Senior Level Clinical Operations Director Jobs

Senior level clinical operations director jobs demand full ownership of clinical strategy, regulatory execution, and the cross-functional teams that deliver trial results. Roles are concentrated in Biotechnology & Pharmaceuticals, Science & Research, and Healthcare & Medical Services, with a 14% remote or hybrid mix, and employers like Revolution Medicines, Revolution Medicines, and Flagship Pioneering hiring at this level now.

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Overview

Open roles26
Top stateMassachusetts
Top employerRevolution Medicines
Top cityBoston, MA
Work type86% On-site
Top industryBiotechnology

Showing 5 of 26+ Senior Level Clinical Operations Director jobs

Cambia Health Solutions
Assistant Director Clinical Regulatory Operations
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Cambia Health Solutions
Added 2w ago
Assistant Director Clinical Regulatory Operations
Cambia Health Solutions
Fargo, North Dakota
Customer Service
Customer Support
$128k - $208k/yr
Remote (US)
Managed care
5,001-10,000

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Neurocrine Biosciences
Director, Clinical Operations
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Neurocrine Biosciences
Added 3w ago
Director, Clinical Operations
Neurocrine Biosciences
San Diego, California
Project & Program Management
Human Resources
Project Management
$191k - $260k/yr
On-Site
Bachelor's

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Atlantic Health
Executive Director Hospital at Home Clinical Operations
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Atlantic Health
Added 1mo ago
Executive Director Hospital at Home Clinical Operations
Atlantic Health
Morristown, New Jersey
Executive Leadership & C-Suite
Healthcare Administration
Human Resources
Project & Program Management
Strategy & Corporate Development
Business Strategy
On-Site
Bachelor's

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Revolution Medicines
Senior Director, Clinical Operations
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Revolution Medicines
Added 1mo ago
Senior Director, Clinical Operations
Revolution Medicines
San Francisco Bay Area
Project & Program Management
Partnerships & Business Development
Compliance & Legal
Healthcare Administration
Project Management
Business Development
$305k/yr
On-Site
Bachelor's

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Flagship Pioneering
Associate Director / Director, Clinical Operations
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Flagship Pioneering
Added 2mo ago
Associate Director / Director, Clinical Operations
Flagship Pioneering
Boston, Massachusetts
Healthcare Administration
$148k - $237k
On-Site
Bachelor's

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Senior Level Clinical Operations Director Job Market

Who's Hiring

Revolution Medicines
Revolution Medicines8 open roles
Flagship Pioneering
Flagship Pioneering2 open roles
ARTBIO
ARTBIO1 open role

Top Industries Hiring

  • Biotechnology & Pharmaceuticals12
  • Science & Research4
  • Healthcare & Medical Services4
  • Education2
  • Insurance1

Senior Level Clinical Operations Director Jobs: Frequently Asked Questions

How do I get a senior level clinical operations director job?

Employers at this level expect candidates who have already led multi-site or global clinical programs from protocol design through regulatory submission. Demonstrated experience managing vendor oversight, CRO relationships, and cross-functional teams is a stronger differentiator than tenure alone. Candidates who can speak to specific outcomes, such as accelerated timelines or successful NDA submissions, consistently stand out in senior level searches.

Which companies hire senior level clinical operations directors?

Companies hiring senior level clinical operations directors right now include Revolution Medicines, Revolution Medicines, and Flagship Pioneering, based on current listings on Migrate Mate as of August 2026. Hiring at this level tends to concentrate in large pharmaceutical and biotechnology companies, contract research organizations, and medical device firms with active late-stage pipelines.

Are there remote senior level clinical operations director jobs?

Yes, though many senior roles involve periodic site visits or executive team presence. About 14% of senior level clinical operations director openings are remote or hybrid as of August 2026, reflecting broader industry adoption of distributed leadership structures while still requiring strategic in-person engagement for sponsor meetings and investigator relationships.

What makes a clinical operations director role senior level?

Senior level clinical operations director roles are defined by enterprise-wide scope, direct accountability for program outcomes, and responsibility for developing junior and mid-level staff. These positions typically own budgets across multiple studies or therapeutic areas, set departmental standards for quality and compliance, and serve as the primary point of escalation when trial execution risks arise.

Which industries hire the most senior level clinical operations directors?

Senior Level clinical operations director roles concentrate in Biotechnology & Pharmaceuticals, Science & Research, and Healthcare & Medical Services, based on current listings on Migrate Mate as of August 2026. These sectors drive the highest demand because they operate complex, regulated clinical programs that require experienced leadership to manage timelines, submissions, and cross-functional accountability at scale.