Clinical Nurse Jobs in Pennsylvania

Clinical Nurse jobs in Pennsylvania are concentrated in Philadelphia, Pittsburgh, and Allentown, where major health systems and academic medical centers drive consistent demand at every level from new graduate through senior staff nurse. Penn Medicine, UPMC, and Lehigh Valley Health Network are among the largest and most established employers in the state, with ongoing openings in med-surg, critical care, and oncology. Pennsylvania's dense hospital infrastructure and aging population keep hiring active year-round across inpatient, outpatient, and long-term care settings. Find a role that fits below and apply directly.

Find Clinical Nurse Jobs

Overview

Open roles164+
Top employerPenn Medicine
Top cityPhiladelphia, PA
Cities hiring46
Work type69% On-site
Top industryHealthcare

Showing 5 of 164+ Clinical Nurse jobs

Penn Medicine
Clinical Nurse 1- Inpatient Medical Oncology at HUP, FT Rotating Shifts
We won't show you this job again
Penn Medicine
New 7h ago
Clinical Nurse 1- Inpatient Medical Oncology at HUP, FT Rotating Shifts
Penn Medicine
Philadelphia, Pennsylvania
Healthcare Administration
Nursing
Patient Services & Wellbeing
CPR Certification
10,000+

Have you applied for this role?

Penn Medicine
Clinical Nurse 2- HUP Inpatient ENT/Plastic Surgical Unit (Rhoads 3)- Full-Time, Rotating Shifts
We won't show you this job again
Penn Medicine
New 7h ago
Clinical Nurse 2- HUP Inpatient ENT/Plastic Surgical Unit (Rhoads 3)- Full-Time, Rotating Shifts
Penn Medicine
Philadelphia, Pennsylvania
Healthcare Administration
Nursing
Patient Services & Wellbeing
CPR Certification
10,000+

Have you applied for this role?

One Senior Care
Nurse – Clinical Documentation Integrity (PACE)
We won't show you this job again
One Senior Care
New 10h ago
Nurse – Clinical Documentation Integrity (PACE)
One Senior Care
Erie, Pennsylvania
Healthcare Administration
Nursing
Patient Services & Wellbeing
Hybrid
501-1,000

Have you applied for this role?

Healthcare for Kids
Clinical Lead Registered Nurse (RN)
We won't show you this job again
Healthcare for Kids
New 11h ago
Clinical Lead Registered Nurse (RN)
Healthcare for Kids
North Versailles, Pennsylvania
Healthcare Administration
Nursing
Patient Services & Wellbeing
On-Site
CPR Certification

Have you applied for this role?

UPMC
Clinical Research Nurse I (RN) - Community Oncology (Uniontown/Mt. Pleasant)
We won't show you this job again
UPMC
New 12h ago
Clinical Research Nurse I (RN) - Community Oncology (Uniontown/Mt. Pleasant)
UPMC
Uniontown, Pennsylvania
Healthcare Administration
Nursing
Patient Services & Wellbeing
$35.15 - $48/hr
CPR Certification
10,000+

Have you applied for this role?

See All 164+ Clinical Nurse Jobs in Pennsylvania

Find roles in Pennsylvania that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs

Clinical Nurse Jobs by City in Pennsylvania

Where Pennsylvania roles are concentrated, by current openings.

Hershey
8 jobs
West Chester
8 jobs
King of Prussia
7 jobs
York
4 jobs
Pittsburgh
4 jobs
Wilkes-Barre
4 jobs
Reading
3 jobs
Lebanon
2 jobs

Clinical Nurse Job Market in Pennsylvania

A snapshot from current Pennsylvania openings, updated as new roles post.

Who's Hiring

  • Penn Medicine
    Penn Medicine61
  • Penn State Health
    Penn State Health11
  • Children's Hospital of Philadelphia
    Children's Hospital of Philadelphia11
  • Geisinger
    Geisinger6
  • WellSpan Health
    WellSpan Health5

Top Industries Hiring

  • Healthcare & Medical Services
  • Education

What Pennsylvania Employers Look For

The qualifications that appear most often in clinical nurse jobs across Pennsylvania.

  • Active Pennsylvania RN license issued or recognized by the Pennsylvania State Board of Nursing
  • Associate or bachelor's degree in nursing from an accredited program
  • Current BLS certification required before start date
  • Minimum one year of acute care or clinical nursing experience preferred
  • Proficiency with electronic health record systems such as Epic or Cerner
  • Strong clinical assessment and patient communication skills in a team-based environment

Clinical Nurse Jobs in Pennsylvania: Frequently Asked Questions

How do you become a clinical nurse in Pennsylvania?

You become a clinical nurse in Pennsylvania by completing an accredited nursing program, either an associate degree in nursing or a bachelor of science in nursing, then passing the NCLEX-RN examination. Licensure is granted by the Pennsylvania State Board of Nursing, which operates under the Pennsylvania Department of State. Some Pennsylvania employers, particularly large academic medical centers, prefer or require a BSN for clinical nurse roles, so confirming the specific education requirement before applying is worthwhile.

How much do clinical nurses make in Pennsylvania?

Clinical nurses in Pennsylvania earn a median of about $96,430 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $70,800 for the lowest 10% to over $117,900 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire clinical nurses in Pennsylvania?

Pennsylvania clinical nurse roles are posted by Penn Medicine, Penn State Health, and Children's Hospital of Philadelphia and others right now, based on current listings on Migrate Mate as of August 2026. Pennsylvania's high concentration of academic medical centers, regional health systems, and specialty hospitals means hiring is distributed across both major metros and mid-size communities throughout the state.

Which Pennsylvania cities have the most clinical nurse jobs?

Philadelphia, Hershey, and West Chester have the most clinical nurse openings in Pennsylvania. Philadelphia leads because of its dense cluster of academic medical centers and large regional health systems, Pittsburgh draws volume from UPMC's extensive network of facilities, and Allentown reflects the significant hiring activity at Lehigh Valley Health Network, which anchors the Lehigh Valley region's healthcare workforce.

Are there remote clinical nurse jobs in Pennsylvania?

Yes, but they're rare. Clinical nursing is a hands-on, patient-facing role that requires physical presence in a hospital, clinic, or long-term care setting the vast majority of the time. About 31% of clinical nurse openings tied to Pennsylvania are remote or hybrid as of August 2026, and those positions are almost exclusively in telehealth triage, utilization review, or case management, which are adjacent functions rather than direct bedside care.

How can I get hired as a clinical nurse in Pennsylvania with little or no experience?

The most realistic entry path is a new graduate residency program, which several large Pennsylvania employers run specifically for nurses without clinical work experience. UPMC, Penn Medicine, and Lehigh Valley Health Network all operate structured nurse residency programs that provide a supported transition from school to practice. Applying to med-surg or general inpatient roles, which see the highest turnover, gives new graduates the best odds. Holding a current Pennsylvania RN license and BLS certification before applications go in is the single clearest differentiator at the entry level.

Where can I find and apply to clinical nurse jobs in Pennsylvania?

You can find and apply to clinical nurse jobs in Pennsylvania on Migrate Mate, which lists current Pennsylvania openings across health systems, hospitals, and outpatient settings. Search the listings for roles that match your experience level and preferred location, then apply directly to the ones that fit.

See All 164+ Clinical Nurse Jobs in Pennsylvania

Find roles in Pennsylvania that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs