Clinical Director Jobs in Pennsylvania
Clinical Director jobs in Pennsylvania are consistently in demand, with the state's dense network of health systems, behavioral health organizations, and academic medical centers driving openings at every level from emerging clinical leaders through senior executive roles. Philadelphia, Pittsburgh, and Harrisburg anchor the largest share of hiring, where employers such as Penn Medicine, UPMC, and Geisinger have sustained clinical director needs across service lines. The most sought-after specialties in Pennsylvania include behavioral health, home health and hospice, and rehabilitation services. Find a role that fits below and apply directly.
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For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage, UK. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.
Director, Oncology Translational Medicine, Clinical Biomarkers
Job Purpose:
The Director, Oncology Translational Medicine, Clinical Biomarkers is responsible for the development and effective implementation of biomarker and translational medicine strategies to support the clinical development of late-stage oncology assets.
As a key member of a Clinical Matrix Team (CMT), the Clinical Biomarker Director will collaborate with the Clinical Biomarker Executive Director to establish clear decision-making criteria, define patient segmentation strategies, and integrate these into clinical development plans.
You will leverage cutting-edge technologies and methodologies to discover and clinically validate biomarkers, ensuring the biomarker strategy is fully aligned with the clinical plan. This integration will optimise decision-making in drug development and enable the identification of the right patient populations for our medicines.
Key responsibilities:
- Collaborating closely with the Clinical Biomarker Executive Director to drive the design, alignment, and execution of clinical biomarker and translational medicine strategies focused on identifying predictive biomarkers that enable clinical success.
- Validating and implementing biomarker strategies, including target engagement, pharmacodynamic, and proof-of-mechanism biomarkers, for clinical-phase programs to support patient stratification, dose selection, and enable clinical go/no-go decisions.
- Participating in tumor-specific Biomarker Matrix teams, with responsibility for executing clinical biomarker strategies for late-stage oncology programs, while working closely with internal and external stakeholders, as well as disease area strategy teams.
- Representing Translational Medicine at Clinical Development Matrix Teams (CMT) to establish biomarker-driven decision-making criteria and their seamless integration into clinical study designs, aligning with clinical study objectives
- Supporting disease area strategies and translational objectives by defining biomarker priorities, areas of interest, and generating decision-enabling evidence packages informed by real-world datasets, internal and external data and partnerships (For e.g., research collaborations, KEE consultations).
- Identifying cutting-edge science and technological advances to incorporate into biomarker strategies for guiding indication selection, patient enrichment, and combination strategies.
- Overseeing and/or developing sample testing plans and delivering high-quality biomarker data packages to inform clinical development and regulatory strategies.
- Managing effective relationships with clinical and scientific operations, diagnostics, medical science, medical affairs, regulatory, portfolio management, and commercial functions.
- Supporting the expansion of mechanism and disease understanding to generate insights for indication expansion and scientific exchange as needed.
- Defining and studying mechanisms of resistance to enable reverse translation, inform next-line strategies, support patient enrichment, and influence life cycle management of assets.
- Contributing to the company’s scientific credibility through publications and presentations.
Why You?
Basic Qualifications:
We are looking for professionals with the following required skills and experience:
- Ph.D. or equivalent with 7+ years or M.Sc. with 10+ years of drug development experience in the pharmaceutical industry, with a solid background in Oncology clinical biomarkers, expertise in late-phase oncology studies, and translational research within clinical development.
- Strong expertise in cancer biology, and clinical development, including the therapeutic landscape, approved and investigational agents, and diagnostic approaches in solid tumor and haematological malignancies.
- Experience in leading cross-functional teams and designing and executing strategic biomarker plans including development of regulated biomarker assays.
- Experience conducting clinical trials and working as part of clinical study teams.
- Experience designing and executing translational biomarker plans for clinical trials. Explores and onboards innovative technologies to advance translational research and new biomarker development
- Experience collaborating effectively with Data Sciences to analyze high-dimensional preclinical and clinical data to guide clinical decisions and inform asset strategy.
- Hands-on experience implementing a broad range of biomarker platforms such as flow cytometry, molecular diagnostics including NGS, FISH and PCR, IHC/IF, liquid biopsy / ctDNA approaches, and multi-omic biomarker analyses.
- undefined
- Direct successful translation of pre-clinical research to human clinical trials, leveraging learnings from genomic, transcriptomic, and proteomic analyses of both preclinical models and patient samples.
- Experience influencing teams and key leaders, with a track record of success.
