Clinical Operations Director Jobs in Massachusetts
Clinical Operations Director jobs in Massachusetts are among the most active in the country, concentrated in biopharma, academic medical centers, and health system administration across a range from senior manager to executive director. Boston, Cambridge, and Worcester anchor most of the hiring, with major employers such as Mass General Brigham, Biogen, and Dana-Farber Cancer Institute maintaining consistent demand. The most in-demand specialties right now are oncology trial operations, decentralized study management, and integrated health system oversight. Find a role that fits below and apply directly.
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Showing 5 of 18+ Clinical Operations Director jobs
Why Sarepta? Why Now?
Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne Muscular Dystrophy and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. Our next-generation siRNA platform is focused on chronically administered therapies for neurodegenerative and pulmonary diseases.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. Additionally, the candidate will work with early research and other stakeholders to build out the oversight model for Feasibility & Study Start-up. The candidate will drive the study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for 1) directing and overseeing the success of Sarepta’s clinical trial feasibility process, 2) leading the development of feasibility and start-up strategies including study-specific plans, 3) directing and overseeing the success of the Sarepta’s clinical trial start-up activities, 4) and working with both internal and external vendors.
This is a highly cross-functional position, collaborating with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
The Opportunity to Make a Difference
Primary Responsibilities Include:
- Develop and implement the feasibility and start-up strategies to support the success of Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study specific meeting series to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO. The candidate will report metrics to larger teams including senior management.
- Lead calls with Sarepta and the CRO to manage feasibility and study start-up activities and ensure the study timelines are achieved.
- Oversee study feasibility activities including country, site, and investigator selection for participation in Sarepta-lead studies.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentoring to junior members of the Study Start-up and Feasibility Team.
- Create reporting tools to measure ongoing activities and other key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations and CRO teams, and other key stakeholders to implement innovative feasibility efforts including collection of data within CTMS.
- Support and or lead the development of Charters or SOPs as it relates to Study Start-up and Feasibility.
- May have direct reports.
More about You
Desired Education and Skills:
- BA / BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs.
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
#LI-Hybrid This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time. The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
Why Sarepta? Why Now?
Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne Muscular Dystrophy and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. Our next-generation siRNA platform is focused on chronically administered therapies for neurodegenerative and pulmonary diseases.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. Additionally, the candidate will work with early research and other stakeholders to build out the oversight model for Feasibility & Study Start-up. The candidate will drive the study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for 1) directing and overseeing the success of Sarepta’s clinical trial feasibility process, 2) leading the development of feasibility and start-up strategies including study-specific plans, 3) directing and overseeing the success of the Sarepta’s clinical trial start-up activities, 4) and working with both internal and external vendors.
This is a highly cross-functional position, collaborating with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
The Opportunity to Make a Difference
Primary Responsibilities Include:
- Develop and implement the feasibility and start-up strategies to support the success of Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study specific meeting series to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO. The candidate will report metrics to larger teams including senior management.
- Lead calls with Sarepta and the CRO to manage feasibility and study start-up activities and ensure the study timelines are achieved.
- Oversee study feasibility activities including country, site, and investigator selection for participation in Sarepta-lead studies.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentoring to junior members of the Study Start-up and Feasibility Team.
- Create reporting tools to measure ongoing activities and other key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations and CRO teams, and other key stakeholders to implement innovative feasibility efforts including collection of data within CTMS.
- Support and or lead the development of Charters or SOPs as it relates to Study Start-up and Feasibility.
- May have direct reports.
More about You
Desired Education and Skills:
- BA / BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs.
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
#LI-Hybrid This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time. The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
See All 18 Clinical Operations Director Jobs in Massachusetts
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Find JobsClinical Operations Director Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Clinical Operations Director Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Science & Research
What Massachusetts Employers Look For
The qualifications that appear most often in clinical operations director jobs across Massachusetts.
- Bachelor's degree in health sciences, nursing, or a related clinical field required
- Minimum five to eight years of progressive clinical operations or research management experience
- Demonstrated leadership of cross-functional clinical teams across multiple concurrent programs
- Working knowledge of ICH-GCP guidelines, FDA regulations, and IRB submission processes
- Experience managing clinical trial budgets, vendor contracts, and CRO relationships
- Strong proficiency with clinical trial management systems such as Medidata or Veeva Vault
Clinical Operations Director Jobs in Massachusetts: Frequently Asked Questions
How do you become a clinical operations director in Massachusetts?
Most clinical operations directors in Massachusetts reach the role by combining a clinical or life sciences degree with progressive experience managing trials or healthcare programs. While Massachusetts does not require a state-issued license specific to this title, many employers strongly prefer candidates who hold credentials such as the ACRP Certified Clinical Research Professional or the SOCRA CCRP. Starting in coordinator or manager roles at Boston-area academic medical centers, hospital systems, or biopharma companies is the most reliable path.
Which companies hire clinical operations directors in Massachusetts?
Employers hiring clinical operations directors in Massachusetts right now include Amylyx Pharmaceuticals, Takeda Pharmaceuticals, and CSL, based on current listings on Migrate Mate as of October 2026. Massachusetts's concentration of biopharma headquarters and large academic health systems means demand is relatively steady year-round compared with most other states.
Which Massachusetts cities have the most clinical operations director jobs?
Boston, Cambridge, and Waltham account for the most clinical operations director openings in Massachusetts. Boston and Cambridge dominate because they host the state's largest hospital networks and a dense cluster of biopharma and biotech headquarters, while Worcester's UMass Memorial Health and Saint Vincent Hospital drive meaningful demand in the central part of the state.
Are there remote clinical operations director jobs in Massachusetts?
Yes, but they are selective. About 78% of clinical operations director openings tied to Massachusetts are remote or hybrid as of October 2026, reflecting the mixed nature of the role. Strategic oversight, vendor management, and reporting functions often accommodate remote work, while site monitoring, investigator meetings, and hands-on program leadership typically require an on-site or hybrid presence.
How can I get hired as a clinical operations director in Massachusetts with little or no experience?
The most realistic entry path is through a clinical research coordinator or operations specialist role at a Massachusetts academic medical center or biopharma company, then building toward a manager title before targeting director-level openings. Mass General Brigham, Dana-Farber, and Boston Children's Hospital all run structured research career development programs that support upward movement. Earning a CCRP or CCRC credential early strengthens applications considerably, and lateral moves from regulatory affairs or project management are common at many Cambridge-based biotechs.
Where can I find and apply to clinical operations director jobs in Massachusetts?
You can find and apply to clinical operations director jobs in Massachusetts on Migrate Mate, which lists current Massachusetts openings updated regularly. Find roles that fit your experience and apply directly to each one without creating a profile or going through a third-party platform.
See All 18 Clinical Operations Director Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
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