Acute Care Nurse Practitioner Jobs
Acute Care Nurse Practitioner jobs are open across hospital systems, academic medical centers, and specialty practices, from new-grad to experienced clinician, with concentrations in critical care, cardiology, and pulmonology. Find a role that fits from the openings below and apply directly.
Find JobsOverview
Showing 5 of 283+ Acute Care Nurse Practitioner jobs











Successful candidates will be comfortable working across multiple care environments and have experience supporting rapid response functions, including MERIT and RAPID teams, as well as triage and the management of deteriorating patients on the floor. They must be confident in identifying clinical decline, initiating timely interventions, and collaborating effectively with multidisciplinary teams.
Candidates must be able to commit to a night shift schedule of 6:00 PM to 6:00 AM, working seven shifts every two weeks, including weekends and rotating holidays.
This role requires individuals who thrive in fast-paced environments, possess strong communication skills, and are committed to delivering high-quality, patient-centered care.
The primary purpose of the Midlevel Provider is to provide patient care in the inpatient setting. The Midlevel Provider will work as a member of the MLP Nocturnal Coverage Team to provide initial assessment and management of urgent issues at night related to internal medicine or critical care needs across the institution. The Midlevel Provider will facilitate communication and carry out orders from attending physicians related to patient care.
KEY FUNCTIONS
1. Provides competent patient care in the inpatient setting across the institution.
2. Provides initial assessment and management for urgent internal medicine or critical care needs at night.
3. Conducts comprehensive health assessments, identifies normal and abnormal health characteristics, initiates appropriate care and continuously evaluates care outcomes.
4. Provides post-admission assessments for night time admissions.
5. Completes sign-out communications and patient care logs as directed by the medical director and administrative director of the Nocturnal Coverage Team.
6. May also perform delegated functions under the supervision of the physician to include differential diagnosis, use of prescriptive authority and treatment of a variety of human responses according to practice guidelines, protocols or standing orders.
7. Uses judgment to collaborate with the healthcare team to manage client care throughout the continuum of care and in a variety of settings.
MD Anderson offers employees:
- Paid employee medical benefits (zero premium) starting on first day for employees who work 30 or more hours per week.
- Group Dental, Vision, Life, AD&D and Disability coverage.
- Paid time off (PTO) and Extended Illness Bank (EIB) paid leave accruals.
- Paid institutional holidays, wellness leave, childcare leave, and other paid leave programs.
- Tuition Assistance Program after six months of service.
- Teachers Retirement System defined-benefit pension plan and two voluntary retirement plans.
- Employer paid life, AD&D and an illness-related reduced salary pay program.
- Extensive wellness, recognition, fitness, employee health programs and employee resource groups.
- Opportunities for professional growth through Career Development Center and Mentoring programs.
EDUCATION
- : Degree requirements as defined by the Texas Board of Nursing (BON) or Texas State Board of Physician Assistant Examiners (TSBPAE) as required for clinical licensure as an Advanced Practice Registered Nurse or Physician Assistant.
- :
WORK EXPERIENCE
- Required: 2 years Professional clinical experience. Required experience may be substituted with the successful completion of a one year advanced practice provider fellowship/residency program.
- Preferred: 3 years Three to five years experience as a clinical advanced practice provider. Previous clinical practice in oncology, critical care, internal medicine, hospital medicine or pediatrics.
LICENSES AND CERTIFICATIONS
- Required: PA - Physician Assistant Written authorization from the Texas State Board of Physician Assistant Examiners (TSBPAE) to function as Physician Assistant. Upon Hire or
- Required: APRN - Adv Practice Registered Nurse Written authorization from the Texas Board of Nursing (BON) to function as an Advanced Practice Registered Nurse. Upon Hire or
- Required: ACNP - Acute Care Nurse Practitioner Upon Hire or
- Required: ACNPC - Acute Care Nurse Practitioner - AACCNCC Upon Hire or
- Required: ACAGNP - Acute Care Adult/Geron NP Upon Hire or
- Required: AGACNP -Adult-Gerontology AcuteCare NP Upon Hire or
- Required: AGPCNP -Adult-Gero Primary Care NP Upon Hire or
- Required: ACNPC-AG - Cert AD GEY Acute Care NP Upon Hire or
- Required: AGNP - Adult/Gerontology NP Upon Hire or
- Required: ACPNP -Acute Care Pediatric Nurs Prac Upon Hire or
- Required: ANP - Adult Nurse Practitioner Upon Hire or
- Required: FNP - Family Nurse Practitioner Upon Hire or
- Required: GNP - Gerontological Nurse Prac Upon Hire or
- Required: PNP - Pediatric Nurse Practit Upon Hire or
- Required: PMHNP - Psych/Mental Health NP Upon Hire or
- Required: WHNP - Womans Health Nurse Pract. Upon Hire or
- Required: APNP - Advanced Practice NP Upon Hire or
- Required: BLS - Basic Life Support Upon Hire or
- Required: Cardiopulmonary Resuscitation (CPR) Upon Hire or
- Preferred: BLS - Basic Life Support American Heart Association Basic Life Support Upon Hire
- Preferred: PALS - Pediatric Advanced Life Support Certification as required by patient care area. Upon Hire
- Required: Clinical Privileges Must obtain and maintain relevant clinical privileges. Continued employment in this position at MD Anderson is contingent upon maintaining these privileges.
The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition.
This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state, or local laws unless such distinction is required by law.http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Additional Information
- Requisition ID: 182821
- Employment Status: Full-Time
- Employee Status: Regular
- Work Week: Nights, Rotating, Varied, Weekends
- Minimum Salary: US Dollar (USD) 117,500
- Midpoint Salary: US Dollar (USD) 146,500
- Maximum Salary : US Dollar (USD) 176,500
- FLSA: exempt and eligible for overtime, paid at a time and a half rate
- Fund Type: Hard
- Work Location: Onsite
- Pivotal Position: Yes
- Referral Bonus Available?: Yes
- Relocation Assistance Available?: Yes
#LI-Onsite
Acute Care Nurse Practitioner Jobs by Experience Level
Top Cities Hiring Acute Care Nurse Practitioners
Explore acute care nurse practitioner openings in the cities hiring most right now.
See All 283+ Acute Care Nurse Practitioner Jobs
Find roles that match your experience and apply in just a few clicks.
Find JobsAcute Care Nurse Practitioner Job Market
Who's Hiring
- Houston Methodist27