Preferred Qualifications:
The following qualifications would be advantageous:
- M.D., Ph.D. or equivalent doctoral degree in a relevant scientific discipline.
- Experience with high-dimensional dataset analysis.
- Prior experience with diagnostic development and regulatory interactions.
- Experience with digital pathology, AI/ML-enabled biomarker analyses, external scientific partnerships, and mentoring or developing scientific colleagues.
- Strong sense of urgency and excellent skills in prioritization, planning as well as timely execution in a very fast-paced environment
- Strong interpersonal skills and ability to thrive in a matrixed environment. Dependable and trustworthy, willing to take ownership and responsibility
- Excellent communication, problem-solving, matrix project-management, and presentation skills.
LI-GSK*
LI-Hybrid*
Skills
If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $189,750 to $316,250. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - usrecruitment.adjustments@gsk.com.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/
For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage, UK. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.
Director, Oncology Translational Medicine, Clinical Biomarkers
Job Purpose:
The Director, Oncology Translational Medicine, Clinical Biomarkers is responsible for the development and effective implementation of biomarker and translational medicine strategies to support the clinical development of late-stage oncology assets.
As a key member of a Clinical Matrix Team (CMT), the Clinical Biomarker Director will collaborate with the Clinical Biomarker Executive Director to establish clear decision-making criteria, define patient segmentation strategies, and integrate these into clinical development plans.
You will leverage cutting-edge technologies and methodologies to discover and clinically validate biomarkers, ensuring the biomarker strategy is fully aligned with the clinical plan. This integration will optimise decision-making in drug development and enable the identification of the right patient populations for our medicines.
Key responsibilities:
- Collaborating closely with the Clinical Biomarker Executive Director to drive the design, alignment, and execution of clinical biomarker and translational medicine strategies focused on identifying predictive biomarkers that enable clinical success.
- Validating and implementing biomarker strategies, including target engagement, pharmacodynamic, and proof-of-mechanism biomarkers, for clinical-phase programs to support patient stratification, dose selection, and enable clinical go/no-go decisions.
- Participating in tumor-specific Biomarker Matrix teams, with responsibility for executing clinical biomarker strategies for late-stage oncology programs, while working closely with internal and external stakeholders, as well as disease area strategy teams.
- Representing Translational Medicine at Clinical Development Matrix Teams (CMT) to establish biomarker-driven decision-making criteria and their seamless integration into clinical study designs, aligning with clinical study objectives
- Supporting disease area strategies and translational objectives by defining biomarker priorities, areas of interest, and generating decision-enabling evidence packages informed by real-world datasets, internal and external data and partnerships (For e.g., research collaborations, KEE consultations).
- Identifying cutting-edge science and technological advances to incorporate into biomarker strategies for guiding indication selection, patient enrichment, and combination strategies.
- Overseeing and/or developing sample testing plans and delivering high-quality biomarker data packages to inform clinical development and regulatory strategies.
- Managing effective relationships with clinical and scientific operations, diagnostics, medical science, medical affairs, regulatory, portfolio management, and commercial functions.
- Supporting the expansion of mechanism and disease understanding to generate insights for indication expansion and scientific exchange as needed.
- Defining and studying mechanisms of resistance to enable reverse translation, inform next-line strategies, support patient enrichment, and influence life cycle management of assets.
- Contributing to the company’s scientific credibility through publications and presentations.
Why You?
Basic Qualifications:
We are looking for professionals with the following required skills and experience:
- Ph.D. or equivalent with 7+ years or M.Sc. with 10+ years of drug development experience in the pharmaceutical industry, with a solid background in Oncology clinical biomarkers, expertise in late-phase oncology studies, and translational research within clinical development.
- Strong expertise in cancer biology, and clinical development, including the therapeutic landscape, approved and investigational agents, and diagnostic approaches in solid tumor and haematological malignancies.
- Experience in leading cross-functional teams and designing and executing strategic biomarker plans including development of regulated biomarker assays.
- Experience conducting clinical trials and working as part of clinical study teams.
- Experience designing and executing translational biomarker plans for clinical trials. Explores and onboards innovative technologies to advance translational research and new biomarker development
- Experience collaborating effectively with Data Sciences to analyze high-dimensional preclinical and clinical data to guide clinical decisions and inform asset strategy.
- Hands-on experience implementing a broad range of biomarker platforms such as flow cytometry, molecular diagnostics including NGS, FISH and PCR, IHC/IF, liquid biopsy / ctDNA approaches, and multi-omic biomarker analyses.
