Clinical Registered Nurse Jobs in Philadelphia, PA

Clinical Registered Nurse jobs in Philadelphia are concentrated in University City, Center City, and North Philadelphia, where major academic medical centers, specialty hospitals, and community health systems drive consistent demand across critical care, oncology, and pediatric nursing. Employers actively hiring include Penn Medicine, Tower Health, and DEER MEADOWS RETIREMENT COMMUNITY. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles143+
Top employerPenn Medicine
Work type69% On-site
Top credentialManaged Registered Nurses (RNs)
Companies hiring14

Showing 5 of 143+ Clinical Registered Nurse jobs

Penn Medicine
Clinical Manager Ambulatory RN for Internal Medicine
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Penn Medicine
Added 6d ago
Clinical Manager Ambulatory RN for Internal Medicine
Penn Medicine
Philadelphia, Pennsylvania
IT Support & Systems Administration
Program Management
Project & Program Management
Technical Product & Program Management
PALS Certification
10,000+

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Penn Medicine
Clinical Nurse - Gateway to the OR - Pennsylvania Hospital - Open to Experienced RN and New Grads
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Penn Medicine
Added 6d ago
Clinical Nurse - Gateway to the OR - Pennsylvania Hospital - Open to Experienced RN and New Grads
Penn Medicine
Philadelphia, Pennsylvania
Healthcare Administration
Nursing
Patient Services & Wellbeing
CPR Certification
10,000+

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Penn Medicine
Clinical Practice Lead RN IV for our EP and Echo Lab
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Penn Medicine
Added 1w ago
Clinical Practice Lead RN IV for our EP and Echo Lab
Penn Medicine
Philadelphia, Pennsylvania
Clinical Support
Healthcare Administration
Human Resources
Nursing
BLS Certification
10,000+

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Penn Medicine
Clinical Manager Ambulatory RN- Float Pool
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Penn Medicine
Added 1w ago
Clinical Manager Ambulatory RN- Float Pool
Penn Medicine
Philadelphia, Pennsylvania
Clinical Support
Healthcare Administration
Human Resources
Nursing
Managed Registered Nurses (RNs)
10,000+

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Thomas Jefferson University & Jefferson Health
Registered Nurse - Clinical Decision Unit (Full Time, Nights) Torresdale-Jefferson
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Thomas Jefferson University & Jefferson Health
Added 2w ago
Registered Nurse - Clinical Decision Unit (Full Time, Nights) Torresdale-Jefferson
Thomas Jefferson University & Jefferson Health
Philadelphia, Pennsylvania
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification
5,001-10,000

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See All 143+ Clinical Registered Nurse Jobs in Philadelphia

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Clinical Registered Nurse Job Market in Philadelphia

Who's Hiring

  • Penn Medicine
    Penn Medicine58
  • Tower Health
    Tower Health11
  • DEER MEADOWS RETIREMENT COMMUNITY
    DEER MEADOWS RETIREMENT COMMUNITY11
  • Thomas Jefferson University & Jefferson Health
    Thomas Jefferson University & Jefferson Health11
  • KeystoneCare
    KeystoneCare5

Top Industries Hiring

  • Healthcare & Medical Services37
  • Education16
  • Agriculture & Farming5

Clinical Registered Nurse Jobs in Philadelphia: Frequently Asked Questions

How do I get a clinical registered nurse job in Philadelphia?

Philadelphia's strongest hiring comes from its academic medical centers in University City, large health systems anchoring Center City, and community hospitals serving North and West Philadelphia neighborhoods. Candidates with experience in critical care, med-surg, or oncology have the clearest path, but behavioral health and pediatric specialties are also in steady demand. Tailoring your application to a system's specific patient population and unit needs gives you a real edge here.

Which companies hire clinical registered nurses in Philadelphia?

Employers hiring clinical registered nurses in Philadelphia right now include Penn Medicine, Tower Health, and DEER MEADOWS RETIREMENT COMMUNITY, based on current listings on Migrate Mate as of August 2026. Philadelphia's market is shaped by a dense concentration of academic health systems, nonprofit community hospitals, and specialty care centers, making it one of the more active clinical nursing markets on the East Coast.

Are there remote clinical registered nurse jobs in Philadelphia?

Yes, but they are uncommon given the hands-on nature of clinical nursing. About 31% of clinical registered nurse openings tied to Philadelphia are remote or hybrid as of August 2026, and those positions tend to involve utilization review, case management, or telephonic triage rather than direct patient care. Philadelphia-based insurers and care management organizations are the most likely employers for those hybrid roles.

How can I get a clinical registered nurse job in Philadelphia with little or no experience?

The most realistic entry path in Philadelphia is through a nurse residency or new-graduate program at one of the city's large academic health systems, which run structured cohorts specifically for RNs with under one year of experience. Med-surg, telemetry, and float pool positions at community hospitals in neighborhoods like Frankford and Roxborough also hire new graduates. Completing clinical rotations at a Philadelphia facility and applying internally before graduation significantly improves your odds.

Which industries hire the most clinical registered nurses in Philadelphia?

Most clinical registered nurse openings in Philadelphia sit in Healthcare & Medical Services, Education, and Agriculture & Farming, per current listings on Migrate Mate as of August 2026. Philadelphia's role as a regional hub for academic medicine, specialty cancer care, and federally qualified health centers means those sectors generate consistently high nursing volume throughout the year.

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