Clinical Nurse Jobs in Pennsylvania
Clinical Nurse jobs in Pennsylvania are concentrated in Philadelphia, Pittsburgh, and Allentown, where major health systems and academic medical centers drive consistent demand at every level from new graduate through senior staff nurse. Penn Medicine, UPMC, and Lehigh Valley Health Network are among the largest and most established employers in the state, with ongoing openings in med-surg, critical care, and oncology. Pennsylvania's dense hospital infrastructure and aging population keep hiring active year-round across inpatient, outpatient, and long-term care settings. Find a role that fits below and apply directly.
Find Clinical Nurse JobsOverview
Showing 5 of 156+ Clinical Nurse jobs
Description
Penn Medicine is dedicated to our tripartite mission of providing the highest level of care to patients, conducting innovative research, and educating future leaders in the field of medicine. Working for this leading academic medical center means collaboration with top clinical, technical and business professionals across all disciplines.Today at Penn Medicine, someone will make a breakthrough. Someone will heal a heart, deliver hopeful news, and give comfort and reassurance. Our employees shape our future each day. Are you living your life's work?
Summary:
The HUP Gift of Life ICU is looking for an experienced critical care RN to join the team! The schedule will be full-time night shift (three 12s, 7p-7a) and includes 4 weekend shifts per 6-week scheduling period.
Gift of Life Donor Program and Penn Medicine have opened the Gift of Life Donor Care Center at the Hospital of the University of Pennsylvania (HUP). As the first intensive care unit in the Northeast U.S. exclusively dedicated for deceased organ donors, the Center is staffed by top clinical experts with access to advanced medicine, tools, and technology that will maximize the impact of each donor’s life-saving gifts.
Located within HUP, the Donor Care Center will be open 24/7 365 days a year for deceased donors who meet specific clinical criteria, and with their family’s support, to be transferred from hospitals across Gift of Life’s region, which spans the eastern half of Pennsylvania, southern New Jersey, and Delaware. The Center is focused on the timely evaluation, allocation, and recovery of precious organs to increase opportunities for successful transplants. The specialized, first-of-its-kind space in this area also benefits the region’s health care systems, creating capacity specifically to help hospitals to best allocate ICU and OR spaces for patients.
- The Clinical Nurse 2 Colleague is an RN that practices as a full partner on the health care team and consistently demonstrates safe practice within the organizational professional practice model. The Clinical Nurse 2 Colleague possesses the knowledge, skills and the attitude to effectively meet standards for competent professional nursing practice as specified in the Clinical Nurse 2 position description addendum. The Clinical Nurse 2 Colleague exhibits UPHS organizational behavioral competencies which reflect its mission and are embedded in the professional practice competency domains. The Clinical Nurse 2 Colleague independently provides patient care through the application of the nursing process and accepts accountability for the nursing care of assigned patients. Assigned patients may range in age from infancy to the elderly. The Clinical Nurse 2 Colleague demonstrates within the competency domains of Continuous Quality Improvement, Evidence Based Practice and Research, Leadership, Person and Family Centered Care, Professionalism, Safety, Technology/Informatics, and Teamwork (Definitions listed below). The Clinical Nurse 2 Colleague works closely with the interprofessional health care team to facilitate the coordination of care across the continuum. The nurse focuses on expanding the knowledge and skills necessary to provide individualized care based on physical, psychosocial, cultural, educational, safety, and age appropriate considerations of assigned patients. The Clinical Nurse 2 Colleague seeks feedback in assuming leadership roles and provides feedback for improved clinical practice. The nurse demonstrates how nursing practice impacts the organizational vision, mission, and goals and the care delivery system. The nurse complies with all regulations and standards of regulatory and accrediting bodies.
Responsibilities:
-
Professional Practice Competency Domains DefinitionsContinuous Quality Improvement (CQI): The nurse utilizes data and QI methods to identify potential and actual problems and opportunities to provide care that is safe, timely, efficient, effective, and equitable.
Evidence Based Practice and Research: The nurse evaluates and integrates best current evidence with clinical expertise and patient and family preferences and values for the delivery of optimal health care and system effectiveness.
Leadership: The nurse effectively collaborates and applies innovative, systems thinking to engage in systematic, evidence-based problem solving and decision making to promote effective changes within a complex care delivery system supporting the vision of Penn Medicine.
Person and Family Centered Care: The nurse recognizes the patient (or the patient’s designee) as the source of control and a full partner in providing compassionate and coordinated care based on respect for the patient’s preferences, values, and needs.
Professionalism: The nurse demonstrates a commitment to the nursing profession through lifelong learning, adherence to ANA’s Code of Ethics for Nurses, participation in a professional organization and advancing community outreach.
Safety: The nurse minimizes risk of harm to patients, families, providers and self through system effectiveness and individual performance.
