Clinical Operations Director Jobs
Clinical Operations Director jobs are open across pharmaceuticals, medical devices, contract research organizations, and health systems, at levels from associate director to VP, with specializations in clinical trial management, regulatory affairs, and site operations. Find a role that fits from the openings below and apply directly.
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Showing 5 of 65+ Clinical Operations Director jobs
Director Clinical Operations
Location: Burr Ridge, IL
Position: Hospice Director of Clinical Operations Registered Nurse
Job ID: 2026-87664
Remote/Virtual Position: No
Coverage Area: South Chicagoland - Chicago south and southwest suburbs, Aurora, Naperville, MacNeal
Find Your Passion and Purpose as a Director of Clinical Operations
Salary: $120,000 - $140,000 / year
Schedule: M-F / Limited On call support as needed
Competitive Health Benefits
- Generous PTO, Matching 401k
- Mileage Reimbursement
IL RN License Required
Inpatient Center or recent hospital/Acute Care setting experience as a floor manager strongly preferred
Caring for others is more than what you do — it’s who you are. At AccentCare, you’ll join a purpose-driven, collaborative culture that sets the standard for excellence and gives you the trust and tools to do your best work. You’ll belong to a team that cares deeply for patients and each other; a team committed to consistently providing exceptional care. We’re proud to be named one of America’s Greatest Workplaces 2025 by Newsweek — a reflection of our shared commitment to excellence, integrity and compassion as we shape the future of aging in place. When you thrive, so does the community of care we’re building together.
If you meet these qualifications, we would love to meet you:
- Bachelor’s degree or commensurate work experience accepted
- 5 years of home based care experience preferred
- Role may require travel up to 80% of business days in supported territory
- Comprehensive knowledge of theories, concepts and practices and ability to use in complex, difficult and/or unprecedented situations
- Licensed to practice as a registered nurse in the state of agency operation
- Must be a licensed driver who can travel to all business locations
Responsibilities:
As a Director of Clinical Operations, you will:
- Supervise all direct patient/family care team members, including nurses, Supportive Care, home health aides and counselors, in collaboration with Site Leadership.
- Be responsible for oversight of and/or scheduling, payroll and other administrative duties.
- Assure that all initial assessments and required reassessments are conducted by qualified team members within required time frames, including documentation completion, submission and/or synchronization.
- Ensure that all patient/family services comply with federal, state(s) and local regulatory requirements and with accepted professional standards.
- Ensure protocols are utilized to guide operations and promote adherence to regulatory and internal process requirements.
- Monitor expenses related to patient/family services to ensure budgetary compliance in collaboration with IDG and Site Leadership.
- Serve as a resource person and liaison for the Social Worker, Volunteer, Music Therapy and Bereavement Departments.
Our benefits include:
- Medical, dental and vision coverage
- Paid time off and paid holidays
- Professional development opportunities
- Company-matching 401(k)
- Flexible spending and health savings accounts
- Wellness offerings such as an employee assistance program, pet insurance and access to Calm, a meditation, sleep and relaxation app
- Programs to celebrate achievements, milestones and fellow employees
- Company store credit for your first AccentCare-branded scrubs for patient-facing employees
- And more!
Come As You Are
At AccentCare, you’re part of a community that cares — for patients and each other. You can rest assured we offer equal employment opportunities regardless of race, ethnicity, sex, sexual orientation, gender identity, religion, national origin, age or disability.
Director Clinical Operations
Location: Burr Ridge, IL
Position: Hospice Director of Clinical Operations Registered Nurse
Job ID: 2026-87664
Remote/Virtual Position: No
Coverage Area: South Chicagoland - Chicago south and southwest suburbs, Aurora, Naperville, MacNeal
Find Your Passion and Purpose as a Director of Clinical Operations
Salary: $120,000 - $140,000 / year
Schedule: M-F / Limited On call support as needed
Competitive Health Benefits
- Generous PTO, Matching 401k
- Mileage Reimbursement
IL RN License Required
Inpatient Center or recent hospital/Acute Care setting experience as a floor manager strongly preferred
Caring for others is more than what you do — it’s who you are. At AccentCare, you’ll join a purpose-driven, collaborative culture that sets the standard for excellence and gives you the trust and tools to do your best work. You’ll belong to a team that cares deeply for patients and each other; a team committed to consistently providing exceptional care. We’re proud to be named one of America’s Greatest Workplaces 2025 by Newsweek — a reflection of our shared commitment to excellence, integrity and compassion as we shape the future of aging in place. When you thrive, so does the community of care we’re building together.
If you meet these qualifications, we would love to meet you:
- Bachelor’s degree or commensurate work experience accepted
- 5 years of home based care experience preferred
- Role may require travel up to 80% of business days in supported territory
- Comprehensive knowledge of theories, concepts and practices and ability to use in complex, difficult and/or unprecedented situations
- Licensed to practice as a registered nurse in the state of agency operation
- Must be a licensed driver who can travel to all business locations
Responsibilities:
As a Director of Clinical Operations, you will:
- Supervise all direct patient/family care team members, including nurses, Supportive Care, home health aides and counselors, in collaboration with Site Leadership.
- Be responsible for oversight of and/or scheduling, payroll and other administrative duties.
- Assure that all initial assessments and required reassessments are conducted by qualified team members within required time frames, including documentation completion, submission and/or synchronization.
- Ensure that all patient/family services comply with federal, state(s) and local regulatory requirements and with accepted professional standards.
