work Shift:
Day Shift (United States of America)Job Type:
Department:
Benefits:
SSM Health values our exceptional employees by offering a comprehensive benefits package to fit their needs.
Paid Parental Leave: we offer eligible team members one week of paid parental leave for newborns or newly adopted children (pro-rated based on FTE).
Flexible Payment Options: our voluntary benefit offered through DailyPay offers eligible hourly team members instant access to their earned, unpaid base pay (fees may apply) before payday.
Upfront Tuition Coverage: we provide upfront tuition coverage through FlexPath Funded for eligible team members.
It's more than a career, it's a calling
MO-SSM Health St. Clare Hospital - FentonWorker Type:
Job Highlights:
Location: St. Clare Hospital – Fenton, MO
Passionate about advancing clinical excellence through simulation-based learning? Join SSM Health as an RN Regional Simulation Clinical Educator and help strengthen critical thinking, clinical judgment, teamwork, and patient outcomes across the region.
In this role, you'll design and facilitate high-impact simulation experiences, lead debriefings, identify learning gaps, and partner with clinical leaders to improve staff competency, patient safety, and quality outcomes. You'll also support simulation technology, equipment, and educator training to ensure the ongoing success of our simulation program.
This is a unique opportunity to influence caregiver development and patient outcomes on a regional scale while helping shape the future of nursing education.
Job Summary:
Assesses, plans, implements and evaluates educational activities planning for an assigned service or population.Job Responsibilities and Requirements:
PRIMARY RESPONSIBILITIES
- Collaborates with nurse managers and staff to assess learning needs and competencies.
- Develops, implements, and evaluates educational plans/programs and utilizes methods, measurements and tools to evaluate achievement of learning goals.
- Identifies and/or develops teaching tools and instructional materials.
- Maintains training record of educational activities in the Learning Management System or similar system.
- Applies the existing body of evidence-based practice and scientific knowledge in health care to nursing practice, ensuring that nursing care is delivered based on patient’s age-specific needs and clinical needs.
- As an SSM Health nurse, I will demonstrate the professional nursing standards defined in the professional practice model. Uses the ANA Code of Ethics for Nurses to guide his/her response to the current and evolving health and nursing needs of our patients and our patient populations.
- Performs other duties as assigned.
EDUCATION
- Bachelor's degree
EXPERIENCE
- Three years' registered nurse experience
- Simulation, critical care, emergency services, or educator experience
- Strong facilitation, coaching, and debriefing skills
PHYSICAL REQUIREMENTS
- Frequent lifting/carrying and pushing/pulling objects weighing 0-25 lbs.
- Frequent sitting, standing, walking, reaching and repetitive foot/leg and hand/arm movements.
- Frequent use of vision and depth perception for distances near (20 inches or less) and far (20 feet or more) and to identify and distinguish colors.
- Frequent use of hearing and speech to share information through oral communication. Ability to hear alarms, malfunctioning machinery, etc.
- Frequent keyboard use/data entry.
- Occasional bending, stooping, kneeling, squatting, twisting and gripping.
- Occasional lifting/carrying and pushing/pulling objects weighing 25-50 lbs.
- Rare climbing.
REQUIRED PROFESSIONAL LICENSE AND/OR CERTIFICATIONS
State of Work Location: Illinois
- Basic Life Support HealthCare Provider (BLS HCP) - American Heart Association (AHA)
- And
- Registered Professional Nurse (RN) - Illinois Department of Financial and Professional Regulation (IDFPR)
State of Work Location: Missouri
- Basic Life Support HealthCare Provider (BLS HCP) - American Heart Association (AHA)
- And
- Registered Nurse (RN) - Missouri Division of Professional Registration
- Or
- Registered Nurse (RN) Issued by Compact State
State of Work Location: Oklahoma
- Basic Life Support HealthCare Provider (BLS HCP) - American Heart Association (AHA)
- And
- Registered Nurse (RN) Issued by Compact State
- Or
- Registered Nurse (RN) - Oklahoma Board of Nursing (OBN)
State of Work Location: Wisconsin
- Basic Life Support HealthCare Provider (BLS HCP) - American Heart Association (AHA)
- And
- Registered Nurse (RN) Issued by Compact State
- Or
- Registered Nurse (RN) - Wisconsin Department of Safety and Professional Services
Work Shift:
Day Shift (United States of America)Job Type:
Department:
Benefits:
SSM Health values our exceptional employees by offering a comprehensive benefits package to fit their needs.
