Oncology Registered Nurse Jobs in Pennsylvania
Oncology Registered Nurse jobs in Pennsylvania are open across Philadelphia, Pittsburgh, and Sayre and other Pennsylvania metros, with employers like Thomas Jefferson University & Jefferson Health, Lehigh Valley Health Network, and UPMC hiring at every experience level. Find a role that fits below and apply directly.
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Showing 5 of 22+ Oncology Registered Nurse jobs











INTRODUCTION
Ready to grow your nursing career in a supportive, high-acuity environment? UPMC St. Margaret is seeking a Full-Time Registered Nurse to join our 5A Oncology Unit. Whether you’re a new graduate registered nurse or an experienced registered nurse looking for your next challenge, this is an exciting opportunity to deliver exceptional patient care while building a meaningful and rewarding career.
At UPMC, our nurses are at the heart of everything we do; providing the right care, at the right time, every time. On 5A Oncology, you’ll work alongside a collaborative, compassionate team dedicated to delivering Life Changing Medicine to patients and families during some of their most critical moments.
This position works rotating 12-hour shifts (7:00 am–7:00 pm or 7:00 pm–7:00 am). Weekends and holidays are required as part of the scheduling guidelines.
Why UPMC?
At UPMC, we believe in delivering the right care, at the right time—every time. Our nurses are at the heart of this mission, creating positive patient experiences with integrity and compassion. Join us and be part of Life Changing Medicine.
What We Offer
- Generous Sign-On Bonus:
- Up to $20,000 with a 2-year commitment for eligible experienced RNs.
- Up to $15,000 with a 2-year commitment for eligible Graduate RNs.
- Eligible Graduate Nurses who are in their role for 6 months will receive $256.41/pay for a total of $20,000 (paid out in about 3 years)
- Career Growth:
- Dedicated nursing career ladders to help you reach your highest potential.
- Education Support:
- Tuition reimbursement up to $6,000/year for you and your dependents.
- Exclusive UPMC employee discounts, including no-cost RN-BSN/MSN options.
- Cutting-Edge Resources:
- Access to leading clinicians, researchers, and advanced technology.
ABOUT 5A ONCOLOGY
- 34-bed medical-surgical unit with private rooms
- Specializes in neurology and oncology care
- Provides treatment for stroke, cancer, and palliative/hospice patients
- Part of a Magnet-designated hospital committed to nursing excellence
- Collaborative, supportive environment focused on high-quality, compassionate care
- Offers exposure to complex medical conditions and advanced treatment plans
Why You’ll Love Working Here
- Positive, team-oriented culture where trust and collaboration thrive.
- Rewarding work supporting patients through recovery and celebrating milestones.
- Opportunities to learn and grow in a dynamic, high-acuity setting.
YOUR ROLE AS A REGISTERED NURSE
- Deliver exceptional care using the Relationship-Based Care model.
- Collaborate with physicians, healthcare providers, patients, and families.
- Demonstrate leadership, critical thinking, and strong communication skills.
- Educate patients and families, mentor new staff, and contribute to quality improvement.
- Embrace flexibility, adaptability, and continuous professional development.
This position is posted as a Professional Staff Nurse (Registered Nurse) which is a valued step in UPMC's My Nursing Career Ladder. The final candidate will be placed in the appropriate title and salary based on experience and education.
QUALIFICATIONS & REQUIREMENTS
- 0+ years of RN experience
- Background in rehabilitation and body mechanics preferred.
- Demonstrated ability to provide age-appropriate care across the lifespan, including understanding growth and development principles and interpreting patient data to meet individual needs.
- Proven ability to build and maintain positive, collaborative relationships with executives, managers, physicians, non-physician providers, ancillary staff, and patients/families.
- Strong organizational skills with the ability to work effectively in a fast-paced, complex environment while managing multiple priorities and specialized equipment.
- Excellent clinical judgment, critical thinking, and problem-solving skills essential for high-quality patient care.
- Leadership capability to guide others in applying the nursing process.
- Physical stamina and mobility required for frequent walking, standing, lifting, and patient positioning, along with visual and manual dexterity.
Licensure, Certifications, and Clearances:
- Basic Life Support (BLS) OR Cardiopulmonary Resuscitation (CPR)
- CPR required based on AHA standards that include both a didactic and skills demonstration component within 30 days of hire.
- Registered Nurse (RN)
- Current licensure as a Registered Professional Nurse either in the state where the facility is located or in a state covered by a licensure compact agreement with the state where the facility is located.
- Graduate nurses must complete licensure examination within FOUR MONTHS of hire or within one year of graduation, whichever comes first.
- Though temporary permits are valid for one year from the date of graduation, not one year from issue of permit (or until the results of the examination are known at which time it becomes null and void), UPMC requires that GNs take the licensure examination within 4 months of their start date or they will be terminated or demoted from the GN position, at the discretion of the BU.
- UPMC approved national certification preferred.
- Act 34
UPMC is an Equal Opportunity Employer/Disability/Veteran
See All 22 Oncology Registered Nurse Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
Find JobsOncology Registered Nurse Jobs by City in Pennsylvania
Where Pennsylvania roles are concentrated, by current openings.
Oncology Registered Nurse Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring
- Thomas Jefferson University & Jefferson Health4

- Lehigh Valley Health Network3

- UPMC3

- Einstein Community Health Associates2

- Guthrie2

Top Industries Hiring
- Healthcare & Medical Services17
- Agriculture & Farming3
- Biotechnology & Pharmaceuticals2
- Insurance1
- Science & Research1
What Pennsylvania Employers Look For
The qualifications that appear most often in oncology registered nurse jobs across Pennsylvania.
- Active RN license in the state of employment with no restrictions
- Oncology Nursing Society OCN certification preferred or required
- Minimum two years of medical-surgical or oncology nursing experience
- Demonstrated experience administering chemotherapy and biotherapy agents safely
- BLS and ACLS certifications current at time of hire
- Familiarity with electronic health record systems such as Epic or Cerner
Oncology Registered Nurse Jobs in Pennsylvania: Frequently Asked Questions
How many oncology registered nurse jobs are there in Pennsylvania?
There are 22+ oncology registered nurse openings in Pennsylvania on Migrate Mate as of June 2026, with the most roles in Philadelphia, Pittsburgh, and Sayre. New positions post regularly as employers across Pennsylvania hire.
How much do oncology registered nurses make in Pennsylvania?
Oncology registered nurses in Pennsylvania earn a median of about $96,430 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $70,800 for the lowest 10% to over $117,900 for the top 10%. Pay rises with experience, specialty, and employer.
Which Pennsylvania cities have the most oncology registered nurse jobs?
Philadelphia, Pittsburgh, and Sayre have the most oncology registered nurse openings in Pennsylvania right now, with additional roles spread across smaller metros statewide.
Which companies hire oncology registered nurses in Pennsylvania?
Employers hiring oncology registered nurses in Pennsylvania include Thomas Jefferson University & Jefferson Health, Lehigh Valley Health Network, and UPMC, based on current listings on Migrate Mate as of June 2026.
Are there remote oncology registered nurse jobs in Pennsylvania?
Yes. About 5% of oncology registered nurse openings tied to Pennsylvania are remote or hybrid as of June 2026. The rest are on-site roles based in Pennsylvania metros.
How do I apply for oncology registered nurse jobs in Pennsylvania?
You can apply to oncology registered nurse jobs in Pennsylvania directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Pennsylvania location, then apply to each one that fits.
See All 22 Oncology Registered Nurse Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
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