Senior Clinical Trial Manager Jobs
Senior Clinical Trial Manager jobs are open across pharmaceutical, biotechnology, contract research, and academic medical center sectors, from mid-level manager to director-track, with specializations in oncology, rare disease, and Phase I–III oversight. Find a role that fits from the openings below and apply directly.
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Showing 5 of 202+ Senior Clinical Trial Manager jobs
Key Responsibilities:
Education, Experience and Knowledge:
Essential Qualifications:
Non-Essential Qualifications:
US Salary Range
$140,000-$155,000
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
Key Responsibilities:
Education, Experience and Knowledge:
Essential Qualifications:
Non-Essential Qualifications:
US Salary Range
$140,000-$155,000
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
Senior Clinical Trial Manager Jobs by Experience Level
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Find JobsSenior Clinical Trial Manager Job Market
Who's Hiring
- IQVIA17
- Medpace10
- Zurich Insurance6
- Thermo Fisher Scientific6
- サイネオス・ヘルス5
Top Industries Hiring
- Biotechnology & Pharmaceuticals21
- Healthcare & Medical Services14
- Science & Research8
- Consulting & Professional Services5
- Education1
What Employers Look For
The qualifications that appear most often in senior clinical trial manager jobs.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- Minimum five to eight years of clinical trial management experience across multiple phases
- Direct site management experience in Phase II or Phase III oncology or specialty therapeutic areas
- Proficiency in electronic data capture systems such as Medidata Rave or Oracle Clinical
- Demonstrated knowledge of ICH E6 Good Clinical Practice guidelines and FDA regulations
- Project Management Professional or equivalent clinical research certification such as CCRA or CCRC
Tips for Your Senior Clinical Trial Manager Job Search
Tailor your resume to trial phase depth
Hiring teams scan for the specific phases you've managed end-to-end. List Phase I, II, or III separately under each role, note the therapeutic area, and quantify site counts or protocol amendments you owned rather than supported.
Highlight ICH E6 and GCP compliance ownership
Senior roles expect you to have led audits, written corrective action plans, and trained site staff, not just followed SOPs. Call out any regulatory authority inspections you prepared for or responded to directly.
Apply early to roles that fit
Migrate Mate lists senior clinical trial manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter openings by therapeutic area first
Oncology, CNS, and rare disease programs often require disease-specific site management experience. Searching by therapeutic area before title lets you focus on roles where your protocol background directly matches what the team needs.
Prepare a cross-functional leadership example
Interviewers at this level probe how you've aligned biostatistics, data management, and regulatory affairs on a single timeline. Walk in with one concrete story where you resolved a cross-functional conflict that had real protocol impact.
Negotiate scope before you negotiate title
Before accepting an offer, clarify portfolio size, the ratio of internal to CRO-managed sites, and whether global coordination is expected. These determine your actual workload and career trajectory more than the title does.
Senior Clinical Trial Manager Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical trial managers?
The companies hiring the most senior clinical trial managers right now include IQVIA, Medpace, and Zurich Insurance, with the largest share of openings in California, Massachusetts, and North Carolina, based on current listings on Migrate Mate as of November 2026. Large CROs and mid-size biotechs tend to post the highest volume of senior-level openings at any given time.
How many senior clinical trial manager jobs are remote?
About 73% of senior clinical trial manager openings are fully remote or hybrid as of November 2026, reflecting the shift toward decentralized trial oversight since site monitoring workflows moved to risk-based models. Roles focused on oversight, vendor management, and data review are most commonly listed as remote, while positions requiring frequent site visits or investigator training tend to require on-site presence.
How do you become a senior clinical trial manager?
You typically start as a clinical research associate or trial coordinator, build several years of on-site monitoring experience across at least two therapeutic areas, then move into a trial manager role overseeing a single study. From there, progressing to senior level means demonstrating cross-functional leadership, managing global or multi-regional protocols, and taking ownership of budget and timeline accountability without direct supervision.
Can you get hired as a senior clinical trial manager without extensive experience?
Transitioning into a senior role with limited management experience is possible if you've held deep hands-on responsibility in a trial coordinator or CRA role, particularly if you've covered protocol deviations, IRB submissions, or site escalations independently. Certifications like CCRA or CCRC help signal readiness, and targeting smaller sponsors or CROs running focused therapeutic programs gives you the best path to a first senior title.
What does the senior clinical trial manager interview process look like?
Most interview processes include an initial recruiter screen, a competency-based interview with the hiring manager focused on protocol complexity and site management decisions, and a panel round with cross-functional stakeholders from regulatory affairs, data management, or medical affairs. Some sponsors add a case study or scenario exercise where you walk through how you'd handle a critical protocol deviation or site underperformance situation before an offer is extended.
Where can I find and apply to senior clinical trial manager jobs?
You can find and apply to senior clinical trial manager jobs on Migrate Mate, which lists current openings from across the United States in one place. Search for roles that match your therapeutic area experience and phase background, then apply directly to each listing that fits.
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