Senior Clinical Trial Manager Jobs
Senior Clinical Trial Manager jobs are open across pharmaceutical, biotechnology, contract research, and academic medical center sectors, from mid-level manager to director-track, with specializations in oncology, rare disease, and Phase I–III oversight. Find a role that fits from the openings below and apply directly.
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Showing 5 of 205+ Senior Clinical Trial Manager jobs
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
Join Us as a Clinical Trial Coordinator I/II FSP – Make an Impact at the Forefront of Innovation
We have successfully supported the top 50 pharmaceutical companies and more than 750 biotech’s, spanning 2,700 clinical trials across 100+ countries in the last 5 years.
Role-related skills
- Excellent technical/IT skills. Able to understand the impact of technology on studies and to use and develop computer skills while making appropriate use of Client systems/software
- Knowledge of relevant operational procedures, systems and quality guidelines regarding clinical studies
- Able to work independently as well as in a team.
- Professional attitude with good customer focus (internal and external)
Role Responsibilities
- Maintain up to date participating center’s information (including all contact details, contracts and reports).
- Responsible for preparing the Investigator and Sponsor files with essential documents for the initiation of sites participating in clinical studies. Assist Client study staff with maintaining the sponsor files during the life of the study. Responsible for archiving at the end of study in accordance with relevant Client SOPs, policies and local regulatory requirements.
- Input and oversee Client clinical study tracking systems
- Proactively identifies issues and raises them to Client study staff to take necessary corrective action to ensure smooth and rapid progress of studies.
- Assist in the planning, logistics and preparation of local Investigator meetings (travel arrangements, assist with preparation and distribution of study related presentation material etc.)
- Responsible for working with the Client Study staff for the management of study materials, non-IMP and IMP supplies - distribution, ordering, tracking, storage, reconciliation and destruction using external vendor. Details of destruction to be filed.
-
As an active participant of clinical study teams, engage in local study meetings during the life of the study to obtain general knowledge about the study and be responsible for given tasks. Assist Client study staff with study related activities such as:
- organizing study meetings and scheduling travel,
- producing minutes for study-related meetings,
- assembling training and study materials,
- updating contact details,
- maintaining study documentation,
- assisting in the preparation of documents and other tasks as required.
- Knowledgeable of Client systems
- Keep up to date with all the changes/required knowledge on ICH GCP, Client written standards and attending appropriate training sessions.
- May be responsible for supporting multiple studies simultaneously and must prioritize appropriately to meet business needs to ensure delivery of results
- Requirement to communicate and work effectively with medical staff/physicians/scientists who are often senior within their field, being mindful of their standing within the medical and/or research community.
Education and Experience:
For CTC I position:
- High / Secondary school diploma or equivalent and relevant formal academic / vocational qualification.
-
Bachelor's degree preferred.
Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 1+ years).
In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
For CTC II position:
- High / Secondary school diploma or equivalent and relevant formal academic / vocational qualification.
-
Bachelor's degree preferred.
Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years).
In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
Knowledge, Skills and Abilities:
- Ability to work in a team or independently, as required
- Strong organizational skills and attention to detail, with proven ability to handle multiple tasks efficiently and effectively
- Proven ability to effectively analyze project-specific data/systems to ensure accuracy and efficiency
- Strong customer focus
- Demonstrated flexibility and adaptability to reprioritize workload and provide efficient support to meet changing project timelines
- Demonstrated ability to attain and maintain a good working knowledge of applicable Country
- Regulations, ICH Good Clinical Practices, and organization/Client SOPs and WPDs for all non clinical/clinical aspects of project implementation, execution and closeout
- Excellent English language and grammar skills and proficient local language skills as needed
- Good presentation skills
- Excellent computer skills, proficient in MS Office (Word, Excel, and PowerPoint) and ability to obtain knowledge and master all clinical trial database systems
- Ability to successfully complete the organizations clinical training program
- Self-motivated, positive attitude with effective strong interpersonal skills
- Effective oral and written communication skills, with the ability to communicate effectively with medical personnel
- Excellent interpersonal skills
- Strong attention to detail and quality of documentation
- Good negotiation skills
- Good computer skills and the ability to learn appropriate software
- Fluency in local language as well as a good command of the English language and grammar skills
- Basic medical/therapeutic area and medical terminology knowledge
- Ability to work in a team environment or independently, under direction, as required
- Basic organizational and planning skills
- Basic knowledge of local health systems
- Ability to attain and maintain a working knowledge of GCP and applicable SOPs
- Excellent customer focus
- Proven flexibility and adaptability
- Ability to work in a matrix environment
- A proven relationship builder
- An independent thinker
- Ability to manage risk and perform risk escalation appropriately
Compensation and Benefits
This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
This job posting is for multiple levels: The salary range estimated for the second level is: $22.00–$27.00Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
Join Us as a Clinical Trial Coordinator I/II FSP – Make an Impact at the Forefront of Innovation
We have successfully supported the top 50 pharmaceutical companies and more than 750 biotech’s, spanning 2,700 clinical trials across 100+ countries in the last 5 years.
