Clinical Operations Director Jobs
Clinical Operations Director jobs are open across pharmaceuticals, medical devices, contract research organizations, and health systems, at levels from associate director to VP, with specializations in clinical trial management, regulatory affairs, and site operations. Find a role that fits from the openings below and apply directly.
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Showing 4 of 202+ Clinical Operations Director jobs
Director of Site Operations-Clinical Research
Put your talents to work at PCM! Whether you work in our Home Care, Clinical Research, Impairments, or Catastrophic Care division, you will support our mission to deliver care and other services that enhance the quality of life of our clients. Be a part of our dynamic client-focused team and make a difference in your career!
The Director Site Operations will have line management responsibility for the personnel at the sites assigned to them ensuring the clinical conduct at the site is being performed according to protocol requirements, local regulations and as delegated by the site principal investigator. This position will employ skills in community-based research and develop innovative site solutions that reach and operate in the heart of the community, supporting our commitment to diversity and inclusion in research, through analysis, experience and strategic solutioning. As Site Director you will promote a healthy, collaborative, and open culture environment at our sites as well as with the larger company.
Qualifications
- Bachelor's degree in health research, public health, or science or a related field
- Five or more years of experience in the clinical research industry or equivalent.3 or more years supervising a team
- Excellent communication skills, demonstrated effective spoken and written communication, including willingness to ask questions when clarification or amplification is required
- Ability to cascade initiatives to site teams and ensure adaptation as well as success of the initiative.
- Demonstrated attention to detail and ability to adhere to instructions/procedures
- Good time management skills; efficient and resourceful in problem-solving
- Demonstrated ability to take ownership of the work, possess initiative, good follow-through; ability to work without supervision.
- Ability to receive and benefit from feedback; willingness to expand skill set and improve
- Flexibility in adapting to new procedures and environments
- Ability to work in a team environment
- Familiarity with research/data collection software
Essential Functions/Areas of Accountability
Community Site Leadership & Management
- Champion and take pride in your assigned research sites and communities internally and externally.
- Invest time in your site teams to hire and build a healthy, compliant, high-performance culture.
- Ensure sites are resourced with appropriated trained, experienced and licensed staff to enable trial conduct
- In collaboration with other Site Directors, ensure adequate back-up and cross licensed staffing to provide coverage for absence, securing the ability to deliver projects
- Maintain relationships with leaseholders to ensure effective collaboration and security of community site locations
- Ensure your site teams set clear personal and business goals, conducting reviews to foster a culture of collaboration, continuous improvement, and personal development.
- Capacity management of research site, collaborating cross functionally with leadership, sales, and fleet.
- Ensure patient experience and community engagement is at the heart of your research site teams.
- Train and mentor, your research staff and teams.
- Hold regular cross-site briefings to share experience, lessons learned and update on targets. Be physically present with your teams on a regular basis:
- Attend Site tours, PSVs, SIVs, COV's and where applicable, monitoring visits
- Conduct site visits and reviews to support, coach, and evaluate needs
- Attend site audits and inspections.
- Ensure effective collaboration between your research teams, the Principal Investigator, Patient Engagement, Regulatory, Project Management and Fleet teams to delivery compliant and coordinated community research whilst mitigating risk
- Provide support to QA in all facets of work related to communications with and management of the site clinical teams
- Perform site self-audits and monitor performance and productivity of assigned sites
Clinical Trial Management
- Support your sites in the attraction, consenting, and retention of clinical trial participants.
- Act as a primary point of contact for Project Managers for matters pertaining to your site
- Manage and develop CRCs to ensure they provide effective protocol training, system training, and study specific support to the research sites.
- Collaborate with patient recruitment to ensure project timelines are met and offer support as needed
- Monitor study randomization plans, patient retention, data completion, and overall compliance; take corrective action where appropriate - often by cross functional collaboration.
- Address CAPAs in an open and expediated fashion.
- Monitor study inventory usage and approve resupply requests
- Be in open communication with Project Management team to solve for how client supply chain management and decision-making impacts delivery at sites
- Customer point of escalation, per study communication plan
- Will serve as liaison between project stakeholders and leadership and maintain professional documentation for projects and deliverables
- Stay current with constantly changing clinical research technology and embrace innovation
Financial Management
- Accountable for assigned research site P&L
- Forecast monthly enrollment goals, in collaboration with Project Management.
- Monitor performance on a daily and weekly basis to ensure monthly targets are achieved.
- Forecast site resource needs and set staffing models to achieve customer delivery
- Monitor Site inventory usage and approve resupply requests.
