Clinical Research Director Jobs in Boston, MA
Clinical Research Director jobs in Boston are in strong and active demand, concentrated in the Longwood Medical Area, Kendall Square, and the Seaport District across biopharma, academic medical centers, and medical device companies. Employers hiring right now include Zoox, Whoop, and PwC. Scan the live roles below and apply to whichever ones fit.
Find JobsOverview
Showing 5 of 51+ Clinical Research Director jobs








We help organizations move AI out of experimentation and into production — safely, reliably, and at scale. From inconsistent performance to limited transparency and challenges with integration and long-term viability, our Applied Intelligence Engine solves the risks that cause most AI initiatives to stall.
Built for some of the most highly regulated industries in the world, we enable teams to deploy AI systems that are auditable, explainable, and aligned with real-world constraints. Our solutions introduce structure, visibility, and control into how AI operates, turning advanced capabilities into a dependable, production-grade infrastructure so our customers can move faster and scale with confidence.
Job Overview
You’ll help build Clearwing: an AI-native cybersecurity system for autonomous vulnerability discovery, exploit validation, pen-testing, reverse engineering, and security reporting. You’ll combine hands-on offensive security work with LLM agent development, eval design, and product engineering. The ideal candidate can chase real bugs, validate exploitability, write production-quality Python, and turn exploratory research into repeatable security capabilities.
Responsibilities
- Develop AI-assisted vulnerability discovery workflows for source code, binaries, networks, and live systems.
- Build and improve Clearwing’s source-code hunting, network pen-testing, N-day exploit, reverse engineering, and validation pipelines.
- Design agentic workflows for reconnaissance, static analysis, dynamic testing, exploit development, patch validation, and reporting.
- Perform static analysis to identify vulnerable patterns, reachable attack surfaces, and exploitability conditions.
- Conduct authorized live testing against networks, services, containers, lab targets, and operational environments.
- Develop and validate proof-of-concept exploits in controlled, authorized settings.
- Build evaluation harnesses for vulnerability discovery quality, false positives, exploitability, reproducibility, and model/tool performance.
- Improve safety, authorization, auditability, guardrails, and human-in-the-loop controls for dual-use cybersecurity capabilities.
- Work with AI researchers and engineers to improve prompts, tools, agent loops, memory systems, scoring systems, and model-routing strategies.
- Produce clear technical reports with evidence, reproduction steps, impact analysis, and remediation guidance.
Requirements
- 3+ years of hands-on cybersecurity experience in vulnerability research, penetration testing, exploit development, reverse engineering, or security engineering.
- Practical experience with at least two of:
- Static analysis
- Dynamic analysis
- Binary exploitation
- Web application security
- Network penetration testing
- Cloud/container security
- Malware analysis or reverse engineering
- Detection engineering
- Strong Python skills and comfort building automation around security tools
- Familiarity with Linux, Docker, Kali/security tooling, Git, CI, and shell workflows
- Ability to reason from vulnerability signal to exploitability, impact, evidence quality, and remediation
- Experience working with LLMs, agents, prompt engineering, evals, or AI-assisted security workflows
- Strong written communication skills for technical findings, customer-facing reports, and internal research notes
- Clear judgment around authorization, responsible disclosure, and dual-use security tooling
Nice-to-haves
- Experience with Ghidra, IDA, Binary Ninja, angr, Semgrep, CodeQL, Joern, AFL++, libFuzzer, ASan/UBSan, or OSS-Fuzz
- Experience developing exploits for memory corruption, deserialization, auth bypass, SSRF, RCE, sandbox escape, or supply-chain vulnerabilities
- Experience with CVE reproduction, N-day analysis, patch diffing, or exploit validation
- Experience building LLM agents, tool-using systems, ReAct loops, eval harnesses, or synthetic-data pipelines
- Familiarity with SARIF, CVSS, CWE, MITRE ATT&CK, MITRE CVE workflows, HackerOne/Bugcrowd-style disclosure, or government security reporting
- Experience with Rust, Go, C/C++, or systems programming
- Prior work with security products, autonomous agents, fuzzing infrastructure, or government/security customers
Benefits
- Comprehensive benefits package, including health, dental, and vision insurance, as well as retirement savings plans
- Opportunities for growth and professional development
- A collaborative and supportive company culture that values diversity and inclusion
- Access to cutting-edge technology and resources for research and development
- Compensation (commensurate with experience): $180,000 - $200,000 (base salary) + equity
Preferred Locations: AZ, CA, CO, CT, DC, FL, KS, ME, MD, MA, MN, NV, NH, NJ, NM, NY, PA, SC, TX, VA, WA
Lazarus AI is an equal opportunity employer. We are committed to equal employment opportunity and nondiscrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. We do not tolerate discrimination or harassment of any kind. This applies to every aspect of employment at Lazarus, including, but not limited to, employment, training, promotion, demotion, transfer, leaves of absence and termination.
See All 51 Clinical Research Director Jobs in Boston
Find roles in Boston that match your experience and apply in just a few clicks.
Find JobsClinical Research Director Job Market in Boston
Who's Hiring
- Zoox7

- Whoop3

- PwC2

- Tempus AI2

- Veeva Systems2

Top Industries Hiring
- Technology & Software13
- Automotive7
- Science & Research6
- Insurance5
- Healthcare & Medical Services5
Clinical Research Director Jobs in Boston: Frequently Asked Questions
How do I get a clinical research director job in Boston?
Boston's clinical research director market is driven by its concentration of biopharma companies, academic medical centers, and contract research organizations, particularly in the Longwood Medical Area and Kendall Square. Candidates with hands-on trial management experience and a strong publication or regulatory submission record stand out. Familiarity with FDA submission processes and experience overseeing Phase II or Phase III trials gives applicants a clear edge in this market.
Which companies hire clinical research directors in Boston?
Boston clinical research director roles are posted by Zoox, Whoop, and PwC and others right now, based on current listings on Migrate Mate as of June 2026. The hiring pool includes large biopharma firms, academic hospital systems, and contract research organizations, all of which maintain active research pipelines and ongoing trial programs in the Boston area.
Are there remote clinical research director jobs in Boston?
Yes, though the role is mostly on-site given the hands-on oversight of active trials and site staff. About 44% of clinical research director openings tied to Boston are remote or hybrid as of June 2026, with the most flexibility typically found in strategic planning, regulatory writing, and vendor oversight responsibilities rather than day-to-day trial operations.
How can I get a clinical research director job in Boston with little or no experience?
The most realistic entry path in Boston is through a clinical research associate or senior CRA role at one of the city's contract research organizations or academic medical centers, such as those in the Longwood Medical Area. Building protocol management and site oversight experience there, then stepping into a clinical research manager position, is the local progression that most commonly leads to director-level roles at Boston-area biopharma and biotech employers.
Which industries hire the most clinical research directors in Boston?
The sectors hiring the most clinical research directors in Boston are Technology & Software, Automotive, and Science & Research, based on current listings on Migrate Mate as of June 2026. Boston's dense cluster of research hospitals, venture-backed biotech startups, and global biopharma headquarters makes it one of the most active markets in the country for this role across those sectors.
Related Jobs in Massachusetts
See All 51 Clinical Research Director Jobs in Boston
Find roles in Boston that match your experience and apply in just a few clicks.
Find Jobs