Senior Level Senior Clinical Trial Manager Jobs
Senior level senior clinical trial manager jobs put experienced professionals in charge of trial strategy, cross-functional oversight, and the operational teams driving complex studies from activation to close-out. Openings are concentrated across on-site, remote, and hybrid settings in Biotechnology & Pharmaceuticals, Science & Research, and Insurance, with employers like Zurich Insurance, Eikon Therapeutics, and Abbott hiring at this level now.
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About EGenesis
eGenesis is a clinical-stage biotechnology company developing human-compatible engineered organs to address the severe global organ shortage. The Company’s proprietary genome engineering platform enables extensive, multiplex gene edits to remove key biological barriers, add protective human transgenes, and inactivate endogenous retroviruses. EGEN-2784, a genetically engineered porcine kidney, is the Company’s lead program and is currently being evaluated in a multi-patient Expanded Access study at MGH. eGenesis is headquartered in Cambridge, MA.
Position Summary
eGenesis is seeking a resourceful and collaborative Senior Clinical Trial Manager to join our Clinical Operations team to support programs across our portfolio. This role will work closely with our teams across Regulatory, Quality, GMP Production, and Development to successfully drive our clinical programs. As the Senior Clinical Trial Manager, you will be responsible for the day-to-day management of our clinical studies, vendors, and sites in alignment with corporate and program goals. You will work closely with clinical sites and CROs to ensure compliance with SOPs and regulatory guidelines. To be successful in this role, you will leverage a passion for the details, excellent communication skills and an eagerness to collaborate.
Primary Responsibilities
- Assist in overall management of clinical trials, including but not limited to managing study timelines and budgets as well as providing CRO and other external vendor oversight
- Assist in preparation and review of clinical study documentation including, but not limited to, protocol, informed consent, study plans, lab manuals, Case Report Forms, Clinical Study Reports, and other study level documents
- Engage cross-functionally to ensure clear, consistent communication to key stakeholders on study status, metrics and timelines
- Ensure implementation and conduct of study(ies) in accordance with SOPs and ICH-GCP guidelines
- Serve as a point of contact for CRO and clinical site communication
- Assist in the set up the Trial Master File (TMF) and ensure appropriate TMF maintenance throughout the trial, including periodic reviews
- Lead internal study team calls and ensure appropriate cross functional follow up and resolution to tasks in a timely manner
- Participate and coordinate resolution of audit findings and ensure audit-ready condition of clinical trial documentation including central clinical files
- Proactively identify risks in study timelines in regard to key milestones and deliverables and work closely with the cross-functional teams to mitigate downstream impacts
Qualifications
- Bachelor’s degree, life science or medical background preferred
- 7+ years work experience in life sciences or medically related field, including 4+ years of biopharmaceutical clinical research experience obtained working on clinical trials in a biotech, pharmaceutical or CRO company
- Experience in oversight of external vendors (e.g. CROs, central labs, etc.)
- Strong interpersonal and organizational skills are needed, with a high degree of attention to detail with ability to flex communication style to all areas of the organization
- Working knowledge of Good Clinical Practices (GCP) and other relevant regulatory requirements
- Ability to travel up to 10% of the time
- Ability to be onsite in the Cambridge office 2 days per week
Base pay range for this job is $142,800 - $176,400.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
About EGenesis
eGenesis is a clinical-stage biotechnology company developing human-compatible engineered organs to address the severe global organ shortage. The Company’s proprietary genome engineering platform enables extensive, multiplex gene edits to remove key biological barriers, add protective human transgenes, and inactivate endogenous retroviruses. EGEN-2784, a genetically engineered porcine kidney, is the Company’s lead program and is currently being evaluated in a multi-patient Expanded Access study at MGH. eGenesis is headquartered in Cambridge, MA.
Position Summary
eGenesis is seeking a resourceful and collaborative Senior Clinical Trial Manager to join our Clinical Operations team to support programs across our portfolio. This role will work closely with our teams across Regulatory, Quality, GMP Production, and Development to successfully drive our clinical programs. As the Senior Clinical Trial Manager, you will be responsible for the day-to-day management of our clinical studies, vendors, and sites in alignment with corporate and program goals. You will work closely with clinical sites and CROs to ensure compliance with SOPs and regulatory guidelines. To be successful in this role, you will leverage a passion for the details, excellent communication skills and an eagerness to collaborate.
Primary Responsibilities
- Assist in overall management of clinical trials, including but not limited to managing study timelines and budgets as well as providing CRO and other external vendor oversight
- Assist in preparation and review of clinical study documentation including, but not limited to, protocol, informed consent, study plans, lab manuals, Case Report Forms, Clinical Study Reports, and other study level documents
- Engage cross-functionally to ensure clear, consistent communication to key stakeholders on study status, metrics and timelines
- Ensure implementation and conduct of study(ies) in accordance with SOPs and ICH-GCP guidelines
- Serve as a point of contact for CRO and clinical site communication
- Assist in the set up the Trial Master File (TMF) and ensure appropriate TMF maintenance throughout the trial, including periodic reviews
- Lead internal study team calls and ensure appropriate cross functional follow up and resolution to tasks in a timely manner
- Participate and coordinate resolution of audit findings and ensure audit-ready condition of clinical trial documentation including central clinical files
- Proactively identify risks in study timelines in regard to key milestones and deliverables and work closely with the cross-functional teams to mitigate downstream impacts
Qualifications
- Bachelor’s degree, life science or medical background preferred
- 7+ years work experience in life sciences or medically related field, including 4+ years of biopharmaceutical clinical research experience obtained working on clinical trials in a biotech, pharmaceutical or CRO company
- Experience in oversight of external vendors (e.g. CROs, central labs, etc.)
- Strong interpersonal and organizational skills are needed, with a high degree of attention to detail with ability to flex communication style to all areas of the organization
- Working knowledge of Good Clinical Practices (GCP) and other relevant regulatory requirements
- Ability to travel up to 10% of the time
- Ability to be onsite in the Cambridge office 2 days per week
Base pay range for this job is $142,800 - $176,400.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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Senior Level Senior Clinical Trial Manager Jobs: Frequently Asked Questions
How do I get a senior level senior clinical trial manager job?
Employers at this level look for candidates who have owned full trial lifecycles independently, not just supported them. Demonstrating cross-functional leadership, regulatory submission experience, and a history of managing CROs or site networks gives you a clear edge. Strong candidates can also articulate how their work directly shaped study timelines, budget outcomes, or protocol decisions.
Which companies hire senior level senior clinical trial managers?
Companies hiring senior level senior clinical trial managers right now include Zurich Insurance, Eikon Therapeutics, and Abbott, based on current listings on Migrate Mate as of August 2026. Hiring at this level comes primarily from large pharmaceutical and biotech sponsors, full-service CROs, and medical device companies running multi-site or global studies.
Are there remote senior level senior clinical trial manager jobs?
Yes, remote and hybrid options are widely available at this experience level. About 80% of senior level senior clinical trial manager openings are remote or hybrid as of August 2026, reflecting how sponsors and CROs have structured trial oversight roles since the shift toward decentralized operations. On-site roles do still exist, particularly at sites tied to specific research facilities.
What makes a senior clinical trial manager role senior level?
Senior level roles carry full operational ownership of one or more trials, often across multiple sites or countries. Candidates are expected to set timelines, resolve escalated site issues, manage vendor relationships independently, and mentor junior or mid-level trial managers. The depth of regulatory knowledge required and the expectation to contribute to process improvement or protocol development also distinguish these positions from mid-level roles.
Which industries hire the most senior level senior clinical trial managers?
Senior level senior clinical trial manager roles concentrate in Biotechnology & Pharmaceuticals, Science & Research, and Insurance, based on current listings on Migrate Mate as of August 2026. These sectors drive demand because they run the largest and most complex clinical programs, requiring experienced managers who can handle regulatory complexity, multi-site logistics, and sponsor or CRO relationships without close supervision.