Senior Level Cluster General Manager Jobs
Senior level cluster general manager jobs place experienced hospitality and operations leaders in charge of multi-property strategy, revenue performance, and the cross-functional teams that execute across each asset. Openings concentrate across Education, Technology & Software, and Biotechnology & Pharmaceuticals, with 75% remote or hybrid availability, and employers like Amazon, NVIDIA, and Perrigo hiring at this level now.
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Showing 5 of 6+ Senior Level Cluster General Manager jobs
At Perrigo, we are driven by our mission to Makes Lives Better Through Trusted Health and Wellness Solutions, Accessible to All. We are proud to be a Top 10 player in the European Consumer Self-Care market and the largest U.S. store brand provider of over the counter and infant formula. Dedicated to providing The Best Self-Care for Everyone, we are the people behind the brands you trust. We are Opill®, Compeed®, Solpadeine®, NiQuitin®, and many more. We Are Perrigo. We are committed to enhancing the wellbeing of our colleagues and consumers alike. We pride ourselves on fostering an inclusive, collaborative culture where each person can experience a sense of belonging.
Join us on our One Perrigo journey as we evolve to win in self-care.
Description Overview
As Senior Manager Regulatory Affairs - Cluster (North America), you are accountable for in-market regulatory activation, execution, and health authority engagement across the cluster. You translate Category Regulatory strategies into effective local execution, ensuring compliant, timely approvals and enabling business growth across North America.
You support Head of Cluster to act as the primary regulatory interface to health authorities (e.g., FDA and Health Canada), and as a strategic partner to in-market commercial teams. You are accountable for regulatory delivery performance and submission readiness, working in partnership with Category Regulatory Affairs and LCM & Regulatory Operations.
This role sits within the Cluster Regulatory Affairs pillar, accountable for in-market execution and regulatory delivery. Category Regulatory Affairs owns ideation-to-launch strategy, regulatory pathways, and global dossier expectations; this role provides market input and executes the agreed strategy locally. LCM & Regulatory Operations owns regulatory classification governance, post-launch lifecycle activities (non-innovation), and operational processes and systems; this role sets market priorities and delivery expectations. Final submission sign-off is owned by Markets in partnership with Category Regulatory Affairs; this role leads readiness, execution, and regulatory recommendation.
Office location preference is to be based out of Allegan, MI or Morristown, NJ with a hybrid working schedule.
Scope of the Role
Cluster Regulatory
- Define and lead the regional regulatory execution priorities, aligned to Category strategies - representing the function on the Commercial Cluster multifunctional team and being a business enabling partner at Cluster level
- Translate Category regulatory strategies into actionable market execution plans, providing key market insight and regulatory intelligence
- Support Cluster Head to lead engagement with FDA and Health Canada
- Collaborate with regional commercial, medical, quality, and policy teams to ensure regulatory execution supports business growth and market competitiveness
Regulatory Operations & Lifecycle Management
- Responsible for cluster regulatory delivery performance and set submission priorities aligned to commercial objectives
- Partner with LCM & Reg Ops ensuring effective execution of post-launch lifecycle activities
Health Authority Engagement & Policy Influence
- Maintain relationships with health authorities across the cluster, representing Perrigo in regional industry associations and policy forums
- Provide strategic input to Category Regulatory Affairs and enterprise governance on regulatory trends, policy developments, and external risks
Innovation Enablement & Business Growth
- Partner with Category Regulatory team to support innovation pipelines. Lead in-market regulatory execution for innovation
- Provide market-specific feasibility, regulatory pathway implications, and timing assessments to inform portfolio decisions and launch planning
- Regulatory business partner to commercial teams
- Support business development, licensing, and M&A activities Identify opportunities to optimize regulatory pathways, accelerate approvals, and enable competitive advantage
-
Compliance, Governance & Risk Management
- Ensure compliance with all applicable regulatory requirements at the market level within the cluster
- Support inspection readiness and regulatory response
- Maintains local trackers; monitors regulatory changes; advises business on local impact and mitigations. Ensure appropriate regulatory governance is applied to submissions, claims, and labelling decisions
-
Regional Vigilance
- Accountable for regulatory vigilance compliance delivered in partnership with Global Patient Safety
- Ensure inspection and audit readiness for vigilance-related regulatory requirements
- Provide regulatory oversight to ensure alignment between local market requirements and global vigilance frameworks
- Support identification, assessment, mitigation of safety-related regulatory risks
- Ensure timely and accurate regulatory reporting and documentation related to vigilance obligations
Team Leadership & Capability Building
- Lead, develop, and inspire high-performing cluster project management regulatory team aligned with Perrigo core values and behaviors
- Build and strengthen capability in health authority engagement, regulatory execution, and business partnering
- Support alignment and ways of working across Cluster Regulatory Affairs, Category Regulatory Affairs, and LCM & Regulatory Operations, ensuring clarity of roles, responsibilities, and decision-making
Act as a role model within the organization, promoting enterprise thinking and cross-functional collaboration across Regulatory, R&D, Commercial, Quality, and Medical
Experience Required
- Degree in Regulatory Affairs, Life Sciences, Pharmacy, or a related field.