Technology/Informatics: The nurse utilizes appropriate information and technology to communicate, manage knowledge, mitigate error, and support decision making across the continuum.
Teamwork: The nurse effectively engages in the process of cooperation, coordination, and collaboration in an effort to provide for safe, quality outcomes for patients within inter and intra-professional teams, including virtual teams.
Credentials:
- BLS/CPR, as a healthcare provider as per the American Heart Association.
- Registered Nurse - PA (Required)
Education or Equivalent Experience:
- Education Specialization: BSN from an accredited school of nursing
- Experience: Minimum 3 years of ICU nursing experience
Live Your Life's Work
We are an Equal Opportunity employer. Candidates are considered for employment without regard to race, ethnicity, color, sex, sexual orientation, gender identity, religion, national origin, ancestry, age, disability, marital status, familial status, genetic information, domestic or sexual violence victim status, citizenship status, military status, status as a protected veteran or any other status protected by applicable law.
Description
Penn Medicine is dedicated to our tripartite mission of providing the highest level of care to patients, conducting innovative research, and educating future leaders in the field of medicine. Working for this leading academic medical center means collaboration with top clinical, technical and business professionals across all disciplines.Today at Penn Medicine, someone will make a breakthrough. Someone will heal a heart, deliver hopeful news, and give comfort and reassurance. Our employees shape our future each day. Are you living your life's work?
Summary:
The HUP Gift of Life ICU is looking for an experienced critical care RN to join the team! The schedule will be full-time night shift (three 12s, 7p-7a) and includes 4 weekend shifts per 6-week scheduling period.
Gift of Life Donor Program and Penn Medicine have opened the Gift of Life Donor Care Center at the Hospital of the University of Pennsylvania (HUP). As the first intensive care unit in the Northeast U.S. exclusively dedicated for deceased organ donors, the Center is staffed by top clinical experts with access to advanced medicine, tools, and technology that will maximize the impact of each donor’s life-saving gifts.
Located within HUP, the Donor Care Center will be open 24/7 365 days a year for deceased donors who meet specific clinical criteria, and with their family’s support, to be transferred from hospitals across Gift of Life’s region, which spans the eastern half of Pennsylvania, southern New Jersey, and Delaware. The Center is focused on the timely evaluation, allocation, and recovery of precious organs to increase opportunities for successful transplants. The specialized, first-of-its-kind space in this area also benefits the region’s health care systems, creating capacity specifically to help hospitals to best allocate ICU and OR spaces for patients.
- The Clinical Nurse 2 Colleague is an RN that practices as a full partner on the health care team and consistently demonstrates safe practice within the organizational professional practice model. The Clinical Nurse 2 Colleague possesses the knowledge, skills and the attitude to effectively meet standards for competent professional nursing practice as specified in the Clinical Nurse 2 position description addendum. The Clinical Nurse 2 Colleague exhibits UPHS organizational behavioral competencies which reflect its mission and are embedded in the professional practice competency domains. The Clinical Nurse 2 Colleague independently provides patient care through the application of the nursing process and accepts accountability for the nursing care of assigned patients. Assigned patients may range in age from infancy to the elderly. The Clinical Nurse 2 Colleague demonstrates within the competency domains of Continuous Quality Improvement, Evidence Based Practice and Research, Leadership, Person and Family Centered Care, Professionalism, Safety, Technology/Informatics, and Teamwork (Definitions listed below). The Clinical Nurse 2 Colleague works closely with the interprofessional health care team to facilitate the coordination of care across the continuum. The nurse focuses on expanding the knowledge and skills necessary to provide individualized care based on physical, psychosocial, cultural, educational, safety, and age appropriate considerations of assigned patients. The Clinical Nurse 2 Colleague seeks feedback in assuming leadership roles and provides feedback for improved clinical practice. The nurse demonstrates how nursing practice impacts the organizational vision, mission, and goals and the care delivery system. The nurse complies with all regulations and standards of regulatory and accrediting bodies.
Responsibilities:
-
Professional Practice Competency Domains DefinitionsContinuous Quality Improvement (CQI): The nurse utilizes data and QI methods to identify potential and actual problems and opportunities to provide care that is safe, timely, efficient, effective, and equitable.
Evidence Based Practice and Research: The nurse evaluates and integrates best current evidence with clinical expertise and patient and family preferences and values for the delivery of optimal health care and system effectiveness.
Leadership: The nurse effectively collaborates and applies innovative, systems thinking to engage in systematic, evidence-based problem solving and decision making to promote effective changes within a complex care delivery system supporting the vision of Penn Medicine.
Person and Family Centered Care: The nurse recognizes the patient (or the patient’s designee) as the source of control and a full partner in providing compassionate and coordinated care based on respect for the patient’s preferences, values, and needs.
Professionalism: The nurse demonstrates a commitment to the nursing profession through lifelong learning, adherence to ANA’s Code of Ethics for Nurses, participation in a professional organization and advancing community outreach.
Safety: The nurse minimizes risk of harm to patients, families, providers and self through system effectiveness and individual performance.
Technology/Informatics: The nurse utilizes appropriate information and technology to communicate, manage knowledge, mitigate error, and support decision making across the continuum.
Teamwork: The nurse effectively engages in the process of cooperation, coordination, and collaboration in an effort to provide for safe, quality outcomes for patients within inter and intra-professional teams, including virtual teams.
Credentials:
- BLS/CPR, as a healthcare provider as per the American Heart Association.
- Registered Nurse - PA (Required)
Education or Equivalent Experience:
- Education Specialization: BSN from an accredited school of nursing
- Experience: Minimum 3 years of ICU nursing experience
Live Your Life's Work
We are an Equal Opportunity employer. Candidates are considered for employment without regard to race, ethnicity, color, sex, sexual orientation, gender identity, religion, national origin, ancestry, age, disability, marital status, familial status, genetic information, domestic or sexual violence victim status, citizenship status, military status, status as a protected veteran or any other status protected by applicable law.
See All 156+ Clinical Nurse Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
Find Clinical Nurse JobsClinical Nurse Jobs by City in Pennsylvania
Where Pennsylvania roles are concentrated, by current openings.
Clinical Nurse Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring
- Penn Medicine78
- Children's Hospital of Philadelphia9
- UPMC5
- Geisinger5
- Care Options For Kids5
Top Industries Hiring
- Healthcare & Medical Services
- Education
What Pennsylvania Employers Look For
The qualifications that appear most often in clinical nurse jobs across Pennsylvania.
- Active Pennsylvania RN license issued or recognized by the Pennsylvania State Board of Nursing
- Associate or bachelor's degree in nursing from an accredited program
- Current BLS certification required before start date
- Minimum one year of acute care or clinical nursing experience preferred
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong clinical assessment and patient communication skills in a team-based environment
Clinical Nurse Jobs in Pennsylvania: Frequently Asked Questions
How do you become a clinical nurse in Pennsylvania?
You become a clinical nurse in Pennsylvania by completing an accredited nursing program, either an associate degree in nursing or a bachelor of science in nursing, then passing the NCLEX-RN examination. Licensure is granted by the Pennsylvania State Board of Nursing, which operates under the Pennsylvania Department of State. Some Pennsylvania employers, particularly large academic medical centers, prefer or require a BSN for clinical nurse roles, so confirming the specific education requirement before applying is worthwhile.
How much do clinical nurses make in Pennsylvania?
Clinical nurses in Pennsylvania earn a median of about $96,430 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $70,800 for the lowest 10% to over $117,900 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire clinical nurses in Pennsylvania?
Pennsylvania clinical nurse roles are posted by Penn Medicine, Children's Hospital of Philadelphia, and UPMC and others right now, based on current listings on Migrate Mate as of October 2026. Pennsylvania's high concentration of academic medical centers, regional health systems, and specialty hospitals means hiring is distributed across both major metros and mid-size communities throughout the state.
Which Pennsylvania cities have the most clinical nurse jobs?
Philadelphia, Pittsburgh, and West Chester have the most clinical nurse openings in Pennsylvania. Philadelphia leads because of its dense cluster of academic medical centers and large regional health systems, Pittsburgh draws volume from UPMC's extensive network of facilities, and Allentown reflects the significant hiring activity at Lehigh Valley Health Network, which anchors the Lehigh Valley region's healthcare workforce.
Are there remote clinical nurse jobs in Pennsylvania?
Yes, but they're rare. Clinical nursing is a hands-on, patient-facing role that requires physical presence in a hospital, clinic, or long-term care setting the vast majority of the time. About 44% of clinical nurse openings tied to Pennsylvania are remote or hybrid as of October 2026, and those positions are almost exclusively in telehealth triage, utilization review, or case management, which are adjacent functions rather than direct bedside care.
How can I get hired as a clinical nurse in Pennsylvania with little or no experience?
The most realistic entry path is a new graduate residency program, which several large Pennsylvania employers run specifically for nurses without clinical work experience. UPMC, Penn Medicine, and Lehigh Valley Health Network all operate structured nurse residency programs that provide a supported transition from school to practice. Applying to med-surg or general inpatient roles, which see the highest turnover, gives new graduates the best odds. Holding a current Pennsylvania RN license and BLS certification before applications go in is the single clearest differentiator at the entry level.
Where can I find and apply to clinical nurse jobs in Pennsylvania?
You can find and apply to clinical nurse jobs in Pennsylvania on Migrate Mate, which lists current Pennsylvania openings across health systems, hospitals, and outpatient settings. Search the listings for roles that match your experience level and preferred location, then apply directly to the ones that fit.
See All 156+ Clinical Nurse Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
Find Clinical Nurse Jobs