Mid Level Senior Clinical Trial Manager Jobs
Mid level senior clinical trial manager jobs go to professionals ready to own protocol execution, coordinate cross-functional teams, and resolve site-level challenges with minimal oversight. 25% of openings are remote or hybrid, concentrated in Biotechnology & Pharmaceuticals, Healthcare & Medical Services, and Consulting & Professional Services, with Medpace, IQVIA, and Iqvia hiring at this level now.
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Showing 5 of 19+ Mid Level Senior Clinical Trial Manager jobs
Job Title: Clinical Trial Manager
Location: North Carolina
Summary
We are seeking an experienced Clinical Trial Manager (CTM) to oversee the clinical operations, quality, timelines, resources, and deliverables of assigned clinical studies. The ideal candidate will have 5+ years of clinical research experience with strong knowledge of clinical monitoring, ICH-GCP, FDA regulations, study start-up, TMF management, and clinical trial operations. This role will primarily support low-to-moderate complexity studies and work closely with cross-functional clinical teams, project managers, study sites, and clients.
Responsibilities
- Manage clinical operational and quality activities for assigned studies in compliance with ICH-GCP, FDA guidelines, and study-specific requirements.
- Develop and maintain Monitoring Plans, Monitoring Guidelines, Data Quality Plans, and clinical tracking tools.
- Ensure timely setup, maintenance, and quality of Trial Master Files (TMF) and essential study documentation.
- Monitor study timelines, milestones, metrics, clinical deliverables, CRF collection, query resolution, and monitoring visit reports.
- Lead clinical team meetings and coordinate resources, responsibilities, timelines, and deliverables.
- Conduct or co-monitor clinical trials and perform Accompanied Field Visits (AFVs) when required.
- Identify study risks, delays, and resource constraints and implement appropriate recovery actions.
- Support study start-up, ethics committee submissions, regulatory submissions, and resolution of committee queries.
- Communicate with clinical sites regarding protocols, patient participation, CRF completion, and study-related issues.
- Collaborate with Project Managers and cross-functional teams for client meetings, study planning, handoffs, and project execution.
- Support clinical resource management, workload allocation, budgeting, forecasting, and financial tracking.
- Ensure clinical activities remain within contractual scope, timelines, quality, and budget requirements.
- Ensure timely archiving of study documents and materials.
Requirements
- Bachelor’s degree or equivalent relevant education/qualification.
- 5+ years of relevant clinical research or clinical trial experience.
- Hands-on experience in clinical trial operations and clinical monitoring.
- Strong understanding of ICH-GCP, FDA regulations, and clinical research requirements.
- Experience with TMF, CRFs, monitoring reports, clinical tracking, and query management.
- Knowledge of study start-up, site management, and ethics/regulatory submissions.
- Strong leadership, mentoring, communication, and team coordination skills.
- Excellent planning, organizational, prioritization, and problem-solving abilities.
- Ability to work effectively in a matrix, multicultural, and changing environment.
- Strong attention to detail and sound judgment/decision-making skills.
- Understanding of clinical trial budgets, forecasting, resource allocation, and financial management.
- Proficiency with Microsoft Office tools including Excel, Word, and Outlook.
- Excellent written and verbal English communication skills.
Job Title: Clinical Trial Manager
Location: North Carolina
Summary
We are seeking an experienced Clinical Trial Manager (CTM) to oversee the clinical operations, quality, timelines, resources, and deliverables of assigned clinical studies. The ideal candidate will have 5+ years of clinical research experience with strong knowledge of clinical monitoring, ICH-GCP, FDA regulations, study start-up, TMF management, and clinical trial operations. This role will primarily support low-to-moderate complexity studies and work closely with cross-functional clinical teams, project managers, study sites, and clients.
Responsibilities
- Manage clinical operational and quality activities for assigned studies in compliance with ICH-GCP, FDA guidelines, and study-specific requirements.
- Develop and maintain Monitoring Plans, Monitoring Guidelines, Data Quality Plans, and clinical tracking tools.
