Senior Clinical Trial Manager Jobs
Senior Clinical Trial Manager jobs are open across pharmaceutical, biotechnology, contract research, and academic medical center sectors, from mid-level manager to director-track, with specializations in oncology, rare disease, and Phase I–III oversight. Find a role that fits from the openings below and apply directly.
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Showing 5 of 48+ Senior Clinical Trial Manager jobs
Position Summary:
Serves as the clinical trial lead responsible for the planning, conduct and oversight of the operational portion of clinical studies per defined scope of work and ensures that clinical studies are conducted in accordance with the protocol, standard operating procedures (SOPs), ICH-GCP and all applicable regulatory requirements.
Essential functions of the job include but are not limited to:
- Primary clinical point of contact with the client
- Collaborate with PM on monthly invoicing and variance management of clinical budget
- Develop study related clinical documents (e.g. clinical plans, Informed Consent Form templates, study specific forms and manuals, CRF completion guidelines, study trackers, PSV/SIV slides and other training materials)
- Identify and develop training needs for CRAs and third-party vendors specific to the study, protocol and practices including presenting these at Investigator Meetings and Study Kick-off meetings
- Generate potential site list from key stakeholders and drive site feasibility process
- Identify potential risks to the enrollment targets based on feasibility analysis and site's contracted commitment
- Develop and finalize the country recruitment/retention strategy
- Develop timely and effective communication and good working relationships with investigators and study team to ensure effective and timely feasibility, site start up, enrollment, maintenance and close out procedures
- Lead internal clinical team meetings and sets expectations for clinical team of CRAs and CTAs
- Address all CRA and site questions and maintains Frequently Asked Question (FAQ) log as appropriate
- Support in planning and conducting investigator meetings
- Review and/or approve of IP release packages
- Oversee, support and track all submissions and approvals to Competent Authorities and IRB/Ethics Committees in conjunction with regulatory departments as applicable
- Develop clinical monitoring strategies for assuring study timelines are met and assuring quality deliverables
- Generate and utilizes metric reporting (e.g., CTMS, DM Query Trends, Outstanding Monitoring Reports) to ensure that the study is conducted per plan and communicates issues to PM and CRAs as appropriate
- Responsible for eTMF implementation and management
- Collaborate with PM, CRAs and QA to develop any Corrective and Preventative Action Plan (CAPA) and is accountable for implementation and timely closure
- Accountable to assist sites, internal staff and CRAs with the preparation for GCP audits
- Work closely with PM for project-specific resourcing issues
- Escalate pertinent CRA performance and site compliance issues when necessary
- Collaborate with data management and CRAs to ensure data quality and compliance with data cleaning timelines
- Manage processes for investigational product (IP) including drug accountability and reconciliation
- When a cross-functional PM is not assigned to a given program, the CTM will assume project management responsibility as needed
- Support business development and marketing activities as appropriate
- May negotiate site budget and investigator contract with support from the legal department and/or site contracts group
- May review site visit reports and ensures monitoring (i.e. scheduling and scope) is executed per monitoring plan
- May be responsible for management of clinical vendors (e.g. labs, IP, patient diary, home health care) in conjunction with PM
- May perform clinical data review of patient profiles, data listings and summary tables, including query generation
- May have line management responsibilities
- Performs other duties as assigned by management
Qualifications
Minimum Required:
- Bachelor's degree or equivalent combination of education/experience in science or health-related field. Advanced degree preferred
- Minimum of 7 years of clinical research experience or proven competencies for the position with significant clinical monitoring experience
Preferred:
- Advanced degree
Other Required:
- Experience with Microsoft Office Products (Outlook, Word, Excel, PowerPoint)
- Excellent communication and interpersonal skills to effectively interface with others in a team setting
- Excellent organizational skills, attention to detail, and a customer service demeanor
- Ability to travel domestically and internationally including overnight stays
Competencies:
- Demonstrates mastery knowledge of ICH-GCP, relevant Precision SOPs, and regulatory guidance, as well as the ability to implement
- Working knowledge of clinical management techniques and tools
- Direct work experience in a cross-functional environment
- Proven experience in functional management including proven experience in delegating while fostering cohesive team dynamics
- Proven experience in planning, risk management and change management
- High level of integrity and must inspire and demand the highest standards from a professional and ethical perspective
- Ability to lead and inspire excellence within a team
- Ability to create an environment where employees have a sense of ownership that will lead to increases in productivity and efficiency
- Results oriented, accountable, motivated and flexible
- Excellent time management, negotiation, critical thinking, decision making, analytical and interpersonal skills
- Excellent presentation, verbal and written communications skills
- In depth proven experience in pharmaceutical and/or device research required
- Demonstrated successful independent negotiation and conflict management strategies
Any data provided as a part of this application will be stored in accordance with our Privacy Policy. For CA applicants, please also refer to our CA Privacy Notice.