- undefined
- Direct successful translation of pre-clinical research to human clinical trials, leveraging learnings from genomic, transcriptomic, and proteomic analyses of both preclinical models and patient samples.
- Experience influencing teams and key leaders, with a track record of success.
Preferred Qualifications:
The following qualifications would be advantageous:
- M.D., Ph.D. or equivalent doctoral degree in a relevant scientific discipline.
- Experience with high-dimensional dataset analysis.
- Prior experience with diagnostic development and regulatory interactions.
- Experience with digital pathology, AI/ML-enabled biomarker analyses, external scientific partnerships, and mentoring or developing scientific colleagues.
- Strong sense of urgency and excellent skills in prioritization, planning as well as timely execution in a very fast-paced environment
- Strong interpersonal skills and ability to thrive in a matrixed environment. Dependable and trustworthy, willing to take ownership and responsibility
- Excellent communication, problem-solving, matrix project-management, and presentation skills.
LI-GSK*
LI-Hybrid*
Skills
If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $189,750 to $316,250. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - usrecruitment.adjustments@gsk.com.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/
See All 80 Clinical Director Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
Find Clinical Director JobsClinical Director Jobs by City in Pennsylvania
Where Pennsylvania roles are concentrated, by current openings.
Clinical Director Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
- Education
- Staffing & Recruiting
- Non-Profit & Social Services
- Biotechnology & Pharmaceuticals
What Pennsylvania Employers Look For
The qualifications that appear most often in clinical director jobs across Pennsylvania.
- Active Pennsylvania clinical license in a relevant field such as nursing, social work, or counseling
- Master's degree or higher in a clinical, health administration, or related discipline
- Minimum five years of direct clinical experience with at least two in a supervisory role
- Demonstrated experience managing clinical staff, quality outcomes, and regulatory compliance
- Familiarity with Pennsylvania Department of Health and accreditation body requirements
- Strong background in budgeting, program development, and interdisciplinary team leadership
Clinical Director Jobs in Pennsylvania: Frequently Asked Questions
How do you become a clinical director in Pennsylvania?
Most clinical directors in Pennsylvania hold an active state-issued license in their clinical discipline, such as a Pennsylvania registered nurse license through the State Board of Nursing, a licensed clinical social worker credential through the State Board of Social Workers, or a licensed professional counselor license through the State Board of Social Workers and Professional Counselors. A master's degree is the standard education threshold, and employers typically require several years of progressively responsible clinical and supervisory experience before promoting or hiring into a director role.
Which companies hire clinical directors in Pennsylvania?
Employers hiring clinical directors in Pennsylvania right now include GSK, CSL, and KeystoneCare, based on current listings on Migrate Mate as of October 2026. Pennsylvania's large integrated health systems and behavioral health networks tend to post the most consistent volume of clinical director openings throughout the year.
Which Pennsylvania cities have the most clinical director jobs?
Philadelphia, Collegeville, and Pittsburgh have the most clinical director openings in Pennsylvania. Philadelphia leads because of its concentration of academic medical centers, large hospital systems, and behavioral health providers, while Pittsburgh's strength in specialty care and research medicine drives demand there, and Harrisburg's role as the state capital brings state-agency and regional health network hiring to central Pennsylvania.
Are there remote clinical director jobs in Pennsylvania?
Yes, but they're limited. Clinical directors typically oversee staff, programs, and patient care operations that require an on-site presence, so fully remote roles are uncommon. About 52% of clinical director openings tied to Pennsylvania are remote or hybrid as of October 2026, and those that are tend to involve administrative oversight, telehealth program management, or utilization review rather than direct care supervision.
How can I get hired as a clinical director in Pennsylvania with little or no experience?
The most realistic entry path is moving into a clinical supervisor or program coordinator role first and building toward a director title from there. Large Pennsylvania employers such as UPMC, Penn Medicine, and Geisinger regularly hire clinical coordinators, team leads, and charge nurses who want to grow into leadership. Earning a Pennsylvania state license in your clinical field and adding a leadership-focused graduate certificate strengthens your candidacy considerably, and lateral moves from case management, quality assurance, or utilization review roles are common stepping stones into director-level positions.
Where can I find and apply to clinical director jobs in Pennsylvania?
You can find and apply to clinical director jobs in Pennsylvania on Migrate Mate, which lists current Pennsylvania openings from employers actively hiring. Find roles that fit your background and apply directly to the ones that match.
See All 80 Clinical Director Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
Find Clinical Director Jobs