Paid Parental Leave: we offer eligible team members one week of paid parental leave for newborns or newly adopted children (pro-rated based on FTE).
Flexible Payment Options: our voluntary benefit offered through DailyPay offers eligible hourly team members instant access to their earned, unpaid base pay (fees may apply) before payday.
Upfront Tuition Coverage: we provide upfront tuition coverage through FlexPath Funded for eligible team members.
See All 87 Clinical Registered Nurse Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find JobsClinical Registered Nurse Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Clinical Registered Nurse Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
- Washington University in St. Louis20
- University Health KC11
- SSM Health9
- Mercy5
- CenterWell5
Top Industries Hiring
- Healthcare & Medical Services14
- Education4
- Technology & Software1
What Missouri Employers Look For
The qualifications that appear most often in clinical registered nurse jobs across Missouri.
- Active registered nurse license issued or recognized by the Missouri State Board of Nursing
- Associate or Bachelor of Science in Nursing degree from an accredited program
- Current BLS certification required, with ACLS preferred for acute care settings
- Minimum one to two years of clinical nursing experience in a hospital or healthcare setting
- Demonstrated proficiency with electronic health record systems such as Epic or Cerner
- Strong patient assessment and critical thinking skills in fast-paced clinical environments
Clinical Registered Nurse Jobs in Missouri: Frequently Asked Questions
How do you become a clinical registered nurse in Missouri?
You become a clinical registered nurse in Missouri by completing an accredited Associate Degree in Nursing or Bachelor of Science in Nursing program, then passing the NCLEX-RN exam and applying for licensure through the Missouri State Board of Nursing. Missouri participates in the Nurse Licensure Compact, so nurses licensed in other compact states can work in Missouri without obtaining a separate state license. Most Missouri hospitals prefer or require a BSN for clinical roles.
How much do clinical registered nurses make in Missouri?
Clinical registered nurses in Missouri earn a median of about $81,780 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $63,230 for the lowest 10% to over $104,390 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire clinical registered nurses in Missouri?
Employers hiring clinical registered nurses in Missouri right now include Washington University in St. Louis, University Health KC, and SSM Health, based on current listings on Migrate Mate as of August 2026. Missouri's large integrated health systems anchor hiring across the state, with major campuses in the St. Louis and Kansas City metro areas driving the highest volume of clinical openings.
Which Missouri cities have the most clinical registered nurse jobs?
St. Louis, Kansas City, and Springfield have the most clinical registered nurse openings in Missouri. St. Louis leads because of its concentration of major academic medical centers and health system headquarters, while Kansas City's large hospital networks and Springfield's growing regional health sector generate consistent demand in those metros and their surrounding communities.
Are there remote clinical registered nurse jobs in Missouri?
Yes, but they're rare. Clinical registered nursing is a hands-on, patient-facing role, so the vast majority of positions require on-site work in a hospital, clinic, or care facility. About 44% of clinical registered nurse openings tied to Missouri are remote or hybrid as of August 2026, and those positions are almost exclusively in telehealth triage, care management, or utilization review rather than bedside care.
How can I get hired as a clinical registered nurse in Missouri with little or no experience?
The most realistic entry path is applying to a new-graduate residency program, which major Missouri health systems including BJC HealthCare, Mercy Health, and Saint Luke's Health System run specifically for nurses without clinical work history. These structured programs place new nurses in cohorts with mentorship on medical-surgical or telemetry units, the two floors where most entry-level openings sit. Holding an active Missouri RN license and a BLS certification before applying gives candidates a clear edge, and prior work as a certified nursing assistant or patient care technician is a strong lateral move that many Missouri hiring managers value highly.
Where can I find and apply to clinical registered nurse jobs in Missouri?
You can find and apply to clinical registered nurse jobs in Missouri on Migrate Mate, which lists current Missouri openings updated regularly. Search the roles that match your experience and specialty, then apply directly to the ones that fit your background and preferred location.
See All 87 Clinical Registered Nurse Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
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