Senior Clinical Trial Manager Jobs in Massachusetts
Senior Clinical Trial Manager jobs in Massachusetts are in high demand, concentrated in the biotechnology, pharmaceutical, and academic medical center sectors, with openings ranging from newly promoted managers through veteran global trial leads. The greatest concentration of hiring is in and around Boston, Cambridge, and Worcester, where established employers like Pfizer, Biogen, and Massachusetts General Hospital Brigham run large-scale clinical operations. The most consistently sought specialties are oncology trial management, rare disease studies, and multi-site Phase II and III oversight. Find a role that fits below and apply directly.
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Showing 4 of 32+ Senior Clinical Trial Manager jobs
About This Role
The Senior Manager, Clinical Trial Lead (CTL) is responsible for leading the operational planning, execution, and delivery of one or more clinical studies across the development lifecycle. This role manages study timelines, budgets, CRO and vendor partnerships, risk mitigation, and cross-functional collaboration through leadership of the Study Management Team (SMT). Key objectives include delivering studies on time, within budget, and in compliance with GCP, regulatory requirements, and quality standards while ensuring patient safety and data integrity. Acting as the central operational leader, the CTL drives protocol feasibility, study execution, and informed decision-making across stakeholders. The role brings value by ensuring operational excellence, proactive issue management, and successful study delivery that advances development program goals. As a core member of Clinical Operations, the CTL partners closely with Medical, Biostatistics, Regulatory, Data Management, and external partners to support broader program and asset strategies.
What You’ll Do:
- Lead the operational planning, execution, and delivery of one or more clinical studies.
- Chair the Study Management Team (SMT) and drive cross-functional study execution.
- Partner with Medical, Biostatistics, Regulatory, and other stakeholders to develop operationally feasible protocols and study strategies.
- Evaluate study feasibility and develop comprehensive operational, monitoring, quality, and risk management plans.
- Manage study timelines, budgets, forecasts, and governance deliverables to ensure on-time, on-budget execution.
- Identify, assess, and mitigate operational risks while maintaining patient safety, data integrity, and regulatory compliance.
- Oversee CROs, vendors, and outsourced partnerships, ensuring performance, milestone achievement, and effective issue resolution.
- Monitor study performance and conduct ongoing data reviews to identify and address quality, safety, or execution issues.
- Maintain accurate, inspection-ready study documentation and data within clinical trial management systems.
- Champion process improvements, operational excellence, and best practices across studies and development programs.
Who You Are:
You are a clinical operations leader who drives the successful planning, execution, and delivery of complex clinical trials, expertly managing timelines, budgets, CRO partnerships, risks, and cross-functional teams while maintaining the highest standards of quality, compliance, patient safety, and data integrity.
You thrive in a fast-paced development environment, leveraging your clinical trial management expertise, strategic problem-solving skills, and collaborative leadership style to ensure studies are delivered on time, within budget, and aligned with broader program objectives.
Required Skills
- Bachelors degree in a scientific discipline
- 6 + years in clinical operations management, overseeing outsourced clinical trials per quality, timeline, and budget expectations, preferably with a sponsor company and a CRO
- Scientific and clinical expertise with strong project management, risk assessment, contingency planning, and communication skills.
- Working knowledge of clinical development across Phase I-IV studies and cross-functional drug development.
- Demonstrated experience managing CROs, vendors, and outsourced clinical trials, including governance, performance oversight, budgets, quality, and outsourcing strategies.
- Expertise in GCP, ICH guidelines, and global regulatory requirements for clinical development.
- Proven ability to develop and execute operational plans that support successful clinical trial delivery.
Preferred Skills
- Experience in Immunology, Rare Disease, or Neurology
This position can be based in either Cambridge, MA or RTP, NC. The pay range posted encompasses the pay range for both potential work locations. Actual pay will be determined by the selected candidate’s work location, as well as relevant experience and qualifications.
Job Level: Management
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
About This Role
The Senior Manager, Clinical Trial Lead (CTL) is responsible for leading the operational planning, execution, and delivery of one or more clinical studies across the development lifecycle. This role manages study timelines, budgets, CRO and vendor partnerships, risk mitigation, and cross-functional collaboration through leadership of the Study Management Team (SMT). Key objectives include delivering studies on time, within budget, and in compliance with GCP, regulatory requirements, and quality standards while ensuring patient safety and data integrity. Acting as the central operational leader, the CTL drives protocol feasibility, study execution, and informed decision-making across stakeholders. The role brings value by ensuring operational excellence, proactive issue management, and successful study delivery that advances development program goals. As a core member of Clinical Operations, the CTL partners closely with Medical, Biostatistics, Regulatory, Data Management, and external partners to support broader program and asset strategies.
What You’ll Do:
- Lead the operational planning, execution, and delivery of one or more clinical studies.
- Chair the Study Management Team (SMT) and drive cross-functional study execution.
- Partner with Medical, Biostatistics, Regulatory, and other stakeholders to develop operationally feasible protocols and study strategies.
- Evaluate study feasibility and develop comprehensive operational, monitoring, quality, and risk management plans.
- Manage study timelines, budgets, forecasts, and governance deliverables to ensure on-time, on-budget execution.
- Identify, assess, and mitigate operational risks while maintaining patient safety, data integrity, and regulatory compliance.
