NP Jobs in Columbia, SC

NP jobs in Columbia, South Carolina are concentrated in healthcare systems anchored in the Midlands corridor, with strong demand across primary care, urgent care, and specialty practices near the Five Points medical district, Forest Acres, and the downtown Congaree health hub. Employers actively hiring include Prisma Health, Medical University of South Carolina, and Lexington Health. See the openings below and apply to the ones that match your experience.

Find NP Jobs in Columbia

Overview

Open roles56
Top employerPrisma Health
Work type81% On-site
Top credentialMaster's
Companies hiring20

Showing 5 of 56+ NP jobs

Medical University of South Carolina
MUSC Health Advanced Practice Provider (NP/PA) – Orthopedic Surgery APP - Midlands Division, SC
We won't show you this job again
Medical University of South Carolina
New 1m ago
MUSC Health Advanced Practice Provider (NP/PA) – Orthopedic Surgery APP - Midlands Division, SC
Medical University of South Carolina
Columbia, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians
10,000+

Have you applied for this role?

Medical University of South Carolina
MUSC Health Advanced Practice Provider (APP NP/PA) – Structural Heart APP (PRN)
We won't show you this job again
Medical University of South Carolina
New 1m ago
MUSC Health Advanced Practice Provider (APP NP/PA) – Structural Heart APP (PRN)
Medical University of South Carolina
Columbia, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians
10,000+

Have you applied for this role?

US Department of Veterans Affairs
HUD VASH Nurse Practitioner
We won't show you this job again
US Department of Veterans Affairs
New 1m ago
HUD VASH Nurse Practitioner
US Department of Veterans Affairs
Columbia, South Carolina
Account Management
Customer Service
Customer Success
Partnerships & Business Development
On-Site
Acute Care Nurse Practitioner Certification - Adult Gerontology
10,000+

Have you applied for this role?

Medical University of South Carolina
MUSC Health Advanced Practice Provider (APP NP/PA) – Advanced Heart Failure APP Nights - Columbia, SC
We won't show you this job again
Medical University of South Carolina
New 1m ago
MUSC Health Advanced Practice Provider (APP NP/PA) – Advanced Heart Failure APP Nights - Columbia, SC
Medical University of South Carolina
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
10,000+

Have you applied for this role?

The Skin Studio Day Spa
Aesthetic Nurse Practitioner – Part-Time (1–2 Days/Week)
We won't show you this job again
The Skin Studio Day Spa
New 1m ago
Aesthetic Nurse Practitioner – Part-Time (1–2 Days/Week)
The Skin Studio Day Spa
Columbia, South Carolina
Allied Health
Healthcare Administration
Nursing
On-Site
Botox and Dermal Filler Certification

Have you applied for this role?

See All 56 NP Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find NP Jobs in Columbia

NP Job Market in Columbia

Who's Hiring

  • Prisma Health
    Prisma Health24
  • Medical University of South Carolina
    Medical University of South Carolina6
  • Lexington Health
    Lexington Health4
  • P
    Prisma Health Urgent Care4
  • Optum
    Optum2

Top Industries Hiring

  • Healthcare & Medical Services31
  • Consulting & Professional Services11
  • Education3

NP Jobs in Columbia: Frequently Asked Questions

How do I get a np job in Columbia?

Focus your search on Columbia's largest healthcare anchors, including hospital-affiliated multispecialty groups, federally qualified health centers serving underserved Midlands communities, and the growing network of urgent care and retail health clinics along Harbison Boulevard and Two Notch Road. Candidates with experience in family medicine, psychiatric mental health, or acute care tend to move fastest in this market, and any existing familiarity with South Carolina Medicaid patient populations is a genuine advantage with local employers.

Which companies hire nps in Columbia?

Columbia np roles are posted by Prisma Health, Medical University of South Carolina, and Lexington Health and others right now, based on current listings on Migrate Mate as of July 2026. The local market is anchored by large academic medical systems, community health organizations, and an expanding footprint of independent and corporate-owned specialty clinics throughout the greater Richland County area.

Are there remote np jobs in Columbia?

Yes, though remote work is limited for nps since most roles require direct patient contact and on-site clinical presence. About 19% of np openings tied to Columbia are remote or hybrid as of July 2026, concentrated in telehealth triage, behavioral health, and care management roles. Columbia's growing telehealth infrastructure, supported by several regional health systems, makes those remote-eligible positions more available here than in smaller South Carolina markets.

How can I get a np job in Columbia with little or no experience?

The most realistic entry path in Columbia is through residency or fellowship programs affiliated with the Midlands health systems, which are designed specifically for new graduate nps and provide supervised clinical hours in high-volume settings. Entry-level candidates often find traction at federally qualified health centers and community clinics in the greater Columbia area, where patient volume is high and mentorship structures are built in. Highlighting any clinical rotations completed in South Carolina and any experience with underserved or complex populations will strengthen your application with local hiring managers.

Which industries hire the most nps in Columbia?

Most np openings in Columbia sit in Healthcare & Medical Services, Consulting & Professional Services, and Education, per current listings on Migrate Mate as of July 2026. Columbia's role as South Carolina's capital and home to a major university health system drives consistent demand across those sectors, with state government health programs and a growing behavioral health services network adding further depth to local hiring.

See All 56 NP Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find NP Jobs in Columbia