Role-related skills
- Excellent technical/IT skills. Able to understand the impact of technology on studies and to use and develop computer skills while making appropriate use of Client systems/software
- Knowledge of relevant operational procedures, systems and quality guidelines regarding clinical studies
- Able to work independently as well as in a team.
- Professional attitude with good customer focus (internal and external)
Role Responsibilities
- Maintain up to date participating center’s information (including all contact details, contracts and reports).
- Responsible for preparing the Investigator and Sponsor files with essential documents for the initiation of sites participating in clinical studies. Assist Client study staff with maintaining the sponsor files during the life of the study. Responsible for archiving at the end of study in accordance with relevant Client SOPs, policies and local regulatory requirements.
- Input and oversee Client clinical study tracking systems
- Proactively identifies issues and raises them to Client study staff to take necessary corrective action to ensure smooth and rapid progress of studies.
- Assist in the planning, logistics and preparation of local Investigator meetings (travel arrangements, assist with preparation and distribution of study related presentation material etc.)
- Responsible for working with the Client Study staff for the management of study materials, non-IMP and IMP supplies - distribution, ordering, tracking, storage, reconciliation and destruction using external vendor. Details of destruction to be filed.
-
As an active participant of clinical study teams, engage in local study meetings during the life of the study to obtain general knowledge about the study and be responsible for given tasks. Assist Client study staff with study related activities such as:
- organizing study meetings and scheduling travel,
- producing minutes for study-related meetings,
- assembling training and study materials,
- updating contact details,
- maintaining study documentation,
- assisting in the preparation of documents and other tasks as required.
- Knowledgeable of Client systems
- Keep up to date with all the changes/required knowledge on ICH GCP, Client written standards and attending appropriate training sessions.
- May be responsible for supporting multiple studies simultaneously and must prioritize appropriately to meet business needs to ensure delivery of results
- Requirement to communicate and work effectively with medical staff/physicians/scientists who are often senior within their field, being mindful of their standing within the medical and/or research community.
Education and Experience:
For CTC I position:
- High / Secondary school diploma or equivalent and relevant formal academic / vocational qualification.
-
Bachelor's degree preferred.
Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 1+ years).
In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
For CTC II position:
- High / Secondary school diploma or equivalent and relevant formal academic / vocational qualification.
-
Bachelor's degree preferred.
Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years).
In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
Knowledge, Skills and Abilities:
- Ability to work in a team or independently, as required
- Strong organizational skills and attention to detail, with proven ability to handle multiple tasks efficiently and effectively
- Proven ability to effectively analyze project-specific data/systems to ensure accuracy and efficiency
- Strong customer focus
- Demonstrated flexibility and adaptability to reprioritize workload and provide efficient support to meet changing project timelines
- Demonstrated ability to attain and maintain a good working knowledge of applicable Country
- Regulations, ICH Good Clinical Practices, and organization/Client SOPs and WPDs for all non clinical/clinical aspects of project implementation, execution and closeout
- Excellent English language and grammar skills and proficient local language skills as needed
- Good presentation skills
- Excellent computer skills, proficient in MS Office (Word, Excel, and PowerPoint) and ability to obtain knowledge and master all clinical trial database systems
- Ability to successfully complete the organizations clinical training program
- Self-motivated, positive attitude with effective strong interpersonal skills
- Effective oral and written communication skills, with the ability to communicate effectively with medical personnel
- Excellent interpersonal skills
- Strong attention to detail and quality of documentation
- Good negotiation skills
- Good computer skills and the ability to learn appropriate software
- Fluency in local language as well as a good command of the English language and grammar skills
- Basic medical/therapeutic area and medical terminology knowledge
- Ability to work in a team environment or independently, under direction, as required
- Basic organizational and planning skills
- Basic knowledge of local health systems
- Ability to attain and maintain a working knowledge of GCP and applicable SOPs
- Excellent customer focus
- Proven flexibility and adaptability
- Ability to work in a matrix environment
- A proven relationship builder
- An independent thinker
- Ability to manage risk and perform risk escalation appropriately
Compensation and Benefits
This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
This job posting is for multiple levels: The salary range estimated for the second level is: $22.00–$27.00Senior Clinical Trial Manager Jobs by Experience Level