Precision Medicine Group is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status or other characteristics protected by law.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact Precision Medicine Group at QuestionForHR@precisionmedicinegrp.com.
It has come to our attention that some individuals or organizations are reaching out to job seekers and posing as potential employers presenting enticing employment offers. We want to emphasize that these offers are not associated with our company and may be fraudulent in nature. Please note that our organization will not extend a job offer without prior communication with our recruiting team, hiring managers and a formal interview process.
Position Summary:
Serves as the clinical trial lead responsible for the planning, conduct and oversight of the operational portion of clinical studies per defined scope of work and ensures that clinical studies are conducted in accordance with the protocol, standard operating procedures (SOPs), ICH-GCP and all applicable regulatory requirements.
Essential functions of the job include but are not limited to:
- Primary clinical point of contact with the client
- Collaborate with PM on monthly invoicing and variance management of clinical budget
- Develop study related clinical documents (e.g. clinical plans, Informed Consent Form templates, study specific forms and manuals, CRF completion guidelines, study trackers, PSV/SIV slides and other training materials)
- Identify and develop training needs for CRAs and third-party vendors specific to the study, protocol and practices including presenting these at Investigator Meetings and Study Kick-off meetings
- Generate potential site list from key stakeholders and drive site feasibility process
- Identify potential risks to the enrollment targets based on feasibility analysis and site's contracted commitment
- Develop and finalize the country recruitment/retention strategy
- Develop timely and effective communication and good working relationships with investigators and study team to ensure effective and timely feasibility, site start up, enrollment, maintenance and close out procedures
- Lead internal clinical team meetings and sets expectations for clinical team of CRAs and CTAs
- Address all CRA and site questions and maintains Frequently Asked Question (FAQ) log as appropriate
- Support in planning and conducting investigator meetings
- Review and/or approve of IP release packages
- Oversee, support and track all submissions and approvals to Competent Authorities and IRB/Ethics Committees in conjunction with regulatory departments as applicable
- Develop clinical monitoring strategies for assuring study timelines are met and assuring quality deliverables
- Generate and utilizes metric reporting (e.g., CTMS, DM Query Trends, Outstanding Monitoring Reports) to ensure that the study is conducted per plan and communicates issues to PM and CRAs as appropriate
- Responsible for eTMF implementation and management
- Collaborate with PM, CRAs and QA to develop any Corrective and Preventative Action Plan (CAPA) and is accountable for implementation and timely closure
- Accountable to assist sites, internal staff and CRAs with the preparation for GCP audits
- Work closely with PM for project-specific resourcing issues
- Escalate pertinent CRA performance and site compliance issues when necessary
- Collaborate with data management and CRAs to ensure data quality and compliance with data cleaning timelines
- Manage processes for investigational product (IP) including drug accountability and reconciliation
- When a cross-functional PM is not assigned to a given program, the CTM will assume project management responsibility as needed
- Support business development and marketing activities as appropriate
- May negotiate site budget and investigator contract with support from the legal department and/or site contracts group
- May review site visit reports and ensures monitoring (i.e. scheduling and scope) is executed per monitoring plan
- May be responsible for management of clinical vendors (e.g. labs, IP, patient diary, home health care) in conjunction with PM
- May perform clinical data review of patient profiles, data listings and summary tables, including query generation
- May have line management responsibilities
- Performs other duties as assigned by management
Qualifications
Minimum Required:
- Bachelor's degree or equivalent combination of education/experience in science or health-related field. Advanced degree preferred
- Minimum of 7 years of clinical research experience or proven competencies for the position with significant clinical monitoring experience
Preferred:
- Advanced degree
Other Required:
- Experience with Microsoft Office Products (Outlook, Word, Excel, PowerPoint)
- Excellent communication and interpersonal skills to effectively interface with others in a team setting
- Excellent organizational skills, attention to detail, and a customer service demeanor
- Ability to travel domestically and internationally including overnight stays
Competencies:
- Demonstrates mastery knowledge of ICH-GCP, relevant Precision SOPs, and regulatory guidance, as well as the ability to implement
- Working knowledge of clinical management techniques and tools
- Direct work experience in a cross-functional environment
- Proven experience in functional management including proven experience in delegating while fostering cohesive team dynamics
- Proven experience in planning, risk management and change management
- High level of integrity and must inspire and demand the highest standards from a professional and ethical perspective
- Ability to lead and inspire excellence within a team
- Ability to create an environment where employees have a sense of ownership that will lead to increases in productivity and efficiency
- Results oriented, accountable, motivated and flexible
- Excellent time management, negotiation, critical thinking, decision making, analytical and interpersonal skills
- Excellent presentation, verbal and written communications skills
- In depth proven experience in pharmaceutical and/or device research required
- Demonstrated successful independent negotiation and conflict management strategies
Any data provided as a part of this application will be stored in accordance with our Privacy Policy. For CA applicants, please also refer to our CA Privacy Notice.