- 12+ years of progressive regulatory affairs experience within consumer health or pharmaceuticals.
- Demonstrated experience in leading regulatory strategy execution and delivery at market or regional level, including health authority interactions.
- Strong experience with North America regulatory frameworks (e.g., FDA and/or Health Canada), or equivalent regional expertise where applicable.
- Proven ability to act as the primary regulatory interface with health authorities, including managing complex submissions, negotiations, and issue resolution.
- Strong business acumen with the ability to partner effectively with commercial and cross-functional stakeholders to enable growth.
Benefits
We believe our people are our greatest asset. Alongside competitive compensation, we offer benefits tailored to supporting you and your family, as well as career development opportunities to ensure you feel valued and supported, both professionally and personally.
Find out more about Total Rewards at Perrigo.
Hybrid Working Approach
We love our offices and the setting they provide for in-person collaboration and celebration. But we also appreciate the opportunity to work remotely can energise you too, so we promote flexibility with the ability to work two days a week from home in many roles.
We are proud to be included in the Forbes list of "America's Best Employers by State 2024". Find out more here
Applicants please note: To apply to this position please click the APPLY button at the bottom of the application. (The SAVE button will only save your profile information but not submit an application for this open position.) All application materials, including resumes and CVs, must be submitted in English. Thank you.
We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or other characteristics protected by law. #weareperrigo
At Perrigo, we are driven by our mission to Makes Lives Better Through Trusted Health and Wellness Solutions, Accessible to All. We are proud to be a Top 10 player in the European Consumer Self-Care market and the largest U.S. store brand provider of over the counter and infant formula. Dedicated to providing The Best Self-Care for Everyone, we are the people behind the brands you trust. We are Opill®, Compeed®, Solpadeine®, NiQuitin®, and many more. We Are Perrigo. We are committed to enhancing the wellbeing of our colleagues and consumers alike. We pride ourselves on fostering an inclusive, collaborative culture where each person can experience a sense of belonging.
Join us on our One Perrigo journey as we evolve to win in self-care.
Description Overview
As Senior Manager Regulatory Affairs - Cluster (North America), you are accountable for in-market regulatory activation, execution, and health authority engagement across the cluster. You translate Category Regulatory strategies into effective local execution, ensuring compliant, timely approvals and enabling business growth across North America.
You support Head of Cluster to act as the primary regulatory interface to health authorities (e.g., FDA and Health Canada), and as a strategic partner to in-market commercial teams. You are accountable for regulatory delivery performance and submission readiness, working in partnership with Category Regulatory Affairs and LCM & Regulatory Operations.
This role sits within the Cluster Regulatory Affairs pillar, accountable for in-market execution and regulatory delivery. Category Regulatory Affairs owns ideation-to-launch strategy, regulatory pathways, and global dossier expectations; this role provides market input and executes the agreed strategy locally. LCM & Regulatory Operations owns regulatory classification governance, post-launch lifecycle activities (non-innovation), and operational processes and systems; this role sets market priorities and delivery expectations. Final submission sign-off is owned by Markets in partnership with Category Regulatory Affairs; this role leads readiness, execution, and regulatory recommendation.
Office location preference is to be based out of Allegan, MI or Morristown, NJ with a hybrid working schedule.
Scope of the Role
Cluster Regulatory
- Define and lead the regional regulatory execution priorities, aligned to Category strategies - representing the function on the Commercial Cluster multifunctional team and being a business enabling partner at Cluster level
- Translate Category regulatory strategies into actionable market execution plans, providing key market insight and regulatory intelligence
- Support Cluster Head to lead engagement with FDA and Health Canada
- Collaborate with regional commercial, medical, quality, and policy teams to ensure regulatory execution supports business growth and market competitiveness
Regulatory Operations & Lifecycle Management
- Responsible for cluster regulatory delivery performance and set submission priorities aligned to commercial objectives
- Partner with LCM & Reg Ops ensuring effective execution of post-launch lifecycle activities
Health Authority Engagement & Policy Influence
- Maintain relationships with health authorities across the cluster, representing Perrigo in regional industry associations and policy forums
- Provide strategic input to Category Regulatory Affairs and enterprise governance on regulatory trends, policy developments, and external risks
Innovation Enablement & Business Growth
- Partner with Category Regulatory team to support innovation pipelines. Lead in-market regulatory execution for innovation
- Provide market-specific feasibility, regulatory pathway implications, and timing assessments to inform portfolio decisions and launch planning
- Regulatory business partner to commercial teams
- Support business development, licensing, and M&A activities Identify opportunities to optimize regulatory pathways, accelerate approvals, and enable competitive advantage
-
Compliance, Governance & Risk Management
- Ensure compliance with all applicable regulatory requirements at the market level within the cluster
- Support inspection readiness and regulatory response
- Maintains local trackers; monitors regulatory changes; advises business on local impact and mitigations. Ensure appropriate regulatory governance is applied to submissions, claims, and labelling decisions
-
Regional Vigilance
- Accountable for regulatory vigilance compliance delivered in partnership with Global Patient Safety
- Ensure inspection and audit readiness for vigilance-related regulatory requirements
- Provide regulatory oversight to ensure alignment between local market requirements and global vigilance frameworks
- Support identification, assessment, mitigation of safety-related regulatory risks
- Ensure timely and accurate regulatory reporting and documentation related to vigilance obligations
Team Leadership & Capability Building
- Lead, develop, and inspire high-performing cluster project management regulatory team aligned with Perrigo core values and behaviors
- Build and strengthen capability in health authority engagement, regulatory execution, and business partnering
- Support alignment and ways of working across Cluster Regulatory Affairs, Category Regulatory Affairs, and LCM & Regulatory Operations, ensuring clarity of roles, responsibilities, and decision-making
Act as a role model within the organization, promoting enterprise thinking and cross-functional collaboration across Regulatory, R&D, Commercial, Quality, and Medical
Experience Required
- Degree in Regulatory Affairs, Life Sciences, Pharmacy, or a related field.
- 12+ years of progressive regulatory affairs experience within consumer health or pharmaceuticals.
- Demonstrated experience in leading regulatory strategy execution and delivery at market or regional level, including health authority interactions.
- Strong experience with North America regulatory frameworks (e.g., FDA and/or Health Canada), or equivalent regional expertise where applicable.
- Proven ability to act as the primary regulatory interface with health authorities, including managing complex submissions, negotiations, and issue resolution.
- Strong business acumen with the ability to partner effectively with commercial and cross-functional stakeholders to enable growth.
Benefits
We believe our people are our greatest asset. Alongside competitive compensation, we offer benefits tailored to supporting you and your family, as well as career development opportunities to ensure you feel valued and supported, both professionally and personally.
Find out more about Total Rewards at Perrigo.
Hybrid Working Approach
We love our offices and the setting they provide for in-person collaboration and celebration. But we also appreciate the opportunity to work remotely can energise you too, so we promote flexibility with the ability to work two days a week from home in many roles.
We are proud to be included in the Forbes list of "America's Best Employers by State 2024". Find out more here
Applicants please note: To apply to this position please click the APPLY button at the bottom of the application. (The SAVE button will only save your profile information but not submit an application for this open position.) All application materials, including resumes and CVs, must be submitted in English. Thank you.
We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or other characteristics protected by law. #weareperrigo
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Top Industries Hiring
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Senior Level Cluster General Manager Jobs: Frequently Asked Questions
How do I get a senior level cluster general manager job?
Employers at this level want candidates who have already owned multi-property or multi-unit performance, not just supported it. Demonstrating a history of leading GMs, hitting portfolio-wide revenue targets, and driving operational consistency across locations is what sets candidates apart. Strong candidates also show they can build and develop management teams, not just manage individual contributors.
Which companies hire senior level cluster general managers?
Companies hiring senior level cluster general managers right now include Amazon, NVIDIA, and Perrigo, based on current listings on Migrate Mate as of November 2026. At this level, hiring tends to come from large hotel groups, hospitality management firms, and multi-site operators with complex portfolio structures that require dedicated cluster-level leadership.
Are there remote senior level cluster general manager jobs?
Yes, though most cluster general manager roles are on-site by nature given the hands-on operational scope. About 75% of senior level cluster general manager openings are remote or hybrid as of November 2026, and those tend to be regional oversight or corporate operations roles rather than property-based positions. Filtering by work setting on Migrate Mate will surface what is available.
What makes a cluster general manager role senior level?
Senior level cluster general manager roles carry accountability for multiple properties or business units simultaneously, including P&L ownership, strategic planning, and leadership of property-level general managers. The distinction from mid-level is scope: senior roles set direction rather than follow it, mentor other leaders rather than just manage staff, and are accountable for portfolio outcomes rather than individual property metrics.
Which industries hire the most senior level cluster general managers?
Senior Level cluster general manager roles concentrate in Education, Technology & Software, and Biotechnology & Pharmaceuticals, based on current listings on Migrate Mate as of November 2026. These sectors drive hiring at this level because they operate multi-unit or multi-property structures that require a single senior leader to unify standards, performance, and team development across multiple locations.