Senior Level Clinical Trial Manager Jobs
Senior level clinical trial manager jobs put experienced professionals in charge of trial strategy, cross-functional team leadership, and end-to-end study execution accountability. Openings concentrate in Biotechnology & Pharmaceuticals, Science & Research, and Education, with 75% remote or hybrid availability, and employers like Eikon Therapeutics, Abbott, and Medpace hiring at this level now.
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About EGenesis
eGenesis is a clinical-stage biotechnology company developing human-compatible engineered organs to address the severe global organ shortage. The Company’s proprietary genome engineering platform enables extensive, multiplex gene edits to remove key biological barriers, add protective human transgenes, and inactivate endogenous retroviruses. EGEN-2784, a genetically engineered porcine kidney, is the Company’s lead program and is currently being evaluated in a multi-patient Expanded Access study at MGH. eGenesis is headquartered in Cambridge, MA.
Position Summary
eGenesis is seeking a resourceful and collaborative Senior Clinical Trial Manager to join our Clinical Operations team to support programs across our portfolio. This role will work closely with our teams across Regulatory, Quality, GMP Production, and Development to successfully drive our clinical programs. As the Senior Clinical Trial Manager, you will be responsible for the day-to-day management of our clinical studies, vendors, and sites in alignment with corporate and program goals. You will work closely with clinical sites and CROs to ensure compliance with SOPs and regulatory guidelines. To be successful in this role, you will leverage a passion for the details, excellent communication skills and an eagerness to collaborate.
Primary Responsibilities
- Assist in overall management of clinical trials, including but not limited to managing study timelines and budgets as well as providing CRO and other external vendor oversight
- Assist in preparation and review of clinical study documentation including, but not limited to, protocol, informed consent, study plans, lab manuals, Case Report Forms, Clinical Study Reports, and other study level documents
- Engage cross-functionally to ensure clear, consistent communication to key stakeholders on study status, metrics and timelines
- Ensure implementation and conduct of study(ies) in accordance with SOPs and ICH-GCP guidelines
- Serve as a point of contact for CRO and clinical site communication
- Assist in the set up the Trial Master File (TMF) and ensure appropriate TMF maintenance throughout the trial, including periodic reviews
- Lead internal study team calls and ensure appropriate cross functional follow up and resolution to tasks in a timely manner
- Participate and coordinate resolution of audit findings and ensure audit-ready condition of clinical trial documentation including central clinical files
- Proactively identify risks in study timelines in regard to key milestones and deliverables and work closely with the cross-functional teams to mitigate downstream impacts
Qualifications
- Bachelor’s degree, life science or medical background preferred
- 7+ years work experience in life sciences or medically related field, including 4+ years of biopharmaceutical clinical research experience obtained working on clinical trials in a biotech, pharmaceutical or CRO company
- Experience in oversight of external vendors (e.g. CROs, central labs, etc.)
- Strong interpersonal and organizational skills are needed, with a high degree of attention to detail with ability to flex communication style to all areas of the organization
- Working knowledge of Good Clinical Practices (GCP) and other relevant regulatory requirements
- Ability to travel up to 10% of the time
- Ability to be onsite in the Cambridge office 2 days per week
Base pay range for this job is $142,800 - $176,400.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
About EGenesis
eGenesis is a clinical-stage biotechnology company developing human-compatible engineered organs to address the severe global organ shortage. The Company’s proprietary genome engineering platform enables extensive, multiplex gene edits to remove key biological barriers, add protective human transgenes, and inactivate endogenous retroviruses. EGEN-2784, a genetically engineered porcine kidney, is the Company’s lead program and is currently being evaluated in a multi-patient Expanded Access study at MGH. eGenesis is headquartered in Cambridge, MA.
