Clinical Operations Director Jobs in California

Clinical Operations Director jobs in California are among the most active in the country, concentrated in biotechnology, pharmaceutical development, academic medical centers, and large integrated health systems, with openings at every level from newly promoted manager stepping into first director roles through seasoned executives overseeing multi-site programs. Los Angeles, San Francisco Bay Area, and San Diego account for the largest share of postings, anchored by employers such as Kaiser Permanente, Cedars-Sinai Health System, and Genentech. The most in-demand specialties in California are clinical trial operations, value-based care program management, and ambulatory care expansion. Find a role that fits below and apply directly.

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Overview

Open roles34
Top employerRevolution Medicines
Top cityRedwood City, CA
Cities hiring20
Work type53% On-site
Top industryBiotechnology

Showing 5 of 34+ Clinical Operations Director jobs

Executive Director Clinical Operations, Humboldt
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New 6h ago
Executive Director Clinical Operations, Humboldt
Providence
Santa Rosa, California
Business Strategy
Corporate Development & M&A
Growth Marketing
$95.99 - $171.6/hr
Master's degree in business administration
10,000+

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Director, Clinical Operations
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Added 3d ago
Director, Clinical Operations
Tr1x
San Diego, California
Executive Leadership & C-Suite
Program Management
Project Management
$210k - $230k/yr
Bachelor's degree

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Director, Clinical Operations
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Added 4d ago
Director, Clinical Operations
Revolution Medicines
Redwood City, California
Biotech & Life Sciences
Clinical Trials
Research & Academia
$211k - $264k/yr
Master's degree
11-50

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Senior Director, Clinical Operations Oncology
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Added 5d ago
Senior Director, Clinical Operations Oncology
Vir Biotechnology
San Francisco, California
Compensation & Benefits
Human Resources
Human Resources (HR) — Generalist
Learning & Development
$236k - $329k/yr
Hybrid
Bachelor's degree
501-1,000

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Clinical Operations Director RN, Hospice
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Added 5d ago
Clinical Operations Director RN, Hospice
AccentCare
El Centro, California
Clinical Support
Healthcare Administration
Human Resources
$145k - $165k/yr
Bachelor's degree
10,000+

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See All 34 Clinical Operations Director Jobs in California

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Clinical Operations Director Jobs by City in California

Where California roles are concentrated, by current openings.

Redwood City
5 jobs
San Diego
4 jobs
Alameda
3 jobs
South San Francisco
3 jobs
Los Gatos
2 jobs
Santa Rosa
2 jobs
San Francisco
2 jobs
Irvine
1 job
Fremont
1 job

Clinical Operations Director Job Market in California

A snapshot from current California openings, updated as new roles post.

Who's Hiring

Revolution Medicines4 open roles
Exelixis3 open roles
Providence3 open roles

Top Industries Hiring

  • Biotechnology & Pharmaceuticals
  • Medical Devices
  • Healthcare & Medical Services

What California Employers Look For

The qualifications that appear most often in clinical operations director jobs across California.

  • Bachelor's degree in nursing, health administration, or a related clinical field required
  • Minimum five to seven years of progressive clinical or healthcare operations management experience
  • Demonstrated experience managing multi-site or multi-department clinical programs in California settings
  • Proficiency with electronic health record systems such as Epic or Cerner
  • Knowledge of California Department of Public Health regulations and Joint Commission accreditation standards
  • Master's degree in health administration, business administration, or clinical specialty strongly preferred

Clinical Operations Director Jobs in California: Frequently Asked Questions

How do you become a clinical operations director in California?

Most clinical operations directors in California build toward the role through a combination of a bachelor's degree in a clinical or health administration field, several years of frontline clinical or operational experience, and progressive management responsibility. Many California employers, particularly large health systems and biotech firms, prefer candidates with a master's in health administration or business administration. Credentials such as a Fellow of the American College of Healthcare Executives or a Project Management Professional designation strengthen applications considerably in the California market.

Which companies hire clinical operations directors in California?

Employers hiring clinical operations directors in California right now include Revolution Medicines, Exelixis, and Providence, based on current listings on Migrate Mate as of October 2026. California's concentration of integrated health systems, academic medical centers, and biotechnology headquarters means hiring is spread across both traditional hospital employers and life sciences companies managing clinical trial operations.

Which California cities have the most clinical operations director jobs?

Redwood City, San Diego, and Alameda have the most clinical operations director openings in California. The Bay Area and Los Angeles dominate because of their density of large health systems, biotech and pharmaceutical headquarters, and academic medical centers, while San Diego draws consistent demand from its established life sciences corridor, particularly among companies managing multi-site clinical trial programs.

Are there remote clinical operations director jobs in California?

Yes, but they are less common than in purely desk-based fields, since clinical operations directors often oversee on-site teams, facility compliance, and patient care workflows that require regular physical presence. About 47% of clinical operations director openings tied to California are remote or hybrid as of October 2026, and those that are tend to involve clinical trial oversight, program development, or administrative functions that can be managed without daily on-site attendance.

How can I get hired as a clinical operations director in California with little or no experience?

The most realistic path is moving into a clinical operations manager or program coordinator role first, which large California health systems such as Kaiser Permanente and Dignity Health regularly post as a step below director level. Gaining experience in quality improvement, care coordination, or ambulatory operations gives you the cross-functional exposure California employers look for when promoting to director. Completing a master's in health administration through a California institution and pursuing a healthcare management certification can offset limited direct leadership experience for strong internal candidates.

Where can I find and apply to clinical operations director jobs in California?

You can find and apply to clinical operations director jobs in California on Migrate Mate, which lists current California openings updated regularly. Find the roles that fit your background and apply directly to each one.

See All 34 Clinical Operations Director Jobs in California

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