Clinical Registered Nurse Jobs in Pennsylvania
Clinical Registered Nurse jobs in Pennsylvania are among the most active in the Mid-Atlantic region, with strong demand across hospital systems, outpatient clinics, long-term care, and specialty practices at every level from new graduate through senior clinical nurse. The heaviest hiring concentrates in Philadelphia, Pittsburgh, and Allentown, where anchor systems like Penn Medicine, UPMC, and Lehigh Valley Health Network maintain large nursing workforces. The most in-demand specialties are critical care, medical-surgical, and oncology nursing. Find a role that fits below and apply directly.
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Description
Penn Medicine is dedicated to our tripartite mission of providing the highest level of care to patients, conducting innovative research, and educating future leaders in the field of medicine. Working for this leading academic medical center means collaboration with top clinical, technical and business professionals across all disciplines.Today at Penn Medicine, someone will make a breakthrough. Someone will heal a heart, deliver hopeful news, and give comfort and reassurance. Our employees shape our future each day. Are you living your life's work?
CUPP 5 South is an Orthopedic/Surgical floor that is rapidly growing and is a viable part of PPMC. The floor is the receiving site for post-operative surgical patients, including General, Orthopedic, Abdominal & Bariatric, Total Joint Replacement, Spinal, Neurosurgery, Trauma, GYN, Oral, Vascular, Urological, Podiatry, Colorectal, ENT, and trauma and neuro overflow.
Summary:
- The Clinical Nurse 2 Colleague is an RN that practices as a full partner on the health care team and consistently demonstrates safe practice within the organizational professional practice model. The Clinical Nurse 2 Colleague possesses the knowledge, skills and the attitude to effectively meet standards for competent professional nursing practice as specified in the Clinical Nurse 2 position description addendum. The Clinical Nurse 2 Colleague exhibits UPHS organizational behavioral competencies which reflect its mission and are embedded in the professional practice competency domains. The Clinical Nurse 2 Colleague independently provides patient care through the application of the nursing process and accepts accountability for the nursing care of assigned patients. Assigned patients may range in age from infancy to the elderly. The Clinical Nurse 2 Colleague demonstrates within the competency domains of Continuous Quality Improvement, Evidence Based Practice and Research, Leadership, Person and Family Centered Care, Professionalism, Safety, Technology/Informatics, and Teamwork (Definitions listed below). The Clinical Nurse 2 Colleague works closely with the interprofessional health care team to facilitate the coordination of care across the continuum. The nurse focuses on expanding the knowledge and skills necessary to provide individualized care based on physical, psychosocial, cultural, educational, safety, and age appropriate considerations of assigned patients. The Clinical Nurse 2 Colleague seeks feedback in assuming leadership roles and provides feedback for improved clinical practice. The nurse demonstrates how nursing practice impacts the organizational vision, mission, and goals and the care delivery system. The nurse complies with all regulations and standards of regulatory and accrediting bodies.
Responsibilities:
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Professional Practice Competency Domains DefinitionsContinuous Quality Improvement (CQI): The nurse utilizes data and QI methods to identify potential and actual problems and opportunities to provide care that is safe, timely, efficient, effective, and equitable.
Evidence Based Practice and Research: The nurse evaluates and integrates best current evidence with clinical expertise and patient and family preferences and values for the delivery of optimal health care and system effectiveness.
Leadership: The nurse effectively collaborates and applies innovative, systems thinking to engage in systematic, evidence-based problem solving and decision making to promote effective changes within a complex care delivery system supporting the vision of Penn Medicine.
Person and Family Centered Care: The nurse recognizes the patient (or the patient’s designee) as the source of control and a full partner in providing compassionate and coordinated care based on respect for the patient’s preferences, values, and needs.
Professionalism: The nurse demonstrates a commitment to the nursing profession through lifelong learning, adherence to ANA’s Code of Ethics for Nurses, participation in a professional organization and advancing community outreach.
Safety: The nurse minimizes risk of harm to patients, families, providers and self through system effectiveness and individual performance.
Technology/Informatics: The nurse utilizes appropriate information and technology to communicate, manage knowledge, mitigate error, and support decision making across the continuum.
Teamwork: The nurse effectively engages in the process of cooperation, coordination, and collaboration in an effort to provide for safe, quality outcomes for patients within inter and intra-professional teams, including virtual teams.
Credentials:
- Basic Cardiac Life Support (Required)
- BLS/CPR, as a healthcare provider as per the American Heart Association.
- Registered Nurse - PA (Required)
- Pennsylvania RN licensure
Education or Equivalent Experience:
- Bachelor of Arts or Science (Required)
- Education Specialization: BSN from an accredited school of nursing Equivalent Experience: •And More than 15 months relevant professional nursing experience and completion of the Nurse Residency Program, if applicable
We believe that the best care for our patients starts with the best care for our employees. Our employee benefits programs help our employees get healthy and stay healthy. We offer a comprehensive compensation and benefits program that includes one of the finest prepaid tuition assistance programs in the region. Penn Medicine employees are actively engaged and committed to our mission. Together we will continue to make medical advances that help people live longer, healthier lives.
Live Your Life's Work
We are an Equal Opportunity employer. Candidates are considered for employment without regard to race, ethnicity, color, sex, sexual orientation, gender identity, religion, national origin, ancestry, age, disability, marital status, familial status, genetic information, domestic or sexual violence victim status, citizenship status, military status, status as a protected veteran or any other status protected by applicable law.
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Find JobsClinical Registered Nurse Jobs by City in Pennsylvania
Where Pennsylvania roles are concentrated, by current openings.
Clinical Registered Nurse Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring
- Allegheny Health Network16