- Requires high degree of independent action and adherence to competitive timelines
Individual base pay depends on various factors, in addition to primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience, skills and other market-based factors.
Available Benefits Include
- Medical
- Dental
- Vision
- 401(k)
- Company Paid Short Term Disability
- Flexible Spending Account (FSA)
- Health Savings Account (HSA)
- Paid Time Off
- Voluntary Benefits
Professional Case Management is an Equal Opportunity Employer.
Director of Site Operations-Clinical Research
Put your talents to work at PCM! Whether you work in our Home Care, Clinical Research, Impairments, or Catastrophic Care division, you will support our mission to deliver care and other services that enhance the quality of life of our clients. Be a part of our dynamic client-focused team and make a difference in your career!
The Director Site Operations will have line management responsibility for the personnel at the sites assigned to them ensuring the clinical conduct at the site is being performed according to protocol requirements, local regulations and as delegated by the site principal investigator. This position will employ skills in community-based research and develop innovative site solutions that reach and operate in the heart of the community, supporting our commitment to diversity and inclusion in research, through analysis, experience and strategic solutioning. As Site Director you will promote a healthy, collaborative, and open culture environment at our sites as well as with the larger company.
Qualifications
- Bachelor's degree in health research, public health, or science or a related field
- Five or more years of experience in the clinical research industry or equivalent.3 or more years supervising a team
- Excellent communication skills, demonstrated effective spoken and written communication, including willingness to ask questions when clarification or amplification is required
- Ability to cascade initiatives to site teams and ensure adaptation as well as success of the initiative.
- Demonstrated attention to detail and ability to adhere to instructions/procedures
- Good time management skills; efficient and resourceful in problem-solving
- Demonstrated ability to take ownership of the work, possess initiative, good follow-through; ability to work without supervision.
- Ability to receive and benefit from feedback; willingness to expand skill set and improve
- Flexibility in adapting to new procedures and environments
- Ability to work in a team environment
- Familiarity with research/data collection software
Essential Functions/Areas of Accountability
Community Site Leadership & Management
- Champion and take pride in your assigned research sites and communities internally and externally.
- Invest time in your site teams to hire and build a healthy, compliant, high-performance culture.
- Ensure sites are resourced with appropriated trained, experienced and licensed staff to enable trial conduct
- In collaboration with other Site Directors, ensure adequate back-up and cross licensed staffing to provide coverage for absence, securing the ability to deliver projects
- Maintain relationships with leaseholders to ensure effective collaboration and security of community site locations
- Ensure your site teams set clear personal and business goals, conducting reviews to foster a culture of collaboration, continuous improvement, and personal development.
- Capacity management of research site, collaborating cross functionally with leadership, sales, and fleet.
- Ensure patient experience and community engagement is at the heart of your research site teams.
- Train and mentor, your research staff and teams.
- Hold regular cross-site briefings to share experience, lessons learned and update on targets. Be physically present with your teams on a regular basis:
- Attend Site tours, PSVs, SIVs, COV's and where applicable, monitoring visits
- Conduct site visits and reviews to support, coach, and evaluate needs
- Attend site audits and inspections.
- Ensure effective collaboration between your research teams, the Principal Investigator, Patient Engagement, Regulatory, Project Management and Fleet teams to delivery compliant and coordinated community research whilst mitigating risk
- Provide support to QA in all facets of work related to communications with and management of the site clinical teams
- Perform site self-audits and monitor performance and productivity of assigned sites
Clinical Trial Management
- Support your sites in the attraction, consenting, and retention of clinical trial participants.
- Act as a primary point of contact for Project Managers for matters pertaining to your site
- Manage and develop CRCs to ensure they provide effective protocol training, system training, and study specific support to the research sites.
- Collaborate with patient recruitment to ensure project timelines are met and offer support as needed
- Monitor study randomization plans, patient retention, data completion, and overall compliance; take corrective action where appropriate - often by cross functional collaboration.
- Address CAPAs in an open and expediated fashion.
- Monitor study inventory usage and approve resupply requests
- Be in open communication with Project Management team to solve for how client supply chain management and decision-making impacts delivery at sites
- Customer point of escalation, per study communication plan
- Will serve as liaison between project stakeholders and leadership and maintain professional documentation for projects and deliverables
- Stay current with constantly changing clinical research technology and embrace innovation
Financial Management
- Accountable for assigned research site P&L
- Forecast monthly enrollment goals, in collaboration with Project Management.
- Monitor performance on a daily and weekly basis to ensure monthly targets are achieved.
- Forecast site resource needs and set staffing models to achieve customer delivery
- Monitor Site inventory usage and approve resupply requests.