- Oversee CROs, vendors, and outsourced partnerships, ensuring performance, milestone achievement, and effective issue resolution.
- Monitor study performance and conduct ongoing data reviews to identify and address quality, safety, or execution issues.
- Maintain accurate, inspection-ready study documentation and data within clinical trial management systems.
- Champion process improvements, operational excellence, and best practices across studies and development programs.
Who You Are:
You are a clinical operations leader who drives the successful planning, execution, and delivery of complex clinical trials, expertly managing timelines, budgets, CRO partnerships, risks, and cross-functional teams while maintaining the highest standards of quality, compliance, patient safety, and data integrity.
You thrive in a fast-paced development environment, leveraging your clinical trial management expertise, strategic problem-solving skills, and collaborative leadership style to ensure studies are delivered on time, within budget, and aligned with broader program objectives.
Required Skills
- Bachelors degree in a scientific discipline
- 6 + years in clinical operations management, overseeing outsourced clinical trials per quality, timeline, and budget expectations, preferably with a sponsor company and a CRO
- Scientific and clinical expertise with strong project management, risk assessment, contingency planning, and communication skills.
- Working knowledge of clinical development across Phase I-IV studies and cross-functional drug development.
- Demonstrated experience managing CROs, vendors, and outsourced clinical trials, including governance, performance oversight, budgets, quality, and outsourcing strategies.
- Expertise in GCP, ICH guidelines, and global regulatory requirements for clinical development.
- Proven ability to develop and execute operational plans that support successful clinical trial delivery.
Preferred Skills
- Experience in Immunology, Rare Disease, or Neurology
This position can be based in either Cambridge, MA or RTP, NC. The pay range posted encompasses the pay range for both potential work locations. Actual pay will be determined by the selected candidate’s work location, as well as relevant experience and qualifications.
Job Level: Management
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
See All 32 Senior Clinical Trial Manager Jobs in Massachusetts
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Find JobsSenior Clinical Trial Manager Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Senior Clinical Trial Manager Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Science & Research
What Massachusetts Employers Look For
The qualifications that appear most often in senior clinical trial manager jobs across Massachusetts.
- Bachelor's degree in life sciences, nursing, or a related clinical field required
- Minimum five years of clinical trial management experience with multi-site oversight
- Demonstrated knowledge of ICH E6 Good Clinical Practice guidelines and FDA regulations
- Experience managing CROs, site contracts, and budgets across complex trial portfolios
- Proficiency with electronic data capture systems such as Medidata Rave or Veeva Vault
- Strong cross-functional leadership skills coordinating medical, regulatory, and operational teams
Senior Clinical Trial Manager Jobs in Massachusetts: Frequently Asked Questions
How do you become a senior clinical trial manager in Massachusetts?
Most senior clinical trial managers in Massachusetts hold a bachelor's degree in a life science, nursing, or allied health field, though many employers prefer a master's degree or advanced clinical background. There is no Massachusetts state license specific to clinical trial management, but the clinical research field widely recognizes the Certified Clinical Research Professional credential from the Society of Clinical Research Associates. Massachusetts employers typically promote candidates who have managed Phase II or III multi-site studies and have direct oncology or rare disease experience.
Which companies hire senior clinical trial managers in Massachusetts?
Employers hiring senior clinical trial managers in Massachusetts right now include Centessa Pharmaceuticals, Vision Source, and Kymera Therapeutics, based on current listings on Migrate Mate as of October 2026. Massachusetts's dense concentration of biopharma headquarters and academic medical centers means hiring is active year-round, with particularly strong demand from companies running oncology and rare disease pipelines out of the Greater Boston and Cambridge corridors.
Which Massachusetts cities have the most senior clinical trial manager jobs?
The cities with the most senior clinical trial manager openings in Massachusetts are Boston, Cambridge, and Watertown. Boston and Cambridge together anchor the state's biopharma and academic medical center ecosystem, generating the majority of postings, while Worcester draws hiring from UMass Memorial Health and nearby biomanufacturing operations that support active trial portfolios.
Are there remote senior clinical trial manager jobs in Massachusetts?
Yes, and more than most clinical roles, because senior clinical trial managers spend significant time coordinating remotely with sites, CROs, and sponsors rather than conducting hands-on patient procedures. About 94% of senior clinical trial manager openings tied to Massachusetts are remote or hybrid as of October 2026, reflecting how heavily this role relies on documentation, vendor oversight, and cross-functional communication. Protocol development, site monitoring oversight, and regulatory coordination are the functions most commonly performed remotely.
How can I get hired as a senior clinical trial manager in Massachusetts with little or no experience?
The most realistic entry path is starting as a clinical trial coordinator or clinical research associate at a Massachusetts academic medical center or sponsor company, then building toward a manager role through a series of progressively larger studies. Boston-area institutions like Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Massachusetts General Hospital Brigham run structured research coordinator programs that give early-career candidates direct trial exposure. Earning the Certified Clinical Research Associate credential and gaining experience with electronic data capture platforms strengthens a candidate's profile considerably for that first manager promotion.
Where can I find and apply to senior clinical trial manager jobs in Massachusetts?
You can find and apply to senior clinical trial manager jobs in Massachusetts on Migrate Mate, which lists current Massachusetts openings updated regularly. Find roles that match your experience and specialization and apply directly to the employers posting them.
See All 32 Senior Clinical Trial Manager Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
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