- Ensure protocols are utilized to guide operations and promote adherence to regulatory and internal process requirements.
- Monitor expenses related to patient/family services to ensure budgetary compliance in collaboration with IDG and Site Leadership.
- Serve as a resource person and liaison for the Social Worker, Volunteer, Music Therapy and Bereavement Departments.
Our benefits include:
- Medical, dental and vision coverage
- Paid time off and paid holidays
- Professional development opportunities
- Company-matching 401(k)
- Flexible spending and health savings accounts
- Wellness offerings such as an employee assistance program, pet insurance and access to Calm, a meditation, sleep and relaxation app
- Programs to celebrate achievements, milestones and fellow employees
- Company store credit for your first AccentCare-branded scrubs for patient-facing employees
- And more!
Come As You Are
At AccentCare, you’re part of a community that cares — for patients and each other. You can rest assured we offer equal employment opportunities regardless of race, ethnicity, sex, sexual orientation, gender identity, religion, national origin, age or disability.
See All 65+ Clinical Operations Director Jobs
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Find JobsClinical Operations Director Job Market
A snapshot from current openings nationwide, updated as new roles post.
Who's Hiring
- Revolution Medicines5
- AccentCare3
- MannKind Corporation3
- Dana-Farber Cancer Institute2
- Dyne Therapeutics2
Top Industries Hiring
- Biotechnology & Pharmaceuticals28
- Healthcare & Medical Services18
- Education8
- Science & Research8
- Consulting & Professional Services3
What Employers Look For
The qualifications that appear most often in clinical operations director jobs.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- Extensive experience managing Phase I through Phase IV clinical trials end to end
- Deep knowledge of ICH-GCP guidelines, FDA regulations, and applicable international standards
- Proven experience selecting, overseeing, and managing contract research organizations
- Proficiency with electronic data capture systems such as Medidata Rave or Veeva Vault
- Strong cross-functional leadership and budget management experience across global clinical programs
Tips for Your Clinical Operations Director Job Search
Quantify trial oversight on your resume
Clinical operations director candidates who list the number of trials managed, therapeutic areas covered, and team sizes supervised stand out immediately. Hiring managers look for concrete scope, not vague leadership language, so replace phrases like 'oversaw clinical programs' with specific deliverables.
Highlight your ICH-GCP and regulatory fluency
Most job postings require hands-on knowledge of ICH-GCP guidelines, FDA regulations, and at minimum one electronic data capture system. Call these out explicitly in your resume's skills section rather than burying them in job descriptions, where reviewers often miss them.
Target openings by therapeutic area, not just title
Clinical operations directors hired in oncology, rare disease, or CNS trials often need therapy-specific protocol experience. Search by therapeutic area alongside the job title to find openings where your background maps cleanly to what the hiring team actually needs.
Apply early to roles that fit
Migrate Mate lists clinical operations director openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare to discuss budget and vendor management
Interviews at the director level almost always include questions about CRO selection, contract negotiations, and budget oversight. Come ready with a specific example of a vendor relationship you managed, including how you handled performance issues or scope changes mid-trial.
Negotiate start date around study timelines
Clinical operations directors who join mid-study face immediate pressure on deliverables. If you're switching roles, ask where a program stands in its lifecycle before accepting an offer so you can negotiate a start date that gives you adequate onboarding time.
Clinical Operations Director Jobs: Frequently Asked Questions
Which companies are hiring the most clinical operations directors?
The companies hiring the most clinical operations directors right now include Revolution Medicines, AccentCare, and MannKind Corporation, with the largest share of openings in California, Massachusetts, and New York, based on current listings on Migrate Mate as of June 2026. Demand is concentrated in pharmaceutical companies, contract research organizations, and large health systems running active clinical programs.
How many clinical operations director jobs are remote?
About 28% of clinical operations director openings are fully remote or hybrid as of June 2026, reflecting the role's heavy reliance on digital trial infrastructure and cross-site coordination. Sub-areas like CRO oversight, regulatory operations, and quality management tend to offer the most remote flexibility, while roles tied to a specific research site or hospital system more often require on-site presence.
How do you become a clinical operations director?
Most clinical operations directors start in clinical research coordinator or clinical research associate roles, building direct trial execution experience before moving into project management and then program leadership. Earning credentials such as the ACRP Certified Clinical Research Professional designation strengthens your profile. Progressively managing larger trial portfolios, therapeutic areas, and CRO relationships is the clearest path to the director level.
Can you get hired as a clinical operations director with limited director-level experience?
Yes, candidates who have managed full trial lifecycles as a senior manager or associate director can move into a clinical operations director role, especially at smaller biotech companies or startups with lean leadership teams. Demonstrating that you've owned budget accountability, CRO contracts, and cross-functional team leadership, even without the formal title, is more persuasive to most hiring teams than title alone.
What does the clinical operations director interview process look like?
The process typically opens with an HR or talent acquisition screen focused on background and seniority fit, followed by a panel interview with clinical development leadership, regulatory, and sometimes finance stakeholders. Candidates are usually asked to walk through a complex trial they managed end to end and to address a scenario involving a CRO performance problem or a protocol deviation. A final round may include a brief strategic exercise or executive presentation.
Where can I find and apply to clinical operations director jobs?
You can find and apply to clinical operations director jobs on Migrate Mate, which lists current openings from across the United States. Find roles that fit your background and apply directly to each listing from the same place, without having to track openings across multiple sources.
See All 65+ Clinical Operations Director Jobs
Jump back to the full list of openings and apply to any clinical operations director role that fits.
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