- Penn Medicine11

- The Guthrie Clinic8

- BAYADA Home Health Care7

- IQVIA5

Top Industries Hiring
- Healthcare & Medical Services21
- Biotechnology & Pharmaceuticals2
- Education1
- Agriculture & Farming1
What Pennsylvania Employers Look For
The qualifications that appear most often in clinical registered nurse jobs across Pennsylvania.
- Active Registered Nurse license issued or recognized by the Pennsylvania State Board of Nursing
- Associate or Bachelor of Science in Nursing degree from an accredited program
- Current BLS certification, with ACLS required for critical care and emergency settings
- Minimum one to two years of clinical bedside experience preferred for most open positions
- Proficiency with electronic health record systems such as Epic or Cerner
- Demonstrated ability to manage multiple patients and prioritize care in fast-paced units
Clinical Registered Nurse Jobs in Pennsylvania: Frequently Asked Questions
How do you become a clinical registered nurse in Pennsylvania?
To become a clinical registered nurse in Pennsylvania, you must earn an Associate Degree in Nursing or a Bachelor of Science in Nursing from an accredited program, then pass the NCLEX-RN exam. Licensure is issued by the Pennsylvania State Board of Nursing, which is part of the Bureau of Professional and Occupational Affairs. Pennsylvania also participates in the Nurse Licensure Compact, so nurses licensed in other compact states may practice without applying for a separate Pennsylvania license.
How much do clinical registered nurses make in Pennsylvania?
Clinical registered nurses in Pennsylvania earn a median of about $96,430 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $70,800 for the lowest 10% to over $117,900 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire clinical registered nurses in Pennsylvania?
Employers hiring clinical registered nurses in Pennsylvania right now include Allegheny Health Network, Penn Medicine, and The Guthrie Clinic, based on current listings on Migrate Mate as of October 2026. Pennsylvania's large integrated health systems and academic medical centers generate consistent volume across inpatient, outpatient, and specialty care settings throughout the state.
Which Pennsylvania cities have the most clinical registered nurse jobs?
Philadelphia, Pittsburgh, and Sayre have the most clinical registered nurse openings in Pennsylvania. Philadelphia leads due to its concentration of major academic medical centers and health systems, Pittsburgh follows as home to UPMC's expansive regional network, and mid-sized cities like Allentown and Harrisburg reflect the growing demand from regional hospital systems and outpatient campuses serving Pennsylvania's suburban and rural communities.
Are there remote clinical registered nurse jobs in Pennsylvania?
Yes, but they're rare. Clinical registered nursing is a hands-on, patient-facing role, so the vast majority of positions require on-site work. About 52% of clinical registered nurse openings tied to Pennsylvania are remote or hybrid as of October 2026, and those roles typically involve utilization review, care coordination, or telephone triage rather than direct bedside care.
How can I get hired as a clinical registered nurse in Pennsylvania with little or no experience?
The most realistic entry path is a nurse residency or new-graduate program run by a large Pennsylvania health system. UPMC, Penn Medicine, and Jefferson Health all operate structured residency programs designed for nurses with no prior experience, typically placing new graduates into med-surg or step-down units before specialty rotations. Candidates with clinical hours from nursing school, a current Pennsylvania RN license, and BLS certification are competitive for these roles. Lateral entry from licensed practical nursing or patient care technician positions is another common path into clinical RN roles at Pennsylvania hospitals.
Where can I find and apply to clinical registered nurse jobs in Pennsylvania?
You can find and apply to clinical registered nurse jobs in Pennsylvania on Migrate Mate, which lists current Pennsylvania openings. Find roles that fit your experience and specialty, then apply directly to the employer through the listing.
See All 133+ Clinical Registered Nurse Jobs in Pennsylvania
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