- Requires high degree of independent action and adherence to competitive timelines
Individual base pay depends on various factors, in addition to primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience, skills and other market-based factors.
Available Benefits Include
- Medical
- Dental
- Vision
- 401(k)
- Company Paid Short Term Disability
- Flexible Spending Account (FSA)
- Health Savings Account (HSA)
- Paid Time Off
- Voluntary Benefits
Professional Case Management is an Equal Opportunity Employer.
Clinical Operations Director Jobs by Experience Level
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Find JobsClinical Operations Director Job Market
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services17
- Biotechnology & Pharmaceuticals17
- Science & Research7
- Education6
- Consulting & Professional Services4
What Employers Look For
The qualifications that appear most often in clinical operations director jobs.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- Extensive experience managing Phase I through Phase IV clinical trials end to end
- Deep knowledge of ICH-GCP guidelines, FDA regulations, and applicable international standards
- Proven experience selecting, overseeing, and managing contract research organizations
- Proficiency with electronic data capture systems such as Medidata Rave or Veeva Vault
- Strong cross-functional leadership and budget management experience across global clinical programs
Tips for Your Clinical Operations Director Job Search
Quantify trial oversight on your resume
Clinical operations director candidates who list the number of trials managed, therapeutic areas covered, and team sizes supervised stand out immediately. Hiring managers look for concrete scope, not vague leadership language, so replace phrases like 'oversaw clinical programs' with specific deliverables.
Highlight your ICH-GCP and regulatory fluency
Most job postings require hands-on knowledge of ICH-GCP guidelines, FDA regulations, and at minimum one electronic data capture system. Call these out explicitly in your resume's skills section rather than burying them in job descriptions, where reviewers often miss them.
Target openings by therapeutic area, not just title
Clinical operations directors hired in oncology, rare disease, or CNS trials often need therapy-specific protocol experience. Search by therapeutic area alongside the job title to find openings where your background maps cleanly to what the hiring team actually needs.
Apply early to roles that fit
Migrate Mate lists clinical operations director openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare to discuss budget and vendor management
Interviews at the director level almost always include questions about CRO selection, contract negotiations, and budget oversight. Come ready with a specific example of a vendor relationship you managed, including how you handled performance issues or scope changes mid-trial.
Negotiate start date around study timelines
Clinical operations directors who join mid-study face immediate pressure on deliverables. If you're switching roles, ask where a program stands in its lifecycle before accepting an offer so you can negotiate a start date that gives you adequate onboarding time.
Clinical Operations Director Jobs: Frequently Asked Questions
Which companies are hiring the most clinical operations directors?
The companies hiring the most clinical operations directors right now include Revolution Medicines, Takeda Pharmaceuticals, and Hill Valley Health Care, with the largest share of openings in California, Massachusetts, and Texas, based on current listings on Migrate Mate as of August 2026. Demand is concentrated in pharmaceutical companies, contract research organizations, and large health systems running active clinical programs.
How many clinical operations director jobs are remote?
About 40% of clinical operations director openings are fully remote or hybrid as of August 2026, reflecting the role's heavy reliance on digital trial infrastructure and cross-site coordination. Sub-areas like CRO oversight, regulatory operations, and quality management tend to offer the most remote flexibility, while roles tied to a specific research site or hospital system more often require on-site presence.
How do you become a clinical operations director?
Most clinical operations directors start in clinical research coordinator or clinical research associate roles, building direct trial execution experience before moving into project management and then program leadership. Earning credentials such as the ACRP Certified Clinical Research Professional designation strengthens your profile. Progressively managing larger trial portfolios, therapeutic areas, and CRO relationships is the clearest path to the director level.
Can you get hired as a clinical operations director with limited director-level experience?
Yes, candidates who have managed full trial lifecycles as a senior manager or associate director can move into a clinical operations director role, especially at smaller biotech companies or startups with lean leadership teams. Demonstrating that you've owned budget accountability, CRO contracts, and cross-functional team leadership, even without the formal title, is more persuasive to most hiring teams than title alone.
What does the clinical operations director interview process look like?
The process typically opens with an HR or talent acquisition screen focused on background and seniority fit, followed by a panel interview with clinical development leadership, regulatory, and sometimes finance stakeholders. Candidates are usually asked to walk through a complex trial they managed end to end and to address a scenario involving a CRO performance problem or a protocol deviation. A final round may include a brief strategic exercise or executive presentation.
Where can I find and apply to clinical operations director jobs?
You can find and apply to clinical operations director jobs on Migrate Mate, which lists current openings from across the United States. Find roles that fit your background and apply directly to each listing from the same place, without having to track openings across multiple sources.
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