Position Summary
eGenesis is seeking a resourceful and collaborative Senior Clinical Trial Manager to join our Clinical Operations team to support programs across our portfolio. This role will work closely with our teams across Regulatory, Quality, GMP Production, and Development to successfully drive our clinical programs. As the Senior Clinical Trial Manager, you will be responsible for the day-to-day management of our clinical studies, vendors, and sites in alignment with corporate and program goals. You will work closely with clinical sites and CROs to ensure compliance with SOPs and regulatory guidelines. To be successful in this role, you will leverage a passion for the details, excellent communication skills and an eagerness to collaborate.
Primary Responsibilities
- Assist in overall management of clinical trials, including but not limited to managing study timelines and budgets as well as providing CRO and other external vendor oversight
- Assist in preparation and review of clinical study documentation including, but not limited to, protocol, informed consent, study plans, lab manuals, Case Report Forms, Clinical Study Reports, and other study level documents
- Engage cross-functionally to ensure clear, consistent communication to key stakeholders on study status, metrics and timelines
- Ensure implementation and conduct of study(ies) in accordance with SOPs and ICH-GCP guidelines
- Serve as a point of contact for CRO and clinical site communication
- Assist in the set up the Trial Master File (TMF) and ensure appropriate TMF maintenance throughout the trial, including periodic reviews
- Lead internal study team calls and ensure appropriate cross functional follow up and resolution to tasks in a timely manner
- Participate and coordinate resolution of audit findings and ensure audit-ready condition of clinical trial documentation including central clinical files
- Proactively identify risks in study timelines in regard to key milestones and deliverables and work closely with the cross-functional teams to mitigate downstream impacts
Qualifications
- Bachelor’s degree, life science or medical background preferred
- 7+ years work experience in life sciences or medically related field, including 4+ years of biopharmaceutical clinical research experience obtained working on clinical trials in a biotech, pharmaceutical or CRO company
- Experience in oversight of external vendors (e.g. CROs, central labs, etc.)
- Strong interpersonal and organizational skills are needed, with a high degree of attention to detail with ability to flex communication style to all areas of the organization
- Working knowledge of Good Clinical Practices (GCP) and other relevant regulatory requirements
- Ability to travel up to 10% of the time
- Ability to be onsite in the Cambridge office 2 days per week
Base pay range for this job is $142,800 - $176,400.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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Senior Level Clinical Trial Manager Jobs: Frequently Asked Questions
How do I get a senior level clinical trial manager job?
Senior level clinical trial manager roles go to candidates who demonstrate ownership of complex, multi-site studies from startup through closeout. Hiring managers look for evidence of regulatory expertise across ICH-GCP guidelines, experience managing CRO relationships, and a history of leading junior team members. Tailoring your application to show scope, budget accountability, and cross-functional leadership gives you the clearest edge at this stage.
Which companies hire senior level clinical trial managers?
Companies hiring senior level clinical trial managers right now include Eikon Therapeutics, Abbott, and Medpace, based on current listings on Migrate Mate as of August 2026. Hiring at this level comes primarily from large pharmaceutical companies, contract research organizations, and mid-size biotechs running late-phase or registrational programs.
Are there remote senior level clinical trial manager jobs?
Yes, though the mix varies by employer and therapeutic area. About 75% of senior level clinical trial manager openings are remote or hybrid as of August 2026, reflecting the shift toward decentralized trial models. Fully on-site roles still exist, particularly at sponsors with large internal clinical operations teams or early-phase site networks.
What makes a clinical trial manager role senior level?
Senior level clinical trial managers own full study execution, not just task completion. That means setting trial timelines, managing vendor contracts, resolving protocol deviations, and serving as the primary escalation point for site and cross-functional issues. They also mentor associate and mid-level managers and contribute to process improvements, SOPs, and departmental strategy, a scope that distinguishes them from coordinators or mid-level managers.
Which industries hire the most senior level clinical trial managers?
Senior Level clinical trial manager roles concentrate in Biotechnology & Pharmaceuticals, Science & Research, and Education, based on current listings on Migrate Mate as of August 2026. These sectors drive demand because they run the largest volumes of Phase II through Phase IV studies and require experienced professionals who can manage regulatory complexity and multi-country site networks at scale.