- Baylor Scott & White Health24

- Cleveland Clinic14

- TeamHealth11

- Penn Medicine9

Top Industries Hiring
- Healthcare & Medical Services73
- Education15
- Consulting & Professional Services2
- Insurance1
- Science & Research1
What Employers Look For
The qualifications that appear most often in acute care nurse practitioner jobs.
- Master of Science in Nursing or Doctor of Nursing Practice from an accredited program
- ACNPC-AG or AGACNP certification from ANCC or AACN
- Active unrestricted RN and APRN licensure in the state of employment
- Minimum one to two years of acute or critical care clinical experience as an RN or NP
- Current BLS, ACLS, and often PALS certification
- Proficiency with electronic health record systems such as Epic or Cerner
Tips for Your Acute Care Nurse Practitioner Job Search
Tailor your resume to patient acuity
Hiring managers for acute care roles scan for evidence of managing high-acuity patients independently. Quantify your case complexity, ventilator management experience, or procedural skills like central line placement rather than listing general NP duties.
Highlight your ACNPC-AG or AGACNP credential prominently
Many acute care postings screen out candidates who bury their certification. Place your adult-gerontology acute care NP credential directly after your name on your resume so recruiters and ATS filters catch it in the first pass.
Filter openings by inpatient versus outpatient scope
Acute care NP postings vary widely in actual setting. Read the job description for phrases like rapid response team, ICU rounding, or hospitalist model to confirm the role matches your clinical background before you apply.
Apply early to roles that fit
Migrate Mate lists acute care nurse practitioner openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare for a clinical scenario interview
Acute care NP interviews often include a rapid-assessment scenario, such as a deteriorating sepsis patient or acute respiratory failure. Practice walking through your clinical reasoning aloud, including your differential, orders, and escalation decision, so your thought process is clear under pressure.
Negotiate scope of practice before accepting
Before signing an offer, ask specifically which procedures you will perform independently, how physician collaboration is structured, and whether the role includes on-call obligations. These details directly affect workload and professional satisfaction and are often negotiable at the offer stage.
Acute Care Nurse Practitioner Jobs: Frequently Asked Questions
Which companies are hiring the most acute care nurse practitioners?
The companies hiring the most acute care nurse practitioners right now include Houston Methodist, Baylor Scott & White Health, and Cleveland Clinic, with the largest share of openings in Texas, Ohio, and New York, based on current listings on Migrate Mate as of September 2026. Large health systems and academic medical centers consistently post the highest volume of acute care NP roles.
How many acute care nurse practitioner jobs are remote?
About 5% of acute care nurse practitioner openings are fully remote or hybrid as of September 2026, reflecting the hands-on nature of most acute care settings. The sub-areas most likely to offer remote or telehealth components include post-discharge follow-up, tele-ICU consultation, and chronic disease management programs attached to acute care systems.
How do you become an acute care nurse practitioner?
You become an acute care nurse practitioner by earning a Bachelor of Science in Nursing, passing the NCLEX-RN, and gaining clinical experience as a registered nurse, ideally in an ICU, ED, or step-down unit. You then complete a graduate-level acute care NP program and pass the ACNPC-AG or AGACNP board exam before applying for APRN licensure in your state.
Can you get hired as an acute care nurse practitioner with little experience?
Yes, some health systems hire new-graduate acute care NPs, particularly those with strong RN backgrounds in critical care or emergency settings. New-grad acute care NP fellowships and residency programs at larger academic hospitals offer structured onboarding and are a practical entry point. Prioritizing postings that explicitly list new graduates as eligible will narrow your search to realistic targets.
What does the acute care nurse practitioner interview process look like?
The acute care NP interview typically begins with a phone or video screen with a recruiter or nurse manager, followed by an in-person panel that includes physicians, fellow NPs, and sometimes nursing leadership. Most hospitals include a clinical scenario or case presentation to assess your diagnostic reasoning. A credentialing review and reference check follow before an offer is extended.
Where can I find and apply to acute care nurse practitioner jobs?
You can find and apply to acute care nurse practitioner jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your specialty, setting, and location, then apply directly to each listing from the same place.
See All 283+ Acute Care Nurse Practitioner Jobs
Find roles that match your experience and apply in just a few clicks.
Find Jobs