- Ensure timely setup, maintenance, and quality of Trial Master Files (TMF) and essential study documentation.
- Monitor study timelines, milestones, metrics, clinical deliverables, CRF collection, query resolution, and monitoring visit reports.
- Lead clinical team meetings and coordinate resources, responsibilities, timelines, and deliverables.
- Conduct or co-monitor clinical trials and perform Accompanied Field Visits (AFVs) when required.
- Identify study risks, delays, and resource constraints and implement appropriate recovery actions.
- Support study start-up, ethics committee submissions, regulatory submissions, and resolution of committee queries.
- Communicate with clinical sites regarding protocols, patient participation, CRF completion, and study-related issues.
- Collaborate with Project Managers and cross-functional teams for client meetings, study planning, handoffs, and project execution.
- Support clinical resource management, workload allocation, budgeting, forecasting, and financial tracking.
- Ensure clinical activities remain within contractual scope, timelines, quality, and budget requirements.
- Ensure timely archiving of study documents and materials.
Requirements
- Bachelor’s degree or equivalent relevant education/qualification.
- 5+ years of relevant clinical research or clinical trial experience.
- Hands-on experience in clinical trial operations and clinical monitoring.
- Strong understanding of ICH-GCP, FDA regulations, and clinical research requirements.
- Experience with TMF, CRFs, monitoring reports, clinical tracking, and query management.
- Knowledge of study start-up, site management, and ethics/regulatory submissions.
- Strong leadership, mentoring, communication, and team coordination skills.
- Excellent planning, organizational, prioritization, and problem-solving abilities.
- Ability to work effectively in a matrix, multicultural, and changing environment.
- Strong attention to detail and sound judgment/decision-making skills.
- Understanding of clinical trial budgets, forecasting, resource allocation, and financial management.
- Proficiency with Microsoft Office tools including Excel, Word, and Outlook.
- Excellent written and verbal English communication skills.
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Top Industries Hiring
- Biotechnology & Pharmaceuticals13
- Healthcare & Medical Services5
- Consulting & Professional Services4
- Medical Devices2
- Technology & Software1
Mid Level Senior Clinical Trial Manager Jobs: Frequently Asked Questions
How do I get a mid level senior clinical trial manager job?
Position yourself as someone who has moved beyond execution into ownership. Highlight experience managing study timelines, vendor relationships, or site escalations independently. Emphasize protocol deviations you resolved, budgets you tracked, and cross-functional teams you coordinated. Tailor your application to show that you drive trial progress without waiting for direction, and quantify your impact wherever possible.
Which companies hire mid level senior clinical trial managers?
Companies hiring mid level senior clinical trial managers right now include Medpace, IQVIA, and Iqvia, based on current listings on Migrate Mate as of August 2026. Hiring at this level comes from a mix of large pharmaceutical companies, mid-size contract research organizations, and emerging biotech sponsors building out their clinical operations teams.
Are there remote mid level senior clinical trial manager jobs?
Yes, though availability varies by sponsor and study phase. About 25% of mid level senior clinical trial manager openings are remote or hybrid as of August 2026, reflecting how much of the coordination work can be handled without being on site. Roles tied to active site visits or sponsor headquarters tend to require more in-person presence.
How do I move up to a mid level senior clinical trial manager role?
Growth from entry level into mid level comes from accumulating ownership, not just exposure. Early-career clinical trial professionals should seek roles where they manage site relationships directly, take lead on protocol training, and handle deviation documentation without heavy supervision. Demonstrating consistent delivery across multiple studies and building cross-functional communication skills accelerates the transition into mid level responsibility.
Which industries hire the most mid level senior clinical trial managers?
Mid Level senior clinical trial manager roles concentrate in Biotechnology & Pharmaceuticals, Healthcare & Medical Services, and Consulting & Professional Services, based on current listings on Migrate Mate as of August 2026. Those sectors drive the most hiring because they operate ongoing pipeline development that requires experienced trial managers who can run studies with limited escalation to senior leadership.