Clinical Registered Nurse Jobs in Philadelphia, PA
Clinical Registered Nurse jobs in Philadelphia are concentrated in University City, Center City, and North Philadelphia, where major academic medical centers, specialty hospitals, and community health systems drive consistent demand across critical care, oncology, and pediatric nursing. Employers actively hiring include Penn Medicine, IQVIA, and Tower Health. Scan the live roles below and apply to whichever ones fit.
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Description
Penn Medicine is dedicated to our tripartite mission of providing the highest level of care to patients, conducting innovative research, and educating future leaders in the field of medicine. Working for this leading academic medical center means collaboration with top clinical, technical and business professionals across all disciplines.Today at Penn Medicine, someone will make a breakthrough. Someone will heal a heart, deliver hopeful news, and give comfort and reassurance. Our employees shape our future each day. Are you living your life's work?
CUPP 5 South is an Orthopedic/Surgical floor that is rapidly growing and is a viable part of PPMC. The floor is the receiving site for post-operative surgical patients, including General, Orthopedic, Abdominal & Bariatric, Total Joint Replacement, Spinal, Neurosurgery, Trauma, GYN, Oral, Vascular, Urological, Podiatry, Colorectal, ENT, and trauma and neuro overflow.
Summary:
- The Clinical Nurse 2 Colleague is an RN that practices as a full partner on the health care team and consistently demonstrates safe practice within the organizational professional practice model. The Clinical Nurse 2 Colleague possesses the knowledge, skills and the attitude to effectively meet standards for competent professional nursing practice as specified in the Clinical Nurse 2 position description addendum. The Clinical Nurse 2 Colleague exhibits UPHS organizational behavioral competencies which reflect its mission and are embedded in the professional practice competency domains. The Clinical Nurse 2 Colleague independently provides patient care through the application of the nursing process and accepts accountability for the nursing care of assigned patients. Assigned patients may range in age from infancy to the elderly. The Clinical Nurse 2 Colleague demonstrates within the competency domains of Continuous Quality Improvement, Evidence Based Practice and Research, Leadership, Person and Family Centered Care, Professionalism, Safety, Technology/Informatics, and Teamwork (Definitions listed below). The Clinical Nurse 2 Colleague works closely with the interprofessional health care team to facilitate the coordination of care across the continuum. The nurse focuses on expanding the knowledge and skills necessary to provide individualized care based on physical, psychosocial, cultural, educational, safety, and age appropriate considerations of assigned patients. The Clinical Nurse 2 Colleague seeks feedback in assuming leadership roles and provides feedback for improved clinical practice. The nurse demonstrates how nursing practice impacts the organizational vision, mission, and goals and the care delivery system. The nurse complies with all regulations and standards of regulatory and accrediting bodies.
Responsibilities:
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Professional Practice Competency Domains DefinitionsContinuous Quality Improvement (CQI): The nurse utilizes data and QI methods to identify potential and actual problems and opportunities to provide care that is safe, timely, efficient, effective, and equitable.
Evidence Based Practice and Research: The nurse evaluates and integrates best current evidence with clinical expertise and patient and family preferences and values for the delivery of optimal health care and system effectiveness.
Leadership: The nurse effectively collaborates and applies innovative, systems thinking to engage in systematic, evidence-based problem solving and decision making to promote effective changes within a complex care delivery system supporting the vision of Penn Medicine.
Person and Family Centered Care: The nurse recognizes the patient (or the patient’s designee) as the source of control and a full partner in providing compassionate and coordinated care based on respect for the patient’s preferences, values, and needs.
Professionalism: The nurse demonstrates a commitment to the nursing profession through lifelong learning, adherence to ANA’s Code of Ethics for Nurses, participation in a professional organization and advancing community outreach.
Safety: The nurse minimizes risk of harm to patients, families, providers and self through system effectiveness and individual performance.
Technology/Informatics: The nurse utilizes appropriate information and technology to communicate, manage knowledge, mitigate error, and support decision making across the continuum.
Teamwork: The nurse effectively engages in the process of cooperation, coordination, and collaboration in an effort to provide for safe, quality outcomes for patients within inter and intra-professional teams, including virtual teams.
Credentials:
- Basic Cardiac Life Support (Required)
- BLS/CPR, as a healthcare provider as per the American Heart Association.
- Registered Nurse - PA (Required)
- Pennsylvania RN licensure
Education or Equivalent Experience:
- Bachelor of Arts or Science (Required)
- Education Specialization: BSN from an accredited school of nursing Equivalent Experience: •And More than 15 months relevant professional nursing experience and completion of the Nurse Residency Program, if applicable
We believe that the best care for our patients starts with the best care for our employees. Our employee benefits programs help our employees get healthy and stay healthy. We offer a comprehensive compensation and benefits program that includes one of the finest prepaid tuition assistance programs in the region. Penn Medicine employees are actively engaged and committed to our mission. Together we will continue to make medical advances that help people live longer, healthier lives.
Live Your Life's Work
We are an Equal Opportunity employer. Candidates are considered for employment without regard to race, ethnicity, color, sex, sexual orientation, gender identity, religion, national origin, ancestry, age, disability, marital status, familial status, genetic information, domestic or sexual violence victim status, citizenship status, military status, status as a protected veteran or any other status protected by applicable law.
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Find JobsClinical Registered Nurse Job Market in Philadelphia
Who's Hiring
- Penn Medicine55

- IQVIA14

- Tower Health14

- BAYADA Home Health Care14

- Guidehealth7

Top Industries Hiring
- Education
- Healthcare & Medical Services
Clinical Registered Nurse Jobs in Philadelphia: Frequently Asked Questions
How do I get a clinical registered nurse job in Philadelphia?
Philadelphia's strongest hiring comes from its academic medical centers in University City, large health systems anchoring Center City, and community hospitals serving North and West Philadelphia neighborhoods. Candidates with experience in critical care, med-surg, or oncology have the clearest path, but behavioral health and pediatric specialties are also in steady demand. Tailoring your application to a system's specific patient population and unit needs gives you a real edge here.
Which companies hire clinical registered nurses in Philadelphia?
Employers hiring clinical registered nurses in Philadelphia right now include Penn Medicine, IQVIA, and Tower Health, based on current listings on Migrate Mate as of November 2026. Philadelphia's market is shaped by a dense concentration of academic health systems, nonprofit community hospitals, and specialty care centers, making it one of the more active clinical nursing markets on the East Coast.
Are there remote clinical registered nurse jobs in Philadelphia?
Yes, but they are uncommon given the hands-on nature of clinical nursing. About 67% of clinical registered nurse openings tied to Philadelphia are remote or hybrid as of November 2026, and those positions tend to involve utilization review, case management, or telephonic triage rather than direct patient care. Philadelphia-based insurers and care management organizations are the most likely employers for those hybrid roles.
How can I get a clinical registered nurse job in Philadelphia with little or no experience?
The most realistic entry path in Philadelphia is through a nurse residency or new-graduate program at one of the city's large academic health systems, which run structured cohorts specifically for RNs with under one year of experience. Med-surg, telemetry, and float pool positions at community hospitals in neighborhoods like Frankford and Roxborough also hire new graduates. Completing clinical rotations at a Philadelphia facility and applying internally before graduation significantly improves your odds.
Which industries hire the most clinical registered nurses in Philadelphia?
Most clinical registered nurse openings in Philadelphia sit in Education and Healthcare & Medical Services, per current listings on Migrate Mate as of November 2026. Philadelphia's role as a regional hub for academic medicine, specialty cancer care, and federally qualified health centers means those sectors generate consistently high nursing volume throughout the year.
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