Top Cities Hiring Senior Clinical Trial Managers
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Find JobsSenior Clinical Trial Manager Job Market
Who's Hiring
- Medpace61
- Thermo Fisher Scientific7
- Biogen3
- Moderna3
- Heartflow3
Top Industries Hiring
- Science & Research62
- Biotechnology & Pharmaceuticals19
- Healthcare & Medical Services12
- Medical Devices6
- Consulting & Professional Services4
What Employers Look For
The qualifications that appear most often in senior clinical trial manager jobs.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- Minimum five to eight years of clinical trial management experience across multiple phases
- Direct site management experience in Phase II or Phase III oncology or specialty therapeutic areas
- Proficiency in electronic data capture systems such as Medidata Rave or Oracle Clinical
- Demonstrated knowledge of ICH E6 Good Clinical Practice guidelines and FDA regulations
- Project Management Professional or equivalent clinical research certification such as CCRA or CCRC
Tips for Your Senior Clinical Trial Manager Job Search
Tailor your resume to trial phase depth
Hiring teams scan for the specific phases you've managed end-to-end. List Phase I, II, or III separately under each role, note the therapeutic area, and quantify site counts or protocol amendments you owned rather than supported.
Highlight ICH E6 and GCP compliance ownership
Senior roles expect you to have led audits, written corrective action plans, and trained site staff, not just followed SOPs. Call out any regulatory authority inspections you prepared for or responded to directly.
Apply early to roles that fit
Migrate Mate lists senior clinical trial manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter openings by therapeutic area first
Oncology, CNS, and rare disease programs often require disease-specific site management experience. Searching by therapeutic area before title lets you focus on roles where your protocol background directly matches what the team needs.
Prepare a cross-functional leadership example
Interviewers at this level probe how you've aligned biostatistics, data management, and regulatory affairs on a single timeline. Walk in with one concrete story where you resolved a cross-functional conflict that had real protocol impact.
Negotiate scope before you negotiate title
Before accepting an offer, clarify portfolio size, the ratio of internal to CRO-managed sites, and whether global coordination is expected. These determine your actual workload and career trajectory more than the title does.
Senior Clinical Trial Manager Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical trial managers?
The companies hiring the most senior clinical trial managers right now include Medpace, Thermo Fisher Scientific, and Biogen, with the largest share of openings in Massachusetts, Ohio, and California, based on current listings on Migrate Mate as of August 2026. Large CROs and mid-size biotechs tend to post the highest volume of senior-level openings at any given time.
How many senior clinical trial manager jobs are remote?
About 55% of senior clinical trial manager openings are fully remote or hybrid as of August 2026, reflecting the shift toward decentralized trial oversight since site monitoring workflows moved to risk-based models. Roles focused on oversight, vendor management, and data review are most commonly listed as remote, while positions requiring frequent site visits or investigator training tend to require on-site presence.
How do you become a senior clinical trial manager?
You typically start as a clinical research associate or trial coordinator, build several years of on-site monitoring experience across at least two therapeutic areas, then move into a trial manager role overseeing a single study. From there, progressing to senior level means demonstrating cross-functional leadership, managing global or multi-regional protocols, and taking ownership of budget and timeline accountability without direct supervision.
Can you get hired as a senior clinical trial manager without extensive experience?
Transitioning into a senior role with limited management experience is possible if you've held deep hands-on responsibility in a trial coordinator or CRA role, particularly if you've covered protocol deviations, IRB submissions, or site escalations independently. Certifications like CCRA or CCRC help signal readiness, and targeting smaller sponsors or CROs running focused therapeutic programs gives you the best path to a first senior title.
What does the senior clinical trial manager interview process look like?
Most interview processes include an initial recruiter screen, a competency-based interview with the hiring manager focused on protocol complexity and site management decisions, and a panel round with cross-functional stakeholders from regulatory affairs, data management, or medical affairs. Some sponsors add a case study or scenario exercise where you walk through how you'd handle a critical protocol deviation or site underperformance situation before an offer is extended.
Where can I find and apply to senior clinical trial manager jobs?
You can find and apply to senior clinical trial manager jobs on Migrate Mate, which lists current openings from across the United States in one place. Search for roles that match your therapeutic area experience and phase background, then apply directly to each listing that fits.
See All 205+ Senior Clinical Trial Manager Jobs
Find roles that match your experience and apply in just a few clicks.
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