Precision Medicine Group is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status or other characteristics protected by law.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact Precision Medicine Group at QuestionForHR@precisionmedicinegrp.com.
It has come to our attention that some individuals or organizations are reaching out to job seekers and posing as potential employers presenting enticing employment offers. We want to emphasize that these offers are not associated with our company and may be fraudulent in nature. Please note that our organization will not extend a job offer without prior communication with our recruiting team, hiring managers and a formal interview process.
See All 48+ Senior Clinical Trial Manager Jobs
Jump back to the full list of openings and apply to any senior clinical trial manager role that fits.
Find JobsSenior Clinical Trial Manager Job Market
A snapshot from current openings nationwide, updated as new roles post.
Who's Hiring
- IQVIA5
- Exelixis3
- Precision Medicine3
- Abbott2
- Insmed Incorporated2
Top Industries Hiring
- Biotechnology & Pharmaceuticals30
- Science & Research11
- Consulting & Professional Services9
- Healthcare & Medical Services4
- Education2
What Employers Look For
The qualifications that appear most often in senior clinical trial manager jobs.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- Minimum five to eight years of clinical trial management experience across multiple phases
- Direct site management experience in Phase II or Phase III oncology or specialty therapeutic areas
- Proficiency in electronic data capture systems such as Medidata Rave or Oracle Clinical
- Demonstrated knowledge of ICH E6 Good Clinical Practice guidelines and FDA regulations
- Project Management Professional or equivalent clinical research certification such as CCRA or CCRC
Tips for Your Senior Clinical Trial Manager Job Search
Tailor your resume to trial phase depth
Hiring teams scan for the specific phases you've managed end-to-end. List Phase I, II, or III separately under each role, note the therapeutic area, and quantify site counts or protocol amendments you owned rather than supported.
Highlight ICH E6 and GCP compliance ownership
Senior roles expect you to have led audits, written corrective action plans, and trained site staff, not just followed SOPs. Call out any regulatory authority inspections you prepared for or responded to directly.
Apply early to roles that fit
Migrate Mate lists senior clinical trial manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter openings by therapeutic area first
Oncology, CNS, and rare disease programs often require disease-specific site management experience. Searching by therapeutic area before title lets you focus on roles where your protocol background directly matches what the team needs.
Prepare a cross-functional leadership example
Interviewers at this level probe how you've aligned biostatistics, data management, and regulatory affairs on a single timeline. Walk in with one concrete story where you resolved a cross-functional conflict that had real protocol impact.
Negotiate scope before you negotiate title
Before accepting an offer, clarify portfolio size, the ratio of internal to CRO-managed sites, and whether global coordination is expected. These determine your actual workload and career trajectory more than the title does.
Senior Clinical Trial Manager Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical trial managers?
The companies hiring the most senior clinical trial managers right now include IQVIA, Exelixis, and Precision Medicine, with the largest share of openings in New Jersey, California, and Massachusetts, based on current listings on Migrate Mate as of June 2026. Large CROs and mid-size biotechs tend to post the highest volume of senior-level openings at any given time.
How many senior clinical trial manager jobs are remote?
About 48% of senior clinical trial manager openings are fully remote or hybrid as of June 2026, reflecting the shift toward decentralized trial oversight since site monitoring workflows moved to risk-based models. Roles focused on oversight, vendor management, and data review are most commonly listed as remote, while positions requiring frequent site visits or investigator training tend to require on-site presence.
How do you become a senior clinical trial manager?
You typically start as a clinical research associate or trial coordinator, build several years of on-site monitoring experience across at least two therapeutic areas, then move into a trial manager role overseeing a single study. From there, progressing to senior level means demonstrating cross-functional leadership, managing global or multi-regional protocols, and taking ownership of budget and timeline accountability without direct supervision.
Can you get hired as a senior clinical trial manager without extensive experience?
Transitioning into a senior role with limited management experience is possible if you've held deep hands-on responsibility in a trial coordinator or CRA role, particularly if you've covered protocol deviations, IRB submissions, or site escalations independently. Certifications like CCRA or CCRC help signal readiness, and targeting smaller sponsors or CROs running focused therapeutic programs gives you the best path to a first senior title.
What does the senior clinical trial manager interview process look like?
Most interview processes include an initial recruiter screen, a competency-based interview with the hiring manager focused on protocol complexity and site management decisions, and a panel round with cross-functional stakeholders from regulatory affairs, data management, or medical affairs. Some sponsors add a case study or scenario exercise where you walk through how you'd handle a critical protocol deviation or site underperformance situation before an offer is extended.
Where can I find and apply to senior clinical trial manager jobs?
You can find and apply to senior clinical trial manager jobs on Migrate Mate, which lists current openings from across the United States in one place. Search for roles that match your therapeutic area experience and phase background, then apply directly to each listing that fits.
See All 48+ Senior Clinical Trial Manager Jobs
Jump back to the full list of openings and apply to any senior clinical trial manager role that fits.
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